追觅 - 2026-01-07

生成时间: 2026−01-07 12:25

分析文章数量: 46

1 Treatment-related Outcomes and Patterns of Relapse in Secondary CNS Involvement by Large B-cell Lymphoma

推荐理由: 该研究基于国际多中心队列，为缺乏治疗共识的继发性中枢神经系统大B细胞淋巴瘤提供了重要的预后数据和影响因素分析，对血液科临床实践具有直接的参考价值。

摘要: Secondary central nervous system (CNS) large B-cell lymphoma (SCNSL) occurs in the de novo setting, as a CNS-isolated relapse, or synchronous (concomitant CNS and systemic) relapse. SCNSL is a devastating event without therapeutic consensus. Thus, we aimed to evaluate treatment outcomes in an international cohort. Progression-free survival (PFS), overall survival (OS) and cumulative incidence of relapse (CIR, estimated using competing-risk models) were reported. Prognostic factors were…

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2 Bone marrow failure, somatic rescue by p53 inactivation, and enhanced leukemogenesis in germline ERCC6L2 disease

推荐理由: 该研究深入揭示了ERCC6L2缺陷导致骨髓衰竭和TP53突变克隆造血的分子机制，对理解骨髓衰竭综合征向血液恶性肿瘤转化具有重要借鉴价值，为临床诊疗提供了新思路。

摘要: Recessively inherited loss-of-function mutations in Excision Repair Cross-Complementing 6 like 2 (ERCC6L2) cause a bone marrow failure (BMF) syndrome characterized by moderate cytopenias, frequent somatic TP53 mutations, and a propensity to develop myeloid malignancies. The pathophysiology and molecular mechanisms underlying the BMF syndrome as well as its association with TP53-mutant clonal hematopoiesis (CH) and myeloid malignancies have remained poorly understood. Using novel preclinical in…

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3 Harnessing the CD2 axis to broaden and enhance the efficacy of CAR T-cell therapies

推荐理由: 该研究针对T细胞淋巴瘤/白血病缺乏有效靶向治疗的临床难题，创新性地提出靶向CD2的CAR-T策略以克服传统T细胞抗原靶点导致的“自相残杀”问题，对血液肿瘤的免疫治疗具有重要借鉴价值。

摘要: Patients with T-cell lymphomas and leukemias have overall poor outcomes due to the lack of targeted and effective treatments, particularly in the relapsed and refractory settings. Development of chimeric antigen receptor (CAR) T-cells against T-cell neoplasms is limited by a lack of discriminating T-cell antigens that allow for effective anti-tumor responses while preventing CAR T-cell fratricide. We hypothesized that targeting CD2, a pan-T-cell antigen, using anti-CD2 CAR T-cells engineered…

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4 Time of Day of CAR T-Cell Infusion and Outcomes in Large B-Cell Lymphoma

推荐理由: 该研究首次在国际多中心大样本中探索CAR-T细胞输注时间与疗效的关系，为优化淋巴瘤免疫治疗策略提供了具有潜在临床转化价值的时间生物学依据，对血液肿瘤治疗具有直接参考意义。

摘要: Circadian rhythms orchestrate immune activation and effector function, yet whether within-day timing influences chimeric antigen receptor (CAR) T-cell therapy outcomes remains unknown. We conducted an international, multicenter retrospective study of 1,052 adults with relapsed or refractory large B-cell lymphoma treated with CD19-directed CAR T-cell therapy across seven centers (2017-2025). The median infusion time was 11:48 AM (interquartile range, 11:06 AM-12:45 PM). Each hour later in…

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5 Harnessing the CD2 axis to broaden and enhance the efficacy of CAR T-cell therapies

推荐理由: 该研究针对T细胞淋巴瘤/白血病缺乏有效靶向治疗的临床难题，创新性地提出以CD2为靶点的CAR-T策略，并尝试解决CAR-T细胞“自相残杀”的关键技术瓶颈，对血液肿瘤的免疫治疗发展具有重要借鉴价值。

摘要: Patients with T-cell lymphomas and leukemias have overall poor outcomes due to the lack of targeted and effective treatments, particularly in the relapsed and refractory settings. Development of chimeric antigen receptor (CAR) T-cells against T-cell neoplasms is limited by a lack of discriminating T-cell antigens that allow for effective anti-tumor responses while preventing CAR T-cell fratricide. We hypothesized that targeting CD2, a pan-T-cell antigen, using anti-CD2 CAR T-cells engineered…

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6 Redefining cell therapy: CAR-engineered innate immune cells to conquer solid and hematologic malignancies

推荐理由: 该文章系统探讨了CAR技术向固有免疫细胞拓展的前沿进展，为血液系统肿瘤（如淋巴瘤、白血病）的免疫治疗提供了新的可借鉴方向，具有显著的临床转化潜力。

摘要: Chimeric antigen receptor (CAR) technology has revolutionized cancer therapy, yet its full potential remains untapped within the innate immune system. Beyond CAR-T cells, a growing cadre of MHC-independent effectors, including NK cells, macrophages, γδ T cells and the emerging innate-like T cells such as invariant NKT (iNKT) and mucosal-associated invariant T (MAIT) cells, offer complementary mechanisms for tumor recognition and elimination. These platforms combine facile, off-the-shelf…

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7 Lactate: elucidating its indispensable role in human health

推荐理由: 该文章系统阐述了乳酸作为信号分子和表观遗传修饰调节剂（乳酸化）的全新角色，为理解血液肿瘤代谢重编程、免疫微环境调控及寻找新的治疗靶点提供了前沿且极具启发性的理论框架。

摘要: Lactate, traditionally considered just a byproduct of metabolism, is now understood to be a vital regulator in energy metabolism, immune function, and epigenetic changes. Besides serving as an alternative energy source through the “lactate shuttle,” it acts as a signaling molecule influencing both normal and abnormal processes in various organs. New research has emphasized its role in lactylation of histones and non-histones, a novel post-translational modification linking metabolic activity…

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8 Chronic Active Epstein-Barr Virus Disease: Molecular Pathogenesis, Evolving Concepts, and Emerging Therapies

推荐理由: 本文系统总结了CAEBV的最新疾病概念、诊断框架及分子免疫病理进展，并整合了2022年国际共识与WHO分类更新，对血液

摘要: Chronic active Epstein-Barr virus (CAEBV) disease is an uncommon, often lethal T and/or NK (T/NK)-cell lymphoproliferative disorder that remains underrecognized outside Asia. Recent advances in molecular and immunopathologic studies-together with the 2022 International Consensus Classification and the 5th World Health Organization lymphoma classification-have consolidated the disease concept and diagnostic framework. Recent studies support a model wherein mutated EBV infects hematopoietic stem…

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9 Automated Classification of Lymphoma Subtypes From Histopathological Images Using a U-Net Deep Learning Model: Comparative Evaluation Study

推荐理由: 该研究将U-Net架构的深度学习技术应用于淋巴瘤亚型自动分类与分级，显著提升了诊断效率和准确性，对血液病理学的智能化诊断具有直接的借鉴价值和临床转化潜力。

摘要: CONCLUSIONS: Deep learning techniques based on the U-Net architecture offer considerable advantages in the automated classification and grading of lymphoma subtypes. The proposed model significantly improved diagnostic accuracy and accelerated pathological evaluation, providing efficient and precise support for clinical decision-making. Future work may focus on enhancing model robustness through integration with advanced algorithms and validating performance across multicenter clinical datasets….

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10 Axicabtagene ciloleucel in combination with rituximab for refractory large B cell lymphoma: the phase 2, single-arm ZUMA-14 trial

推荐理由: 该研究针对CAR-T治疗后CD19阴性复发的临床难题，提出了联合利妥昔单抗的潜在解决方案，对优化淋巴瘤治疗策略具有直接参考价值。

摘要: CD19-negative relapse occurs in  30% of persons with relapsed or refractory large B cell lymphoma (LBCL) who respond to axicabtagene ciloleucel (axi-cel; CD19-directed chimeric antigen receptor (CAR) T cell therapy). In this phase 2 single-arm study, 26 participants with chemorefractory LBCL received axi-cel in combination with rituximab. The primary endpoint was investigator-assessed complete response rate; select secondary endpoints included duration of response (DOR), axi-cel pharmacokinetics…

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11 High-resolution single-cell RNA sequencing using canFam4 reveals novel immune subsets and checkpoint programs in healthy dogs

推荐理由: 该研究首次在健康犬类中通过单细胞测序解析免疫检查点机制，其创新的方法学和高质量数据可为人类血液病（如自身免疫性溶血性贫血、淋巴瘤）的免疫调控研究提供跨物种参考。

摘要: CONCLUSION: To our knowledge, this study represents the first comprehensive, gene-resolved single-cell analysis to reveal immunoregulatory checkpoint mechanisms underlying immune homeostasis in healthy dogs. Our dataset will serve as a valuable resource for future comparative and translational immunology research in dogs.

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12 Integrative Bioinformatics Reveals Novel Molecular Mechanisms and Therapeutic Targets in Acute Myeloid Leukaemia

推荐理由: 该研究通过多数据集整合分析，揭示了不同AML亚型及药物处理下保守的分子机制，方法严谨且结果对开发靶向治疗策略具有较高借鉴价值。

摘要: Acute myeloid leukaemia (AML) is a genetically heterogeneous malignancy associated with poor prognosis and limited treatment options. To identify molecular programs conserved across AML subtypes and perturbations, we analysed three RNA sequencing datasets that captured venetoclax treatment under metabolic stress and the knockdown of chromatin regulators (PSPC1, JMJD1C, and RUNX1). Differential expression analysis was performed using DESeq2, followed by functional enrichment and network analyses….

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13 Integrative transcriptomics defines CD36 as a key regulator of immunometabolic signaling in acute myeloid leukemia

推荐理由: 该研究通过整合转录组学与空间验证技术，揭示了AML中CD36介导的免疫代谢信号机制，为血液肿瘤的靶向治疗提供了新的潜在方向，具有较高的方法学借鉴价值。

摘要: CONCLUSION: Integration of transcriptomics and spatial validation revealed robust CD36-mediated immunometabolic signaling in AML, which further requires comprehensive in-vitro and in-vivo validation.

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14 Acute Myeloid Leukemia With a Non-Canonical

FLT3</em> V491L Mutation: A Case Report With Ex Vivo</em> FLT3 Inhibitors Sensitivity Testing

推荐理由: 该文章针对罕见FLT3 V491L突变提供了临床治疗案例与分子机制探讨，对血液科医生处理非经典FLT3突变及特殊信仰患者具有直接借鉴价值。

摘要: Approximately 30% of patients with acute myeloid leukemia (AML) harbor FMS-like tyrosine kinase 3 (FLT3) mutations, which are associated with poor overall survival. Although United States Food and Drug Administration (FDA)-approved FLT3 inhibitors are available, their efficacy against non-canonical FLT3 mutations remains elusive. Here we present a case of a 72-year-old female Jehovah’s Witness with newly diagnosed AML carrying a rare pathogenic FLT3 V491L mutation identified by next-generation…

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15 Lactylation at the metabolic-epigenetic interface in cardiovascular diseases: context-dependent mechanisms and translational roadmap

推荐理由: 该文章创新性地阐述了乳酸化修饰在代谢-表观遗传耦合中的关键作用，为血液疾病（如缺血/炎症相关贫血、白血病代谢重编程）的研究提供了新颖的分子机制视角和潜在干预靶点。

摘要: BACKGROUND: Lysine lactylation has redefined lactate’s biological role from a metabolic byproduct to a signaling molecule. This post-translational modification directly couples cellular energetics with gene regulation, creating a metabolic-epigenetic axis particularly relevant to cardiovascular pathophysiology. Ischemic and inflammatory stress drive glycolytic reprogramming and lactate accumulation in these diseases. Lactylation modifies both histone and non-histone proteins, enabling metabolic…

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16 Phase 3 study of intensive chemotherapy with or without dasatinib in core-binding factor acute myeloid leukemia

推荐理由: 该研究虽为阴性结果，但明确了达沙替尼在CBF-AML强化疗中未能改善生存且增加毒性，对临床治疗路径选择具有重要警示价值，可避免不必要的治疗风险。

摘要: CONCLUSION: In patients with CBF-AML, the addition of dasatinib to intensive chemotherapy failed to improve survival outcomes. The addition of dasatinib was associated with an increase in toxicity. This trial was registered at www.

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17 Clonal Hematopoiesis and Lymphoma-Associated Mutations in Hematopoietic Progenitors in B-Cell Non-Hodgkin Lymphoma

推荐理由: 该研究揭示了克隆造血在淋巴瘤中的具体作用模式，特别是TP53与DNMT3A突变的不同动力学特征，为理解血液肿瘤的起源和演进提供了新的机制视角，对血液科临床与基础研究均有较高借鉴价值。

摘要: Gene-specific expansion patterns were evident among the most frequent CH lesions, with DNMT3A-mutant clones exhibiting impaired hematopoietic differentiation and TET2-mutant clones showing multi-lineage propagation. Notably, identical CH clones were detected in 41% of corresponding lymphomas, displaying distinct clonal dynamics: tumor-promoting CH (expansion in B-NHL; 10/16 clones; mainly TP53) and tumor-infiltrating CH (no expansion; mainly DNMT3A). Moreover, we identified lymphoma-associated…

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18 Distribution and prognostic significance of myelotoxicity in newly diagnosed glioblastoma in a real-life cohort: Time to treat more aggressively?

推荐理由: 该研究挑战了传统观念，提出基于个体血液指标调整化疗剂量的创新思路，对血液毒性管理及肿瘤治疗个体化具有重要临床借鉴意义。

摘要: CONCLUSION: Myelotoxicity at the time of glioblastoma diagnosis does not seem to be detrimental to patient outcomes. Our findings highlight the importance of pneumocystis jiroveci prophylaxis in the Stupp regimen. This raises the intriguing question of whether future chemotherapy dosages could be tailored based on individual blood values, potentially exceeding current standard doses. Prospective studies are needed to explore these possibilities, including the feasibility of high-dose therapies…

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19 Advances in BRET probes for intracellular target engagement studies

推荐理由: 该文章介绍的基于BRET的活细胞药物靶点结合检测技术方法先进、可靠，对血液病药物研发（如靶向治疗、小分子抑制剂评估）具有重要的方法学借鉴价值。

摘要: Assessing drug-target engagement in living cells is essential for verifying the activity of pharmacological agents. Traditional binding assays often overlook key factors such as permeability, intracellular distribution and complex formation that influence target occupancy in cells. Bioluminescence resonance energy transfer (BRET)-based probes enable direct, quantitative assessment of small-molecule binding to proteins in live, intact cells. BRET provides sensitive detection of target engagement…

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20 Sulfur-containing class of broad-spectrum antivirals improves influenza virus vaccine development

推荐理由: 该研究揭示了一种通过调节病毒膜脂质组成与物理特性来广谱抑制包膜病毒的新机制，对研究病毒相关血液疾病（如HIV、HBV感染）及细胞膜生物学具有重要借鉴价值。

摘要: Enveloped viruses are significant zoonotic disease threats with the potential to cause global pandemics. We identified a class of small-molecule sulfur-containing antiviral compounds (XM series) that broadly inhibit enveloped viruses. Multidisciplinary approaches revealed that XM compounds alter the viral membrane lipid chemical composition, enhance membrane order within the hydrophobic bilayer, and increase membrane phase transition temperatures. This mechanism inhibits membrane fusion and…

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21 scHyperLink: Revealing Cell-Type-Specific Gene Regulation with Hypergraph Neural Networks

推荐理由: 该文章提出的基于图神经网络的单细胞GRN推断方法具有显著的方法学创新性，为血液疾病（如白血病、淋巴瘤）中异常基因调控网络的解析提供了新的可借鉴技术路径。

摘要: Single-cell RNA sequencing (scRNA-seq) allows gene expression to be measured at single-cell resolution, offering new opportunities to investigate Gene Regulatory Networks (GRNs), which represent the regulatory interactions between transcription factors (TFs) and their target genes. Given their relational structure, GRNs are formulated as graphs, enabling gene interaction inference to be framed as a link prediction task among graph nodes (i.e., genes). Prior work adopts Graph Neural Networks…

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22 Hgtsynergy: a transfer learning method for predicting anticancer synergistic drug combinations based on a drug-drug interaction heterogeneous graph

推荐理由: 该研究提出的HGTSynergy模型通过整合多类型药物相互作用和迁移学习，显著提升了抗癌药物协同作用的预测效能，对血液肿瘤领域的联合疗法开发具有重要方法论借鉴价值。

摘要: CONCLUSIONS: This study suggests that drug synergy prediction can be improved by comprehensively modeling diverse drug-drug interaction types and leveraging transfer learning to extract prior knowledge from them. The ability of HGTSynergy to discover new anticancer synergistic drug combinations outperforms other state-of-the-art methods. HGTSynergy promises to be a powerful tool to pre-screen anticancer synergistic drug combinations.

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23 MODCAN: driver gene identification based on multi-omics features and differential co-association networks for tumor subtypes

推荐理由: 该研究提出的MODCAN算法在癌症驱动基因预测方面表现出显著优势，其对于肿瘤异质性的揭示具有普遍参考价值，可为血液肿瘤的分子分型与靶点挖掘提供方法学借鉴。

摘要: CONCLUSIONS: When applied to ten cancer datasets from TCGA, MODCAN significantly outperforms both existing supervised and unsupervised learning algorithms, exhibiting superior performance in terms of precision, recall, and AUPR. Furthermore, MODCAN demonstrates substantial advantages in predicting potential tumor-specific driver genes. Notably, these genes not only exhibit strong specificity for their respective cancers, but also reveal tumor heterogeneity across distinct subtypes.

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24 Microbiota and tumor epigenetics: deep interconnections and emerging therapeutic perspectives

推荐理由: 该综述系统阐述了微生物群通过表观遗传调控影响肿瘤发生发展的机制，为血液肿瘤研究提供了跨学科的新视角和潜在干预靶点，值得血液领域研究者借鉴。

摘要: Cancer is a major global public health problem. Epigenetic regulation, such as DNA methylation, histone modifications, and non-coding RNA (ncRNA) dysregulation, is a main driver of tumorigenesis and progression. Recent studies are suggesting that the human microbiota, commonly referred to as a “super-organ,” are not only associated with tumors but play an active role in regulating the epigenetic state of the host. The aim of this review is to systematically explain the main regulatory mechanisms…

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25 A machine learning-enabled blood transcriptomic signature for digital diagnosis and subtyping of Alzheimer’s disease

推荐理由: 该研究将血液转录组学与机器学习结合，为阿尔茨海默病的无创早期检测提供了新思路，其基于乳酰化基因的模型构建方法对血液炎症及免疫相关疾病的研究具有

摘要: Early and accessible detection of Alzheimer’s disease (AD) remains a major clinical challenge. We developed a machine learning-based blood transcriptomic model, the Lactylation-Derived Score (LDS), from lactylation-related genes across nine AD cohorts, using a standardized pipeline with z-score normalization, random forest-based feature screening, plsRglm modeling, and 10-fold cross-validation. LDS was externally tested in seven independent brain transcriptomic datasets and clinically validated…

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26 Lactylation: the metabolic-immune hub in autoimmune diseases

推荐理由: 该文章聚焦乳酸化修饰这一新兴免疫调控机制，为自身免疫病治疗提供了新靶点思路，对研究免疫相关血液疾病（如自身免疫性溶血性贫血等）具有潜在借鉴价值。

摘要: In recent years, lactate modification, as an emerging post-translational modification mechanism, has attracted increasing attention for its role in the regulation of the immune system. Autoimmune diseases are a category of complex disorders characterized by abnormal attacks of the immune system on self-tissues. The limitations of traditional treatments have made the search for new therapeutic targets a hot topic in research. Lactate modification plays a significant role in the development and…

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27 deMEM: a novel divide-and-conquer framework based on de Bruijn graph for scalable multiple sequence alignment

推荐理由: 该文章介绍了一种能高效处理海量序列比对的新工具DeMEM，其方法学创新和强大的扩展能力对于处理大规模基因组数据（包括某些血液病原体或血液相关基因数据集）具有重要的借鉴价值。

摘要: CONCLUSIONS: DeMEM enables existing methods like MAFFT to align an extremely large number of sequences, including long sequences that cannot be directly aligned, such as those in a dataset of a thousand monkeypox virus genomes. The deMEM package is free and available at https://github.com/malabz/deMEM.

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28 Exploring the Potential Value of Lactylation and Macrophage Polarization-Related Genes as Biomarkers for TNF-alpha Inhibitor Response in Inflammatory Bowel Disease

推荐理由: 该研究创新性地提出乳酰化修饰和巨噬细胞相关基因可作为TNF-α抑制剂疗效的潜在生物标志物，并通过动物实验提示乳酸补充的增效作用，对风湿免疫相关性血液病治疗策略具有重要借鉴意义。

摘要: CONCLUSION: Overall, we identified lactylation and macrophage-related genes as potential biomarkers for TNF-α inhibitor response. Lactate supplementation was found to enhance the efficacy of TNF-α inhibitor based on animal experimental validation. Nevertheless, the findings were based on secondary analyses of public datasets, and the animal experiments remained preliminary. Further studies should be conducted to validate these findings and explore the molecular pathways involved.

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29 Inhibiting macrophage-derived lactate transport restores cGAS-STING signalling and enhances antitumour immunity in glioblastoma

推荐理由: 该研究揭示了肿瘤微环境中乳酸代谢与运输的新机制，特别是巨噬细胞与肿瘤干细胞之间的代谢偶联，为理解肿瘤代谢重编程及靶向肿瘤微环境的治疗策略提供了新视角，对血液肿瘤中类似代谢交互研究具有启发意义。

摘要: Glioblastoma (GBM) is a malignancy with a complex tumour microenvironment (TME) dominated by GBM stem cells (GSCs) and infiltrated by tumour-associated macrophages (TAMs) and exhibits aberrant metabolic pathways. Lactate is a critical glycolytic metabolite that promotes tumour progression; however, the mechanisms of lactate transport and lactylation in the TME of GBM remain elusive. Here we show that lactate is transported from TAMs to GSCs via MCT4-MCT1. TAMs provide lactate to GSCs, promoting…

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30 Delirium after surgery: a retrospective study of predictors, complications, and screening patterns in the national surgical quality improvement program

推荐理由: 该研究虽非直接针对血液疾病，但术后谵妄的预测与防治对血液肿瘤患者接受重大手术时的围术期管理具有重要参考价值，尤其适用于老年或造血干细胞移植等高风险人群的临床决策支持。

摘要: BACKGROUND: Postoperative delirium is a serious yet underrecognized complication affecting diverse surgical populations, with profound implications for morbidity, mortality, and long-term cognitive function. Its prediction remains imprecise, and screening practices vary widely.

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31 Research protocol for BootStRaP assessment phase: A nine-nation study on boosting societal adaptation and mental health in a rapidly digitalising, post-pandemic Europe

推荐理由: 该研究聚焦青少年网络成瘾这一全球性公共卫生问题，具有较高的社会关注度和政策参考价值，虽然与血液疾病无直接关联，但其严谨的风险因素研究方法可为行为医学研究提供借鉴。

摘要: BACKGROUND: There is increasing global concern about the harms associated with problematic usage of the internet (PUI) affecting young people. Various risk factors have been proposed, but there is a scarcity of reliable evidence on the extent of the problem, who is most at risk of developing PUI and why, and how best to tackle it.

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32 Designing network based intervention strategies for epidemics of infectious diseases from edge based infection probability

推荐理由: 该文章虽非直接研究血液疾病，但其对传染病传播网络与影响因素的分析方法，可为血液科院内感染防控及血液传播性疾病（如病毒性肝炎、HIV）的流行规律研究提供重要的模型借鉴与思路参考。

摘要: Epidemics underscore the critical role of human contact networks in shaping the spread of infectious diseases. Transmission varies depending on a range of factors, including virus characteristics, the type and duration of contact, and whether it occurs indoors or outdoors. However, not only does the probability of transmission differ, but the impact of each transmission event depends on the ability of a single event to spread the virus to new, previously unaffected, socially segmented groups in…

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33 Fusobacterium nucleatum Enhances Immune Escape in Colorectal Cancer by Inducing H3K18 Lactylation of CD274 (PD-L1) Protein Through Lactate Accumulation

推荐理由: 该研究在肿瘤免疫微环境与细菌感染相互作用的机制上方法学严谨，其关于PD-L1调控和T细胞功能的研究范式对淋巴瘤等血液肿瘤的免疫治疗研究具有可借鉴的参考价值。

摘要: Fusobacterium nucleatum (Fn), an intratumoral pathogenic bacterium, is confirmed to be associated with tumor progression in colorectal cancer (CRC). To evaluate CD8^(+) T cell function against CRC cells, their cytotoxicity was determined via live/dead staining and ELISA, while proliferation was assessed using the CFSE assay. CD274 (PD-L1) expression in CRC was quantified by qPCR, flow cytometry, and immunofluorescence. Lactate accumulation in CRC cells was measured using LDHA and lactate assay…

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34 Histone Lactylation-Mediated Metabolic Remodeling in Vascular Smooth Muscle Cells Aggravates Aortic Aneurysm and Dissection by Promoting Lactate Accumulation

推荐理由: 该研究揭示了组蛋白乳酸化在主动脉夹层（AAD）发病机制中的新作用，并提出了靶向PDK1/KAT7的治疗新思路，对血管疾病与代谢-表观遗传交叉领域的研究具有启发意义。

摘要: CONCLUSIONS: Histone lactylation changes the metabolism and phenotype of VSMC in AAD. Inhibition of PDK1 or KAT7 may be a novel approach to treat or prevent AAD.

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35 Effectiveness of and Mechanisms of Change in a Self-Help Web- and App-Based Resilience Intervention on Perceived Stress in the General Working Population: Randomized Controlled Trial

推荐理由: 该研究虽非直接针对血液疾病，但其关于心理韧性干预和压力调节的严谨方法论及中介分析思路，对血液科研究患者心理干预和生存质量提升具有可借鉴的参考价值。

摘要: CONCLUSIONS: In a sample of employees experiencing heightened work-burden levels, RESIST was effective in reducing perceived stress and increasing self-perceived resilience as well as the targeted resilience factors. Mediation analyses suggested that developing a positive future outlook and a self-compassionate attitude toward oneself may be key drivers to enhance resilience. Changing the quality of social relationships and strengthening the belief in one’s abilities may require more time, the…

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36 Efficacy of carotid devices for resistant hypertension: a systematic review

推荐理由: 该综述聚焦颈动脉装置治疗难治性高血压这一前沿技术，虽指出仍需更多标准化研究验证，但其对心血管器械疗法在血压管理中的创新应用具有明确的临床借鉴价值。

摘要: CONCLUSION: Carotid devices offer a promising solution for managing RHT, with Barostim Neo emerging as a safer alternative than Rheos. While MobiusHD demonstrates efficacy, further trials are needed to confirm its safety. Additional studies with standardized trial designs and long-term follow-ups will enhance our understanding of the role of carotid-based therapies in hypertension management.

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37 Targeting MLCK1 uncouples immune checkpoint inhibitor-induced colitis from antitumour immunity

推荐理由: 该研究揭示了MLCK1调控紧密连接在免疫检查点抑制剂相关结肠炎中的关键机制，为屏障修复治疗提供了新靶点，虽非直接血液病研究，但对免疫相关不良反应的机制探讨具有可借鉴性。

摘要: CONCLUSIONS: These findings suggest that MLCK1-dependent tight junction regulation is essential for ICIs colitis, positioning barrier restoration as a potential therapeutic strategy.

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38 Cognitive function in patients with myelin oligodendrocyte glycoprotein antibody-associated disease

推荐理由: 该研究通过对比MOGAD与其他神经免疫疾病的认知障碍风险，为自身免疫性疾病的中枢神经影响提供了可靠数据，虽与血液病直接关联较弱，但其方法学对研究免疫介导的血液系统并发症有参考价值。

摘要: CONCLUSION: pwMOGAD performed worse in information processing speed, verbal learning, storage and retrieval compared to HC. RR for CImp in pwMOGAD compared to HC was similar to that estimated for pwAQP4+NMOSD and pwdsNMOSD.

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39 Mismatch between intact electrical excitability and lost heat pain in diabetic neuropathy

推荐理由: 该文章在糖尿病神经病变的疼痛机制研究方法上较为严谨，对神经生理学研究具有参考价值，但与血液疾病直接关联较弱，血液科医生可借鉴其痛觉研究思路而非直接应用。

摘要: Patterns of sensory involvement in diabetic neuropathy vary between studies and diagnostic approaches. Although some report early thermal deficits, others find predominant large-fiber changes, and hypersensitivity in early disease is inconsistently observed. Elevated heat pain thresholds (HPTs) may indicate either selective loss of heat transduction or advanced peripheral denervation of polymodal nociceptors. We examined whether thermal and mechanical pain functions align with psychophysical…

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40 Was Motorized Spiral Enteroscopy Too Risky? A Systematic Review and Meta-Analysis Including German Registry Data

推荐理由: 该文章虽非直接针对血液病，但其关于新技术安全性监测与不良事件报告的方法学讨论，对血液领域引入创新技术时的风险评估与规范化管理具有重要借鉴意义。

摘要: CONCLUSIONS: MSE was associated with higher AE and SAE rates than balloon enteroscopy. These findings highlight the need for cautious adoption, rigorous safety monitoring, and more robust AE reporting when introducing innovative endoscopic technologies.

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41 Collision Lesion

推荐理由: 由于未提供摘要，无法评估文章的具体内容与价值。建议提供摘要信息以便进行准确评价。

摘要: No abstract

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42 Paediatric-Onset Folliculitis Decalvans and Lichen Planopilaris Phenotypic Spectrum: Is It a Different Disease?

推荐理由: 该文章主要聚焦于皮肤科瘢痕性脱发的临床表型研究，对血液疾病的直接关联较弱，但其中涉及的免疫炎症机制可能为某些血液系统免疫相关疾病的研究提供间接参考。

摘要: Folliculitis decalvans (FD) and lichen planopilaris (LPP) are classified as neutrophilic and lymphocytic cicatricial alopecias respectively. FD and LPP have distinctive clinical, trichoscopic and histopathological features. Cases with concomitant or sequential features of both forms of primary cicatricial alopecia (PCA) have been described since 2020, and the term folliculitis decalvans and lichen planopilaris phenotypic spectrum (FDLPPPS) has been proposed. This study aimed to describe the…

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43 Predicting the pathway involvement of metabolites annotated in the MetaCyc knowledgebase

推荐理由: 该研究展示了代谢通路预测领域的技术稳定性，虽不直接针对血液疾病，但其方法论对血液代谢组学或相关通路分析具有潜在参考价值

摘要: CONCLUSIONS: These performance results are pragmatically the same, demonstrating that in aggregate, the 4055 MetaCyc pathways can be effectively predicted at the current state-of-the-art performance level.

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44 Association of the rs17822931 (538G &gt; A, G180R) in the ABCC11 gene with risk of middle ear cholesteatoma in older adults: a hospital-based case-control study at Heidelberg University Hospital, Germany

推荐理由: 该研究虽在遗传流行病学方法上较为严谨，但研究对象为胆脂瘤（耳部疾病），与血液疾病无直接关联，对血液学研究的借鉴价值有限。

摘要: CONCLUSIONS: These findings from a German cohort replicate the association between the rs17822931 (538G > A, G180R) polymorphism in the ABCC11 gene and cholesteatoma risk in a non-Japanese population, suggesting a broader role of rs17822931 across ethnicities.

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45 European Society of Gynaecological Oncology resource-stratified guidelines for the management of patients with cervical cancer

推荐理由: 该摘要侧重于医疗资源分配的基本原则，虽未涉及具体血液病研究，但对于理解临床转诊与优化医疗资源配置有普遍参考意义。

摘要: CONCLUSION: Efforts should always focus on providing optimal available care. In the absence of key resources, the primary effort should be directed toward consulting and referring patients to other facilities that provide better conditions.

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46 My Brother’s Sister

推荐理由: 由于摘要缺失，无法评估具体研究内容与价值，但若主题涉及血液疾病，可待获取全文后判断其可借鉴性；目前仅基于标题推测有一定血液学相关性，建议谨慎参考。

摘要: No abstract

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