追觅 - 2026-01-12

生成时间: 2026−01-12 22:28

分析文章数量: 22

1 Hypomethylating agents alone or in combination with venetoclax in very elderly acute myeloid leukemia patients: less treatment, better care?

推荐理由: 该研究挑战了老年AML强化联合治疗的常规思维，通过严谨的非劣效性设计证实了HMA单药在特定人群中的等效性，对临床治疗决策有直接指导价值。

摘要: Hypomethylating agents (HMA) alone or in combination with venetoclax (VEN) are a mainstay for disease control in elderly acute myeloid leukemia (AML). We evaluated the non-inferiority of HMA monotherapy compared to HMA/VEN combination in 227 AML patients aged ≥ 75 years receiving HMA or HMA/VEN combination. No difference in overall survival (OS) was observed between the two groups, with HMA monotherapy demonstrating statistical non-inferiority. HMA-treated patients with favorable performance…

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2 Molecularly targeted therapy and immunotherapy in leukemias

推荐理由: 该文章系统阐述了高通量测序与精准医疗在白血病诊疗中的转化应用，为血液科医生提供了从基因特征到靶向治疗的清晰临床借鉴路径。

摘要: The advent of next-generation high-throughput sequencing and precision medicine has allowed the identification of recurrent genetic events of vital interest for leukemic cells and for the management of patients with leukemia, since it has a direct impact on prognosis and therapeutic stratification. The precise cytogenetic characterization of these diseases has rapidly enabled the development of innovative therapeutic strategies to improve outcomes and limit toxicities. New targeted therapies,…

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3 Urolithin A Attenuates Sleep Deprivation-Induced Neutrophilic Inflammation by Suppression of the ROS-H3K18la Feedback Loop

推荐理由: 该研究创新性地揭示了睡眠剥夺通过组蛋白乳酸化修饰驱动中性粒细胞炎症的表观遗传机制，为血液系统炎症性疾病的研究提供了新的思路和潜在干预靶点。

摘要: Sleep loss drives metabolic and immune dysfunction, yet the epigenetic links to inflammation remain poorly defined. Using larval zebrafish with a continuous-swim paradigm, we demonstrate that acute sleep deprivation (SD) induces sleep fragmentation, systemic oxidative stress, and sustained neutrophilic inflammation─phenotypes associated with elevated histone H3K18 lactylation (H3K18la), an epigenetic modification from glycolytic lactate. Critically, gut microbiota metabolite Urolithin A (UA)…

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4 Curcumol overcomes cisplatin resistance and rewires glycolysis-H3K9la-ORC6 axis to trigger ferroptosis in bladder cancer

推荐理由: 该研究揭示了代谢重编程通过组蛋白乳酸化调控铁死亡的全新机制，这一前沿交叉发现对研究血液肿瘤（如白血病、淋巴瘤）的耐药性与细胞死亡途径具有重要的借鉴价值。

摘要: CONCLUSIONS: Our findings demonstrated that curcumol effectively counteracted cisplatin resistance and inhibited bladder cancer progression by targeting the glycolysis-H3K9la-ORC6 axis to induce ferroptosis. This study established a critical link between metabolic reprogramming, histone lactylation, and ferroptosis, providing a novel therapeutic avenue for treating chemoresistant bladder cancer.

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5 Targeting Lactate and Lactylation in Cancer Metabolism and Immunotherapy

推荐理由: 该文章系统阐述了乳酸从代谢副产物到关键调控因子的范式转变，并引入乳酸化修饰这一新兴概念，为血液肿瘤的代谢重编程及肿瘤微环境研究提供了新的理论视角和潜在干预靶点。

摘要: Lactate has evolved from being regarded as a byproduct of glycolysis to a pivotal regulator of cancer metabolism and signaling. The Warburg effect underscores how elevated lactate production meets the biosynthetic demands of highly proliferative cancer cells, while shaping an immunosuppressive tumor microenvironment (TME) that supports cancer growth and metastasis. The discovery of lactylation, a novel post-translational modification, has further expanded the conceptual landscape, revealing how…

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6 Human herpesvirus 7 and the risk of developing multiple sclerosis

推荐理由: 该研究首次大规模探讨人类疱疹病毒7型与多发性硬化症的关联，采用瑞典生物样本库的嵌套病例对照设计，方法严谨且具有创新性，为多发性硬化的病毒病因学提供了新的视角。

摘要: Epstein-Barr virus is now regarded as the critical risk factor for multiple sclerosis. However, Cytomegalovirus and human herpesvirus 6A have also been associated with altered multiple sclerosis risk, suggesting a multifactorial aetiology. Here, we present the first large-scale study of the association between human herpesvirus 7 and the risk of developing multiple sclerosis. A nested case-control study was performed by crosslinking Swedish registries and biobanks, identifying blood samples from…

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7 Targeting Lactate and Lactylation in Cancer Metabolism and Immunotherapy

推荐理由: 该文章系统阐述了乳酸代谢在肿瘤微环境中的关键作用及新型修饰“乳酸化”的发现，为血液肿瘤（如白血病、淋巴瘤）的代谢重编程研究和免疫治疗策略提供了重要的理论借鉴与潜在靶点思路。

摘要: Lactate has evolved from being regarded as a byproduct of glycolysis to a pivotal regulator of cancer metabolism and signaling. The Warburg effect underscores how elevated lactate production meets the biosynthetic demands of highly proliferative cancer cells, while shaping an immunosuppressive tumor microenvironment (TME) that supports cancer growth and metastasis. The discovery of lactylation, a novel post-translational modification, has further expanded the conceptual landscape, revealing how…

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8 Decoding protein lactylation in the pathogenesis and progression of gynecological cancer

推荐理由: 该文章虽聚焦妇科肿瘤，但其中关于蛋白质乳酸化修饰的机制研究为血液肿瘤领域（如代谢重编程与表观遗传调控交叉方向）提供了可借鉴的新视角与潜在研究思路。

摘要: Gynecological tumors represent a significant health burden worldwide. Protein lactylation has emerged as a novel post-translational modification (PTMs) that directly links metabolic reprogramming to epigenetic and functional regulation. Lactylation occurs when lactate covalently modifies the lysine residues of proteins. Initially discovered on histones, lactylation was shown to influence gene transcription; however, accumulating evidence reveals its broader impact on nonhistone proteins,…

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9 Urolithin A Attenuates Sleep Deprivation-Induced Neutrophilic Inflammation by Suppression of the ROS-H3K18la Feedback Loop

推荐理由: 该研究通过斑马鱼模型揭示了睡眠剥夺诱导组蛋白H3K18乳酸化修饰驱动中性粒细胞炎症的新机制，为血液疾病中炎症调控提供了可借鉴的表观遗传学视角。

摘要: Sleep loss drives metabolic and immune dysfunction, yet the epigenetic links to inflammation remain poorly defined. Using larval zebrafish with a continuous-swim paradigm, we demonstrate that acute sleep deprivation (SD) induces sleep fragmentation, systemic oxidative stress, and sustained neutrophilic inflammation─phenotypes associated with elevated histone H3K18 lactylation (H3K18la), an epigenetic modification from glycolytic lactate. Critically, gut microbiota metabolite Urolithin A (UA)…

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10 Curcumol overcomes cisplatin resistance and rewires glycolysis-H3K9la-ORC6 axis to trigger ferroptosis in bladder cancer

推荐理由: 该研究揭示了代谢重编程、组蛋白乳酸化与铁死亡之间的新联系，其机制对研究血液肿瘤耐药及细胞死亡途径具有重要借鉴价值。

摘要: CONCLUSIONS: Our findings demonstrated that curcumol effectively counteracted cisplatin resistance and inhibited bladder cancer progression by targeting the glycolysis-H3K9la-ORC6 axis to induce ferroptosis. This study established a critical link between metabolic reprogramming, histone lactylation, and ferroptosis, providing a novel therapeutic avenue for treating chemoresistant bladder cancer.

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11 N-Heterocyclic Carbene Monolayers on Nickel, Iron, and Steel by a Radical-to-Carbene Strategy

推荐理由: 该文章提出的NHC单层制备新方法在表面化学领域具有显著创新性，虽然不直接涉及血液疾病，但其在生物相容性材料表面修饰方面的潜在应用，可能为血液接触性医疗器械的研发提供新的技术思路。

摘要: N-Heterocyclic carbenes (NHCs) have recently emerged as the next-generation surface ligands with improved stability and molecular flexibility. Despite these premises, research on NHC-enriched flat surfaces is mainly limited to noble metals, while formation of free NHCs often requires the use of vacuum, bases, or strictly air- and moisture-free conditions. We hereby report an unprecedented radical-to-carbene-based approach for fabricating NHC monolayers on earth-abundant and naturally oxidized…

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12 Decoding protein lactylation in the pathogenesis and progression of gynecological cancer

推荐理由: 该文章系统阐述了蛋白质乳酸化修饰这一新兴领域，虽以妇科肿瘤为切入点，但其揭示的代谢-表观遗传调控机制对研究血液肿瘤的代谢重编程与表观遗传失调具有重要借鉴价值。

摘要: Gynecological tumors represent a significant health burden worldwide. Protein lactylation has emerged as a novel post-translational modification (PTMs) that directly links metabolic reprogramming to epigenetic and functional regulation. Lactylation occurs when lactate covalently modifies the lysine residues of proteins. Initially discovered on histones, lactylation was shown to influence gene transcription; however, accumulating evidence reveals its broader impact on nonhistone proteins,…

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13 Meta-Analysis of Durable Compared to Temporary Left Ventricular Assist Devices Compared to Venoarterial Extracorporeal Membrane Oxygenation for Bridging to Heart Transplantation or Treatment of Primary Graft Dysfunction

推荐理由: 该研究虽聚焦心脏移植后循环支持，但对血液科医生有重要借鉴意义，尤其在处理机械辅助装置相关凝血病、抗凝管理及血液并发症方面提供了临床决策参考。

摘要: CONCLUSIONS: Both d-LVAD and t-LVAD bridging methods appear to have comparable 1-year survival rates, which are higher than those after VA-ECMO bridging. Nonetheless, more prospective clinical studies are needed to investigate outcomes after using circulatory support devices for PGD after HTx. The PROSPERO registration: CRD420251149065, https://www.crd.york.ac.uk/PROSPERO/view/CRD420251149065.

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14 General practitioner-pharmacist collaboration to enhance deprescribing of psychotropics, sedatives, and anticholinergics among older polypharmacy patients in primary care: study protocol of a cluster-randomized controlled trial (PARTNER)

推荐理由: 该研究虽不直接针对血液疾病，但其关于多重用药老年患者减少不适当用药的干预策略和方法学设计，对血液科临床中管理老年患者药物相互作用及减少药源性血液学不良反应具有重要的借鉴意义。

摘要: BACKGROUND: Appropriate deprescribing of psychotropic, sedative, and anticholinergic potentially inappropriate medication (PSA-PIM) in older adults with polypharmacy can reduce the risk of adverse drug reactions, but is inconsistently implemented in primary care. The PARTNER intervention was designed to address challenges in PSA-PIM deprescribing at both provider and patient levels.

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15 Radiotherapy-induced abscopal effects in immune checkpoint inhibitor-refractory metastatic disease: results from a large multicenter real-world cohort study

推荐理由: 该研究通过大规模真实世界数据探讨放疗联合免疫治疗的远端效应，虽非血液病专属，但其揭示的系统性免疫激活机制对血液肿瘤的免疫治疗策略具有重要借鉴意义。

摘要: Combining radiotherapy with immune checkpoint inhibitors (RT-ICI) triggers systemic antitumor responses, such as abscopal effects (AbE). Predictors of AbE and its impact on survival in real-world settings remain poorly defined. This multicenter, retrospective cohort study assessed the prevalence of AbE in ICI-refractory progressive metastatic patients by evaluating the additive effect of RT on nonirradiated lesions (NIL). We screened 3773 cases to identify patients with stage IV tumors receiving…

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16 Can equalizing education weaken the link between parental education and cognitive function? Evidence from a non-parametric decomposition analysis

推荐理由: 该研究首次探讨了教育干预如何调节代际教育与认知功能的关系，为减少健康不平等提供了新的政策杠杆，具有重要的公共卫生参考价值。虽然与血液疾病无直接关联，但其社会决定因素的研究思路对慢性病管理有启发意义。

摘要: Cognitive function is a key determinant of quality of life, making the maintenance of cognitive health a public health priority. Because individuals with both low parental and individual education exhibit lower cognitive function, it is essential to identify levers that can reduce such inequalities. This study is the first to examine how interventions targeting educational attainment may alter the relationship between parental education and adult children’s cognitive function. We evaluate three…

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17 Molecular Classification in a Cohort of Occupational Dermatological Patients: Diagnostic Results and Course of Ability to Work and Sick Leave Over Two Years

推荐理由: 该研究在职业性皮肤病的分子分型方法学上具有严谨性，其建立的队列与分子诊断思路可为血液疾病（如炎症性或免疫性血液病）的鉴别诊断研究提供方法学借鉴。

摘要: Hand eczema is the most common occupational skin disease (OSD), often leading to sick leave or job termination. Standard diagnostic procedures are often ambiguous. Molecular classification has been described to improve differentiation between eczema and psoriasis, which is the most common differential diagnosis. Since 2020, a cohort of 287 patients with suspected, occupational hand and/or foot dermatoses (eczema or psoriasis) has been established in Germany. The current analysis focuses on…

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18 Genetic dissection of serum pro-neurotensin suggests potential causal impact on brain structure

推荐理由: 该研究虽主要关注代谢调节，但神经降压素及其前体在炎症过程中的潜在作用可能间接影响血液疾病（如与慢性炎症相关的贫血），为血液学中的代谢-炎症交叉研究提供了可借鉴的思路。

摘要: BACKGROUND: Pro-neurotensin (pro-NT) is the stable circulating precursor of neurotensin (NT), a neuropeptide expressed mainly in the central nervous system and small intestine that regulates key physiological processes like fatty acid absorption in the gut and suppresses appetite via central mechanisms. Studies in NT-deficient mice and humans implicate NT in obesity and insulin resistance, highlighting its role in metabolic regulation.

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19 Perioperative antibiotic prophylaxis-current clinical practise in total joint arthroplasty (TJA) in Germany and establishment of an standard operating procedure (SOP) for primary, revision, and tumor TJA

推荐理由: 该文章主要聚焦于骨科手术的抗生素预防规范，与血液疾病的核心研究方向直接关联性较弱；但其关于青霉素过敏患者的差异化用药策略，对血液科临床中处理药物过敏与抗感染治疗的平衡有一定间接参考价值。

摘要: CONCLUSION: The survey findings demonstrate guideline-conform implementation of PAP in primary TJA but reveal a heterogeneous situation in revision TJA. The interdisciplinary SOP written by the authors is based on the recommendations of the currently valid German guideline regarding the choice of antibiotic, dosing, and timing of PAP administration as well as on the differentiated approach in patients with a documented penicillin allergy. In deviation from the currently valid German guideline,…

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20 CSF-venous fistulas Reconsidered: Pressure paradox and the Volume-Elastance Relationship

推荐理由: 该研究虽聚焦于脑脊液动力学与颅静脉瘘，对血液病学直接借鉴有限，但其对血管压力调节和体液循环系统紊乱机制的探讨，可为研究血管源性血液疾病（如颅内静脉血栓等）提供跨学科病理生理视角。

摘要: CONCLUSIONS: Fistula radius, altered states of CSF production, and dural stiffening complicate the clinical presentation of CVFs. Current hypotheses do not adequately account for raised opening pressures and rebound intracranial hypertension. Instead, global CSF dysregulation, including increased production and impaired secondary outflow, may co-exist in patients with CVFs. Future management should evaluate CSF volume-pressure dynamics, rather than exclusively focusing on the fistula, to improve…

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21 Assessing Mandibular Condylar and Coronoid Pathologies: A Computed Tomography-Based Normalization Approach

推荐理由: 该研究在颌骨CT测量方法学上具有规范性参考价值，但内容与血液疾病无直接关联，仅适合对颌面解剖或影像学测量方法感兴趣的研究者阅读。

摘要: This study aimed to establish a CT-based normalization protocol for the mandibular condylar (CoP) and coronoid (CrP) processes and to determine whether pathology-specific patterns can be distinguished from physiologic variation. Retrospective CT data of 251 patients without mandibular pathology (502 hemi-mandibles) were analyzed. Posterior mandibular height (PMH) was defined as the distance between the mandibular angle tangent and the deepest point of the mandibular notch. CoP and CrP lengths…

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22 Functional connectivity in electroencephalography of brain tumor patients in status epilepticus: a retrospective evaluation of prognostic value

推荐理由: 该研究虽聚焦于神经电生理与肿瘤预后，方法学较为严谨，但对血液疾病直接借鉴价值有限，主要适用于神经肿瘤或脑电图分析方法学的研究者参考。

摘要: CONCLUSIONS: Functional connectivity analysis in source space did not reliably differentiate patients by survival or tumor type following SE. These findings suggest that current connectivity metrics are insufficient as standalone prognostic tools in this context. Larger, more homogeneous cohorts and stratification by clinical and tumor characteristics are needed to clarify the potential prognostic value of EEG connectivity in this population.

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