追觅 - 2026-01-11

生成时间: 2026−01-11 22:36

分析文章数量: 54

1 Cilta-cel in lenalidomide-refractory multiple myeloma (CARTITUDE-4): an updated analysis including overall survival from an open-label, multicentre, randomised, phase 3 trial

推荐理由: 该研究提供了CARTITUDE-4试验中cilta-cel治疗多发性骨髓瘤的长期总生存数据和安全性更新，对血液肿瘤临床实践具有重要指导价值。

摘要: BACKGROUND: In CARTITUDE-4, a single infusion of ciltacabtagene autoleucel (cilta-cel) significantly prolonged progression-free survival in patients with lenalidomide-refractory multiple myeloma. We report updated overall survival and longer-term efficacy and safety outcomes.

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2 ProTCR: a protein language model-driven framework for decoding TCR-antigen recognition toward precision immunotherapies

推荐理由: 该研究提出的ProTCR模型创新性地结合了蛋白质语言模型与深度学习，能更精准预测TCR-肽段相互作用，对开发针对血液肿瘤的TCR免疫疗法具有重要参考价值。

摘要: The ability of T-cell receptors (TCRs) to recognize neoantigens is fundamental to the initiation and maintenance of adaptive immune responses. In TCR-based immunotherapies, elucidating the recognition patterns of TCRs for peptides and accurately identifying therapeutically relevant TCR-peptide pairs remain critical challenges. Here, we present a novel dual-pathway network model, ProTCR, which integrates the protein language model ProtT5 with deep learning methods. By incorporating both global…

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3 ProTCR: a protein language model-driven framework for decoding TCR-antigen recognition toward precision immunotherapies

推荐理由: 该文章提出的ProTCR模型创新性地融合了蛋白语言模型与深度学习，为精准预测TCR-肽段相互作用提供了新工具，对推动血液肿瘤（如白血病）的TCR免疫疗法研发具有直接且重要的参考价值。

摘要: The ability of T-cell receptors (TCRs) to recognize neoantigens is fundamental to the initiation and maintenance of adaptive immune responses. In TCR-based immunotherapies, elucidating the recognition patterns of TCRs for peptides and accurately identifying therapeutically relevant TCR-peptide pairs remain critical challenges. Here, we present a novel dual-pathway network model, ProTCR, which integrates the protein language model ProtT5 with deep learning methods. By incorporating both global…

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4 Single-cell multiplex approaches deeply map ON-target CRISPR-genotoxicity and reveal its mitigation by palbociclib and long-term engraftment

推荐理由: 该研究开发了高灵敏度的单细胞水平CRISPR基因编辑毒性监测方法，对推动血液病基因治疗的安全性评估具有重要参考价值，尤其适用于镰状细胞贫血等疾病的治疗优化。

摘要: Genome editing by CRISPR-Cas9-nuclease is promising for gene therapy. However, safety concerns remain. Monitoring ON-target genotoxicity is essential, especially to assay megabasic rearrangements at the targeted locus. Here, we developed a combined single-cell resolution approach with DNA sequencing focused on single nucleotide polymorphism (scSNP-DNAseq), micronuclei and LOH cytometry-reporter assays. This sensitive multiplexed strategy enables the sensitive monitoring of CRISPR-mediated…

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5 Improved protein binder design using β-pairing targeted RFdiffusion

推荐理由: 该研究展示了RFdiffusion在针对亲水性蛋白靶点（包括多个血液疾病相关受体如KIT、PDGFRα等）设计高亲和力结合蛋白方面的突破性方法，为血液肿瘤等疾病的靶向治疗开发提供了创新的蛋白质设计策略和重要借鉴。

摘要: Designing proteins that bind with high affinity to hydrophilic protein target sites remains a challenging problem. Here we show that RFdiffusion can be conditioned to generate protein scaffolds that form geometrically matched extended β-sheets with target protein edge β-strands in which polar groups on the target are complemented with hydrogen bonding groups on the design. We use this approach to design binders against edge-strand target sites on KIT, PDGFRɑ, ALK-2, ALK-3, FCRL5, NRP1, and…

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6 Genome-wide association study of event-free survival in follicular lymphoma patients treated with front-line immunochemotherapy

推荐理由: 本研究首次通过大规模GWAS探索滤泡性淋巴瘤预后相关的遗传标记，采用多中心临床试验数据，方法严谨，结果对实现个体化预后评估和精准治疗具有重要参考价值。

摘要: Genome-wide association studies (GWAS) have identified germline genetic variants for follicular lymphoma (FL) susceptibility. We conducted a GWAS of prognosis in FL patients to identify genetic predictors of event-free survival (EFS) as well as failure within the first 24 months after treatment initiation (EFS24) using patients treated with rituximab-based immunochemotherapy from three clinical trials and one prospective observational study (N = 1054). Statistical approaches consisted of a…

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7 App supporting surveillance for (likely) pathogenic TP53 variant carriers: acceptance among a German cohort

推荐理由: 该研究将数字化医疗工具（PatientConcept应用）有针对性地应用于携带TP53胚系变异这一特定高危人群的监测管理，展现了精准数字健康干预的创新实践，对血液遗传性肿瘤综合征的长期随访模式具有直接的借鉴价值。

摘要: The rapid digitalization of healthcare is transforming medical care strategies. Individuals carrying (likely) pathogenic TP53 germline variants (P/LP TP53) require complex surveillance protocols. To support these individuals, we provided the adapted PatientConcept app to adults with a P/LP TP53 variant and their relatives. We analyzed the value of this adapted app for this cohort, as well as general aspects of Internet use, web-based healthcare options, mental and physical health, and fear of…

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8 Structural basis for late maturation steps of mitochondrial respiratory chain complex IV within the human respirasome

推荐理由: 该研究采用前沿冷冻电镜技术解析线粒体呼吸链超复合体组装机制，方法学具有高度创新性和严谨性，虽未直接涉及血液疾病，但其对细胞能量代谢的深入理解可为红细胞代谢异常或白血病细胞线粒体功能研究提供重要基础参考。

摘要: The mitochondrial respiratory chain comprises four multimeric complexes (CI-CIV) that drive oxidative phosphorylation by transferring electrons to oxygen and generating the proton gradient required for ATP synthesis. These complexes can associate into supercomplexes (SCs), such as the CI + CIII₂ + CIV respirasome, but how SCs form, by joining preassembled complexes or by engaging partially assembled intermediates, remains unresolved. Here, we use cryo-electron microscopy to determine…

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9 Structure of SHOC2-KRAS-PP1C complex reveals RAS isoform-specific determinants and insights into targeting complex assembly by RAS inhibitors

推荐理由: 该研究深入揭示RAS亚型在MAPK信号通路中的调控差异，对理解RAS突变型血液肿瘤（如急性髓系白血病）的分子机制具有重要借鉴价值，为靶向SHOC2复合物的治疗策略提供理论依据。

摘要: RAF activation is essential for MAPK signaling and is mediated by RAS binding and the dephosphorylation of a conserved phosphoserine by the SHOC2-RAS-PP1C complex. MRAS forms a high-affinity SHOC2-MRAS-PP1C (SMP) complex, while canonical RAS isoforms (KRAS, HRAS, NRAS) form analogous but lower-affinity assemblies. Yet, cancers driven by oncogenic KRAS, HRAS, or NRAS remain strongly SHOC2-dependent, suggesting that these weaker complexes contribute to tumorigenesis. To elucidate how canonical RAS…

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10 Markers predicting lymphoma development in Sjogren disease: current status and future perspectives

推荐理由: 该文章系统总结了干燥综合征中淋巴瘤发生的预测标志物最新进展，对血液科和风湿免疫科临床工作者具有直接的参考价值，有助于早期识别高危患者并优化管理策略。

摘要: We aim to present recent advancements in predictive markers for lymphomagenesis in SjD, concisely organize existing knowledge, and identify corresponding unmet needs and future perspectives. First, we briefly describe the mechanisms of lymphomagenesis in SjD. Followingly, the reasons justifying the importance of early lymphoma diagnosis in SjD are presented. Subsequently, recent advancements regarding lymphoma risk factors in SjD, both in translational and clinical research, are discussed, and…

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11 CoBRA: compound binding site prediction using RNA language model

推荐理由: 该研究提出的CoBRA工具在RNA-药物结合位点预测上具有方法学创新性，为靶向RNA的药物开发提供了高效计算手段，对血液肿瘤等RNA相关疾病的治疗策略有潜在借鉴价值。

摘要: RNA performs a variety of functions within cells and is implicated in various human diseases. Because druggable proteins occupy a small portion of the genome, considerable interest has been increasing in developing drugs targeting RNAs. Thus, precise prediction of small-molecule binding sites across different classes of RNAs is important. In this study, a lightweight deep learning program for predicting RNA-drug binding sites, called compound binding site prediction for RNA (CoBRA), is…

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12 GRAFT: a graph-aware fusion transformer for cancer driver gene prediction

推荐理由: 该文章提出的GRAFT框架通过多视角图编码整合多种生物网络，在方法学上具有创新性和较强的可扩展性，对于血液肿瘤驱动基因的识别与机制研究具有较好的借鉴价值。

摘要: Identifying cancer driver genes is essential for precision oncology, but existing computational methods are often limited by their reliance on single biological networks and their inability to capture long-range molecular dependencies. To address these challenges, we propose GRAFT, a Graph-Aware Fusion Transformer. This framework learns modality-specific features from protein-protein interactions, pathway co-occurrence, and gene semantic similarity using a multi-view graph encoder. These…

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13 MACFIV: a novel framework for nonlinear causal inference in the body mass index-hypertension relationship with many weak and pleiotropic genetic instruments

推荐理由: 该研究提出的非线性因果推断方法能更准确地揭示生物学性状间的复杂关系，对于研究血液疾病中非线性的病因机制具有重要的方法论借鉴价值。

摘要: Causal inference is an essential approach for understanding biological processes. Traditional causal inference methods assume a linear relationship between different biological traits, whereas their true causal relationship may be nonlinear, such as U-shaped. Moreover, when the instrument set includes weak and pleiotropic genetic instruments, accurately capturing the shape of these relationships becomes challenging. To address these issues, we propose model-averaged control function-based…

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14 Benchmarking knowledge graph embedding models for the prediction of oligogenic combinations

推荐理由: 该研究针对罕见病的寡基因致病机制提出了基于结构化生物信息的新方法，对血液系统罕见病的基因诊断和致病网络研究具有较高的借鉴价值。

摘要: Identifying the potential oligogenic causes of rare diseases remains a challenge, notwithstanding the advancements made in the last decade. While a variety of predictive and ranking approaches have been proposed, their precision remains limited, as only a small number of high-quality training cases are available and it remains difficult to know which features may be most relevant for the design of new predictors. We hypothesize here that structured biological information, which provides an…

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15 HSPA8 lactylation attenuates neuronal pyroptosis via E3 ligase-mediated NLRP3 degradation after ischemic stroke

推荐理由: 该研究揭示了蛋白质乳酸化修饰在缺血性脑损伤中的关键调控机制，其研究思路和方法（如靶向翻译后修饰调控炎症通路）对血液疾病中炎症相关机制的研究具有可借鉴的参考价值。

摘要: CONCLUSIONS: HSPA8 lactylation at K524 is a critical regulator of neuronal pyroptosis and ischemic brain injury. This modification facilitates E3 ligase-mediated NLRP3 degradation and suppression of inflammasome activation. Targeting protein lactylation pathways may offer a promising therapeutic strategy for neuroprotection in ischemic stroke.

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16 HSPA8 lactylation attenuates neuronal pyroptosis via E3 ligase-mediated NLRP3 degradation after ischemic stroke

推荐理由: 该研究揭示了蛋白质乳酰化修饰在缺血性脑损伤中的新机制，其调控炎症小体活性的发现对血液系统炎症性疾病（如自身免疫性血液病）的研究具有重要借鉴价值。

摘要: CONCLUSIONS: HSPA8 lactylation at K524 is a critical regulator of neuronal pyroptosis and ischemic brain injury. This modification facilitates E3 ligase-mediated NLRP3 degradation and suppression of inflammasome activation. Targeting protein lactylation pathways may offer a promising therapeutic strategy for neuroprotection in ischemic stroke.

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17 Lipid-induced granules in hepatocytes alleviate liver fibrosis

推荐理由: 该研究聚焦于通过液-液相分离（LLPS）机制发现新的无膜细胞器，这一前沿机制在血液系统疾病（如白血病相关核体形成或应激颗粒异常）中具有高度借鉴价值，为血液学领域提供了新的潜在研究视角和靶点。

摘要: Intracellular membraneless organelles, including granules, bodies, speckles, etc., play critical roles in physiological and pathological processes. The discovery of new membraneless organelles has generated significant attention. DEAD-box helicase (DDX) family members possess the potential to undergo liquid-liquid phase separation (LLPS), the foundation for the assembly of membraneless organelles. Here, to identify new granules assembled in steatotic hepatocytes, we screened DDX family members…

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18 Transcriptomic signature-guided depletion of intermediate alveolar epithelial cells ameliorates pulmonary fibrosis in mice

推荐理由: 该研究开发的RNA感应依赖性蛋白翻译技术具有高度创新性，能精准靶向特定细胞亚群，其方法学思路对血液肿瘤的单细胞精准干预研究具有重要借鉴价值。

摘要: Single-cell RNA sequencing (scRNA-seq) has identified intermediate epithelial states in pulmonary fibrosis, including KRT5-/KRT17+ aberrant basaloid cells in humans and Krt8+ alveolar differentiation intermediates (ADIs) in mice. Their functional contributions to fibrogenesis, however, remain unclear. Here, we introduce an RNA-sensing-dependent protein translation technology that enables selective targeting of Krt8+ ADI cells in vitro and in vivo. Transcriptomic analysis revealed Small…

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19 Wearable textile-based phototherapy platform with customized NIR OLEDs toward non-invasive hair loss treatment

推荐理由: 该研究创新性地将柔性电子技术与生物光学特性结合，为脱发治疗提供了非药物疗法的前沿思路，对生物医学工程交叉领域具有较高借鉴价值。

摘要: Hair loss presents a widespread clinical and psychological challenge, yet conventional pharmacological treatments often incur systemic side effects such as hormonal imbalance and mood disturbances. To provide a non-pharmacological alternative, a wearable textile-integrated near-infrared (NIR) organic light-emitting diode (OLED) platform was developed with emission closely aligned with the action spectrum of human dermal papilla cells (hDPCs). By employing a top-emitting microcavity structure, we…

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20 Rad51 determines pathway usage in post-replication repair

推荐理由: 该研究通过Rad51突变体揭示了DNA复制后修复的路径调控机制，对理解血液系统疾病（如骨髓衰竭、白血病）中基因组不稳定的分子基础具有重要借鉴价值。

摘要: Stalled replication forks are processed in post-replication repair by homologous recombination, fork regression, and translesion DNA synthesis. However, the regulation of pathway usage is not fully understood. Rad51 protein maintains genomic stability through its roles in recombination and in protecting stalled replication forks. We report isolation of mutations in Saccharomyces cerevisiae Rad51 that shift post-replication repair from recombination to alternate pathways including mutagenic…

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21 Dual-action bisphosphonate hydrogel preserves cortical bone integrity and restores healing cascade in osteoporotic fracture-related infection

推荐理由: 该研究开发的双功能水凝胶不仅控制感染，还主动修复骨质疏松性骨缺损，为骨感染治疗提供了创新材料学思路，对研究骨髓微环境及骨相关血液病并发症具有借鉴价值。

摘要: In osteoporotic fracture-related infection (FRI), the coordinated bone healing is compromised by cortical bone lysis and persistent bacterial colonization. Current treatments primarily focus on infection control, but fail to preserve bone microarchitecture or restore disrupted healing cascade, particularly in fragile osteoporotic bone. Here, we develop a bioactive nanocomposite hydrogel based on bisphosphonate-modified hyaluronan (HABP) and either free bisphosphonate (BP) or pyrophosphate…

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22 Rapid wavefront shaping using an optical gradient acquisition

推荐理由: 该研究提出的快速波前整形系统通过算法创新显著提升了深层组织成像效率，对血液疾病研究中微循环或骨髓等深层结构的观测具有潜在技术借鉴价值。

摘要: Wavefront shaping systems enable deep tissue imaging by correcting scattering aberrations, but estimating optimal modulation correction is challenging, since it depends on the unknown tissue structures. Most current methods use slow coordinate descent algorithms, which sequentially scan all modulation parameters and query them independently, thus their complexity scales prohibitively with the number of parameters. We introduce a rapid wavefront shaping system, replacing coordinate descent with…

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23 EPOP restricts PRC2.1 targeting to chromatin by directly modulating enzyme complex dimerization

推荐理由: 该研究揭示了PRC2.1复合物中EPOP调控染色质沉默的新机制，对理解血液系统发育及血液肿瘤（如骨髓增生异常综合征、白血病）的表观遗传失调具有重要借鉴价值。

摘要: Polycomb repressive complex 2 (PRC2) mediates developmental gene repression as two classes of holocomplexes, PRC2.1 and PRC2.2. EPOP is an accessory subunit specific to PRC2.1, which also contains PCL proteins. Unlike other accessory subunits that collectively facilitate PRC2 targeting, EPOP was implicated in an enigmatic inhibitory role, together with its interactor Elongin BC. We report an unusual molecular mechanism whereby EPOP regulates PRC2.1 by directly modulating its oligomerization…

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24 Decoding brain border immunity to enable future therapeutic avenues

推荐理由: 该文章系统阐释了脑-免疫界面及其免疫微环境调控机制，尤其涉及颅骨骨髓这一造血生态位，为理解免疫细胞迁移、抗原呈递及神经-血液-免疫互作提供了前沿视角，对血液肿瘤及自身免疫性血液病的发病机制与治疗研究具有重要借鉴意义。

摘要: The brain is no longer viewed as immunologically isolated but as an organ surrounded by dynamic border compartments that coordinate surveillance, drainage, and communication with the periphery. Key interfaces - including the meninges, blood-brain barrier, choroid plexus (ChP), and skull bone marrow - host specialized immune niches that regulate antigen sampling, leukocyte trafficking, and neuroimmune signaling. Recent advances in imaging and in single-cell and spatial profiling have revealed…

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25 Inflame and restrain - the paradoxical roles of IL-12 and IL-23 in immunity

推荐理由: 该文章系统阐述了IL-12与IL-23在免疫调节中的核心作用，对理解血液系统相关免疫疾病（如自身免疫性血细胞减少、炎症相关骨髓异常）的发病机制具有重要参考价值。

摘要: Within the IL-12 superfamily of heterodimeric cytokines, IL-12 and IL-23, which share a subunit, are among the most pro-inflammatory members. Both are primarily produced by phagocytes and have key roles in activating and regulating T lymphocytes, natural killer cells and innate lymphoid cells. IL-12 predominantly promotes type 1 immune responses, whereas IL-23 is closely associated with type 3 immunity. Their receptors are also heterodimeric and, upon engagement, they trigger ‘cytokine…

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26 The OAS-RNase L pathway: Insights from experiments of nature

推荐理由: 该研究揭示了OAS/RNase L遗传缺陷与血液疾病（如免疫缺陷或骨髓衰竭）的潜在关联，为罕见血液疾病的机制研究与临床诊疗提供了新的分子视角。

摘要: The 2′−5′ oligoadenylate synthetases (OASs) are type I interferon-inducible enzymes that, with ribonuclease L (RNase L), have been studied in the context of their coupled action as antiviral effectors. RNase L degrades host and viral ssRNA, affecting diverse cellular processes including translational arrest, interferon response, and apoptosis, all of which are thought to restrict viral replication. Recent studies of recessive inborn errors of human OAS1, OAS2, and RNase L, however, revealed that…

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27 Mycobacterial α-glucans hijack dectin-1 to facilitate intracellular bacterial survival

推荐理由: 该研究揭示了病原体通过靶向先天免疫受体dectin-1逃逸巨噬细胞清除的新机制，对理解免疫细胞功能紊乱相关的血液疾病（如炎症性粒细胞浸润、噬血细胞综合征等）具有重要借鉴意义。

摘要: Mycobacteria have a cell envelope that can act as a shield against host defense. This study shows that mycobacteria survive in host macrophages by targeting the innate host receptor dectin-1 through a noncanonical ligand. Compared with wild-type (WT) mice, dectin-1-deficient mice were more resistant to infection to mycobacteria. Dectin-1-deficient mice presented with substantially reduced bacterial burdens, inflammatory cytokines, and infiltrating myeloid cells, such as neutrophils and…

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28 Arachidonic acid induces pyroptosis via a non-autophagic function of mitophagy and enhances immunotherapy in a PDAC model

推荐理由: 该研究创新性地利用对比学习图神经网络鉴定出花生四烯酸可作为一种泛癌性焦亡诱导剂，其揭示的免疫逆转机制与“冷肿瘤”调控策略，对于研究血液系统恶性肿瘤的免疫逃逸与细胞死亡途径具有重要的方法学借鉴与机制启发价值。

摘要: Pancreatic ductal adenocarcinoma (PDAC) presents a therapeutic hurdle owing to its immunotherapy resistance and limited treatment options. Pyroptosis, a lytic inflammatory cell death pathway, holds promise for reversing immunosuppression in “cold” tumors, yet tumor-specific induction strategies remain unclear. Here, we employ a contrastive learning graph neural network to identify arachidonic acid (AA), an endogenous ω-6 polyunsaturated fatty acid, as a pan-cancer pyroptosis inducer operating…

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29 AI-Powered Histology for Molecular Profiling in Brain Tumors: Toward Smart Diagnostics from Tissue

推荐理由: 该研究展示了人工智能在整合病理与分子诊断中的前沿应用，其方法学思路对血液肿瘤的数字化诊断与精准分型具有可借鉴的跨学科参考价值。

摘要: The integration of molecular features into histopathological diagnoses has become central to the World Health Organization (WHO) classification of central nervous system (CNS) tumors, improving prognostic accuracy and supporting precision medicine. However, unequal access to molecular testing limits the universal application of integrated diagnosis. To address this, artificial intelligence (AI) models are being developed to predict molecular alterations directly from histological data. In…

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30 Detection of alternative splicing: deep sequencing or deep learning?

推荐理由: 该文章聚焦于基因可变剪接检测这一基础且关键的技术挑战，提出的方法可能降低测序深度需求，对研究剪接异常相关的血液恶性肿瘤（如白血病、淋巴瘤）具有潜在技术借鉴价值。

摘要: Alternative splicing is a crucial mechanism of gene regulation that enables condition- and tissue-specific expression of gene isoforms. Its dysregulation plays a role in various diseases such as cancer, neurological disorders, and metabolic conditions. Despite its importance, accurate detection of alternative splicing events remains challenging. Comprehensive alternative splicing event detection typically requires deep sequencing with over 100 million reads; however, much of the publicly…

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31 Pruning random resistive memory for optimizing analog AI

推荐理由: 该研究在软硬件协同设计方法上具有显著创新性和技术严谨性，虽不直接涉及血液疾病，但其高效能计算优化思路对跨学科研究方法有借鉴价值。

摘要: The rapid expansion of AI models has intensified concerns over energy consumption. Analog in-memory computing with resistive memory offers a promising, energy-efficient alternative, yet its practical deployment is hindered by programming challenges and device non-idealities. Here, we propose a software-hardware co-design that trains randomly weighted resistive-memory neural networks via edge-pruning topology optimization. Software-wise, we tailor the network topology to extract high-performing…

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32 Developmental variations in recurrent spatiotemporal brain propagations from childhood to adulthood

推荐理由: 该研究在神经发育领域方法学上有显著创新，对理解大脑活动时空传播的成熟模式具有重要价值，其研究思路与分析方法可为血液病发展进程的类似动态研究提供方法论借鉴。

摘要: The brain undergoes profound structural and functional development from childhood to adolescence. Convergent evidence suggests that neurodevelopment proceeds in a hierarchical manner, characterized by heterogeneous maturation patterns across brain regions and networks. However, the maturation of the intrinsic spatiotemporal propagations of brain activity remains largely unexplored. This study aims to bridge this gap by delineating spatiotemporal propagations from childhood to early adulthood. By…

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33 Transcriptomic signature-guided depletion of intermediate alveolar epithelial cells ameliorates pulmonary fibrosis in mice

推荐理由: 该研究开发的RNA感应依赖性蛋白翻译技术具有高度创新性，其单细胞靶向方法可为血液疾病中罕见细胞亚群的功能研究提供重要的技术借鉴。

摘要: Single-cell RNA sequencing (scRNA-seq) has identified intermediate epithelial states in pulmonary fibrosis, including KRT5-/KRT17+ aberrant basaloid cells in humans and Krt8+ alveolar differentiation intermediates (ADIs) in mice. Their functional contributions to fibrogenesis, however, remain unclear. Here, we introduce an RNA-sensing-dependent protein translation technology that enables selective targeting of Krt8+ ADI cells in vitro and in vivo. Transcriptomic analysis revealed Small…

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34 DGAT-driven futile lipid cycling has a pronounced, yet concealed, thermogenic function

推荐理由: 该研究揭示了脂肪组织代谢在产热中的新机制，虽非直接针对血液疾病，但其对能量代谢和体温调节的深入理解可为贫血、骨髓衰竭等血液病的代谢调控研究提供有价值的思路借鉴。

摘要: Thermoregulation is an essential yet incompletely understood homeostatic process in mammals. UCP1-mediated thermogenesis, while efficient, is dispensable, suggesting the existence of alternative mechanisms. Using a pharmacogenetic approach, we show that the adipose tissue futile lipid cycling (FLC) contributes to UCP1-independent thermogenesis, with DGATs being involved in the regulation of FLC. The loss of DGAT-driven FLC-mediated thermogenesis is compensated for by the hierarchical recruitment…

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35 Lipedema World Alliance Delphi Consensus-Based Position Paper on the Definition and Management of Lipedema: Results from the 2023 Lipedema World Congress in Potsdam

推荐理由: 该研究通过德尔菲法推动脂水肿国际诊断共识，方法严谨，对统一临床标准具有直接参考价值，尤其有助于内分泌科与血管相关疾病鉴别诊断的规范化。

摘要: Lipedema predominantly affects women and is characterized by an abnormal distribution of adipose tissue, accompanied by pain or discomfort in affected areas. Despite growing awareness, inconsistent diagnostic criteria and treatment approaches hinder medical care and research. This multi-phase Delphi study was conducted to address the need for internationally accepted consensus on fundamental aspects of the disease. Through online surveys and an in-person discussions, experts representing 19…

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36 Mixing protocols determine liquid-liquid phase separation dynamics in polyelectrolyte complex coacervation

推荐理由: 该研究通过分子动力学模拟揭示了生物大分子相分离的动态机制，为理解血液中蛋白质异常聚集或凝血相关疾病的分子基础提供了潜在的理论借鉴。

摘要: Polyelectrolyte complex coacervation underpins many critical biological processes, yet how different initial mixing protocols determine its liquid-liquid phase separation (LLPS) dynamics remains unclear. Using molecular dynamics simulations, we show that when polycations and polyanions are initially randomly mixed, coacervate domain growth exhibits transient t^(1/2) scaling, driven by polymer network formation. This phase is followed by either t¹ scaling due to hydrodynamic pumping or t^(1/3)…

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37 Once and thrice weekly interval training in adults with central obesity: a randomized controlled trial

推荐理由: 该研究采用严格的随机对照试验设计，探讨了不同高强度间歇训练模式对成人肥胖的干预效果，其方法学具有较高参考价值，尤其适用于关注生活方式干预与代谢健康的研究者。

摘要: Obesity is a global public health crisis that is aggravated and mirrored by the high prevalence of physical inactivity. This single-center, assessor-blinded, three-group, randomized controlled trial in Hong Kong examined the therapeutic value of high-intensity interval training (HIIT) delivered in one session per week via a “weekend warrior” approach versus three sessions per week for reducing body adiposity in adults with overweight and central obesity. Participants were randomly assigned in a…

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38 A programmable ribozyme for RNA signal transduction

推荐理由: 该研究提出的可编程核酶平台（UNBAR）在RNA传感与功能转导技术上具有显著创新性，为未来开发新型RNA工具提供了通用化设计思路，对血液疾病中RNA靶向治疗或诊断技术的潜在发展有间接借鉴价值。

摘要: RNA detection applications can be augmented if a sensed RNA can be directly functionally transduced. However, there is no generalisable approach that allows an RNA trigger itself to directly activate diverse non-coding RNA effectors. Here, we report engineering of a programmable, RNA trigger-activated, dual-site self-cleaving ribozyme with modular sensing domain and cleavage product. This platform, UNlocked by Activating RNA (UNBAR), is entirely encoded within one RNA strand. The ribozyme can be…

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39 Ex vivo drug sensitivity profiling to complement molecular profiling in pediatric precision oncology

推荐理由: 该研究虽然主要针对实体瘤，但其基于PDX模型的离体药物筛选方法学严谨、流程高效，为血液肿瘤的体外药敏测试体系构建提供了可靠的技术借鉴。

摘要: Pediatric patients with high-risk extra-cranial solid tumors face a 5-year survival rate below 50%. As molecular profiling alone is insufficient to guide treatment at relapse, complementary strategies like drug screening are urgently needed. We evaluated short-term drug screening as a rapid, reliable method to assess drug sensitivities in pediatric solid tumors using ex vivo cultures from previously established patient-derived xenograft (PDX) models. Ex vivo drug screening was performed within…

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40 Critical scaling of novelty in the cortex

推荐理由: 该研究采用前沿的全息刺激技术探究大脑对新异事件的神经机制，方法学创新性强，虽与血液疾病无直接关联，但其单细胞精度操控思路可为血液细胞动态研究提供方法论借鉴。

摘要: To guide behavior in uncertain environments, the brain must rapidly detect novel or unexpected events. The neocortex, involved with complex perception and decision-making, is thought to contribute to this computation, but underlying mechanisms are poorly understood. Here, we test how a few unanticipated action potentials influence local circuitry in the resting mouse visual cortex. Using targeted holographic stimulation, we evoked sparse “surprise” spikes in single pyramidal neurons and…

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41 The transcription factor HHEX maintains glucocorticoid levels and protects adrenals from androgen-induced lipid depletion

推荐理由: 该研究虽聚焦于肾上腺皮质细胞与应激反应，但其揭示的糖皮质激素调控机制对理解免疫性血液疾病（如自身免疫性溶血性贫血）及糖皮质激素治疗原理具有间接但重要的参考价值。

摘要: Glucocorticoid-producing cells of the adrenal cortex (i.e. zona fasciculata, zF) constitute the critical effectors of the hypothalamic-pituitary-adrenal axis, mediating the mammalian stress response. With glucocorticoids being essential for life, zF dysfunction perturbs multiple organs that participate in optimizing cardiometabolic fitness. The zF forms a dynamic and heterogenous cell population endowed with the capacity to remodel through the engagement of both proliferative and differentiation…

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42 Global nitrogen enrichment impacts plant diversity more than soil bacterial and fungal diversity: a meta-analysis

推荐理由: 该研究虽不直接涉及血液疾病，但其大规模数据整合与跨生态系统分析方法对血液学研究中的多系统影响评估具有方法学借鉴价值。

摘要: Anthropogenic nitrogen enrichment has significant effects on plant and soil biodiversity across local to global scales, yet how the nitrogen-induced changes in plant diversity differ from those in soil organisms across multiple ecosystems and climatic conditions remains virtually unknown. By synthesizing plant and soil studies globally (3,816 paired observations from 458 articles), we demonstrate that nitrogen enrichment has stronger negative effects on plant diversity but surprisingly modest to…

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43 Universal modulus-free transfer of scalable laser-induced graphene for electronic skins

推荐理由: 该文章提出的低温转移激光诱导石墨烯技术具有显著创新性，为多功能电子皮肤开发提供了新思路，虽不直接涉及血液疾病，但其在可穿戴健康监测方面的突破对血液循环参数监测有潜在借鉴意义。

摘要: Electronic skin (E-skin) with multifunctionality and large-scale features is highly desirable for human-machine interactions and wearable health monitoring. Laser-induced graphene (LIG) affords such devices with tailorable physical and chemical properties. However, relatively high Young’s modulus of precursors that derive LIG hinders its application scenarios. Here, we report a universal cryogenic transfer approach for LIG via regulating the glass transition temperature or freezing point of the…

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44 Very-large-scale mimetic optogenetic synapses for physical reservoir computing

推荐理由: 该研究在纳米材料与物理储层计算领域具有前沿创新性，其高密度界面工程思路可为血液病相关生物计算模型（如细胞网络模拟）提供跨学科方法借鉴。

摘要: The scaling law of deep learning, which governs the relationship between model size and performance, has led to critical concerns regarding efficiency and sustainability. To address these challenges, this study presents a computational approach using self-organized submillimeter-long tungsten disulfide nanotube cluster as a 3D very-large-scale physical reservoir. The reservoir, with its 0D van der Waals interfaces on the order of 10⁸, or 1.0×10^(10) mm^(−3), matches the synaptic quantity and…

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45 Mobile Health Application for the Prevention of Stroke (MAPS): a pilot, single-arm study on an innovative health application designed for primary stroke prevention

推荐理由: 该研究初步探索了数字健康工具对卒中预防的潜在价值，并提示了性别差异的可能影响，对公共卫生及行为干预研究有一定启发，但结论尚需进一步验证。

摘要: CONCLUSIONS: Our results suggest that the MAPS app may help promote healthier daily habits and reduce stroke risk. While promising, these preliminary findings require further validation through larger randomized controlled trials. Additionally, they indicate potential gender-specific responses that need more investigation.

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46 Alkynyltriazenes in Photochemical Metal-Free Doyle-Kirmse Rearrangements

推荐理由: 该文献在有机合成方法学上具有显著创新性和技术严谨性，但仅对从事血液病相关化学探针或药物合成的研究者具有间接参考价值，并非直接针对血液疾病机制或临床研究。

摘要: Doyle-Kirmse rearrangement reactions are widely recognized as versatile and powerful synthetic tools, promoting the simultaneous generation of C─C and C─S bonds. While notable progress has been attained, Doyle-Kirmse rearrangement reactions involving cyanocarbenes have rarely been reported owing to the limited strategies available for the preparation of cyanocarbene precursors and its inherently restricted reactivity. Herein, we report photochemical Doyle-Kirmse rearrangement reactions of…

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47 UBD: incorporating uncertainty in cell type proportion estimates from bulk samples to infer cell-type-specific profiles

推荐理由: 本文聚焦于统计反卷积方法的关键局限性改进，若能提升细胞类型特异性分析的准确性，对血液病研究中涉及混合细胞样本（如骨髓、外周血）的数据解读具有潜在借鉴价值。

摘要: Statistical deconvolution methods offer a powerful solution for estimating cell-type-specific (CTS) profiles from readily available bulk tissue data. However, a critical limitation of existing methods is that they require the knowledge of cell type proportions of individuals in the bulk data. While the ground truth of cell type proportions in bulk samples are unknown, those methods use the estimated proportions to approximate the truth, which potentially introduces additional uncertainties in…

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48 Regular-wrinkling tunable MXene lattice for electromagnetic interference shielding

推荐理由: 该文章在超薄电磁屏蔽膜领域提出了仿生创新思路并针对关键挑战进行研究，对材料科学和电子工程领域有较高借鉴价值，但与血液疾病研究无直接关联。

摘要: Protecting sensitive equipment from electromagnetic radiation damage requires the development of high-performance electromagnetic interference shielding films. As the film thickness is reduced to micro/nano scales, electromagnetic interference shielding capability generally decreases rapidly due to the weaker reflection. As a result, enhanced electromagnetic interference shielding performance in sub-μm thin films remains as an unsolved challenge. Inspired by the naturally wrinkling of fruit…

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49 Metabolic Messengers: testosterone

推荐理由: 该文章系统梳理了睾酮的发现历史、作用机制与代谢途径，对理解激素在人体内的调控具有清晰的参考价值，但未直接涉及血液疾病或相关病理机制，对血液学研究的直接借鉴性有限。

摘要: Testosterone, discovered during the endocrine gold rush of the 1930s, was the first hormone chemically synthesized for replacement therapy. In both men and women, testosterone functions directly through the androgen receptor (AR) and indirectly as a prohormone, converted by aromatase into 17β-oestradiol (oestradiol), which activates the oestrogen receptors ERα and ERβ. Testosterone is also metabolized to dihydrotestosterone-a potent, non-aromatizable AR agonist-through steroid 5α-reductases….

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50 Decoupling slab gliding and lattice contraction in Na layered oxides to enable high-voltage Na-ion batteries

推荐理由: 该文章聚焦钠离子电池正极材料的结构演化机制，对能源存储领域具有较高参考价值，但内容与血液疾病研究无直接关联，仅建议从事交叉材料学或电池技术的研究者选择性阅读。

摘要: Layered transition metal oxide cathodes (Na(x)TMO(2)) demonstrate a classic type of cathode for Sodium-ion batteries (SIBs), however their practical application faces a long-standing challenge of irreversible phase transitions at high voltages, which causes unsatisfied specific energy and cycling stability, particularly for P-type (Na^(+) located at prismatic sites) cathodes. This phenomenon is conventionally ascribed to the Na^(+) re-coordination from prismatic to octahedral (O-type)…

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51 Erratum for the Research Article “T cell receptor-triggered nuclear actin network formation drives CD4<sup>+</sup> T cell effector functions” by N. Tsopoulidis <em>et al</em>

推荐理由: 由于未提供摘要内容，无法评估具体研究价值，建议补充信息后再进行针对性推荐。

摘要: No abstract

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52 Closed-loop wearable neurostimulation system with triboelectric sensing to alleviate hemifacial spasms

推荐理由: 该文主要探讨神经系统疾病面肌痉挛的诊疗现状与局限，与血液疾病直接关联较弱，但对理解神经肌肉接头相关疾病有一定间接参考价值；血液科医生若非涉及交叉领域则借鉴有限。

摘要: Hemifacial spasm (HFS) is a neurological disorder characterized by involuntary contractions of the facial muscles, which can significantly influence patients’ quality of life. Traditional diagnostic methods are often subjective, and electromyography (EMG) monitoring is constrained by equipment limitations and interference. Current treatments include short-term Botulinum toxin (BTX) injections and high-risk microvascular decompression (MVD), both of which suffer from low patient compliance. This…

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53 JULGI coordinates vascular development and leaf patterning through non-cell-autonomous regulation of miR165/166

推荐理由: 本文虽在植物血管发育机制上有创新发现，但与血液疾病无直接关联，仅对研究RNA结合蛋白在生物过程中的调控机制有间接参考价值。

摘要: The interplay between vascular development and leaf development is central to the evolutionary success of vascular plants, yet the underlying mechanisms remain poorly understood. Here, we identify the RNA-binding protein JULGI1 (JUL1) as a key integrator of vascular and leaf development in Arabidopsis. JUL1 is transcribed in leaf veins, while the protein distributes throughout the leaf, where it binds G-rich regions of pri-MIR165a transcripts on the abaxial side. This interaction disrupts…

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54 Elasto-magnetic instabilities for amplified actuation and mechanical memory

推荐理由: 该文章主要聚焦于机械工程领域的弹性-磁耦合不稳定系统研究，虽然方法严谨且有创新性，但与血液疾病或血液学研究无直接关联，对血液学领域的借鉴价值极低。

摘要: Instabilities can generate fast and amplified motion in mechanical systems. Here, we present an elasto-magnetic instability that combines magnetic attraction and elastic tension to create bistable dynamics. To demonstrate this, we built a coupled elasto-magnetic vibration system that produces amplified motion and greater displacement and force than a control system across a wide frequency range. We also establish design principles that can be applied to different configurations by studying the…

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