追觅 - 2026-01-13

生成时间: 2026−01-13 22:45

分析文章数量: 77

1 Long-term efficacy and safety results of betibeglogene autotemcel gene therapy for transfusion-dependent β-thalassemia

推荐理由: 该研究展示了针对输血依赖性β-地中海

摘要: Betibeglogene autotemcel (beti-cel) gene therapy for transfusion-dependent β-thalassemia (TDT) involves autologous transplantation of hematopoietic stem and progenitor cells transduced with a modified β-globin gene to produce functional adult hemoglobin (HbAT87Q). Sixty-three participants with TDT (median [range] age: 17 [4-35] years) received beti-cel in phase 1/2 (n = 22) or phase 3 (n = 41) studies and enrolled in the long-term follow-up LTF-303 study (clinicaltrials.gov/NCT02633943; median…

—

2 Optimized CRISPR-Cas12a genome-wide screen reveals PTPA phosphatase pathway in fetal hemoglobin silencing

推荐理由: 该研究采用系统性的全基因组方法解析胎儿血红蛋白沉默的调控网络，针对血红蛋白病的治疗靶点具有明确的创新性和高度可借鉴性，对血液疾病尤其是镰状细胞病和地中海贫血的机制研究与治疗开发有重要价值。

摘要: Reactivating the fetal globin genes HBG1 and HBG2 in adult erythroid cells represents a validated therapeutic approach for hemoglobinopathies. Central mediators of the fetal-to-adult hemoglobin transition include the direct transcriptional HBG1/2 repressors BCL11A1,2, LRF3, and NFIA/X4. Limited-scale screens have attempted to expand the regulatory circuity surrounding fetal globin silencing, but systematic genome-wide dissection of such pathways is lacking. We employed a two-tiered genetic…

—

3 Randomized phase 3 trial of Ropeginterferon alfa-2b versus surveillance after tyrosine kinase inhibitor discontinuation in chronic myeloid leukemia (ENDURE/CML-IX)

推荐理由: 该研究通过III期临床试验前瞻性验证了干扰素在促进慢性粒细胞白血病患者无治疗缓解中的作用，为临床实现停药目标提供了高级别证据，对血液科诊疗实践具有直接指导价值。

摘要: Treatment-free remission (TFR) after discontinuation of ABL tyrosine kinase inhibitors (TKIs) is an important therapeutic goal in chronic myeloid leukemia (CML). Interferon-α (IFN) has been suggested to promote durable TFR. The phase 3 ENDURE trial (NCT03117816; EUDRA-CT 2016-001030-94) prospectively tested this hypothesis in patients with stable deep molecular remission after TKI therapy. A total of 203 patients were randomised 1:1 to receive ropeginterferon alfa-2b (ropeg-IFN; 100 µg…

—

4 Optimized CRISPR-Cas12a genome-wide screen reveals PTPA phosphatase pathway in fetal hemoglobin silencing

推荐理由: 该研究通过系统性的全基因组筛选方法，深入揭示了胎儿珠蛋白沉默的调控网络，为血红蛋白病的靶向治疗提供了新的潜在干预位点，具有重要的转化医学价值。

摘要: Reactivating the fetal globin genes HBG1 and HBG2 in adult erythroid cells represents a validated therapeutic approach for hemoglobinopathies. Central mediators of the fetal-to-adult hemoglobin transition include the direct transcriptional HBG1/2 repressors BCL11A1,2, LRF3, and NFIA/X4. Limited-scale screens have attempted to expand the regulatory circuity surrounding fetal globin silencing, but systematic genome-wide dissection of such pathways is lacking. We employed a two-tiered genetic…

—

5 CHEK2 loss endows chemotherapy resistance to hematopoietic stem cells

推荐理由: 该研究利用CRISPR筛选揭示了CHEK2缺失导致造血干细胞化疗耐药的机制，对理解血液肿瘤治疗后继发克隆性造血及白血病转化具有重要参考价值。

摘要: Individuals with history of chemo- or radiotherapy frequently exhibit somatic mosaicism in the blood, often involving mutations in genes responsible for DNA damage responses (DDR), such as CHEK2. However, the mechanisms by which CHEK2 mutations promote the expansion of mutant cells following chemo- or radiotherapy remain poorly understood. Here, we demonstrate that loss of CHEK2 confers resistance to chemotherapy in hematopoietic stem and progenitor cells (HSPCs). Through a CRISPR-based screen,…

—

6 Modulation of the clonal burden in patients with lower-risk myelodysplastic neoplasms treated with imetelstat

推荐理由: 该研究报道了首创端粒酶抑制剂imetelstat在治疗低危MDS中取得突破性疗效，标志着该疾病从对症支持治疗向改变疾病进程的范式转变，对血液肿瘤的靶向治疗具有重要的借鉴价值。

摘要: Existing treatments for lower-risk myelodysplastic syndromes/neoplasms (LR-MDS) focus on symptom relief. Until recently, altering the disease course was rarely considered a therapeutic objective. The first-in-class, direct, competitive telomerase inhibitor, imetelstat, demonstrated significantly higher rates of red blood cell (RBC) transfusion independence (TI) versus placebo in patients with non-del(5q), RBC transfusion-dependent LR-MDS who were relapsed/refractory to or ineligible for…

—

7 Modulation of the clonal burden in patients with lower-risk myelodysplastic neoplasms treated with imetelstat

推荐理由: 该研究报道了首个直接竞争性端粒酶抑制剂imetelstat在低危MDS中的突破性III期临床结果，为改变疾病自然病程提供了全新治疗策略，对血液科医生和研究者具有重要参考价值。

摘要: Existing treatments for lower-risk myelodysplastic syndromes/neoplasms (LR-MDS) focus on symptom relief. Until recently, altering the disease course was rarely considered a therapeutic objective. The first-in-class, direct, competitive telomerase inhibitor, imetelstat, demonstrated significantly higher rates of red blood cell (RBC) transfusion independence (TI) versus placebo in patients with non-del(5q), RBC transfusion-dependent LR-MDS who were relapsed/refractory to or ineligible for…

—

8 The Landscape and Evolution of Clonal Hematopoiesis in Chronic Lymphocytic Leukemia

推荐理由: 该研究通过大规模临床试验队列和先进测序技术，深入揭示了慢性淋巴细胞白血病与克隆造血的关联，对老年血液肿瘤的精准治疗和预后评估具有重要参考价值。

摘要: Chronic lymphocytic leukemia (CLL) and clonal hematopoiesis (CH) both commonly occur in elderly individuals. To characterize CH in CLL, 620 patients from two German CLL Study Group trials were analyzed (CLL12 (ibrutinib vs. placebo) and CLL14 (venetoclax-obinutuzumab [Ven-Obi] vs. chlorambucil-obinutuzumab [Clb-Obi])) using error-corrected next-generation sequencing with a VAF threshold of 0.5%. Median follow-up was 76.1 months, median age 68 years. CH was detected in 58.2%, most commonly…

—

9 Compartmentalized inflammatory landscape and macrophage plasticity regulate Tet2+/- mediated clonal hematopoiesis

推荐理由: 该研究从骨髓空间微环境的新颖视角探讨CHIP的克隆扩增机制，为理解血液肿瘤的早期发生及骨髓生态位调控提供了关键见解，对血液疾病的基础与临床研究具有较高的借鉴价值。

摘要: Clonal hematopoiesis of indeterminate potential (CHIP) is driven by hematopoietic stem cells (HSCs) carrying leukemia-associated mutations that expand in the bone marrow. Several prior studies have revealed that the spatial organization of hematopoietic cells in the bone marrow impacts clonal behaviors. Specifically, leukemic blasts have been found to expand almost exclusively in a subset of marrow cavities that are undergoing active bone remodeling, but whether these cavities also support the…

—

10 EpiXFormer: a cross-attention neural network for predicting cell type-specific transcription factor binding sites

推荐理由: 该研究提出的EpiXFormer模型能高效预测细胞特异性转录因子结合位点，为血液病研究中细胞分化与异常调控机制的分析提供了可借鉴的计算工具。

摘要: Transcription factors (TFs) bind to specific sequences in the genome to regulate gene expression and specify cell states. TF binding sites (TFBSs) are cell type-specific, which can be attributed to epigenomic contexts. Comprehensive profiling of TFBSs across various cell types through experimental approaches is neither practical nor cost-friendly. Accurately identifying cell type-specific TFBSs through computational approaches remains challenging. Here, we develop EpiXFormer, a novel…

—

11 The Landscape and Evolution of Clonal Hematopoiesis in Chronic Lymphocytic Leukemia

推荐理由: 该研究基于大规模临床试验队列，采用高灵敏度测序技术深入解析慢性淋巴细胞白血病与克隆造血的关联，对理解疾病机制及治疗策略具有重要参考价值。

摘要: Chronic lymphocytic leukemia (CLL) and clonal hematopoiesis (CH) both commonly occur in elderly individuals. To characterize CH in CLL, 620 patients from two German CLL Study Group trials were analyzed (CLL12 (ibrutinib vs. placebo) and CLL14 (venetoclax-obinutuzumab [Ven-Obi] vs. chlorambucil-obinutuzumab [Clb-Obi])) using error-corrected next-generation sequencing with a VAF threshold of 0.5%. Median follow-up was 76.1 months, median age 68 years. CH was detected in 58.2%, most commonly…

—

12 Compartmentalized inflammatory landscape and macrophage plasticity regulate Tet2+/- mediated clonal hematopoiesis

推荐理由: 该研究聚焦骨髓微环境空间结构对克隆造血的影响，为理解血液疾病发生机制提供了新颖的视角，对白血病早期干预研究具有重要借鉴价值。

摘要: Clonal hematopoiesis of indeterminate potential (CHIP) is driven by hematopoietic stem cells (HSCs) carrying leukemia-associated mutations that expand in the bone marrow. Several prior studies have revealed that the spatial organization of hematopoietic cells in the bone marrow impacts clonal behaviors. Specifically, leukemic blasts have been found to expand almost exclusively in a subset of marrow cavities that are undergoing active bone remodeling, but whether these cavities also support the…

—

13 Randomized phase 3 trial of Ropeginterferon alfa-2b versus surveillance after tyrosine kinase inhibitor discontinuation in chronic myeloid leukemia (ENDURE/CML-IX)

推荐理由: 该研究通过III期临床试验前瞻性验证了干扰素在促进慢性髓系白血病患者停药后无治疗缓解中的作用，为血液科临床实践提供了高质量循证依据，对优化治疗策略具有直接参考价值。

摘要: Treatment-free remission (TFR) after discontinuation of ABL tyrosine kinase inhibitors (TKIs) is an important therapeutic goal in chronic myeloid leukemia (CML). Interferon-α (IFN) has been suggested to promote durable TFR. The phase 3 ENDURE trial (NCT03117816; EUDRA-CT 2016-001030-94) prospectively tested this hypothesis in patients with stable deep molecular remission after TKI therapy. A total of 203 patients were randomised 1:1 to receive ropeginterferon alfa-2b (ropeg-IFN; 100 µg…

—

14 Modeling donor age and type trade-offs for personalized selection in allogeneic hematopoietic cell transplantation with post-transplant cyclophosphamide prophylaxis

推荐理由: 该研究创新性地采用机器学习模型，重新评估了造血干细胞移植中供者选择的年龄与类型交互作用，对优化临床供者选择策略具有直接参考价值。

摘要: The prevailing fixed-hierarchy approach to donor selection for allogeneic hematopoietic cell transplantation (HCT) fails to capture critical interactions between donor age and type. We addressed this by analyzing 1713 adult recipients of matched related (MRD), matched unrelated (MUD), or haploidentical donors, receiving post-transplantation cyclophosphamide, using both regularized-Cox and XGBoost machine learning models. Our analysis revealed that the overall, independent association of donor…

—

15 DOT1L activity limits transcription elongation velocity and favors RNAPII pausing to facilitate mutagenesis by AID

推荐理由: 该研究揭示了DOT1L在AID介导的免疫球蛋白基因突变和致癌易位中的关键机制，对理解淋巴瘤发生及靶向治疗具有重要参考价值。

摘要: Activation-induced deaminase (AID) mutates immunoglobulin genes to initiate antibody diversification by class switch recombination and somatic hypermutation but can also target non-immunoglobulin loci with oncogenic consequences. The mechanisms determining gene susceptibility to AID remain unclear. Here, we show that the H3K79 histone methyltransferase DOT1L is proximal to nuclear AID and promotes both class switch recombination and off-target AID activity, including Igh-cMyc translocations in…

—

16 Mechanical rejuvenation of senescent stem cells and aged bone via chromatin remodeling

推荐理由: 该研究创新性地从细胞机械力学角度揭示骨髓干细胞衰老的机制，为理解骨老化和骨髓微环境提供了新视角，对血液疾病如骨髓衰竭或造血干细胞衰老相关研究具有直接借鉴价值。

摘要: Bone aging compromises skeletal integrity and increases vulnerability to osteoporosis and other age-related disorders, underscoring the need for new therapeutic strategies. Although pharmacological and genetic approaches have been widely explored, how cellular mechanical remodeling contributes to bone aging remains unclear. Here, we find that senescent bone marrow stem cells show markedly reduced intracellular force and impaired mechanical behavior. Moderate mechanical stimulation in cell…

—

17 Impact of Complete Response on Long-Term Survival in Patients With Relapsed or Refractory Large B-cell Lymphoma: A CIBMTR Prospective Study and SLR/Meta-Analysis

推荐理由: 该研究为CAR-T细胞疗法的临床试验设计提供了关键的替代终点证据，对血液肿瘤领域的疗效评估和试验方案优化具有直接参考价值。

摘要: CONCLUSIONS: These results suggest that CR at Day 100 or Month 6 are viable surrogate endpoints for OS in patients who receive CAR T-cell therapies, supporting their inclusion as endpoints in clinical trial design.

—

18 Venetoclax combined with ML385 overcomes chemotherapy resistance in acute myeloid leukemia by modulating Nrf2/ARE-mediated oxidative stress

推荐理由: 该研究针对白血病耐药这一临床难题，探索Venetoclax联合ML385的新策略，并深入分析Nrf2的预后价值，对急性髓系白血病的治疗策略优化和机制研究具有直接借鉴意义。

摘要: This study aimed to investigate the potential of Venetoclax combined with ML385 to overcome drug resistance in leukemia cells and the related mechanisms. Analysis of Nrf2 expression and its prognostic significance in AML was performed utilizing the GEO and GEPIA2 databases. Bone marrow specimens were collected from newly diagnosed AML patients to evaluate Nrf2 expression levels and assess their correlation with established risk stratification and clinical prognosis. Two doxorubicin-resistant…

—

19 Living sensor display implanted on skin for long-term biomarker monitoring

推荐理由: 该研究创新性地利用皮肤干细胞开发生物标志物动态监测技术，为炎症性血液疾病（如细胞因子风暴）的实时追踪提供了全新思路，具有显著的血科研究借鉴价值。

摘要: This study introduces an approach to biomarker monitoring through the development of a “Living Sensor Display” implanted on the skin, designed for long-term, continuous tracking of biomarkers, such as inflammatory cytokines. By leveraging the natural high selectivity and sensitivity of keratinocyte stem cells (KSCs) to environmental stimuli, we genetically engineered these cells to express fluorescent proteins in response to specific biomarker signals, specifically TNF-α signalling. This…

—

20 Small molecule splicing modulators that disrupt O-GlcNAc homeostasis

推荐理由: 该研究通过药物重筛选策略揭示了O-GlcNAc修饰与临床相关化合物及通路的交叉作用，为血液疾病代谢调控机制研究和潜在治疗靶点开发提供了新的可借鉴思路。

摘要: O-Linked N-acetylglucosamine (O-GlcNAc) is a nucleocytoplasmic post-translational modification that is tightly regulated by O-GlcNAc transferase (OGT) and O-GlcNAcase (OGA). Dysregulation of O-GlcNAc in human disease has motivated efforts to therapeutically modulate O-GlcNAc. Drug repurposing efforts can accelerate these campaigns and unveil how clinically relevant compounds and pathways intersect with O-GlcNAc. Here we report the results of three parallel drug repurposing screens against the…

—

21 Metabolites as signalling molecules in the tumour immune microenvironment

推荐理由: 该文章系统阐述了肿瘤代谢重编程与免疫微环境调控的最新机制，对理解血液肿瘤（如白血病、淋巴瘤）的免疫逃逸及开发靶向代谢的免疫疗法具有重要借鉴价值。

摘要: Alterations in key metabolic pathways are required for tumour development and the adaptation of tumour cells to intrinsic or extrinsic stresses, as well as for the regulation of immune cell fate and immune responses in the tumour microenvironment. In particular, the dysregulation or alteration of certain metabolites produced by tumour cells has been shown to be important in creating the immunosuppressive tumour microenvironment. Recent studies have broadened our understanding of the interactions…

—

22 Exploration of the genomic diversity of third-generation cephalosporin-resistant <em>Escherichia coli</em> in Australian clinical settings

推荐理由: 该文章对引起血流感染的耐药大肠杆菌进行基因组分析，直接关联菌血症这一血液科核心临床问题，同时其监测数据对公共卫生防控具有重要参考价值。

摘要: Escherichia coli resistant to third-generation cephalosporins (3GCs) is a WHO priority pathogen due to its antimicrobial resistance (AMR). In high-income countries, such as Australia, 3GC-resistant E. coli are a common cause of extra-intestinal infections in both healthcare and community settings. Long-term targeted surveillance efforts of AMR in E. coli routinely identify E. coli as a leading pathogen in bacteraemic infections. To date, there has been limited detailed genomic analysis of the…

—

23 Interpretable inflammation landscape of circulating immune cells

推荐理由: 该文章利用前沿的单细胞转录组学技术系统性解析炎症过程，为血液疾病中炎症机制的研究提供了创新的方法论参考和潜在干预思路。

摘要: Inflammation is a biological phenomenon beneficial for homeostasis, but it is unfavorable if dysregulated. Although major progress has been made in characterizing inflammation in specific diseases, a global, holistic understanding is still elusive. This is particularly intriguing, considering its function for human health and the potential for modern medicine if fully deciphered. In this study, we leveraged advances in single-cell transcriptomics to delineate inflammatory processes of…

—

24 Unlocking CRISPR-Cas9 editing for widely diverse Dictyostelid species

推荐理由: 该研究首次在网柄菌中建立了高效、跨物种的CRISPR-Cas9基因编辑方法，为利用这类经典细胞生物学模型开展比较进化研究提供了关键工具，其技术思路对血液系统相关细胞运动、分化等机制研究具有方法学借鉴价值。

摘要: Dictyostelids are a species-rich clade of cellular slime molds that are widely found in soils and have been studied for over a century. Due to a lack of genome editing methods, most molecular research in Dictyostelids has focused on only a single species, Dictyostelium discoideum, which has severely limited broad-scale comparative analyses. Here, we introduce the first CRISPR-Cas9 editing approach that is cloning-free, selection-free, highly efficient, and effective across Dictyostelid species…

—

25 Serum cytokines predict response and survival in esophageal squamous cell carcinoma receiving chemoradiotherapy combined with anti-PD-1 antibody: analyses of two phase II clinical trials

推荐理由: 该研究虽聚焦实体瘤，但其基于关键细胞因子（IL-8, CCL3, CCL4）构建预测模型的思路，对于血液肿瘤（如淋巴瘤、CAR-T治疗相关毒性）的疗效预测与预后评估具有直接且重要的借鉴价值。

摘要: CONCLUSIONS: The CYTOscore based on IL-8, CCL3, and CCL4 effectively predicts treatment response and survival in ESCC patients receiving CRT plus anti-PD-1 antibody.

—

26 GraphSTAR: Proximal Operator-Based Graph Neural Network Enhanced by Dynamic Graph Aggregation for Spatial Transcriptomics

推荐理由: 该文章介绍了空间转录组学的前沿整合方法，其技术创新与数据分析思路对血液肿瘤微环境或骨髓生态位的研究具有重要借鉴意义，有助于推动血液疾病的空间分子机制探索。

摘要: Spatial transcriptomics technologies carry out advanced sequencing analysis of molecular profiles with a spatial context, providing multi-source information essential for elucidating biological regulatory mechanisms. Nonetheless, it poses challenges in the integration of raw spatial coordinates with high-dimensional gene expression profiles in their native feature space. While spatial-aware methods effectively aggregate molecular information from local spatial neighborhoods, they fail to explore…

—

27 Adaptive multi-view information bottleneck for multi-omics data clustering

推荐理由: 该文章针对单细胞多组学数据整合这一前沿方法学挑战提出了创新思路，对于血液系统细胞异质性研究、稀有细胞群鉴定及血液肿瘤微环境分析具有重要的方法学借鉴价值。

摘要: MOTIVATION: Recent advances in single-cell sequencing have transformed precise measurement of gene expression at cellular resolution, enabling unprecedented dissection of cellular heterogeneity and intricate biological processes. The accumulation of multi-omics data offers new avenues for cell clustering-a critical foundation for cell-type identification and downstream analyses. However, substantial challenges persist in simultaneously achieving effective integration of complementary information…

—

28 Benchmarking community drug response prediction models: datasets, models, tools, and metrics for cross-dataset generalization analysis

推荐理由: 该研究提出的标准化评估框架能显著提升药物反应预测模型的可靠性和可比较性，对血液病精准治疗中的算法应用具有重要参考价值。

摘要: Deep learning and machine learning models have shown promise in drug response prediction (DRP), yet their ability to generalize across datasets remains an open question, raising concerns about their real-world applicability. Due to the lack of standardized benchmarking approaches, model evaluations and comparisons often rely on inconsistent datasets and evaluation criteria, making it difficult to assess true predictive capabilities. In this work, we introduce a benchmarking framework for…

—

29 NPM1 and IDH1/2 Mutations Show Limited Prognostic Impact in Relapsed/Refractory AML: Evidence From the AVALON Cohort

推荐理由: 该研究挑战了传统上依赖突变状态预测AML预后的模型，强调了治疗背景的重要性，对临床治疗决策具有直接参考价值。

摘要: In the AVALON cohort of relapsed/refractory AML treated with venetoclax plus hypomethylating agents, NPM1 and IDH1/2 mutations showed no significant impact on response or survival. These findings indicate that prognostic models for relapsed AML should consider treatment context rather than baseline mutation status.

—

30 Precise excision of expanded GGC repeats in NOTCH2NLC via CRISPR/Cas9 for treating neuronal intranuclear inclusion disease

推荐理由: 该研究在针对高度同源基因的精准编辑策略上具有显著创新性，其方法学思路可为血液遗传病（如动态突变相关疾病）的基因治疗研究提供重要技术借鉴。

摘要: Neuronal intranuclear inclusion disease (NIID) is an adult-onset neurodegenerative disease caused by expanded GGC repeats in the 5′ untranslated region of the human-specific NOTCH2NLC gene. The high sequence similarity between NOTCH2NLC and its paralogs poses a significant challenge for precise gene editing. Here, we develop a CRISPR/spCas9-based gene-editing strategy that precisely excises the expanded GGC repeats in NOTCH2NLC without detectable off-target effects on the highly homologous…

—

31 Binary mineral nanoparticles enable intravascular delivery of metal ions to tumors for metalloimmunotherapy

推荐理由: 该研究提出的二元矿物纳米颗粒技术，通过协同干扰钙、钠离子稳态诱导细胞死亡，其创新性的递送策略和微流控制备方法，对研发针对血液肿瘤（如白血病、淋巴瘤）的新型靶向疗法具有重要的借鉴价值。

摘要: Although disruptions in metal ion homeostasis leading to severe cellular damage and regulated cell death are a promising strategy for cancer immunotherapy, challenges in overloading these ions to tumor cells without premature release have limited their therapeutic applications. In this study, we develop binary mineral nanoparticles incorporating both Ca^(2+) and Na^(+) ions to enhance the cytotoxic effects of ion interference in cancer immunotherapy. Engineered using a microfluidic system for…

—

32 Atomically precise ligand engineering of gold nanoparticles via interphase mass transfer

推荐理由: 该文章提出了一种创新的金纳米簇表面工程方法，通过界面辅助配体交换实现了对配体传质的精确控制，对开发高精度生物成像探针具有重要参考价值，可为血液疾病相关成像技术研究提供新思路。

摘要: Precise surface engineering of gold nanoclusters (Au NCs) is critical for bioimaging. However, conventional methods often compromise the structural integrity of Au NCs or result in uncontrolled ligand distribution due to rapid reaction kinetics and etching side reactions. Herein, we develop an interphase-assisted ligand exchange method, which leverages mass transfer resistance between immiscible phases to precisely control the mass transfer of ligands. This approach significantly suppresses side…

—

33 RAS/MEK/PI3K pathway inhibition augments response to CD40 agonism by targeting CD11b<sup>+</sup> Bregs thereby overcoming melanoma PD1-resistance

推荐理由: 该研究揭示了免疫检查点抑制剂耐药的关键机制之一——Breg细胞的免疫抑制功能，并提出了针对性的联合治疗新策略，对肿瘤免疫治疗领域的研究者具有重要的

摘要: Development of effective second-line treatment options for patients with BRAF^(wt)NRAS^(wt) or BRAF^(wt)NRAS^(mut) melanoma resistant to immune checkpoint blockade (ICB) is crucial. While systemic delivery of agonist CD40 (aCD40) plus anti-PD1 (αPD1) showed activity in patients with ICB-resistant melanoma, the objective response rate was modest (15%), in part due to induction of B regulatory cells (Bregs) which suppress CD8^(+) effector T cell responses. We previously reported that…

—

34 AMPK at the interface of nutrient sensing, metabolic flux and energy homeostasis

推荐理由: 该综述系统总结了AMPK在细胞代谢调控中的最新进展，为血液疾病（如白血病、贫血等）中代谢重编程的研究提供了关键的理论借鉴和分子机制参考。

摘要: The orchestration of cellular metabolism requires the integration of signals related to energy stores and nutrient availability through multiple overlapping mechanisms. AMP-activated protein kinase (AMPK) is a pivotal energy sensor that responds to reductions in adenylate charge; however, studies over the past decade have also positioned AMPK as a key integrator of nutrient-derived signals that coordinate metabolic function. This Review highlights recent advances in our understanding of how AMPK…

—

35 A miRNA screen reveals a transcriptional network controlling the initiation of mammary organoids

推荐理由: 该研究采用前沿的3D类器官模型和miRNA筛选策略，方法学严谨，其技术框架和调控网络解析思路对血液肿瘤类器官研究具有重要借鉴价值。

摘要: Organoid formation is driven by poorly understood intrinsic cellular properties and transcriptional programs that govern plasticity and differentiation. Deciphering these regulatory networks is essential for understanding normal tissue homeostasis and tumor initiation. Using a 3D organotypic model, which better recapitulates cell-matrix interactions and biochemical cues, we performed a miRNA-based screening strategy to identify key regulators of organoid initiation from human primary mammary…

—

36 Artificial intelligence agents in cancer research and oncology

推荐理由: 该文章系统阐述了AI智能体的自主规划与推理能力进展，虽非血液病直接研究，但其方法论对构建血液学复杂数据分析与决策辅助系统具有前瞻性借鉴价值。

摘要: Since 2022, artificial intelligence (AI) methods have progressed far beyond their established capabilities of data classification and prediction. Large language models (LLMs) can perform logical reasoning, enabling them to plan and orchestrate complex workflows. By using this planning ability and equipped with the ability to act upon their environment, LLMs can function as agents. Agents are (semi-)autonomous systems capable of sensing, learning and acting upon their environments. As such, they…

—

37 The dynamics of mutational selection in cutaneous squamous carcinogenesis

推荐理由: 该研究在肿瘤突变筛选的

摘要: Identifying the mutant genes that are selected during carcinogenesis is key to identifying candidates for intervention and understanding the processes that promote transformation. Here we applied two selection metrics to study the dynamics of mutational selection in a mouse model of ultraviolet light driven skin carcinogenesis in which multiple synchronous tumors develop in each animal. Sequencing normal skin and tumors over a time course revealed two genetic routes to squamous carcinoma….

—

38 Enhancing TFEA.ChIP with ENCODE regulatory maps for generalizable transcription factor enrichment

推荐理由: 该研究基于实验支持的CRE-基因关联，为转录因子功能分析提供了更可靠的方法论工具，对研究血液疾病中转录调控异常具有潜在借鉴价值。

摘要: Identifying transcription factors (TFs) responsible for gene expression changes remain a central challenge in functional genomics. TFEA.ChIP is a ChIP-seq-based TF enrichment analysis tool that addresses this by linking TF binding profiles to differentially expressed genes through experimentally supported cis-regulatory element (CRE)-gene associations. Unlike motif- or heuristic-based approaches, TFEA.ChIP adopts a biologically grounded strategy by intersecting TF binding data from ReMap2022…

—

39 Locating the atoms at the hard-soft interface of gold nanoparticles

推荐理由: 该研究在纳米材料表面原子级结构表征方法上具有重要创新，虽然不直接针对血液疾病，但其揭示的界面调控机理对开发新型药物载体或血液相容性纳米材料具有潜在借鉴价值。

摘要: Surface structure affects the growth, shape and properties of nanoparticles. In wet chemical syntheses, metal additives and surfactants are used to modify surfaces and guide nanocrystal growth. To understand this process, it is critical to understand how the surface structure, and hence its energy, is modified. However, measuring the type and arrangement of atoms at hard-soft interfaces on nanoscale surfaces, especially in the presence of surfactants, is extremely challenging. Here, we determine…

—

40 Cross-species evidence for a developmental origin of adult hypersomnia with loss of synaptic adhesion molecules beat-Ia/CADM2

推荐理由: 该研究通过跨物种模型揭示了睡眠调节的新分子机制，方法学严谨创新，虽不直接针对血液疾病，但其分子通路研究思路对血液学领域的粘附分子相关研究具有借鉴价值。

摘要: Idiopathic hypersomnia (IH) is a poorly understood sleep disorder characterized by excessive daytime sleepiness despite normal nighttime sleep. Combining human genomics with behavioral and mechanistic studies in fish and flies, we uncover a role for beat-Ia/CADM2, synaptic adhesion molecules of the immunoglobulin superfamily, in excessive sleepiness. Neuronal knockdown of Drosophila beat-Ia results in sleepy flies and loss of the vertebrate ortholog of beat-Ia, CADM2, results in sleepy fish. We…

—

41 Integrated multi-omic atlas reveals the hierarchy of spatiotemporal regulatory networks of mouse gastrulation

推荐理由: 该研究通过构建高精度时空多组学图谱，为解析细胞命运决定的调控机制提供了前沿方法学参考，对造血发育等血液学研究具有间接但重要的借鉴价值。

摘要: Spatiotemporal coordination of cellular and molecular events is crucial for cell fate commitment during mouse gastrulation. However, the high-precision mechanisms governing the timing and spatial dynamics remain poorly understood. Here, we present a time-series single-cell multi-omic dataset of the gastrulating mouse embryos and construct a hierarchical gene regulatory landscape. Integrating this with real three-dimensional transcriptomic coordinate, we created ST-MAGIC and ST-MAGIC (+) atlas,…

—

42 Targeting SPAK suppresses progression and averts an immune exhaustive microenvironment in hepatocellular carcinoma

推荐理由: 该研究通过激酶筛选发现SPAK在肝癌免疫逃逸中的作用机制，其整合多组学与功能实验的研究方法对血液肿瘤（如

摘要: Protein kinases contribute to hepatocellular carcinoma (HCC) development and immune evasion, posing major challenges for HCC management. Here we show STE20/SPS1-related proline/alanine-rich kinase (SPAK) as a candidate immune exhaustion-associated gene identified through a pooled screen of protein kinases. By integrating bioinformatic analyses, data from patient cohorts, and functional studies in mouse models and cell lines, we demonstrate that elevated expression of SPAK promotes HCC…

—

43 All-fibre-coupled terahertz single-pixel imaging for biomedical applications

推荐理由: 该文章在太赫兹成像技术上实现了紧凑化与灵活性的突破，虽未直接针对血液疾病，但其无损检测与活体成像能力为血液样本分析或血管成像研究提供了潜在的新工具参考。

摘要: Real-time, non-invasive imaging techniques are essential for advancing biomedical diagnostics and material analysis, yet existing terahertz (THz) systems often suffer from limited speed, bulky designs, and poor adaptability to in situ environments. Addressing these challenges, we present a fully fibre-coupled THz attenuated total internal reflection single-pixel imaging system, offering a compact, flexible, and robust platform for non-destructive spectroscopy and in vivo imaging. This all-fibre…

—

44 A general one-step protocol to generate impermeable fluorescent HaloTag substrates for in situ live cell application and super-resolution imaging

推荐理由: 该研究通过化学修饰优化HaloTag染料的膜渗透性控制，为细胞表面蛋白标记提供了更精准的工具，对血液病研究中涉及细胞膜蛋白（如免疫标记物、受体）的可视化与追踪具有潜在技术借鉴价值。

摘要: Visualization of proteins can be achieved by genetically grafting HaloTag Protein (HTP) into the protein of interest followed by incubation with a dye-linked HaloTag Ligand (HTL). This approach allows for use of fluorophores optimized for specific optical techniques or of cell-impermeable dyes to selectively label cell surface proteins. However, these two goals often conflict, as many high-performing dyes exhibit membrane permeability. Here we show that several dye-HTL reagents can be made…

—

45 Reversible lipid-mediated pH-gating of connexin-46/50 by cryo-EM

推荐理由: 该研究通过冷冻电镜揭示了连接蛋白pH门控的结构机制，为理解细胞间通讯在缺血等病理条件下的调控提供了重要参考，对血液系统中细胞间信号传递的研究具有间接借鉴价值。

摘要: Gap junctions, formed by connexin proteins, establish direct electrical and metabolic coupling between cells, enabling coordinated tissue responses. These channels universally respond to intracellular pH changes, closing under acidic conditions to limit the spread of cytotoxic signals during cellular stress, such as ischemia. Using cryo-electron microscopy (cryo-EM), we uncover insights into the structural mechanism of pH-gating in native lens connexin-46/50 (Cx46/50) gap junctions. Mild…

—

46 Tucatinib plus trastuzumab for chemotherapy-refractory, HER2 + , RAS wild-type metastatic colorectal cancer (MOUNTAINEER): final analysis

推荐理由: 该研究提供了HER2靶向双联疗法在结

摘要: MOUNTAINEER was a multicenter, open-label, phase 2 trial (NCT03043313) that evaluated the efficacy and safety of tucatinib plus trastuzumab, a dual HER2-targeted chemotherapy-free regimen. Patients were included if they had chemotherapy-refractory, HER2+, RAS wild-type unresectable or metastatic colorectal cancer. This final analysis reports updated efficacy and safety after a median follow-up of 32.4 months. Of the 84 patients who received tucatinib plus trastuzumab, the confirmed objective…

—

47 Fine-mapping a genome-wide meta-analysis of 98,374 migraine cases identifies 181 sets of candidate causal variants

推荐理由: 该研究通过大规模荟萃分析与精细定位，为复杂疾病的遗传机制研究提供了方法学参考，虽非直接血液疾病，但其研究思路与技术可借鉴于血液遗传病研究。

摘要: Migraine is a highly prevalent neurovascular disorder for which genome-wide association studies (GWAS) have identified over one hundred risk loci, yet the causal variants and genes remain mostly unknown. Here, we meta-analyze three migraine GWAS including 98,374 cases and 869,160 controls and identify 122 independent risk loci of which 35 were new. Fine-mapping of a meta-analysis is challenging because some variants may be missing from some participating studies and accurate linkage…

—

48 Evaluating MRI correlates of lifestyle-based dementia risk reduction: Results from the AgeWell.de imaging study

推荐理由: 该研究采用多中心试验和神经影像学标记物，方法学严谨，虽不直接涉及血液疾病，但其多模态干预研究设计对血液病领域的复杂干预研究具有方法学借鉴价值。

摘要: BackgroundMultidomain lifestyle interventions can improve dementia risk by risk factor modification. Little is known about possible mechanisms underlying this effect.ObjectiveAnalyze whether changes in a validated dementia risk score were linked to changes in neuroimaging markers in a sample of older adults at increased dementia risk, participating in a multimodal lifestyle intervention.MethodsParticipants of the multi-centric AgeWell.de-trial at the Leipzig study site were examined using 3…

—

49 CSRefiner: a lightweight framework for fine-tuning cell segmentation models with small datasets

推荐理由: 该文章聚焦空间组学中细胞分割的技术瓶颈，虽未直接关联血液疾病，但其提升单细胞空间转录组分析精度的方法对血液肿瘤微环境等前沿研究具有可借鉴的计算生物学价值。

摘要: Recent advances in spatial omics technologies have enabled transcriptome profiling at subcellular resolution. By performing cell segmentation on nuclear or membrane staining images, researchers can acquire single cell level spatial gene expression data, which in turn enables subsequent biological interpretation. Although deep learning-based segmentation models achieve high overall accuracy, their performance remains suboptimal for whole-tissue analysis, particularly in ensuring consistent…

—

50 Lactate-driven H3K27 lactylation promotes Olig2-dependent remyelination and motor recovery after spinal cord injury

推荐理由: 该研究创新性地揭示了乳酸在脊髓损伤后通过激活Olig2促进髓鞘再生的分子机制，其研究思路与方法对探索代谢微环境在血液疾病中的作用具有可借鉴价值。

摘要: Demyelination caused by oligodendrocyte death is a key contributor to neurological deficits after spinal cord injury (SCI), highlighting the critical need to promote oligodendrocyte precursor cell (OPC) differentiation and remyelination. The transcription factor Olig2 is a master regulator of this process; however, its activation mechanism remains unclear. Given the marked lactate accumulation in post-SCI ischemic microenvironments, we investigated the role of lactate in SCI as well as its…

—

51 Enhancing carbon sinks in China using a spatially-optimized forestation strategy

推荐理由: 该研究在方法学上具有创新性和严谨性，其空间优化策略对跨学科研究具有参考价值，但内容与血液疾病领域无直接关联，仅可作为方法论借鉴。

摘要: China plans expanding 49.5 million hectares of new forests by 2050 to strengthen carbon sequestration. However, estimates of the carbon benefits from this expansion rarely consider the effect of ‘forest edge’, where tree mortality increases under intensified stress from wind, drought, pests, and fire. Here we show that proximity to forest edges substantially reduces biomass carbon storage, and develop a spatial optimization strategy that prioritizes planting in areas that minimize edge effects….

—

52 Cooperative atomic motion during shear deformation in metallic glass

推荐理由: 该研究揭示了非晶材料中引发塑性流动的“触发组”原子协同机制，其关于“局部重排”与“级联效应”的核心概念，可为研究红细胞变形性、镰状细胞病病理或血栓形成中细胞聚集等血液学关键力学过程提供创新的理论借鉴和模型思路。

摘要: Elucidating mechanical deformation in glassy materials at the atomic level is challenging due to their disordered atomic structure. Using our frozen-atom analysis of the simulation data, we reveal that anelastic deformation in CuZr metallic glasses is fundamentally driven by cooperative atomic motions of tens of atoms elastically linked to one another, forming trigger groups. They initiate localized rearrangements, which can cascade into plastic flow. These cores show no clear structural or…

—

53 Development of an ultra-efficient prime editing system in tomato

推荐理由: 该研究在基因编辑技术上实现了重要突破，其高效、精准的编辑策略可为血液病基因治疗研究提供方法论借鉴，尤其在提升编辑效率与可遗传性方面具有启发意义。

摘要: Prime editing (PE) enables precise genome modifications without donor DNA or double-strand breaks, but its application in dicot plants has faced challenges due to low efficiency, locus dependence, and poor heritability. Here, we develop an ultra-efficient prime editing (UtPE) system for dicots by integrating evolved PE6 variants (PE6c and PE6ec), an altered pegRNA (aepegRNA), an RNA chaperone, and a geminiviral replicon. UtPE significantly improves editing performance in tomatoes, with UtPEv1…

—

54 Transforming wearable data into personal health insights using large language model agents

推荐理由: 该文章提出的工具增强型LLM代理框架（PHIA）在复杂健康数据分析方法上具有创新性和技术借鉴价值，虽然不直接针对血液疾病，但其多步推理与代码生成的范式可为血液学纵向数据研究提供方法学参考。

摘要: Deriving personalized insights from popular wearable trackers requires complex numerical reasoning that challenges standard LLMs, necessitating tool-based approaches like code generation. Large language model (LLM) agents present a promising yet largely untapped solution for this analysis at scale. We introduce the Personal Health Insights Agent (PHIA), a system leveraging multistep reasoning with code generation and information retrieval to analyze and interpret behavioral health data. To test…

—

55 Environmental metagenomics enhances detection of circulating viruses from live poultry markets in Cambodia

推荐理由: 该研究创新性地应用宏基因组学进行环境病原监测，方法学上有借鉴意义；尽管不直接聚焦血液疾病，但其高效的病原筛查策略可为血液系统感染性疾病的早期预警研究提供方法学参考。

摘要: Environmental surveillance has emerged as a pivotal strategy for early detection of pathogens that pose a threat to humans. In Asia, live-bird markets (LBMs) are key human-animal interfaces for zoonotic virus transmission. Traditional sampling strategies are time-consuming, expensive and carry significant biosafety risks. Here, we assess the performance of metagenomics on environmental samples (ES) versus traditional poultry swabs for detecting viral pathogens in two Cambodian LBMs between…

—

56 Propellane-free access to bicyclo[1.1.1]pentanes

推荐理由: 该文章在合成方法学上具有显著创新性，为药物化学中三维生物电子等排体的开发提供了新策略，对涉及小分子药物设计的血液病研究具有间接参考价值。

摘要: Bicyclo[1.1.1]pentane (BCP) has emerged over the past decade as a valuable three-dimensional bioisostere for benzene, attracting considerable interest in pharmaceutical research for its ability to improve drug-like properties. Although [1.1.1]propellane has traditionally served as the key precursor to mono- and 1,3- disubstituted BCPs, the growing demand for multisubstituted and bridge-functionalized BCP derivatives has spurred the development of alternative, propellane-free synthetic…

—

57 Lactate-driven H3K27 lactylation promotes Olig2-dependent remyelination and motor recovery after spinal cord injury

推荐理由: 该研究虽聚焦脊髓损伤，但其对乳酸代谢与转录因子调控机制的探讨，为血液疾病中缺氧微环境下的细胞分化与修复研究提供了可借鉴的思路。

摘要: Demyelination caused by oligodendrocyte death is a key contributor to neurological deficits after spinal cord injury (SCI), highlighting the critical need to promote oligodendrocyte precursor cell (OPC) differentiation and remyelination. The transcription factor Olig2 is a master regulator of this process; however, its activation mechanism remains unclear. Given the marked lactate accumulation in post-SCI ischemic microenvironments, we investigated the role of lactate in SCI as well as its…

—

58 Developing an Evidence-Based and Patient-Centred Care Concept to Address Deficits in German Primary Care of Venous Leg Ulcers: Results of an Expert Survey Within the ULCUS CRURIS CARE Project

推荐理由: 该研究针对静脉性腿部溃疡这一临床常见问题，提出了多模式干预方案，对改善基层医疗实践具有直接参考价值；虽然与核心血液病学关联较弱，但其在慢性伤口管理中的方法学思路可为相关血管或凝血障碍研究提供借鉴。

摘要: Venous leg ulcers (VLU) account for the majority of chronic wounds, with an estimated rise in prevalence due to demographic change. Care often does not comply with evidence, and patients remain passive and uninformed. To support general practice VLU care, the ‘UlcusCrurisCare’ (UCC) project developed a multimodal intervention comprising provider training, software-supported case management and standardised patient education. Experts from the medical community (physicians, nurses, association of…

—

59 Chamber-specific chromatin architecture guides functional interpretation of disease-associated Cis-regulatory elements in human cardiomyocytes

推荐理由: 该研究在表观基因组和染色质空间互作方法学上具有严谨性，可为血液病中非编码区调控机制研究提供方法学参考，但直接与血液疾病的相关性有限。

摘要: Cis-regulatory elements (CREs) are noncoding DNA regions regulating cell-type-specific gene expression programs by interacting with distal gene promoters. Here, we aim to decode the function and spatial organization of CRE-promoter interactions in human cardiomyocytes. We analyzed the epigenome and chromatin interactions of human male atrial, ventricular, and failing cardiomyocytes. Atrial and ventricular cardiomyocytes harbored chamber-specific CRE-promoter interactions modulating gene…

—

60 Desilylative allylation of 3,3-borylsilylpropene under metallaphotoredox catalysis

推荐理由: 该文章在协同光氧化还原与铬催化领域提出了创新方法，对有机合成化学具有较高参考价值，但直接与血液疾病的相关性较弱，适合从事合成方法学或药物化学基础研究的人员阅读。

摘要: Chemoselective functionalization of hetero-gem-dimetalloid represents an attractive strategy in terms of diversity-oriented synthesis. In particular, desilylative functionalization of gem-silylboronate esters remains a challenging task and existing solutions heavily relied on ionic reactions. Herein, we report a desilylative functionalization of allylic gem-silylboronate esters with aldehydes under synergistic photoredox and chromium(II) catalysis. With different substrates, both α- and…

—

61 Cross-species dissection of saline-related genes by genetically deciphering a euryhaline microalga Chlorella sp

推荐理由: 该研究在基因组组装与适应性进化分析方面方法严谨、创新性强，但其研究对象为绿藻盐度适应机制，与血液疾病直接关联较弱，仅在其比较基因组学方法上对血液进化研究有潜在参考价值。

摘要: Deciphering adaptation to habitat shifts across the salinity boundary necessitates investigation of “lost” and “acquired” saline genes. By assembling a telomere-to-telomere genome, we propose that the euryhaline Chlorophyta Chlorella sp. MEM25 represents an early-diverging saltwater species that has evolved numerous genes essential for saltwater-freshwater transitions. By comparison with Viridiplantae genomes, we identify ancestral genes and lineage-specific genes related to salinity adaptation….

—

62 Harnessing acoustic topology for dynamic control of liquid crystal defects

推荐理由: 该研究在软物质拓扑缺陷的动态操控方法上具有显著创新性和技术严谨性，为复杂结构调控提供了新思路，虽与血液疾病无直接关联，但其物理方法学对跨学科研究有启发价值。

摘要: Topological soft matter systems rely on controllable defect structures to encode functionality, yet robust, large-scale, and reconfigurable manipulation strategies remain elusive. Here we present a versatile acoustic platform for dynamic control of liquid crystal defect arrays via engineered topological wavefields. By coherently superimposing surface acoustic waves, we generate spatially structured potential landscapes and acoustic streaming vortices that interact with the molecular orientation…

—

63 Temporal constraints on enhancer usage shape the regulation of limb gene transcription

推荐理由: 该研究在增强子动态调控方面方法学创新性强，虽不直接涉及血液疾病，但其揭示的时空调控机制对研究造血发育与白血病等疾病的表观遗传调控具有潜在借鉴价值。

摘要: Enhancer repertoires orchestrate gene expression during embryonic development, shaping organ structure and function. Individual enhancers can act in overlapping or distinct spatial domains, but their temporal specificity and coordinated action over time remain poorly understood. Here, we identify temporally restricted enhancer repertoires at multiple loci involved in mouse limb development. To capture their dynamic roles, we introduce the regulatory trajectory framework comprising initiation,…

—

64 Single-cell-resolved transcriptional dynamics of human subcutaneous adipose tissue during lifestyle- and bariatric surgery-induced weight loss

推荐理由: 该研究在肥胖与脂肪组织重塑的机制探讨上方法严谨，对理解代谢炎症有一定参考价值，但直接与血液疾病的关联性较弱，适合关注代谢-炎症交叉领域的研究者拓展视野。

摘要: Human white adipose tissue undergoes major remodelling during sustained weight gain that may compromise tissue function and drive cardiometabolic comorbidities. Although weight loss reverses many of these complications, the cellular and molecular adaptations of adipose tissue to different weight loss interventions are poorly understood. Here we show how abdominal subcutaneous adipose tissue (SAT) in men and women with severe obesity adapts to modest lifestyle-induced (8-10%) weight loss followed…

—

65 Evaluation of magnetic resonance imaging parameters and compliance with guidelines in soft tissue sarcomas

推荐理由: 该文章强调了影像学标准化在软组织肉瘤诊断中的质量控制价值，对优化临床影像检查流程具有实践指导意义，适合放射科及肿瘤科医生参考。

摘要: CONCLUSIONS: MRI protocol selection is primarily guided by the clinical referral question. Our analysis indicates that a substantial proportion of examinations deviated from recommended protocols. Contributing factors may include inaccurate clinical referral questions, limited guideline awareness, reimbursement constraints in outpatient settings, or diagnostic considerations. Standardized imaging represents a key instrument for quality assurance in the diagnosis of STS and forms the foundation…

—

66 Limblab: pipeline for 3D analysis and visualisation of limb bud gene expression

推荐理由: 该文章虽聚焦肢体发育，但其创新的三维基因表达分析流程在方法学上具有高度可借鉴性，可为血液系统发育或肿瘤空间转录组研究提供技术参考。

摘要: CONCLUSIONS: The pipeline advances 3D gene expression analysis in limb development by integrating flexible tools for staging, alignment, and visualization. It is user-friendly, scalable to other samples, and optimized for research needs. Future updates will enhance customization and expand applicability to other species and developmental biology fields.

—

67 A waterproof and ultra-elastic thermoelectric foam for underwater human signal detection

推荐理由: 该文章报道的高灵敏、多信号解耦与自供电传感技术，其核心原理（如精确的温度传感与调控、多参数监测）对开发新型血液储存监测设备或可穿戴式凝血/成分分析仪具有潜在的方法学借鉴价值。

摘要: Underwater tasks such as ocean exploration and emergency rescue demand advanced wearable sensors. However, multifunctional underwater sensors capable of integrating self-powered signal transmission, effective thermal-moisture regulation, and multi-signal decoupling remain unreported. Here, we present a three-dimensional multi-functional thermoelectric device composed of highly porous polyurethane foam coated with a waterproof conductive layer made from single-walled carbon nanotubes,…

—

68 Chamber-specific chromatin architecture guides functional interpretation of disease-associated Cis-regulatory elements in human cardiomyocytes

推荐理由: 该研究在表观遗传学和染色质互作分析方面方法严谨、具有创新性，但主要聚焦于心肌细胞领域，对血液疾病研究的直接借鉴价值有限，适合相关交叉领域研究者参考其技术思路。

摘要: Cis-regulatory elements (CREs) are noncoding DNA regions regulating cell-type-specific gene expression programs by interacting with distal gene promoters. Here, we aim to decode the function and spatial organization of CRE-promoter interactions in human cardiomyocytes. We analyzed the epigenome and chromatin interactions of human male atrial, ventricular, and failing cardiomyocytes. Atrial and ventricular cardiomyocytes harbored chamber-specific CRE-promoter interactions modulating gene…

—

69 Hypertensive crisis due to secondary aldosteronism from polyarteritis nodosa

推荐理由: 该病例报告对高血压危象伴低钾血症的鉴别诊断提供了临床思路，尤其展示了原发性醛固酮增多症的非典型表现，对内分泌科与心血管科医生在处理复杂高血压时具有参考价值。

摘要: Primary aldosteronism is common in those diagnosed with hypertension and distinguishing primary aldosteronism from its mimics allows tailored management. A woman in her 30s presented to an Australian hospital with hypertensive crisis (209/100 mm Hg) and spontaneous hypokalaemia (2.9 mmol/L). Laboratory tests revealed hyperreninaemic hyperaldosteronism with a normal aldosterone-renin ratio. CT imaging showed focal areas of soft tissue encasement and enhancement surrounding multiple arteries,…

—

70 IL-27, a metabolic regulator secreted by astrocytes in response to GLP-1RA OHP2, modulates microglial reprogramming in Alzheimer’s disease by regulating cGAS lactylation

推荐理由: 由于未提供摘要内容，无法评估文章的具体价值，建议补充摘要后再进行判断。

摘要: No abstract

—

71 Non-polar nanocluster confinement engineering realizes high capacitive energy storage in Pb-free high-entropy relaxors

推荐理由: 该文章在无铅弛豫铁电体的相场模拟与设计方面具有高度的创新性与方法论严谨性，但其研究对象为介电陶瓷电容器，与血液疾病领域无直接关联，可借鉴性极低。

摘要: Dielectric ceramic capacitors with ultrahigh power density have become indispensable in modern power electronics, yet the persistent challenge of achieving superior energy density with high energy efficiency remains a critical bottleneck for practical applications. Herein, we propose an effective non-polar nanocluster confinement strategy through phase-field simulation-guided design of high-entropy (Bi(0.2)Na(0.2)Ba(0.2)Sr(0.2)Ca(0.2))(Ti(1-x)Sn(x))O(3) lead-free relaxor ferroelectrics. The…

—

72 Fate of Pomeranchuk effect in ultrahigh magnetic fields

推荐理由: 该文章虽在凝聚态物理领域具有较高创新性与方法严谨性，揭示了电子系统中的Pomeranchuk效应，但其内容与血液疾病研究无直接关联，仅可能在自旋熵等基础物理机制上为极少数交叉学科研究提供间接参考。

摘要: The Pomeranchuk effect is a counterintuitive phenomenon where liquid helium-3 (³He) solidifies under specific pressures, not when cooled, but when heated. This behaviour originates from the magnetic entropy of nuclear spins, suggesting a magnetic field should influence it. However, its detailed response to magnetic fields remains elusive due to the small nuclear magneton of ³He and lack of analogous fermion systems. Here, we show that an electron system also exhibit the Pomeranchuk effect, where…

—

73 Sequence-encoded layered heteroleptic metalla-[2]catenanes for programmable supramolecular function

推荐理由: 该文章在超分子化学领域具有较高的方法学创新性和严谨性，但其研究内容与血液疾病或血液学研究的直接关联性较弱，适合对配位化学和分子架构设计感兴趣的研究者阅读，对血液病学的可借鉴性有限。

摘要: Molecular information encoded within supramolecular frameworks offers a powerful paradigm for directing emergent function beyond the genetic code, but systematic investigations into alternative spatial configurations and their consequences remain scarce. Here we use metalla-[2]catenanes to probe sequence-function relationships in layered architectures. By combining two or three size-matched N-heterocyclic carbene ligands with Ag(I) nodes, we selectively construct heteroleptic…

—

74 A nano-structured reporter for high-sensitivity contaminant detection in groundwater

推荐理由: 本文虽在纳米传感与地下水修复技术方面具有显著创新性和方法学严谨性，但与血液疾病研究无直接关联，对血液学领域的可借鉴性极低，仅适合环境科学与分析化学领域的研究者阅读。

摘要: Groundwater remediation is vital for meeting the ever-growing demand for clean water. However, accurately delineating subsurface contamination by free-phase organic contaminants (FPOCs) remains a major remediation hurdle. Here, we design a nano-structured reporter featuring a hydrophobic contaminant probe embedded within the framework of polyvinyl alcohol (PVA)-grafted carboxylated carbon black, for ultrahigh-sensitivity FPOC detection. When injected into the subsurface, the reporter moves with…

—

75 Flavonoid-mediated bacterial spermidine biosynthesis enhances vitamin accumulation in tomato fruits

推荐理由: 该文章在植物与微生物互作领域的研究方法严谨，对次级代谢调控通路有细致阐释，但其研究对象（番茄果实品质）与血液疾病研究无直接关联，仅其中关于黄酮类化合物调控通路的分子机制可能为血液代谢研究提供极有限的间接参考。

摘要: Rhizosphere microbes benefit plant growth and health. How plant-microbe interactions regulate fruit quality remains poorly understood. Here, we elucidate the multi-level modulation of vitamin accumulation in tomato by flavonoid-mediated crosstalk between host plants and rhizosphere microbes. SlMYB12-overexpressing plants with up-regulated flavonoid biosynthesis accumulate higher levels of vitamins C and B(6) in fruits compared to wild-type plants grown in natural soil. Flavonoid-mediated…

—

76 Erratum to: Detection of myeloma-associated osteolytic bone lesions with energy-integrating and photon-counting detector CT

推荐理由: 由于摘要缺失，无法评估文章的具体内容、方法和价值，因此不建议在没有更多信息的情况下阅读本文。

摘要: No abstract

—

77 ERECTA genes and their ligands regulate shoot and inflorescence architecture in maize

推荐理由: 该文章虽然方法严谨，聚焦玉米分生组织发育的信号通路，但内容与血液疾病或血液学研究无直接关联，缺乏对血液学领域的可借鉴性，不推荐血液学研究者优先阅读。

摘要: In maize, several yield-related traits are associated with meristem activity, regulated by CLAVATA3/EMBRYO SURROUNDING REGION-related (CLE) peptide signals perceived by CLAVATA(CLV) receptors in the CLAVATA-WUSCHEL (CLV-WUS) pathway. However, additional signaling pathways in maize meristem development remain poorly understood. Here, we identify three receptor-like kinases, ZmERECTA1 (ZmER1), ZmER2 and ZmER1-like (ZmERL), and their ligands, EPIDERMAL PATTERNING FACTOR-like (ZmEPFL), as critical…

—