追觅 - 2026-01-09

生成时间: 2026−01-09 22:47

分析文章数量: 81

1 Tumor burden-guided dosing contributes to mitigation of immunotoxicities following treatment with obecabtagene autoleucel in adult patients with relapsed/refractory B-cell acute lymphoblastic leukemia

推荐理由: 该研究针对难治/复发B细胞急性淋巴细胞白血病，采用新型CD19 CAR-T疗法（obe-cel）并探索了基于肿瘤负荷的分次输注策略，对血液肿瘤的临床治疗与细胞免疫疗法研发具有重要参考价值。

摘要: Obecabtagene autoleucel (obe-cel) is a CD19-targeted autologous chimeric antigen receptor T-cell therapy (CAR T) with a fast off-rate binding domain, administered as split-dose infusions guided by pre-lymphodepletion tumor burden (low-tumor-burden [TB] group: ≤20%; high-TB group: >20% bone marrow [BM] blasts). Obe-cel treatment in adult relapsed/refractory B-cell acute lymphoblastic leukemia (R/R B-ALL) was investigated in the phase 1b/2 FELIX trial. Here, we report pharmacokinetics, safety, and…

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2 Multicenter real-life evaluation of the Post-CAR prognostic index for patients with large B-cell lymphoma after CAR-T failure

推荐理由: 该研究提出的PC-PI预后指数基于常规临床变量，能有效对CAR-T治疗后复发的难治性大B细胞淋巴瘤患者进行风险分层，为临床决策提供了即时可用的实用工具，填补了该领域预后评估的空白。

摘要: Most patients with large B-cell lymphoma (LBCL) progressing after CAR-T therapy experience poor survival and lack standardized treatment strategies. Prognostic tools are needed to guide decision-making at relapse. The Post-CAR Prognostic Index (PC-PI), recently proposed by Iacoboni et al., combines five routine clinical variables to stratify outcomes after CAR-T failure: ECOG (> 0), hemoglobin (< 10 g/dL), LDH (≥ 2xULN), number of extranodal sites (> 1) and time from CAR-T to progression (< 4...

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3 Spatiotemporal regulation of MKK4 dictates switch-like JNK activation and binary cell-fate decisions

推荐理由: 该研究揭示了JNK信号通路中MKK4时空动态变化在细胞命运决定中的新机制，为血液疾病（如白血病）中异常细胞存活或死亡的调控提供了潜在的可借鉴分子靶点。

摘要: The JNK pathway converts graded (analogue) stress stimuli into a switch-like (digital) response, thereby dictating binary, all-or-none cell-fate decisions such as survival or death. However, the underlying mechanism remains unclear. Here, we report that the stress-induced modulation of MKK4 spatiotemporal dynamics serves as an analogue-to-digital converter for JNK signalling. Under steady-state conditions, MKK4 shuttles slowly between the nucleus and cytoplasm, but its shuttling rate increases…

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4 Molecular mechanism of exchange coupling in CLC chloride/proton antiporters

推荐理由: 该研究首次完整揭示了CLC转运蛋白的2:1氯离子/质子交换分子机制，其采用的多技术融合方法为血液病相关离子通道研究提供了可借鉴的范式。

摘要: The ubiquitous CLC membrane transporters are unique in their ability to exchange anions for cations. Despite extensive study, there is no mechanistic model that fully explains their 2:1 Cl^(‒)/H^(+) stoichiometric exchange mechanism. Here, we provide such a model. Using differential hydrogen-deuterium exchange mass spectrometry, cryo-EM structure determination, and molecular dynamics simulations, we uncovered conformational dynamics in CLC-ec1, a bacterial CLC homolog that has served as a…

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5 Novel adenovirus vaccine vectors lacking thrombosis-associated interactions with platelet factor 4

推荐理由: 该研究通过系统筛选腺病毒载体，为降低疫苗相关血栓风险提供了直接实验依据，对血液科理解免疫性血栓形成机制及临床安全用药具有重要参考价值。

摘要: The adenoviral vector-based AstraZeneca and Janssen COVID-19 vaccines have been associated with rare cases of thrombosis, believed to be triggered, among other factors, by vector binding to the blood protein platelet factor 4 (PF4). To identify vectors with lower thrombosis risk, we screened 50 natural and hexon-modified adenoviruses (Ads). Unlike the applied COVID-19 vaccines and most tested vectors, Ad34 and Ad80, as well as Ad5 vectors with deleted or chemically shielded hexon hyper-variable…

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6 Improving the predictive value of end-of-treatment PET/CT in diffuse large B-cell lymphoma

推荐理由: 该研究针对弥漫大B细胞淋巴瘤疗效评估中Deauville评分阳性预测值不足的临床痛点，创新性地结合定量PET参数与临床数据，对提高治疗失败预测精度具有直接参考价值。

摘要: The 5-point Deauville score (DS) assesses end-of-treatment (EOT) response on PET/CT in diffuse large B-cell lymphoma patients, categorizing scans as ‘positive’ or ‘negative’ for complete metabolic response. However, the positive predictive value (PPV) is suboptimal at 60%. We evaluated whether quantitative PET parameters combined with clinical data could improve prediction of treatment failure in EOT PET-positive patients. Baseline and EOT PET/CT scans of 138 DS4-5 patients were analyzed….

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7 Identifying targeted therapies for CBFA2T3::GLIS2 acute myeloid leukemia

推荐理由: 该研究通过CRISPR-Cas9筛选创新性地发现CBFA2T3::GLIS2阳性儿童AML对JAK2的特异性依赖，并完成体内外功能验证，为这一高危亚型提供了明确的靶向治疗方向，对儿童AML临床转化具有重要参考价值。

摘要: CBFA2T3::GLIS2-positive pediatric acute myeloid leukemia (AML) remains one of the worst prognostic AML subgroups. To uncover innovative targeted therapy approaches in this disease subtype we performed genome-scale CRISPR-Cas9 screening that highlighted a strong, selective dependency on JAK2 compared to other types of cancer. Using a doxycycline-inducible JAK2 knockout (KO) system, we validated JAK2 dependency in CBFA2T3::GLIS2 cell lines, observing impaired proliferation in vitro and in vivo and…

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8 Ethnicity affects relapse-free survival in immune-mediated thrombotic thrombocytopenic purpura

推荐理由: 该研究聚焦iTTP复发风险的异质性，触及精准医疗的核心问题，对临床治疗策略优化和血液病机制探索具有直接参考价值。

摘要: Immune-mediated thrombotic thrombocytopenic purpura (iTTP) is caused by a severe, antibody-mediated deficiency of ADAMTS13 (A Disintegrin And Metalloproteinase with ThromboSpondin-1 motifs, 13th member) activity. The B-cell depleting agent rituximab is effective in restoring ADAMTS13 activity and therefore preventing relapses. However, the risk of relapse appears heterogeneous among patients, although the underlying causes are elusive. Preliminary reports suggested that African ancestry could be…

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9 EcDNA-borne structural variants drive oncogenic fusion transcript amplification

推荐理由: 该研究揭示了ecDNA在驱动癌基因融合中的关键机制，其跨癌种的发现对理解血液肿瘤（如淋巴瘤、白血病）的基因组不稳定性具有重要借鉴意义。

摘要: Extrachromosomal DNA (ecDNA) amplifications are key drivers of human cancers. Here, we show that ecDNAs are major platforms for generating and amplifying oncogene fusion transcripts across diverse cancer types. By integrating analysis of whole-genome and transcriptome sequences from tumor samples and cancer cell lines of a wide variety of tissue types, we reveal that ecDNAs have the highest rate of oncogene fusion events of any copy-number alteration. Focusing on the most common ecDNA fusion…

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10 TIGIT disruption rescues the antitumor activity of low avidity TCR-engineered T cells by increasing TCR signal strength

推荐理由: 该研究通过靶向TIGIT逆转T细胞耗竭来增强低亲和力T细胞的抗肿瘤功能，其机制研究对血液肿瘤（如淋巴瘤、白血病）的CAR-T或TCR-T疗法具有直接借鉴价值，为优化过继性细胞免疫治疗提供了新思路。

摘要: T-cell avidity is a major determinant of Adoptive T cell therapy (ACT) efficacy for cancer treatment. However, high-avidity tumor-specific T cells can rarely be isolated from cancer patients, highlighting the need for strategies to enhance the cytotoxic capacity of low-avidity cells. Here, we rescue the anti-tumor functions of low-avidity T cells against pancreatic ductal adenocarcinoma (PDAC) by knocking-out TIGIT, a key inhibitory molecule expressed on exhausted CD8^(+) T cells infiltrating…

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11 A Mechanophenotyping chip for high-throughput detection of metastatic bacteria-infected circulating tumor cells

推荐理由: 该研究开发的微流控芯片技术能高效捕获循环肿瘤细胞并评估其力学特性，对理解肿瘤血行转移机制具有直接参考价值，为血液肿瘤研究提供了创新的方法学借鉴。

摘要: Emerging evidence underscores biophysical characteristics of cancer cells as key modulators of cancer progression and metastasis. Herein, we reported a cell-mechanophenotyping screening microfluidic chip (termed LesM) for the high-efficient capture of circulating tumor cells (CTCs) and evaluation of single-cell deformation to reveal the hematogenous metastatic potential of bacteria-infected breast cancer. LesM employs L-shaped traps to capture single cells, leveraging bacteria-infected CTCs with…

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12 AI-enabled electrocardiogram alert for potassium imbalance treatment: a pragmatic randomized controlled trial

推荐理由: 该研究采用AI实时心电图预警，通过严格的随机对照试验验证其在急诊高钾血症管理中的应用价值，为急诊医学的数字化干预提供了高质量证据，具有直接的临床借鉴意义。

摘要: Life-threatening dyskalemia, defined as an abnormal serum potassium concentration, is common in emergency settings that requires timely recognition and treatment and can be detected via AI-enabled electrocardiography. We conducted a pragmatic, open-label, randomized controlled trial with physician-level randomization to evaluate whether a real-time AI-enabled electrocardiography alert could improve physicians’ management of dyskalemia. Over a six-month period in 2022, 70 emergency physicians…

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13 Angelicae Sinensis Radix extract attenuates synovial fibrosis via H3K18la/ METTL3/m 6A axis-dependent modification of Netrin-1

推荐理由: 该研究从表观遗传学新视角（H3K18la/METTL3/m6A轴）探讨中药抗纤维化机制，其调控网络对研究骨髓纤维化等血液系统纤维化疾病具有重要借鉴价值。

摘要: This study explores whether Angelicae Sinensis Radix extract alleviates fibrosis of human fibroblast-like synoviocytes(FLSs) by regulating the histone H3 lysine 18 lactylation(H3K18la)/methyltransferase-like protein 3(METTL3)/N 6-methyladenosine(m 6A) axis-mediated m 6A methylation of Netrin-1. FLSs were grouped as follows: control, transforming growth factor(TGF)-β1, TGF-β1+Angelicae Sinensis Radix extract drug-containing serum(AS), and TGF-β1+AS+sodium lactate(Nala). Other groups except the…

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14 In vivo detection of immune responses via cytokine activity labeling

推荐理由: 该研究开发的CyCLoPs技术为追踪细胞因子响应细胞提供了创新工具，对理解免疫调控及血液疾病中细胞因子信号通路具有重要借鉴价值。

摘要: While much is known about the identity and regulation of cytokine-producing cells, the cell types that respond to cytokines remain largely uncharacterized. To address this knowledge gap, we developed “cytokine cellular locating platforms” (CyCLoPs), a reporter system that translates cytokine receptor engagement into a genetically traceable signal. In vitro, CyCLoPs demonstrated high specificity, robust signal-to-background ratios, and broad applicability for probing diverse cytokine receptor…

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15 Chlorella-derived extracellular vesicle-based nanogels suppress cGAS-STING for treatment of radiation-induced lung injury

推荐理由: 该研究创新性地将小球藻外泌体与cGAS抑制剂结合构建纳米凝胶平台，为辐射损伤修复提供了跨学科的新思路，其

摘要: Radiation-induced lung injury (RILI) represents a critical complication associated with radiation exposure, requiring targeted treatment strategies in clinical practice. Here, we pioneered the extraction of extracellular vesicles (EVs) from Chlorella and innovatively developed a multifunctional nanogel platform (RU.521-EVs NPs) by combining them with the cGAS inhibitor RU.521. The Chlorella-derived EVs possess a naturally high abundance of antioxidant enzymes (e.g., SOD2, CAT) and…

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16 Butyrophilin 2A2 promotes T cell immunoregulation via CD45 phosphatase activation and protects against murine autoimmune glomerulonephritis and pregnancy loss

推荐理由: 该研究通过多技术手段首次阐明BTN2A2与CD45RO的互作机制，为血液肿瘤免疫治疗及T细胞相关疾病研究提供了新的分子靶点参考。

摘要: B7 costimulatory family member Butyrophilin 2A2 (BTN2A2) is predominantly expressed by antigen presenting cells and regulates T cell immunity, but molecular mechanisms are unclear. Using immunoblots analyzing TCR-initiated signaling intermediaries, co-immunoprecipitation studies, confocal microscopy, structural modeling-guided mutational analyses, and microscale thermophoresis, we demonstrate that BTN2A2 directly interacts with CD45RO, resulting in CD45 retention within the immune synapse during…

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17 THP-1-derived polarized macrophages differ by drug transporter transcriptomics, P-glycoprotein activity and rifampicin uptake kinetics

推荐理由: 该研究通过巨噬细胞极化模型探讨药物转运蛋白在抗生素疗效中的作用，为血液病领域研究药物耐药机制（如P-gp在白血病细胞中的表达）提供了可借鉴的实验思路与分子靶点参考。

摘要: Inferior efficacy of antibiotics (e.g. rifampicin) in M2 macrophage-dominant tuberculosis granuloma might be related to poor drug uptake into these cells, potentially mediated by altered expression and activity of drug transporters such as P-glycoprotein (P-gp, encoded by ABCB1). Consequently, THP-1 cells were differentiated (200 nM phorbol 12-myristate 13-acetate; 72 h) and polarized to M1 (50 ng/mL lipopolysaccharide, 20 ng/mL interferon-gamma; 48 h) or M2 (20 ng/mL interleukin-4,…

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18 Clinical White Paper From the “Hadrontherapy for Life” Symposium-Clinical Expansion of Carbon Ion Facilities Worldwide

推荐理由: 该文章提出了碳离子放疗（CIRT）向全球标准化、临床一体化发展的战略倡议，对血液肿瘤等难治性疾病的放射治疗研究具有重要的方向性指导与协作参考价值。

摘要: CONCLUSIONS: CIRT is transitioning from pioneering programs to a coordinated global network. Collaborative initiatives and shared data platforms are essential to establish evidence-based indications, optimize biological modeling, and ensure economic sustainability. The “Hadrontherapy-for-Life” initiative calls for a strategic step toward internationally standardized, clinically integrated heavy-ion therapy.

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19 The angiosome and woundosome concepts in guiding revascularization for chronic limb-threatening ischemia and diabetic foot ulcers-a narrative review

推荐理由: 该文章提出了结合血管区域与创面血流动力学的治疗策略，对研究缺血性疾病的血液循环干预具有直接参考价值，尤其能为血栓、周围血管病变等血液相关疾病的管理提供新思路。

摘要: CONCLUSIONS: Incorporating angiosome- and woundosome-based strategies in CLTI management may improve limb- and patient-related outcomes. The decision on which particular territory needs primary attention and how many vessels require revascularization largely depends on the patency of feeding arteries in the wound area. In the future, a standardized way to measure the intra- and post-procedural arterial flow to the wound would be necessary, to study the clinical applications of the mentioned…

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20 CK2 inhibitor, CX-4945, enhances BH3 priming and promotes apoptosis of venetoclax-resistant AML by targeting antiapoptotic proteins

推荐理由: 该研究聚焦AML耐药机制，尤其针对BCL2抑制剂维奈克拉耐药这一临床难题，深入探讨CK2激酶的作用，为克服耐药提供了新靶点思路，对血液肿瘤研究者具有直接参考价值。

摘要: Acute myeloid leukemia (AML), the most common hematologic malignancy, generally has a poor prognosis. Despite initial favorable responses to the BCL2 inhibitor venetoclax (VEN), remission is transient, and AML is eventually fatal. Resistance to VEN is primarily due to the overexpression of anti-apoptotic proteins, including MCL-1, BCL2L1 (BCL-XL), and BCL2A1. Casein kinase II (CK2) is a serine-threonine kinase and a known suppressor of apoptosis. We and others have reported that protein kinase…

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21 PANoptosis in diabetes: immunometabolic insights and treatments

推荐理由: 该文章提出的PANoptosis机制为理解免疫代谢紊乱与炎症性细胞死亡提供了创新框架，虽然以糖尿病为核心，但其涉及的先天免疫通路和程序性死亡概念对血液系统炎症性疾病及造血微环境研究具有重要的可借鉴价值。

摘要: The core pathological mechanism of diabetes mellitus and its complications is rooted in the interactive regulation between immunometabolic dysregulation and inflammatory programmed cell death, with PANoptosis serving as a critical hub in this process. PANoptosis is a distinct innate immune-mediated inflammatory lytic cell death pathway initiated by pattern-recognition receptors and propagated via the PANoptosome complex, which plays a critical hub role in the interactive regulation between…

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22 A lactylation-driven prognostic model for lung adenocarcinoma: cellular lactylation heterogeneity and immune insights

推荐理由: 该研究

摘要: CONCLUSIONS: This study presents a lactylation-based prognostic model for LUAD and uncovers potential immune-related mechanisms by which highly lactylated epithelial cells may contribute to immune evasion and tumor progression.

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23 NKX2-1 regulates cell survival, maturation, and DNA-damage responses as a cofactor of RUNX1 in T-cell acute lymphoblastic leukemia

推荐理由: 该研究利用CRISPR-Cas9技术深入探讨NKX2-1在T-ALL发病机制中的作用，对于理解特定亚型白血病的代谢依赖性具有重要参考价值，为靶向治疗提供了潜在新思路。

摘要: T-cell acute lymphoblastic leukemia (T-ALL) is characterized by ectopic expression of transcription factors, including NKX2-1, which is overexpressed in 5% of patients. NKX2-1 is associated with a cortical immunophenotype and drives metabolic addiction to the serine/glycine synthesis pathway in T-ALL. However, a complete picture of the role of NKX2-1 in T-ALL pathogenesis is missing. We characterized a CRISPR-Cas9 NKX2-1 knockout model of RPMI-8402, the only known NKX2-1-expressing T-ALL cell…

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24 Comprehensive Multi-Omics Analysis Identifies Lactylation-Related Gene RAN as a Novel Prognostic Biomarker and Therapeutic Target in Glioma

推荐理由: 该研究首次提出乳酰化修饰在肿瘤微环境中的关键作用，并创新性地结合多组学与机器学习鉴定出RAN作为新型生物标志物，其调控机制（PI3K/AKT通路）对血液肿瘤的靶向治疗研究具有重要借鉴意义。

摘要: CONCLUSION: Our study established lactylation modifications as a crucial regulator of the TME and glioma progression. Through integrative multi-omics analysis and robust machine learning techniques, we determined that RAN was a novel lactylation-associated gene. RAN is a potent, independent prognostic biomarker that promotes glioma malignancy via the PI3K/AKT pathway. Our results demonstrate RAN as a prospective therapeutic target and establish a novel framework for individualized therapy for…

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25 State-specific enhancer landscapes govern microglial plasticity

推荐理由: 本文虽聚焦神经免疫的小胶质细胞，但其探讨的细胞亚群异质性、表观遗传调控

摘要: Single-cell transcriptomic studies have identified distinct microglial subpopulations with shared and divergent gene signatures across development, aging, and disease. Whether these microglial subsets represent ontogenically separate lineages of cells or are manifestations of plastic changes in microglial states downstream of some converging signals is unknown. Furthermore, despite the well-established role of enhancer landscapes underlying the identity of microglia, the extent to which histone…

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26 Volumetric compression regulates the phase separation of AXIN and acts as an operational amplifier to bidirectionally modulate Wnt signaling in organoids

推荐理由: 该研究揭示了相分离在整合力学与生化信号中的新机制，为理解血液细胞命运决定及白血病等血液疾病的信号异常调控提供了新的理论视角。

摘要: Protein phase separation has emerged as a crucial mechanism for spatiotemporal regulation of intracellular processes, yet its potential to integrate and compute diverse extracellular signals is not fully understood. Here, we show a mechano-biochemical circuit that harnesses phase separation to process mechanical and biochemical inputs, modulating cell fate decisions. We demonstrate that volumetric compression bidirectionally regulates canonical Wnt/β-catenin signaling, where the presence of Wnt…

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27 Integrative transcriptome-wide association analyses reveal PRKCG-linked GABAergic dysfunction in Fragile X-associated tremor/ataxia syndrome

推荐理由: 该研究采用多组学结合TWAS的创新策略，揭示了FXTAS神经元特异性分子机制，其研究范式对探索其他重复序列扩增疾病的发病机理具有较高的可借鉴价值。

摘要: Fragile X-associated tremor/ataxia syndrome (FXTAS) is a neurodegenerative disorder caused by CGG repeat expansions in the FMR1 gene. While CGG repeat toxicity is established, the precise molecular mechanisms driving neurodegeneration remain unclear. Here, we show that a multi-omics strategy combined with TWAS reveals brain-region-specific molecular signatures and striking gene dysregulation in inhibitory neurons. Using conditional mouse models, we demonstrate that selective expression of…

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28 USP10 promotes glioma stem cell maintenance and glioblastoma growth by antagonizing DTX3L-mediated SATB2 ubiquitination

推荐理由: 该研究首次揭示SATB2在胶质瘤干细胞中受USP10/DTX3L调控的泛素化新机制，其调控通路可能为血液肿瘤领域提供新的表观遗传治疗靶点参考。

摘要: Special AT-rich sequence-binding protein 2 (SATB2) is a nuclear matrix-associated protein with a pivotal role in glioblastoma (GBM) progression. However, the mechanisms underpinning aberrant SATB2 expression remain elusive. Here, we identify the ubiquitin specific peptidase 10 (USP10) as a deubiquitinase and the deltex E3 ubiquitin ligase 3 L (DTX3L) as a ubiquitin ligase of SATB2 in glioma stem cells (GSCs). USP10 and DTX3L regulate SATB2 ubiquitination at the K266 residue through mutually…

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29 Quantitative optical nanoscopy of mitochondrial-derived vesicles in neurons classifies pre-peroxisomal and clearing organelles

推荐理由: 该文章展示了超分辨率成像技术在活体神经元线粒体囊泡研究中的突破性应用，其方法学创新对研究细胞器动态交互具有重要借鉴意义，尤其可为血细胞中线粒体相关疾病机制提供潜在研究思路。

摘要: Healthy mitochondria are crucial for maintaining neuronal homeostasis. Their activity depends on a dynamic lipid and protein exchange through fusion, fission, and vesicular trafficking. Studying vesicles in neurons is challenging with conventional microscopy due to their small size, heterogeneity, and dynamics. We use multicolour stimulated emission depletion nanoscopy to uncover the ultrastructure of mitochondrial-derived vesicles (MDVs) in live neurons, biosensors to define their functional…

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30 Noncanonical calcium-independent TRPM4 activation governs intestinal fluid homeostasis

推荐理由: 该研究揭示了临床常用药物bisacodyl通过靶向TRPM4通道调控肠道稳态的新机制，其离子通道靶向性研究思路对血液病相关离子通道研究具有直接借鉴价值。

摘要: Imbalance in intestinal fluid homeostasis leads to nutrient malabsorption, intestinal tissue destruction, and systemic inflammation. Transient receptor potential melastatin 4 (TRPM4) is a calcium-activated, non-selective monovalent cation channel converting chemical signals (Ca^(2+)) into electrical signals (membrane depolarization). Here, we show the TRPM4 channel as a direct target of bisacodyl (BIC), a widely used clinical drug for chronic constipation management, and its active metabolite,…

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31 The Right to Know About CMV-Perspectives of Pregnant Women and Families With Lived Experience of CMV

推荐理由: 该文章系统阐述了巨细胞病毒（CMV）在母婴传播及新生儿先天残疾中的重要作用，虽非直接针对血液病，但对研究CMV在造血系统感染、免疫功能低下患者（如血液肿瘤患者）中的影响及输血相关传播具有重要参考价值。

摘要: Cytomegalovirus (CMV) is a common herpesvirus that is transmitted from person to person via bodily fluids, including urine, saliva, blood and semen. If a pregnant woman acquires CMV for the first time (maternal primary infection) or has CMV reactivation or reinfection with a new strain in pregnancy, a resulting congenital infection can cause damage to the developing foetus. CMV is the leading infectious cause of newborn disability in high income countries, where an estimated 1 in 200 babies are…

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32 METTL3 abrogation promotes glioma progression through regulating the ISG15-FASN axis-mediated lipid metabolism in macrophages

推荐理由: 该研究通过揭示m6A甲基转移酶METTL3在巨噬细胞脂代谢中的调控机制，为肿瘤微环境中免疫代谢研究提供了新视角，其发现对于理解髓系细胞在血液肿瘤及免疫相关血液疾病中的作用具有潜在借鉴意义。

摘要: Tumor-associated macrophages (TAMs) constitute a pivotal cellular component within the intricate tumor microenvironment (TME). However, the relationship between the N6-methyladenosine (m6A) and metabolic pattern of TAMs remains poorly understood. Here we show that the m6A methyltransferase METTL3 is conspicuously downregulated in monocyte-derived macrophages from glioblastoma (GBM) patients. Conditional knockout of Mettl3 in myeloid cells augments lipid metabolism and accelerates glioma…

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33 Hypoxia Affects Stem Cell Fate in Patient-Derived Ileum Enteroids in a HIF-1α-Dependent Manner

推荐理由: 该文章深入探讨了低氧梯度对肠道干细胞增殖与分化的调控机制，其研究思路和方法对研究造血干细胞在骨髓微环境中的分化调控具有重要的借鉴价值。

摘要: The intestinal epithelium maintains tissue homeostasis through a dynamic balance of stem cell proliferation and differentiation. This process is spatially regulated along the crypt-villus axis, with intestinal stem cells in the crypt regions proliferating and progenitor cells differentiating as they migrate toward the villus tips. Because the lumen of the gut contains very low levels of oxygen (i.e., hypoxia), an oxygen gradient is established within the crypt-villus axis, placing the crypt…

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34 Optimizing PSMA-617-based inhibitors through charged linker modifications: Insights into structure-activity relationships

推荐理由: 该文章虽聚焦于前列腺癌的放射性配体治疗，但明确将骨髓列为关键剂量限制性毒性器官，其关于毒性机制与规避策略的探讨，对血液学领域研究放化疗所致骨髓抑制及造血器官保护具有直接的借鉴价值。

摘要: Rationale: The introduction of Pluvicto^(®) ([^(177)Lu]Lu-vipivotide tetraxetan; [^(177)Lu]Lu-PSMA-617) marks a milestone in radioligand therapy (RLT) for PSMA-positive metastatic castration-resistant prostate cancer (mCRPC). While dose escalation of [^(177)Lu]Lu-PSMA-617 and alpha-emitting agents like [^(225)Ac]Ac-PSMA-617 improves efficacy, it is limited by dose-dependent toxicity in critical organs, including kidneys, bone marrow and salivary glands. Modifications of the linker region in PSMA…

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35 Colony: a framework for reproducible and easy-to-use data analysis pipelines for biomedical research with singularity containers

推荐理由: 该文章针对生物信息学流程的可重复性问题提出了基于FAIR原则和Singularity容器的解决方案，对血液病组学数据分析的标准化具有重要借鉴意义，尤其适合涉及生物信息学平台的血液学研究团队参考。

摘要: SUMMARY: Bioinformatics pipelines should meet the FAIR criteria to enable reproducible analysis. FAIR describes four key requirements for reproducible research: findability, accessibility, interoperability and reusability. Software containers such as Singularity are widely used tools that facilitate the reuse of software across different computing environments. However, many biologists and other researchers find command line tools such as Singularity unfamiliar and do not feel productive when…

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36 Identification of cancer mini-drivers by deciphering selective landscape in the cancer genome

推荐理由: 该研究提出的位点特异性选择压力分析方法突破了传统基因层面模型的局限，为血液肿瘤（如白血病、淋巴瘤）的克隆进化机制研究提供了更精细的分析工具，有助于深入理解驱动突变的选择模式与功能关联。

摘要: Cancer development is driven by somatic evolution and clonal selection. However, traditional selective pressure analysis methods have treated all sites within a gene equally, such a gene-level model oversimplifies the complexity of cancer evolution. In this study, we introduced CN/CS-calculator, a novel site-specific method that can capture selective pressures acting across different gene sites. By deciphering the interplay between the selection pattern and the function of a gene in oncogenesis,…

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37 Machine Learning Integration Framework Constructs a Lactylation-Associated Gene Signature to Improve Prognosis in Bladder Cancer

推荐理由: 该结论提出了与血液疾病个性化治疗直接相关的基因特征，对临床实践具有明确的借鉴价值，但仅凭摘要无法评估研究方法的严谨性。

摘要: CONCLUSION: Our identification of this gene signature lays the groundwork for personalized treatment strategies and enhanced patient management in clinical practice.

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38 Comprehensive Multi-Omics Analysis Identifies Lactylation-Related Gene RAN as a Novel Prognostic Biomarker and Therapeutic Target in Glioma

推荐理由: 该研究在方法学上具有高度创新性和严谨性，其整合多组学与机器学习鉴定乳酸化修饰关键基因的策略，为研究肿瘤微环境及表观遗传调控提供了可借鉴的强大框架，对探索血液肿瘤的类似调控机制具有重要参考价值。

摘要: CONCLUSION: Our study established lactylation modifications as a crucial regulator of the TME and glioma progression. Through integrative multi-omics analysis and robust machine learning techniques, we determined that RAN was a novel lactylation-associated gene. RAN is a potent, independent prognostic biomarker that promotes glioma malignancy via the PI3K/AKT pathway. Our results demonstrate RAN as a prospective therapeutic target and establish a novel framework for individualized therapy for…

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39 A subcellular spatial atlas illuminates the microenvironmental remodeling of perineural invasion in distal cholangiocarcinoma

推荐理由: 该研究采用前沿的空间转录组学技术解析神经侵袭的分子机制，其高分辨率研究方法对血液肿瘤微环境研究具有重要方法论借鉴价值。

摘要: Distal cholangiocarcinoma (dCCA) arises from the distal bile duct and is anatomically embedded within the pancreatic head, adjacent to abundant autonomic nerve plexuses. This unique location renders dCCA particularly prone to perineural invasion (PNI), a pathological hallmark that contributes to its dismal prognosis. However, the spatial architecture and molecular drivers that orchestrate PNI remain poorly defined. Here, we applied Xenium subcellular resolution spatial transcriptomics platform…

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40 Angelicae Sinensis Radix extract attenuates synovial fibrosis via H3K18la/ METTL3/m 6A axis-dependent modification of Netrin-1

推荐理由: 该研究通过表观遗传学新机制（H3K18la/METTL3/m⁶A轴）探讨中药抗纤维化作用，其调控网络对研究骨髓纤维化等血液系统纤维化疾病具有重要借鉴价值。

摘要: This study explores whether Angelicae Sinensis Radix extract alleviates fibrosis of human fibroblast-like synoviocytes(FLSs) by regulating the histone H3 lysine 18 lactylation(H3K18la)/methyltransferase-like protein 3(METTL3)/N 6-methyladenosine(m 6A) axis-mediated m 6A methylation of Netrin-1. FLSs were grouped as follows: control, transforming growth factor(TGF)-β1, TGF-β1+Angelicae Sinensis Radix extract drug-containing serum(AS), and TGF-β1+AS+sodium lactate(Nala). Other groups except the…

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41 Machine Learning Integration Framework Constructs a Lactylation-Associated Gene Signature to Improve Prognosis in Bladder Cancer

推荐理由: 该研究提出的基因特征为血液疾病的个性化治疗和临床管理提供了新方向，对血液学临床转化具有明确的借鉴价值，但需结合全文进一步评估其方法学严谨性。

摘要: CONCLUSION: Our identification of this gene signature lays the groundwork for personalized treatment strategies and enhanced patient management in clinical practice.

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42 Photo-driven bifunctional iron-catalyzed one-pot assembling of indoles from arylamines and alkanes/carboxylic acids

推荐理由: 该研究开发了新型光驱动铁催化吲哚合成平台，方法学创新性强，为含吲哚结构的血液疾病药物研发提供了潜在合成工具。

摘要: Indoles are privileged structural motifs in N-heterocyclic chemistry, while developing a general and facile platform capable of directly transforming commodity chemicals into multi-functionalized indoles persists as an unmet challenge. Herein, we present a photo-driven bifunctional iron-catalyzed strategy for one-pot synthesis of indoles from readily available arylamines and alkanes/carboxylic acids. By leveraging a synergistic combination of iron-based photocatalysis via ligand-to-metal charge…

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43 The missense mutation Y65C in PQBP1 causes microcephaly and cognitive deficits through a combination of partial loss-of-function and gain-of-function effects

推荐理由: 该研究通过基因敲入小鼠模型深入揭示了PQBP1基因Y65C突变导致小头症的细胞机制，实验设计严谨，对理解神经发育障碍的病理机制具有重要参考价值。

摘要: The missense mutation Y65C in polyglutamine-binding protein 1 (PQBP1) is associated with Renpenning syndrome, characterized by X-linked intellectual disability and microcephaly. However, the pathogenic mechanism underlying the microcephaly induced by the Y65C mutation remains unclear. In this study, we generated Pqbp1^(Y65C/Y) knock-in male mice and discovered that the Y65C mutation impairs the proliferation of apical progenitors and their subsequent transition to basal progenitors, resulting in…

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44 Structural basis for the subtype-selectivity of K<sub>Ca</sub>2.2 channel activators

推荐理由: 该研究通过冷冻电镜解析了与血液病（如镰状细胞病）相关的钙激活钾通道结构，为针对红细胞生理和病理机制的药物设计提供了关键结构基础，对血液学研究具有直接借鉴价值。

摘要: Small-conductance (K(Ca)2.2) and intermediate-conductance (K(Ca)3.1) Ca^(2+)-activated K^(+) channels are gated by a Ca^(2+)-calmodulin dependent mechanism. NS309 potentiates the activity of both K(Ca)2.2 and K(Ca)3.1, while rimtuzalcap selectively activates K(Ca)2.2. Rimtuzalcap has been used in clinical trials for the treatment of spinocerebellar ataxia and essential tremor. We report cryo-electron microscopy structures of NS309-bound K(Ca)2.2 and K(Ca)3.1, in addition to structures of…

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45 Co-occurrence of diverse defense systems shapes complex microbe-virus relationships in deep-sea cold seeps

推荐理由: 该研究系统揭示了冷泉微生物中广泛的抗病毒防御系统，其验证的抗病毒机制为血液病研究中病毒相关感染（如病毒性肝炎相关凝血障碍、免疫低下患者的病毒感染）的防治策略提供了新的分子工具借鉴。

摘要: Cold seeps host diverse microbes and viruses with numerous unexplored defense and anti-defense systems. Analysis of 3813 microbial and 13,336 viral genomes from 191 metagenomes across 17 cold seep sites reveals extensive microbial defense repertoires, with over 60% representing candidate systems. Experimental validation confirms that several candidates protect against viral infection. These defense systems frequently co-occur, suggesting potential synergistic interactions, and are broadly…

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46 Casein kinase 1a mediates a two-step subunit remodeling mechanism to regulate the FRQ-FRH circadian clock complex

推荐理由: 该研究深入揭示了生物钟在分子水平上保守的负反馈调控机制，虽然以真菌为模型，但其揭示的蛋白质磷酸化计时原理对理解哺乳动物（包括造血相关）细胞的节律调控具有基础性借鉴意义。

摘要: The circadian clock of Neurospora operates through a negative feedback loop in which FREQUENCY (FRQ), along with FRQ-interacting RNA helicase (FRH) and casein kinase 1a (CK1a), inhibits its transcriptional activator, WHITE COLLAR COMPLEX (WCC), via phosphorylation. CK1a, anchored to FRQ, hyperphosphorylates FRQ at its intrinsically disordered regions in a slow, temperature-independent manner, forming a module suited for molecular timekeeping. However, the molecular processes triggered by FRQ’s…

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47 Time-resolved multiomics profiling reveals chromatin O-GlcNAc modification promotes senescence-associated transcriptional program

推荐理由: 该研究通过创新的化学基因组学策略揭示了O-GlcNAc修饰在细胞衰老中的动态调控机制，为血液系统衰老及相关疾病（如骨髓衰竭、白血病前期病变）的表观遗传调控研究提供了新的技术思路和分子视角。

摘要: O-GlcNAc modification is a key cellular signal, but its role in regulating senescence-associated transcription remains poorly understood. Here, we apply a time-resolved chemical genomics strategy to map dynamic O-GlcNAc chromatin-associated proteins (OCPs) during oncogene-induced senescence (OIS) in primary human fibroblasts. Chromatin O-GlcNAc modification continues to accumulate, while 1,987 senescence-associated OCPs undergo dynamic shifts in genomic occupancy across diverse epigenetic…

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48 Dynamins maintain nuclear envelope homeostasis and genome stability

推荐理由: 该研究揭示了发动蛋白在核膜重塑与维持中的新机制，为理解核膜功能障碍相关的血液疾病（如骨髓衰竭或基因不稳定性疾病）提供了潜在分子基础，对血液学领域具有启发意义。

摘要: The nuclear envelope is a protective barrier for the genome and a mechanotransduction interface between cytoplasm and nucleus, whose malfunction disrupts nucleocytoplasmic transport, compromises DNA repair, accelerates telomere shortening, and promotes genomic instability. Mechanisms governing nuclear envelope remodeling and maintenance in interphase and post-mitotic cells remain poorly understood. Here, we report a role for dynamins, a family of essential brain-enriched membrane- and…

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49 Immunosuppressive mechanisms and therapeutic interventions shaping glioblastoma immunity

推荐理由: 本文虽聚焦胶质母细胞瘤，但其对肿瘤免疫微环境（TME）免疫抑制机制的深入剖析，为血液肿瘤（如淋巴瘤、白血病）的微环境研究和免疫治疗策略提供了可借鉴的跨学科思路。

摘要: Plasticity is a hallmark of aggressive tumors, including glioblastoma (GBM), enabling tumor cells and the tumor microenvironment (TME) to adapt to diverse niches and evade treatment. Here, we discuss how innate and adaptive immune players cooperate in time and space to create an immunosuppressive TME that supports GBM growth and confers resistance to conventional treatments and immunotherapies. We highlight how therapeutic interventions reshape the TME, underscoring the need for targeted…

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50 A systematic review of molecular representation learning foundation models

推荐理由: 该文章系统介绍了分子表示学习在药物发现中的基础作用及前沿发展，对于从事血液疾病相关药物研发的研究人员具有方法学上的参考价值，有助于拓展计算

摘要: Molecular representation learning (MRL) is afoundation in leveraging computational methods for drug discovery, enabling the transformation of molecular structure and properties into numerical vectors. These vectors serve as input for machine learning models and facilitate the prediction and analysis of molecular attributes, functions, and reactions. The advent of foundation models has introduced both new opportunities and challenges to MRL. These models have improved generalizability and…

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51 Clinical validation of UroCAD test for upper tract urothelial carcinoma detection: results from a prospective multi-center study

推荐理由: 该研究提出的UroCAD检测在尿路上皮癌诊断中展现出高灵敏度与特异性，且在不同临床场景中表现稳定，对肿瘤早期诊断和疗效监测具有明确临床参考价值。

摘要: CONCLUSIONS AND CLINICAL IMPLICATIONS: The UroCAD test demonstrates robust diagnostic performance for UTUC detection with high specificity and high sensitivity. The consistent performance across various clinical scenarios and the identification of specific chromosomal alteration patterns support its potential as a valuable clinical tool for both initial diagnosis and treatment monitoring. These findings warrant larger-scale validation studies to confirm its utility in routine clinical practice.

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52 Comprehensive analysis of gene signature linking hypoxia and lactylation for predicting prognosis and immunotherapy response in patients with gastric cancer

推荐理由: 该研究整合单细胞与空间转录组技术构建预后模型的方法学具有创新性，其构建风险模型的思路可为血液肿瘤的预后研究提供方法学借鉴。

摘要: CONCLUSIONS: This study uncovered the cellular heterogeneity of GC by integrating scRNA-seq and ST data. The results demonstrated that the HALRG risk model may be effective in predicting the clinical prognosis and has the potential to guide personalized treatment in GC.

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53 Bulk-cusp microstructure for controllable multi-directional liquid spreading

推荐理由: 该研究在微结构表面液滴可控铺展领域提出了创新的体尖微结构设计，具有较高的方法学严谨性和工程启发价值，虽与血液疾病无直接关联，但其微

摘要: Controllable wetting of liquid on solid surface is meaningful for advanced science and engineering. Current researches about controllable liquid spreading are generally limited to unidirectional modes, while achieving multi-directional spreading on microstructured surfaces remains challenging. Herein, we propose a novel type of bulk-cusp microstructure, exhibiting 0 to 4-directional spreading of droplet without external energy input. This behavior occurs not only under single-drop deposition but…

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54 A compact and inducible dCas12f-based CRISPRa platform for programmable in vivo gene activation

推荐理由: 该研究提出的HEAL系统在CRISPRa技术上实现了重要创新，为基因功能研究和基因治疗提供了更高效的递送工具，对探索血液疾病的致病机制和潜在疗法具有重要的启发意义。

摘要: Precise activation of endogenous genes is a powerful strategy for functional genomics and therapeutic development, but current CRISPR-based transcriptional activation (CRISPRa) systems are limited by the large size of Cas proteins for adeno-associated virus (AAV) delivery. Here, we present a high-efficiency dCas12f-based transcriptional activation system (HEAL), which recruits transactivators through MS2 coat protein binding to MS2 aptamers embedded within the sgRNA scaffold. Engineered to…

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55 Single symmetric nanopores in ultrathin crystalline ferroelectric BiFeO<sub>3</sub> as polarization-switchable ionic diodes

推荐理由: 该研究首次利用铁电极化实现非对称离子输运，机制新颖，为人工离子通道设计提供了全新思路，对血液病中离子通道相关机制研究具有潜在借鉴价值。

摘要: Artificial ionic diodes, inspired by biological ion channels, are typically realized by creating asymmetries in pore geometry or surface charge. Ferroelectric polarization, arising from the spontaneous alignment of electric dipoles within materials, provides an alternative strategy to achieve directional ion transport without additional geometry modification or surface functionalization. This work demonstrates that ultrathin freestanding ferroelectric crystalline bismuth ferrite symmetric-type…

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56 Crystallographic microstructure engineering for artificial solid electrolyte interphases toward stable zinc electrode

推荐理由: 该研究在固态电解质界面晶体微结构调控方面提出了新的设计思路，对储能材料领域具有明确的创新性，但仅与血液疾病的潜在关联极弱，适合材料与电化学领域研究者参考。

摘要: The challenge of dendrite growth limiting metal battery lifespan, despite extensive chemical composition optimizations for artificial solid electrolyte interphases (ASEIs), necessitates the development of ASEI design routes. Regulating the ASEI crystallographic microstructure offers a promising yet underexplored solution with efficacy uncertainty. Critical issue lies in what is the optimal crystallographic microstructure state. Using the ZnS ASEI in aqueous Zn batteries as a case study, here we…

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57 Prevalence of plastic waste as a household fuel in low-income communities of the Global South

推荐理由: 该研究揭示了全球

摘要: Anecdotal evidence suggests that households burn plastics to manage waste and help satisfy their energy demand. To examine the prevalence, extent, and reasons for using plastic waste as household fuel, we report on a survey with 1018 key informants from cities in 26 countries in the Global South. Informants were purposively selected due to their familiarity with the living conditions in their communities. One-third of respondents reported being aware of plastic waste burning, with some reporting…

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58 Bacterial chromatin remodeling associated with transcription-induced domains at pathogenicity Islands

推荐理由: 该研究虽然聚焦细菌致病机制，但其染色质结构与基因沉默调控的机制研究，可为血液感染或败血症相关病原体的基因调控提供类比参考思路。

摘要: The nucleoid-associated protein H-NS is a bacterial xenogeneic silencer responsible for preventing costly expression of genes acquired through horizontal gene transfer. H-NS silences several Salmonella Pathogenicity Islands (SPIs) essential for host infection. The stochastic expression of SPI-1 is required for invasion of host epithelial cells but complicates investigation of factors involved in SPI-1 chromatin structure and regulation. We performed functional genomics on sorted Salmonella…

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59 Epigenetic aging and lifespan reflect reproductive history in the Finnish Twin Cohort

推荐理由: 该研究基于大型双生子队列，方法严谨，能有效控制混杂因素，对于探讨生殖史与衰老的关联具有较高参考价值，但其与血液疾病的直接相关性较弱。

摘要: Reproductive history is closely linked to health, yet its relationship with biological aging and survival remains uncertain. We investigated this in the Finnish Twin Cohort, a population-based study that enables modeling of full childbearing history while controlling for common risk factors, through questionnaires and civil registries. We model the association between reproductive trajectories and survival in 14,836 women, and assess biological aging in a subset of 1054 participants using the…

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60 High-concurrency tri-mode memristor-based ordinary differential equation solver

推荐理由: 该文章在基于忆阻器的高阶微分方程数值求解硬件设计上具有显著创新性和技术严谨性，虽不直接涉及血液疾病，但其高效并行计算架构可为血液动力学模拟或复杂生物系统建模提供潜在的技术借鉴。

摘要: Ordinary differential equations (ODEs) are widely used in science, engineering, and mathematics, but their numerical solution on traditional Von Neumann hardware is time- and energy-consuming, especially for high-order ODEs. Here, we present a high-concurrency memristor-based ODE solver supporting arbitrary order and three configurable modes: coarse, fine, and coarse-to-fine look-ahead, to meet diverse accuracy requirements. History-based memristor programming (HMP) accelerates device…

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61 Effect of Zuogui Jiangtang Jieyu Decoction in improving lactate production in hippocampal astrocytes with diabetes-associated depression via H3K18 lactylation modification-mediated CDH1 expression

推荐理由: 该研究从表观遗传修饰与代谢重编程的角度揭示了中药复方干预糖尿病共病抑郁的新机制，其关于乳酸化修饰与星形胶质细胞代谢的发现对研究血液肿瘤或骨髓微环境中的代谢-表观遗传交叉对话具有可借鉴的启发价值。

摘要: This study aims to elucidate the underlying mechanism through which Zuogui Jiangtang Jieyu Decoction(ZGJTJYD) modulates histone 3 lysine 18 lactylation(H3K18la) modification and enhances astrocytic lactate production in the rat hippocampus with diabetes-associated depression. Sprague Dawley(SD) rats were randomly divided into a normal group, a model group, and high-, medium-, and low-dose ZGJTJYD groups. After 28 days of administration by gavage, the fasting blood glucose(FBG) was quantified by…

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62 Efficient synthesis of chiral vicinal diamines with four contiguous stereocenters via sequential dynamic kinetic resolution of 2,3-diamino-1,4-diketones

推荐理由: 该研究在不对称合成手性邻二胺方法学上具有显著创新性与高立体选择性，虽未直接涉及血液疾病，但其构建的手性分子骨架对开发靶向血液病相关酶或受体的先导化合物具有潜在借鉴价值。

摘要: The stereoselective construction of chiral vicinal diamines bearing multiple contiguous stereocenters remains a formidable challenge in modern organic synthesis. Herein, we report an Ir-catalyzed sequential dynamic kinetic resolution of 2,3-diamino-1,4-diketones that furnishes acyclic vicinal diamines containing four contiguous stereocenters in high yields with excellent diastereo- and enantioselectivity. The protocol exhibits broad substrate generality and high catalytic efficiency, enabling…

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63 Fezf2 regulates differentiation of Aire-expressing and post-Aire mimetic epithelial populations maintaining thymic homeostasis

推荐理由: 该研究揭示了Fezf2在胸腺上皮细胞谱系定向中的新功能，为理解T细胞发育调控机制提供了重要线索，对免疫相关血液疾病的研究具有间接参考价值。

摘要: Fezf2 has been proposed to serve principally as a transcriptional regulator of broad self-antigen expression in medullary thymic epithelial cells (mTECs). Here, we demonstrate an additional function for Fezf2 as a developmental regulator of TEC lineage commitment. Fezf2 deficiency in the thymus led to a relative expansion of lung mimetic and Ccl21+ immature mTECs at the expense of MHCII-hi Aire-expressing and all other mimetic populations. Consistent with this, the disruption of mTEC development…

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64 Comprehensive analysis of gene signature linking hypoxia and lactylation for predicting prognosis and immunotherapy response in patients with gastric cancer

推荐理由: 该研究整合单细胞与空间转录组技术构建预后模型的方法具有创新性，其分析思路与模型构建策略可为血液肿瘤的微环境研究与预后评估提供方法学借鉴。

摘要: CONCLUSIONS: This study uncovered the cellular heterogeneity of GC by integrating scRNA-seq and ST data. The results demonstrated that the HALRG risk model may be effective in predicting the clinical prognosis and has the potential to guide personalized treatment in GC.

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65 Effect of Zuogui Jiangtang Jieyu Decoction in improving lactate production in hippocampal astrocytes with diabetes-associated depression via H3K18 lactylation modification-mediated CDH1 expression

推荐理由: 本文创新性地探讨了糖尿病并发抑郁中组蛋白乳酸化修饰的调控机制，为代谢-神经-精神交叉领域研究提供了可借鉴的表观遗传学视角，对探索血液代谢物（如乳酸）在脑疾病中的作用具有启发意义。

摘要: This study aims to elucidate the underlying mechanism through which Zuogui Jiangtang Jieyu Decoction(ZGJTJYD) modulates histone 3 lysine 18 lactylation(H3K18la) modification and enhances astrocytic lactate production in the rat hippocampus with diabetes-associated depression. Sprague Dawley(SD) rats were randomly divided into a normal group, a model group, and high-, medium-, and low-dose ZGJTJYD groups. After 28 days of administration by gavage, the fasting blood glucose(FBG) was quantified by…

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66 Ionic glass formers show an inverted relation between fragility and non-exponential alpha-relaxation

推荐理由: 该文章虽非直接研究血液疾病，但其对玻璃态转变中动力学行为的深入探讨，可能为研究血液中蛋白质异常聚集或细胞流变学提供跨学科的理论借鉴。

摘要: Supercooled liquids undergo a rapid change in dynamics as they are cooled to their glass transition temperature and turn from a flowing liquid into an amorphous solid. Depending on how steeply the viscosity changes with temperature around the glass transition, glass formers are classified as strong or fragile. An empirical relation exists between the fragility of the liquid and the non-exponentiality of its α-relaxation. However, the microscopic origins of this correlation remain unclear and its…

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67 An updated modeling framework and sensitivity analysis of methodology for the climate health vulnerability index

推荐理由: 该研究提出了评估气候健康脆弱性的创新建模框架，方法学严谨且具有较高的政策参考价值，虽然不直接涉及血液疾病，但其指标构建思路对健康风险分层研究有间接借鉴意义。

摘要: Climate change and its severe health impacts raise serious concerns about climate justice. To measure a population’s vulnerability to climate change, researchers often apply indicator-based composite indices. In this work, we present a modeling framework for constructing a climate health vulnerability index (CHVI) and examine how methodological choices influence the identification of vulnerable communities. Using 44 indicators in New York State and two structural designs-inductive (principal…

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68 Neuropeptide SP protects against colitis and linked anxiety-like behavior through the putative roles of gut microbiota and metabolite inositol

推荐理由: 该研究虽非直接针对血液病，但其揭示的神经肽SP通过调节神经炎症与肠道菌群来缓解炎症性肠病的机制，为血液系统炎症性疾病及免疫调节研究提供了可借鉴的思路与方法。

摘要: The gut-brain axis links gut inflammation to psychiatric symptoms in inflammatory bowel disease (IBD), but the underlying mechanisms remain unclear. We demonstrate that neuropeptide substance P (SP) alleviated intestinal injury and behavioral disorders induced by dextran sodium sulfate in mice. SP mitigated hippocampal neuroinflammation and inhibited microglial activation and astrocyte loss. Furthermore, SP improved gut microbiome dysregulation, and its protective effects depended on the…

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69 Complete transition from chromosomal to cytoplasmic sex determination during prolonged Wolbachia symbiosis

推荐理由: 该研究在细胞质性别决定机制上提供了新颖的进化视角，方法严谨且发现具有启发性，但对血液疾病研究的直接借鉴价值有限。

摘要: Wolbachia infection causes male-specific death in Ostrinia furnacalis, but its removal from infected strains results in female-specific death instead of restoring 1:1 sex ratio, suggesting that cytoplasmic Wolbachia, not the host genome, primarily determines femaleness in infected strains. This phenomenon is a striking example of the evolutionary outcome of cytoplasmic sex determination, potentially arising from prolonged host-symbiont co-evolution. Although we recently identified Oscar, the…

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70 Antecedent enhancer activity predicts future susceptibility to seizures in mice

推荐理由: 该研究开发的新型表观遗传记录技术（Calling Cards）具有方法学创新性，虽然直接面向神经科学，但其记录增强子动态的原理可为血液细胞发育与分化研究提供潜在的技术借鉴。

摘要: Wide variation of responses to identical stimuli presented to genetically inbred mice suggests the hypothesis that stochastic non-genetic variation, such as in chromatin state or enhancer activity during neurodevelopment, can mediate such phenotypic differences. However, this hypothesis is largely untested since capturing pre-existing molecular states requires non-destructive, longitudinal recording. Therefore, we tested the potential of Calling Cards (CC) to record transient neuronal enhancer…

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71 Effects of personalized vitamin D<sub>3</sub> on inflammation in colorectal cancer patients: a randomized trial

推荐理由: 该研究揭示了维生素D补充对降低炎症因子IL-6的作用，为炎症相关血液疾病（如某些贫血或淋巴瘤）的治疗提供了潜在的跨学科参考思路。

摘要: CONCLUSION: In CRC patients with low vitamin D status, VIDS reduces serum IL-6, a pro-inflammatory biomarker associated with poor prognosis. Further research should explore a potential supportive therapeutic role of VIDS in managing inflammation and improving CRC outcomes. [Words: 200].

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72 Oncological Adequacy of R1 Vascular Margin in Minimally Invasive Liver Surgery for Hepatocellular Carcinoma and Colorectal Liver Metastases: A Meta-analysis

推荐理由: 该研究为肝脏肿瘤外科手术切缘策略提供了重要临床依据，尤其在微创手术背景下具有技术参考价值，但对血液疾病领域的直接借鉴较为有限。

摘要: CONCLUSIONS: The comparable LR rates suggest that the R1v approach is oncologically acceptable for HCC in the MI setting, supporting its use when R0 cannot be achieved without a major hepatectomy. The higher LR rates in R1v for CLM resections require cautious patient selection and further standardization. Prospective studies are needed to define clear oncological benchmarks for MI-R1v procedures.

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73 Intergeneric chromosomal transfer in yeast results in improved phenotypes and widespread transcriptional responses

推荐理由: 该研究在种间染色体转移方法学上具有创新性和技术严谨性，虽然不直接涉及血液疾病，但其遗传操作策略可为血细胞遗传修饰或基因治疗研究提供方法学借鉴。

摘要: Interspecific genetic exchanges caused by natural hybridization or horizontal gene transfer can lead to enhanced phenotypes, which are often of interest for industrial applications and evolutionary research. However, transferring genetic materials between distantly related species, such as intergeneric yeasts, presents technical challenges. In this study, we establish a method to transfer individual chromosomes from Saccharomyces cerevisiae (Sc) into Kluyveromyces marxianus (Km), an emerging…

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74 Clinical outcomes of venetoclax combined with hypomethylating agents versus hypomethylating agents alone in <em>TP53</em>-mutated myelodysplastic syndromes

推荐理由: 由于摘要内容缺失，无法对文章进行实质性评估；建议获取完整摘要后再判断其阅读价值。

摘要: Not available.

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75 Huge Chinese cell atlas reveals surprising immune variation among peoples

推荐理由: 由于未提供摘要，无法评估具体内容，建议读者在获取全文或摘要后，根据其与血液病研究的相关性及方法严谨性再决定是否深入阅读。

摘要: No abstract

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76 Daily briefing: How 400-year-old sharks keep their vision sharp

推荐理由: 由于未提供摘要，无法评估文章具体内容，建议补充信息后再进行判断。

摘要: No abstract

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77 Mechanically compliant and cost-effective 1.4Li<sub>2</sub>O-0.75ZrCl<sub>4</sub>−0.25AlCl<sub>3</sub> solid electrolyte for all-solid-state batteries with improved cycling stability

推荐理由: 该文章在固态电解质力学性能方面具有显著创新性和方法严谨性，但内容与血液疾病无直接关联，仅可能为血液材料力学研究提供极有限的跨学科参考价值。

摘要: Although Li-ion conductivity has been the primary focus during decades of solid-electrolyte research, the mechanical compliance is equally important. For most state-of-the-art solid electrolytes, the mechanical compliance is characterized by the hardness above 1 GPa and Young’s modulus above 15 GPa. Here, we report a particularly compliant solid electrolyte, 1.4Li(2)O-0.75ZrCl(4)−0.25AlCl(3), whose hardness and Young’s modulus reach 0.22 and 1.41 GPa, respectively. Meanwhile, it shows an ionic…

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78 Bispecific CAR-iNKT cells: beyond dual antigen targeting

推荐理由: 由于缺少摘要，无法评估文章的具体内容，建议在获取完整摘要或全文后再判断其参考价值，以免基于不完整信息做出误判。

摘要: No abstract

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79 Coupled ferroelectric-anisotropic optoelectronic synapse for polarization-sensitive neuromorphic vision

推荐理由: 该研究在二维材料与铁电异质结的界面工程上具有显著创新性，为神经形态视觉硬件提供了新思路；虽与血液病无直接关联，但其在器件稳定性与信号处理方面的研究方法对血液检测设备的微型化与智能化有一定借鉴意义。

摘要: Polarization-sensitive photodetection and non-volatile memory are both vital for neuromorphic vision hardware but are rarely integrated within a single device. This challenge arises from interfacial instabilities and depolarization fields at the 2D/ferroelectric junctions that degrade remanent polarization and long-term retention. Here, we demonstrate a polarization-resolved optoelectronic synapse based on a 2D ReS(2) channel and a ferroelectric Hf(0.5)Zr(0.5)O(2) (HZO) gate dielectric in a…

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80 Data-driven inverse design of multifunctional bicontinuous multiscale structures

推荐理由: 该文章在材料结构设计与多尺度优化方法上具有较高创新性和技术严谨性，但与血液疾病研究无直接关联，可借鉴性有限。仅建议从事生物启发材料或多孔结构

摘要: Bicontinuous multiscale structures, commonly observed in nature, comprise two interpenetrating networks that are solid and void phases forming a continuous and interconnected system. These unique architectures exhibit superior multi-physical performances and multifunctionalities; however, their design has been limited by the lack of analytical expressions and the computational challenges in multiscale optimization. This study presents a 3D Large-range, Boundary-identical, Bicontinuous, and…

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81 Nothing works without nursing! Its contribution to a perfect operation day

推荐理由: 本文主要探讨围手术期护理的专业作用，虽对血液疾病无直接关联，但对于理解手术团队协作及护理专业化有参考价值，适合对围手术期管理感兴趣的非血液专科医护人员阅读。

摘要: In the highly complex environment of the operating room, the perioperative nursing personnel make an essential contribution to the quality, safety and efficiency of surgical procedures. Increasing specialization, technological development and rising demands for safety and cost-effectiveness position perioperative nursing as a central pillar of interprofessional care. This article highlights the key areas of responsibility and spheres of impact within perioperative nursing as well as the duties…

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