追觅 - 2026-01-15

生成时间: 2026−01-15 22:46

分析文章数量: 77

1 Evaluation of dual BCL-2/BCL-XL inhibition in AML preclinical models with and without prior venetoclax therapy

推荐理由: 该研究揭示了BCL-XL在AML患者对venetoclax产生耐药性的关键机制，不仅深化了对白血病耐药的认识，也为克服

摘要: Acute Myeloid Leukemia (AML) is an aggressive hematologic malignancy that relies heavily on the anti-apoptotic protein B-cell lymphoma 2 (BCL-2) for survival.¹ Venetoclax, a BCL-2 inhibitor, exploits this dependency and is currently approved for treatment of elderly AML patients. BCL-XL, another pro-survival protein in the BCL-2 family, has been identified as a key driver of both intrinsic and acquired resistance to venetoclax.² Patients often develop resistance to BCL-2 inhibition through…

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2 Older patients with lymphoma: navigating a landscape of clinical controversies and barriers to innovation

推荐理由: 该文章批判性地反思了老年淋巴瘤治疗中依赖单一年龄阈值的局限，倡导基于综合老年评估的个体化策略，对血液科临床实践具有直接的革新意义和借鉴价值。

摘要: Older patients with lymphoma represent a growing, heterogeneous population whose care is challenged by diverse outcomes, limited evidence, and one-dimensional age definitions. Historically, arbitrary age thresholds such as ≥60 or ≥80 years have guided treatment decisions, yet they fail to capture the biological and functional diversity of aging and can limit opportunities for cure and progress. Current practice relies on arbitrary dose reductions in old age, such as RminiCHOP, despite limited…

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3 Hepatic response criteria in light chain amyloidosis: a multicenter validation study

推荐理由: 该研究针对轻链淀粉样变性肝受累这一预后不良亚群，提出了可量化的肝脏反应评估标准，对优化血液科临床预后分层和治疗评估具有直接参考价值。

摘要: Liver involvement in light chain amyloidosis (AL) is seen in 10-20% of patients and is associated with poor prognosis. The goal of this study was to assess the prognostic impact of the hepatic response criteria. AL patients diagnosed between 2010 and 2015 with liver involvement [serum alkaline phosphatase (AP) >1.5 upper reference limit (URL)] who achieved hematological response were included. Hepatic response was defined as >50% reduction (or normalization) of AP from baseline. Hepatic response…

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4 KMT2A is a prerequisite of malignant transformation during IDH-mutant gliomagenesis

推荐理由: 该研究深入探讨了表观遗传调控因子KMT2A在肿瘤发生中的作用机制，其“微环境感知”的治疗探索思路对理解血液肿瘤（如MLL重排白血病）的耐药性和复发具有极高的借鉴价值。

摘要: CONCLUSIONS: Disrupting KMT2A-mediated H3K4me3 reshapes the epigenome and attenuates LGG-relevant programs and phenotypes in vitro, supporting a strong role in tumor initiation. In vivo, the TS603 survival result highlights context-dependent maintenance and motivates cautious, microenvironment-aware therapeutic exploration of the KMT2A axis and downstream targets such as SCD.

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5 CADS: A Causal Inference Framework for Identifying Essential Genes to Enhance Drug Synergy Prediction

推荐理由: 该文章提出通过建模基因对药物反应的因果影响来改进药物协同预测，这一方法创新对血液肿瘤（如白血病、淋巴瘤）的联合疗法开发具有重要借鉴价值，能帮助更精准地筛选有效的药物组合。

摘要: MOTIVATION: Drug synergy is crucial for developing effective combination therapies, but traditional screening methods suffer from inefficiency and high costs. While deep learning shows promise for predicting drug synergy, current approaches using Transformers and graph neural networks focus on combining drug and cell line features without modelling how genes causally influence drug responses.

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6 CoxMDS: multiple data splitting for high-dimensional mediation analysis with survival outcomes in epigenome-wide studies

推荐理由: 该文章提出的CoxMDS方法针对高维中介分析中错误发现率的控制问题进行了创新改进，尤其适用于DNA甲基化等血液疾病相关研究，对血液病机制探索具有重要方法论参考价值。

摘要: Causal mediation analysis investigates whether the effect of an exposure on an outcome operates through intermediate variables known as mediators. Although progress has been made in high-dimensional mediation analysis, current methods do not reliably control the false discovery rate (FDR) in finite samples, especially when mediators are moderately to highly correlated or follow non-Gaussian distributions. These challenges frequently arise in DNA methylation studies. We introduce CoxMDS, a…

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7 Artificial intelligence in mitotic checkpoint modeling: transforming our understanding of cellular division through machine learning and predictive biology

推荐理由: 该文章将人工智能与细胞有丝分裂调控机制相结合，为理解染色体错误分离导致的血液肿瘤（如白血病）提供了创新研究方法，对血液疾病机理探索具有重要借鉴价值。

摘要: Mitotic checkpoints safeguard genomic integrity by orchestrating the precise segregation of chromosomes during cell division. Yet their complex, nonlinear dynamics have long defied full understanding through traditional experimental and computational approaches. In recent years, artificial intelligence (AI) has begun to transform this landscape. Machine learning and deep learning methods now achieve substantial accuracies in predicting cellular behaviors and uncovering novel regulatory…

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8 <em>QKI</em> dysregulation induces extensive splicing changes in T-cell acute lymphoblastic leukemia

推荐理由: 该研究聚焦RNA结合蛋白QKI在T-ALL中的肿瘤抑制功能与剪接调控机制，通过双队列临床数据验证，为血液肿瘤的靶向治疗提供了新的分子视角和潜在干预靶点。

摘要: Understanding the molecular mechanisms underlying T-cell acute lymphoblastic leukemia (T-ALL) is essential for developing more effective therapeutic strategies. Despite therapeutic advances, the role of RNA-binding proteins in the pathogenesis of T-ALL remains poorly understood. Here, we investigate the RNA-binding protein Quaking (QKI), identifying it as a key regulator of splicing with tumor-suppressive properties in T-ALL. Through the analysis of two independent pediatric T-ALL cohorts, we…

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9 Evaluation of acute myeloid leukemia using genomic proximity mapping-based next generation cytogenomics

推荐理由: 该研究评估了基因组邻近映射（GPM）这一创新技术用于AML细胞基因组分析，与现行标准方法相比，可能提升细胞遗传学风险变异的检测效能，对优化AML风险分层和治疗决策具有直接的临床借鉴价值。

摘要: Cytogenetic analysis encompasses a suite of standard-of-care diagnostic testing methods that is applied routinely in cases of acute myeloid leukemia (AML) to assess chromosomal changes that are clinically relevant for risk classification and treatment decisions. In this study, we assess the use of Genomic Proximity Mapping® (GPM) for cytogenomic analysis of AML diagnostic specimens for detection of cytogenetic risk variants included in the European Leukemia Network (ELN) risk stratification…

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10 GATA2 at 14: genotype-phenotype correlations

推荐理由: 该研究基于大样本临床数据系统总结了GATA2突变相关血液学表型，对骨髓衰竭综合征的临床诊断与预后评估具有直接指导价值。

摘要: GATA2 mutations cause adult-onset bone-marrow failure characterized by cytopenias, infections and increased risk of myeloid malignancy. We reviewed hospital records and referrals of 232 GATA2 mutated individuals from 122 families to gather hematopoietic and syndromic features. Mutations were categorized by GATA2 protein effect: mutation after the 2nd Zinc-finger (Cterm, n=10); missense in the 2nd Zinc-Finger (ZF2, n=104); mutations producing stable truncated protein (Truncation, n=22); Null…

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11 Polyamine-dependent metabolic shielding regulates alternative splicing

推荐理由: 该研究创新性地揭示了多胺代谢对前体mRNA可变剪接的调控机制，为血液肿瘤（如骨髓异常增生综合征、白血病）中剪接体突变致病机理提供了新的代谢视角，对血液病机制研究与治疗靶点开发具有重要借鉴价值。

摘要: Metabolites are central to cellular homeostasis. Although much emphasis has been placed on their relevance to meet energetic and biosynthetic demands, metabolic intermediates also function as signalling molecules. Here we show that polyamines, small polycations that are critical to cellular homeostasis^(1-3), regulate the process of alternative pre-mRNA splicing. We find that inhibition of polyamine synthesis increases phosphorylation of spliceosomal proteins, concomitant with perturbation of…

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12 Unravelling co-mutational patterns with prognostic implications in NPM1 mutated adult acute myeloid leukemia - a HARMONY study

推荐理由: 该研究基于大规模临床数据库提出了NPM1突变AML的新型基因共突变风险分层模型，对急性髓系白血病的精准预后评估和临床治疗决策具有直接参考价值。

摘要: NPM1-mutated (NPM1-mut) acute myeloid leukemia (AML) is generally associated with a more favorable outcome, although the presence of additional gene mutations can influence patient prognosis. We analyzed intensively-treated adult NPM1-mut AML patients included in the HARMONY Alliance database. A newly developed risk classification, which included combinations of co-mutations in FLT3-ITD, DNMT3A, IDH1/IDH2, and TET2 genes, was applied to a training cohort of NPM1-mut AML patients included in…

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13 Platelet recovery delay and survival in patients with myelofibrosis undergoing allogeneic hemopoietic stem cell transplantation

推荐理由: 该研究明确了骨髓纤维化患者移植后血小板恢复的预后价值，对临床预后判断和治疗策略调整具有直接参考意义。

摘要: We studied platelet recovery in 93 patients with myelofibrosis, following an allogeneic hemopoietic stem cell transplant (HSCT). The primary end point of the study was achieving a platelet count of 50x10^9/L within day +100, which occurred in 62 patients (67%) and predicted 5 year non relapse mortality (5% vs 55%; p=0.0009) and 5 year actuarial survival (85% vs 38%; p=.

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14 A scalable two-step genome editing strategy for generating full-length gene-humanized mice at diverse genomic loci

推荐理由: 该研究提出的全基因人源化小鼠技术路径具有重要方法学突破，为血液疾病中人类基因功能的体内研究提供了更可靠、高效的平台，对血液学基础与转化研究具有直接借鉴价值。

摘要: Full-length gene-humanized mice engineered by completely replacing mouse loci with human counterparts, including untranslated and regulatory regions, provide a robust in vivo platform for human gene function studies. However, reliably humanizing large genomic regions remains challenging due to limited DNA insert sizes, complex protocols, and specialized material requirements. This study introduces a streamlined approach that enables full-length gene humanization through two sequential…

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15 Loss of Fsr quorum sensing promotes biofilm formation and worsens outcomes in enterococcal infective endocarditis

推荐理由: 该研究通过微流控和体内模型，发现了粪肠球菌群体感应系统在感染性心内膜炎中独特的负调控作用，对理解血流感染中细菌生物膜形成的机制具有重要借鉴价值，尤其有助于血液科相关感染并发症的机制研究与潜在治疗策略开发。

摘要: Infective endocarditis (IE) is a severe heart infection caused predominantly by Gram-positive bacteria forming biofilm on heart valves. While biofilm formation is central to disease progression, the underlying bacterial mechanisms remain poorly understood. Here, we identify the Fsr quorum sensing (QS) system of Enterococcus faecalis as an unexpected negative regulator of biofilm and pathogenesis in IE. Using microfluidic and in vivo models, we show that blood flow prevents Fsr activation in…

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16 Comprehensive mapping of RNA modification dynamics and crosstalk via deep learning and nanopore direct RNA-sequencing

推荐理由: 该研究提出的ORCA框架首次实现了多种RNA修饰的同步检测，为血液疾病中RNA表观遗传调控机制的深入研究提供了创新工具，具有较高的方法论借鉴价值。

摘要: Despite the extensive studies of individual RNA modifications, the lack of methods to detect multiple modification types simultaneously has left the global epitranscriptomic landscape and its underlying crosstalk largely unexplored. Here, we present ORCA (Omni-RNA modification Characterization and Annotation), a deep learning framework that enables comprehensive mapping of RNA modification landscape using nanopore direct RNA sequencing. ORCA employs domain adversarial learning to detect and…

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17 Unravelling co-mutational patterns with prognostic implications in NPM1 mutated adult acute myeloid leukemia - a HARMONY study

推荐理由: 该研究基于大规模临床数据库提出了新的NPM1突变AML风险分层模型，对精准预后评估和治疗策略选择具有直接临床借鉴价值。

摘要: NPM1-mutated (NPM1-mut) acute myeloid leukemia (AML) is generally associated with a more favorable outcome, although the presence of additional gene mutations can influence patient prognosis. We analyzed intensively-treated adult NPM1-mut AML patients included in the HARMONY Alliance database. A newly developed risk classification, which included combinations of co-mutations in FLT3-ITD, DNMT3A, IDH1/IDH2, and TET2 genes, was applied to a training cohort of NPM1-mut AML patients included in…

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18 A comprehensive survey of genome language models in bioinformatics

推荐理由: 该综述将基因组语言模型引入生命科学领域，方法具有前沿创新性，对于从基因组层面解析血液疾病的遗传调控机制和发现新的生物标记物具有重要的启发和借鉴价值。

摘要: Large language models have revolutionized natural language processing by effectively modeling complex semantics and capturing long-range contextual relationships. Inspired by these advancements, genome language models (gLMs) have recently emerged, conceptualizing DNA and RNA sequences as biological texts and enabling the identification of intricate genomic grammar and distant regulatory interactions. This review examines the need for gLMs, emphasizing their capacity to overcome the limitations…

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19 GPCRact: a hierarchical framework for predicting ligand-induced GPCR activity via allosteric communication modeling

推荐理由: 该文章提出的GPCRact框架在方法学上有显著创新，能更精确模拟GPCR的三维动态变构通讯，对血液病相关GPCR靶点的药物研发具有重要的跨学科借鉴价值。

摘要: Accurate prediction of ligand-induced activity for G-protein-coupled receptors (GPCRs) is a cornerstone of drug discovery, yet it is challenged by the need to model allosteric communication-the long-range signaling linking ligand binding to distal conformational changes. Prevailing sequence-based models often fail to capture these three-dimensional dynamics, a limitation frequently masked by averaged performance on simpler Class A targets. To address this, we introduce GPCRact, a novel framework…

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20 Hepatic response criteria in light chain amyloidosis: a multicenter validation study

推荐理由: 该研究针对轻链淀粉样变性肝受累这一预后不良亚群，明确了肝脏反应标准的预后评估价值，为临床精准判断治疗反应及预后提供了重要参考依据。

摘要: Liver involvement in light chain amyloidosis (AL) is seen in 10-20% of patients and is associated with poor prognosis. The goal of this study was to assess the prognostic impact of the hepatic response criteria. AL patients diagnosed between 2010 and 2015 with liver involvement [serum alkaline phosphatase (AP) >1.5 upper reference limit (URL)] who achieved hematological response were included. Hepatic response was defined as >50% reduction (or normalization) of AP from baseline. Hepatic response…

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21 Enriching African genome representation through the AGenDA project

推荐理由: 该研究聚焦非洲人群基因组多样性这一关键空白，其发现可为血液疾病的群体遗传学研究、稀有血型或贫血相关基因变异探索提供重要参考，尤其对 sickle cell disease 等具有人群特异性的血液病有潜在借鉴价值。

摘要: African populations remain substantially under-represented in research studies and global genomic databases. As the ancestral home of anatomically modern humans, Africa holds pride of place regarding human genetic diversity, with a deep and complex evolution over hundreds of thousands of years of human migration, admixture, and exposure to climate changes and infectious agents. Yet our present view of genomic diversity in Africa is sparse and poorly captures the rich variation across its more…

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22 The ubiquitin ligase KLHL6 drives resistance to CD8<sup>+</sup> T cell dysfunction

推荐理由: 该研究通过整合计算分析与体内CRISPR筛选，创新性地探索蛋白质稳态在T细胞功能障碍中的作用，为改善癌症免疫疗法及血液肿瘤的T细胞治疗提供了新的机制见解与潜在靶点。

摘要: The multifaceted dysfunction of tumour-infiltrating T cells, including exhaustion and mitochondrial dysfunction, remains a major obstacle in cancer immunotherapy^(1-6). Transcriptomic and epigenomic regulation of T cell dysfunction have been extensively studied^(7-9), but the role of proteostasis in regulating these obstacles remains less defined. Here we combined computational analyses of atlases of T cell exhaustion and mitochondrial fitness with performed targeted in vivo CRISPR screens,…

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23 Myelin antigen capture in the CNS by B cells expressing EBV latent membrane protein 1 leads to demyelinating lesion formation

推荐理由: 该研究创新性地揭示了病毒感染背景下B细胞在中枢神经系统自身免疫中的直接作用机制，为理解多发性硬化等疾病的发病原理及B细胞靶向治疗提供了重要的实验依据。

摘要: The efficacy of B cell depletion therapies, and their association with Epstein-Barr virus (EBV), implicate B cells in the pathogenesis of multiple sclerosis (MS). In mice, we observed that viral infections induce infiltration of B cells into the brain, independent of phenotype and specificity, and that myelin-reactive B cells then capture antigens directly from parenchyma. Trafficking of these antigen-loaded B cells to draining lymph nodes was not observed, and without T cell help,…

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24 EBV infection and HLA-DR15 jointly drive multiple sclerosis by myelin peptide presentation

推荐理由: 该研究从EBV调控B细胞HLA分子呈递的崭新角度揭示了自身免疫疾病的潜在机制，为血液病研究中病毒感染与免疫应答的交叉领域提供了可借鉴的分析思路。

摘要: Epstein-Barr virus (EBV) is involved in causing and probably also in perpetuating multiple sclerosis (MS). Among several mechanisms of how EBV may contribute are transcriptome alterations, including changes of antigen processing and preferential presentation of both viral and self-antigens. Here, we report that EBV reprograms the transcriptome and immunopeptidome presented on the MS-associated human leukocyte antigen (HLA)-DR15 molecules of infected B cells. Identical myelin basic protein (MBP)…

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25 A head start: Bone channels shape meningeal immunity

推荐理由: 该研究揭示了颅骨骨髓作为神经免疫防御发育检查点的新机制，为血液学领域理解骨髓免疫细胞外迁路径与调控提供了新颖的跨学科视角，尤其对探索骨髓微环境与免疫细胞迁移具有重要借鉴意义。

摘要: Immune cells from the skull marrow reach the meninges through bone channels. In this issue of Immunity, Eme-Scolan and colleagues show that these channels form neonatally and can be remodeled to alter immune access to the brain’s borders. Their work suggests that the skull is a developmental checkpoint for neuroimmune defense, potentially shaping vulnerability or resilience across the lifespan.

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26 IRF4 sends alveolar macrophages spiraling into an identity crisis during type 2 immunity

推荐理由: 该研究通过揭示IRF4调控肺泡巨噬细胞身份重塑的新机制，不仅解决了领域内长期争议，还为过敏性疾病及巨噬细胞相关血液病研究提供了潜在干预靶点。

摘要: A long-standing debate in the field asks whether resident tissue macrophages are terminally differentiated or remain capable of changing their fate and function during inflammation. In this issue of Immunity, Verwaerde et al. uncover an IRF4-driven circuit that reshapes alveolar macrophage identity and positions them as contributors to allergic pathophysiology.

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27 Not aIL Treg-mediated suppress10n is equal

推荐理由: 该研究揭示了调节性T细胞

摘要: Regulatory T (Treg) cells suppress immune responses and are considered a major barrier to productive anti-tumor immunity. In this issue of Immunity, Huang et al. report that interleukin (IL)−10-producing Treg cells restrain tumor growth by suppressing IL-17 production in colorectal cancer, highlighting a functional division of labor within the Treg compartment with significance for immunotherapy treatments.

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28 6-Phosphogluconate dehydrogenase promotes mitochondrial fusion and immune suppression in tumor-associated monocytic suppressor cells

推荐理由: 该研究揭示了肿瘤微环境中髓系免疫细胞代谢调控的新机制（IL-6/STAT3-6PGD轴），为靶向髓系来源抑制细胞的肿瘤免疫治疗及血液系统疾病相关研究提供了直接的理论依据和潜在干预靶点。

摘要: The mechanisms underlying the metabolic adaptation of myeloid cells within the tumor microenvironment remain incompletely understood. Here, we identify 6-phosphogluconate dehydrogenase (6PGD), a rate-limiting enzyme in the pentose phosphate pathway (PPP), as an important regulator of monocytic-myeloid derived suppressor cell (M-MDSC) function. Our findings reveal that tumor M-MDSCs upregulate 6PGD expression via IL-6/STAT3 signaling. Blocking 6PGD, using either genetic or pharmacological…

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29 Optical interference for the guidance of cryogenic focused ion beam milling beyond the axial diffraction limit

推荐理由: 该研究提出的三束共定位系统与干涉测量光学响应技术，为低温电子断层扫描的靶向制样提供了创新性方法学突破，虽未直接针对血液疾病，但其提升细胞结构解析精度的技术路径对血细胞形态学与病理机制研究具有重要借鉴价值。

摘要: Cryogenic focused ion beam (Cryo-FIB) milling has become a standard step in the cryogenic electron tomography (Cryo-ET) workflow and is required to thin cells to electron-semitransparency. However, this destructive process removes the vast majority of the cellular material and raises a critical question: what thin section should be preserved for Cryo-ET analysis? Using a tri-coincident cryogenic FIB-SEM-LM system, we identify an interferometric optical response that can be used for targeting…

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30 Sequence-based generative AI design of versatile tryptophan synthases

推荐理由: 该研究展示了利用蛋白质语言模型设计新型酶的高效方法，其在酶稳定性与催化活性上的成功验证为血液病相关酶学研究（如代谢酶设计或酶替代疗法）提供了创新的技术借鉴。

摘要: Enzymes are powerful and sustainable catalysts, but their widespread application is limited by the difficulty of identifying functional starting points for optimization, creating a major bottleneck in early- stage biocatalyst discovery. Designing libraries of such starting enzymes remains particularly challenging. Here, we use the GenSLM protein language model to generate novel β-subunit of tryptophan synthase (TrpB) enzymes that express in Escherichia coli and are both stable and catalytically…

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31 Simultaneous epigenomic profiling and regulatory activity measurement using e2MPRA

推荐理由: 该文章开发了一种同时分析序列调控功能与表观基因组修饰的新技术，对于研究血液疾病中顺式调控元件的功能机制具有重要的方法论借鉴价值。

摘要: Using various biochemical assays that identify transcription factor (TF) binding and histone modifications, cis-regulatory elements (CREs) can be annotated in a genome-wide manner. However, these assays are descriptive and require functional validation. To the best of our knowledge, no technology can simultaneously analyze the regulatory function and epigenomic modifications of a specific sequence. Here, we develop an enrichment followed by epigenomic profiling massively parallel reporter assay…

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32 Effect of long-term sepiapterin treatment on dietary phenylalanine tolerance in patients with phenylketonuria: interim results from the Phase 3 APHENITY Extension Study

推荐理由: 该研究为苯丙酮尿症（PKU）患者提供了长期安全性的中期证据，并提出了饮食自由化的潜在可能，对罕见病治疗策略优化和患者生活质量提升具有重要参考价值。

摘要: CONCLUSION: Interim results support the long-term safety of sepiapterin and demonstrate the potential for diet liberalization in adults and children with phenylketonuria.

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33 Multidisciplinary guidelines on renal replacement therapy in intensive care medicine

推荐理由: 该指南基于循证医学制定，虽聚焦透析依赖性急性肾损伤，但对处理危重血液病患者并发的肾损伤及血液净化治疗有直接参考价值，有助于临床医生优化综合管理策略。

摘要: CONCLUSIONS: This evidence-based bi-national guideline should provide physicians with guidance for delivering best practice to critically ill patients with a dialysis-dependent AKI.

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34 Ponatinib for CML patients in routine clinical practice: the PONDEROSA study

推荐理由: 该研究提供了真实世界中帕纳替尼治疗慢性髓系白血病的临床数据，对处理耐药或T315I突变患者具有直接的临床借鉴意义。

摘要: Ponatinib, a third-generation tyrosine kinase inhibitor, is effective in patients with chronic myeloid leukemia (CML), particularly in cases of resistance or BCR::ABL1 T315I mutation. However, arterial occlusive events (AOEs) remain an important safety concern. The PONDEROSA registry evaluated ponatinib use under routine clinical conditions in Germany and the Czech Republic. This observational cohort study included 99 adult CML patients treated with ponatinib; patient recruitment took place…

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35 Dynamic allele usage of X-linked genes ameliorates neurodevelopmental disease phenotypes in brain organoids

推荐理由: 该研究利用人诱导多能干细胞模型追踪X染色体失活动态，为研究X连锁血液疾病的基因表达调控和女性疾病易感性差异提供了新的可借鉴技术思路。

摘要: While random X-chromosome inactivation in female cells of placental mammals silences one allele of the majority of X-chromosomal genes, a considerable fraction is only incompletely and variably inactivated. Human model systems to study the dynamics of incomplete X-inactivation are limited mostly to postmortem tissue, thereby disregarding developmental trajectories. Here, we used clonal human female induced pluripotent stem cells to track allele-specific expression of X-chromosomal genes along…

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36 CNAttention: an attention-based deep multiple-instance method for uncovering copy number aberration signatures across cancers

推荐理由: 该文章系统综述了体细胞拷贝数变异（CNA）的景观，其基于数十年积累的可靠数据，对于研究血液系统恶性肿瘤（如白血病、淋巴瘤）的基因组不稳定性、驱动基因识别和分子分型具有重要的借鉴与参考价值。

摘要: Somatic copy number aberrations (CNAs) represent a distinct class of genomic mutations associated with oncogenetic effects. Over the past three decades, significant volumes of CNA data have been generated through molecular-cytogenetic and genome sequencing-based techniques. These data have been pivotal in identifying cancer-related genes and advancing research on the relationship between CNAs and histopathologically defined cancer types. However, comprehensive studies of CNA landscapes and…

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37 Ligand-specific activation trajectories dictate GPCR signalling in cells

推荐理由: 该研究通过遗传密码扩展技术在活细胞中解析GPCR动态构象，方法学创新性强，为理解受体信号转导机制提供了新视角，对血液系统中GPCR相关疾病（如免疫调节、血小板功能等）的基础研究具有潜在借鉴价值。

摘要: G-protein-coupled receptors (GPCRs) are key mediators of cell communication and represent the most important class of drug targets^(1,2). Biophysical studies with purified GPCRs in vitro have suggested that they exist in an equilibrium of distinct inactive and active states, which is modulated by ligands in an efficacy-dependent manner^(3-11). However, how efficacy is encoded and whether multiple receptor states occur in living cells remain unclear. Here we use genetic code expansion^(12) and…

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38 Anoctamin-2-specific T cells link Epstein-Barr virus to multiple sclerosis

推荐理由: 该研究揭示了EB病毒与自身免疫疾病交叉免疫反应的新机制，为血液科中自身免疫性血细胞疾病（如免疫性血小板减少症、自身免疫性溶血性贫血）的发病机制提供了可借鉴的免疫学视角。

摘要: Epstein-Barr virus (EBV) infection constitutes a prerequisite for multiple sclerosis (MS) development, and cross-reactivity between EBV nuclear antigen 1 (EBNA1) and anoctamin-2 (ANO2) antibodies was previously demonstrated in persons with MS (pwMS). Here, we show that ANO2-specific CD4^(+) T cells are more frequent in pwMS. Immunization of SJL/J mice with ANO2 or EBNA1 led to cross-reactive CD4^(+) T cell and antibody responses. ANO2 pre-immunization led to exacerbated experimental autoimmune…

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39 To the nines: IL-9 boosts T cell function

推荐理由: 该研究打破了IL-9的传统认知框架，揭示了其在肿瘤免疫中的新机制，为免疫细胞功能调控提供了创新视角，虽聚焦实体瘤，但其中T细胞持久性增强的机制对血液肿瘤研究具有潜在借鉴意义。

摘要: IL-9 is canonically associated with anti-helminth and allergic immunity. However, in this issue of Immunity, Jiang et al. and Castelli et al. demonstrate how integrating IL-9 signaling in T cells enhances their persistence and anti-tumor function in solid cancer models.

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40 Multi-center multi-omics integration predicts individualized prognosis in medullary thyroid carcinoma

推荐理由: 该研究通过大规模蛋白质组学分析为甲状腺髓样癌的复发风险分层提供了新见解，其多中心队列设计和分子-临床关联分析方法对血液肿瘤的预后研究具有重要借鉴价值。

摘要: Medullary thyroid carcinoma (MTC) is a rare, aggressive neuroendocrine tumor with limited treatment options and frequent recurrence. Comprehensive recurrence risk stratification remains lacking. Here, we profile 482 MTC samples from 452 patients across ten Chinese clinical centers, identifying 10,092 proteins and mutations in 87.0% of patients. Clinically, MTC grading, concurrent papillary thyroid carcinoma, and lymph node metastasis are significant recurrence risk factors, whereas at the…

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41 Identification of antimicrobial peptides from ancient gut microbiomes

推荐理由: 该研究开发的轻量化抗菌肽识别工具（AMPLiT）在方法学上具有创新性和高效性，虽未直接研究血液疾病，但其在微生物组中挖掘抗菌肽的策略可为血液感染或免疫相关血液病的研究提供方法学借鉴。

摘要: Fecal coprolites preserve ancient microbiomes and are a potential source of extinct but highly efficacious antimicrobial peptides (AMPs). Here, we develop AMPLiT (AMP Lightweight Identification Tool), an efficient tool deployable to portable hardware for AMP screening in metagenomic datasets. AMPLiT demonstrates AUPRC performances of 0.9486 ± 0.0003 and reasonable overall training time of 3200 ± 53 s. By computationally utilizing AMPLiT, we analyze seven ancient human coprolite metagenomes,…

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42 Identification of modifiable plasma protein markers of cardiometabolic risk in children and adolescents with obesity

推荐理由: 该研究采用前沿蛋白质组学技术在大规模儿童队列中系统识别了肥胖相关炎症蛋白标志物，虽然不直接针对血液疾病，但其对全身性炎症的深入剖析为血液系统炎症相关研究提供了重要的方法与生物标志物参考。

摘要: Pediatric obesity is linked to multi-organ inflammation and an increased risk of cardiometabolic and steatotic liver disease. To identify circulating biomarkers of cardiometabolic risk, we performed proximity extension assay proteomics, to quantify 149 inflammation- and cardiovascular-related proteins in a cross-sectional study of 4024 children and adolescents (2377 with obesity and 1647 with normal weight). We identified protein signatures linked to obesity, dyslipidemia, insulin resistance,…

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43 H3K27me3-dependent imprinting and transcriptional regulation in early mouse embryos requires EZHIP-mediated restriction of PRC2 activity

推荐理由: 该研究揭示了H3K27me3依赖的表观遗传调控新机制，为血液肿瘤中PRC2复合体异常导致的疾病（如淋巴瘤、白血病）提供了潜在的表观遗传学借鉴思路。

摘要: Zygotes inherit parental genomes with distinct chromatin structures. In eutherian mammals, this asymmetry is considered crucial for embryonic development, notably because it enables genomic imprinting. Besides the well-established role of DNA methylation in this process, a transient form of imprinting in mice has been shown to rely instead on H3K27me3. Here, we show that maternal deletion of Ezhip, encoding a negative regulator of PRC2, initially increases the asymmetric distribution of H3K27me3…

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44 Cholesterol-lowering effects of oats induced by microbially produced phenolic metabolites in metabolic syndrome: a randomized controlled trial

推荐理由: 该研究通过随机对照试验揭示了燕麦干预提升血浆阿魏酸的机制，其关于膳食代谢物与宿主互作的发现可为研究营养干预改善贫血或炎症性血液疾病提供新思路。

摘要: Oats have various positive effects on human health, but the underlying mechanisms are not fully understood. To identify oat-microbiome-host interactions contributing to metabolic improvements, we conducted two randomized controlled dietary interventions in parallel-design in individuals with metabolic syndrome, comparing a short-term, high-dose and a six-week, moderate oat intake with respective controls (DRKS00022169). Both oat diets lead to an increase in plasma ferulic acid (0.64 [0.26,…

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45 Near field optical visualization of the nanoscale phase percolation dynamics of a VO<sub>2</sub> oscillator

推荐理由: 该文章在相变动力学与高分辨率成像方法上具有高度创新性，虽非血液学直接相关，但其研究相变机制的思路与成像技术可为血液细胞状态变化研究提供方法论借鉴。

摘要: Self-sustained resistance oscillation in vanadium dioxide (VO(2)) are of significant interest for phase-based information encoding applications. However, the underlying mechanism behind the current-induced insulator-to-metal phase oscillation and its spatiotemporal dynamics remains elusive. Here, using high-resolution near-field optical imaging, we uncover distinct current-induced phase transition pathways in VO(2)(001) thin films. We show that the formation of a persistent metallic patch within…

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46 Synthetic gain for electron-beam spectroscopy

推荐理由: 该文章介绍了高分辨电子束显微技术在多尺度激发分析中的前沿方法，虽未直接涉及血液疾病，但其纳米级表征技术对研究血细胞超微结构或血液纳米药物载体具有潜在借鉴价值。

摘要: Electron-beam microscopy and spectroscopy featuring atomic-scale spatial resolution have become essential tools used daily in almost all branches of nanoscale science and technology. As a natural supercontinuum source of light, free electrons couple with phonons, plasmons, electron-hole pairs, inter- and intra-band transitions, and inner-shell ionization. The multiple excitations, intertwined with the intricate nature of nanostructured samples, present significant challenges in isolating…

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47 Efficient and stable catalytic hydrolysis of perfluorocarbon enabled by SO<sub>2</sub>-mediated proton supply

推荐理由: 该研究在催化水解PFAS领域提出了创新的SO₂驱动策略，机制研究深入，对理解C-F键活化具有重要参考价值；虽不直接涉及血液疾病，但其催化化学思路或可为血液毒理学中PFAS代谢研究提供间接启发。

摘要: Catalytic hydrolysis is an effective strategy for decomposing tetrafluoromethane (CF(4)), one of the most chemically inert per- and polyfluoroalkyl substances (PFAS). A key challenge in this process lies in enhancing proton availability to facilitate efficient and stable C-F bond activation while ensuring long-term catalyst stability. Here we present an SO(2)-driven approach to significantly enhance H(2)O dissociation and proton-supplying through the in situ formation of Al-HSO(4) and Ga-HS…

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48 Dynamic allele usage of X-linked genes ameliorates neurodevelopmental disease phenotypes in brain organoids

推荐理由: 该研究通过克隆性人源诱导多能干细胞追踪X染色体失活动态，为血细胞发育及X连锁血液病机制研究提供了创新的实验模型，对理解表观遗传调控在血液系统中的作用具有潜在借鉴价值。

摘要: While random X-chromosome inactivation in female cells of placental mammals silences one allele of the majority of X-chromosomal genes, a considerable fraction is only incompletely and variably inactivated. Human model systems to study the dynamics of incomplete X-inactivation are limited mostly to postmortem tissue, thereby disregarding developmental trajectories. Here, we used clonal human female induced pluripotent stem cells to track allele-specific expression of X-chromosomal genes along…

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49 Impact of a single fecal microbiome transplantation in adult women with anorexia nervosa: an open-label feasibility pilot trial

推荐理由: 该研究从肠-脑轴的全新视角探讨神经性厌食症的病理机制，为代谢-精神共病研究提供了可借鉴的跨学科思路，虽不直接聚焦血液疾病，但其关于肠道菌群与系统性炎症的关联对研究营养性贫血等血液学问题具有间接参考价值。

摘要: Anorexia nervosa (AN) is a severe mental disorder characterized by restrictive eating and disturbance in the way one’s body weight or shape is experienced, often accompanied by depression and anxiety. Current evidence-based treatments for AN have limited efficacy, with less than half of the patients achieving full recovery in long-term follow-up studies. Recent findings have identified gut microbiota (GM) dysbiosis as a potential contributor to AN pathology through the gut-brain axis. This…

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50 A reconfigurable photosensitive split-floating-gate memory for neuromorphic computing and nonlinear activation

推荐理由: 该文章在神经形态计算与集成硬件领域展示了高水平的方法创新与实验严谨性，虽然与血液病学无直接关联，但其在器件集成与信号处理方面的研究思路对跨学科方法学有潜在借鉴意义。

摘要: The rapid growth of artificial intelligence and the Internet of Things calls for compact hardware platforms that integrate sensing, computing, and nonlinear processing within a unified architecture. However, most existing neuromorphic systems implement only partial functionalities and rely on heterogeneous device integration, limiting scalability and efficiency. Here, we show a high-speed, reconfigurable multi-modal split-floating-gate memory that monolithically integrates in-sensor computing,…

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51 Precision phenotyping of type 2 diabetes in chinese populations using a variational autoencoder-informed tree model

推荐理由: 该研究基于大规模中国人群队列验证了糖尿病分型模型的跨人群适用性，方法严谨且对中国糖尿病精准医疗有重要参考价值，但血液疾病直接相关性较弱。

摘要: Type 2 diabetes (T2D) exhibits clinical heterogeneity, yet most existing classification models are derived from European populations and face challenges in clinical application. Here, we evaluate the generalizability of a tree-like graph structure from Scottish data to 32,501 newly diagnosed T2D patients from a multi-center Chinese cohort comprising over 8.6 million individuals. We observe similar distribution between the Scottish and Chinese individuals in heart and kidney outcomes, but…

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52 Decoding the gradient-distributed colour centers in electrochromic WO<sub>3</sub>

推荐理由: 该文章在电致变色材料的微观机理研究方面方法先进、创新性突出，但内容与血液疾病无直接关联，主要推荐给材料科学或纳米技术领域的研究者参考其方法学。

摘要: The optical properties of electrochromic windows can be modulated by embedding electrons and ions simultaneously to realize energy-saving functions. However, the microscopic electrochromic mechanism in cathode materials remains controversial. Herein, we have discovered that the single-crystal WO(3) nanosheets exhibit thickness-dependent electrochromic characteristics. The multislice electron ptychography experiments revealed that the colour centers in electrochromic WO(3) are associated with…

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53 Application and performance of deep learning models for the automated diagnosis of cervical central spinal stenosis on MRI: a systematic review

推荐理由: 该研究在医学影像AI自动化诊断方面方法严谨、具有创新性，虽然主题非血液病直接相关，但其深度学习模型构建与验证思路对血液病影像学分析（如骨髓MRI）有较高借鉴价值。

摘要: INTRODUCTION: Cervical central spinal stenosis (CCSS) is a leading cause of adult spinal cord dysfunction. Magnetic resonance imaging (MRI) is the reference standard, but reporting is time-consuming and subject to inter-observer variability. Artificial intelligence (AI)-especially deep-learning-may enable automated, consistent assessment.

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54 Decoding of Inconsistent Biological Data: A Critical Step toward Enhanced AI Predictivity in Drug Discovery

推荐理由: 该文章虽未直接涉及血液疾病，但其对生物活性数据可靠性和机器学习模型训练中潜在噪声的深入探讨，为血液学研究中使用类似方法提供了重要的方法论警示和参考价值。

摘要: Combining bioactivity data of assays against the same target, which are obtained from different sources, was recently shown to lead to considerable noise for training data sets of machine learning (ML) models. In this Viewpoint, we address the profound impact originating from often overlooked changes to an assay protocol relating to the buffer composition and experimental setup. We cover two examples of protein targets that undergo conformational changes driven by extrinsic factors: enzymes as…

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55 Coherent nonlinear X-ray four-photon interaction with core-shell electrons

推荐理由: 该文章展示了先进的X射线非线性光谱技术，虽不直接涉及血液疾病，但其高时空分辨的电子态探测方法对研究血红素蛋白或血液相关分子动力学具有潜在的方法学借鉴价值。

摘要: Coherent nonlinear light-matter interaction with X-rays gives access to a regime in ultrafast spectroscopy in which atomic resolution meets femtosecond and attosecond timescales^(1,2). Particularly, X-ray four-wave mixing, involving several resonant transitions in a single coherent nonlinear process, has the potential to provide information on the electronic states coupling, coherent electron motion, correlation and dynamics, with state and site selectivity^(3-5). Here we demonstrate coherent,…

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56 Polypharmacy and nephrotoxicity

推荐理由: 该文献虽非直接针对血液病，但涉及钙调磷酸酶抑制剂（常用于造血干细胞移植后）的用药安全，对血液科临床实践中合并用药的肾毒性管理具有重要借鉴意义。

摘要: CONCLUSIONS: In patients receiving calcineurin inhibitors, any additional prescriptions should be carefully reviewed for potential interactions and accompanied by dose adjustment and close therapeutic drug monitoring where appropriate. The concurrent use of several agents with structural tubular toxicity generally increases risk, whereas functional mechanisms, such as those seen with combined ACE inhibitor and sodium-glucose cotransporter 2 inhibitor (SGLT2) inhibitor therapy, are usually well…

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57 Regional variation for tumour-directed treatment and survival in patients with pancreatic adenocarcinoma: a nationwide population-based analysis

推荐理由: 该研究通过多中心数据揭示了胰腺癌治疗率不足及地区差异的系统性问题，虽非直接针对血液疾病，但其关于治疗差异与生存结局的分析方法对血液肿瘤领域的卫生服务研究具有参考价值。

摘要: CONCLUSION: Although the likelihood of receiving chemotherapy and resection for patients with PAC varied between Dutch oncology networks, no clinical meaningful survival differences were found after case-mix adjustment. Concerningly, the majority of patients with PAC do not receive any tumour-directed treatment.

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58 Exciplex-enabled high-efficiency, fully stretchable OLEDs

推荐理由: 该研究在可拉伸发光器件领域实现了重要的技术突破，其创新的激子调控机制对开发柔性生物传感器具有启发意义，虽不直接涉及血液疾病，但可为未来可穿戴血液监测设备提供材料学参考。

摘要: Fully stretchable organic light-emitting diodes (OLEDs), composed entirely of intrinsically stretchable materials, are essential for on-skin displays^(1-3). However, their low device efficiency has been a persistent barrier to practical applications for more than a decade⁴. Here we addressed this challenge by incorporating an intrinsically stretchable exciplex-assisted phosphorescent (ExciPh) layer. The elastomer-tolerant triplet-recycling mechanism mitigates exciton energy transfer limitations…

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59 An electrically injected solid-state surface acoustic wave phonon laser

推荐理由: 该文章虽然未直接涉及血液疾病，但其中关于声表面波操控微流体的技术对开发新型“芯片实验室”血液检测装置具有潜在借鉴意义，适合关注交叉技术应用的研究者参考。

摘要: Surface acoustic waves (SAWs) enable a wide array of technologies, including radiofrequency filters^(1,2), chemical and biological sensors^(3-5), acousto-optic devices^(6-8), acoustic control of microfluidic flow in lab-on-a-chip systems^(9-11) and quantum phononics^(12-19). Although numerous methods exist for generating SAWs, they each have intrinsic limitations that inhibit performance, operation at high frequencies and use in systems constrained in size, weight and power. Here we present a…

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60 Variable temperature processing by plasmodesmata regulates robust bud dormancy release

推荐理由: 该研究在植物休眠机制上有创新发现，其关于胞间连丝调控的见解可能为细胞间通讯研究提供跨学科启发，但直接血液病相关性较弱。

摘要: Dormancy is a key mechanism in perennial plants in boreal and temperate regions, protecting buds from winter damage by repressing precocious bud break before spring onset. How plants robustly time dormancy release under fluctuating environments remains unknown. Here, we show that, rather than simply sensing cold duration, buds leverage warm spikes to sense winter progression and time dormancy release. This timing mechanism is mediated by previously unrecognized regulation of plasmodesmata by…

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61 Antigravity confined interfacial self-assembly approach for the synthesis and characterization of nanofilms

推荐理由: 该文章在纳米薄膜制备方法上具有显著创新性，但内容与血液疾病直接关联较弱，主要借鉴价值可能局限于生物材料界面研究的方法学思路。

摘要: Gravitationally induced stratification during self-assembly often leads to density-driven vertical segregation, resulting in an inherent density gradient that severely limits the synthesis of metastable nanofilms requiring inverted architectures. Here we show an antigravity confined interfacial self-assembly approach based on a liquid-liquid interface formed between hydrophilic and hydrophobic porous membranes, where capillary forces suppress gravitational effects to enable precise molecular…

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62 Variations in the Natural History of High-Risk HPV Types Following HPV-16/18 Bivalent Vaccination in Females Aged 18-45 Years

推荐理由: 该研究基于10年随机试验数据探讨HPV疫苗对感染自然史的影响，方法学严谨且对宫颈癌筛查策略有重要参考价值，但仅间接涉及血液疾病领域（如癌症相关生物标志物），对血液病研究的直接可借鉴性有限。

摘要: Existing evidence regarding the impact of vaccination on the natural history of high-risk human papillomavirus (HPV) infections remains limited, understanding such effects is essential for optimizing cervical cancer screening in post-vaccination era. Using 10-year follow-up data from a phase 3 randomized trial of the Escherichia coli-produced HPV-16/18 bivalent vaccine (NCT01735006) and its extension study (NCT05045755, NCT04969445), we compared the spectra and natural history (persistence,…

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63 In situ visualization of Clostridioides difficile phenotypic heterogeneity and single-cell morphology during gut infection

推荐理由: 该文章在单细胞水平可视化微生物表型异质性的方法具有创新性和技术参考价值，但主要面向基础微生物学研究，与血液疾病的直接关联较弱，适合关注前沿微生物技术的血液研究者拓展思路。

摘要: Phenotypic heterogeneity refers to the ability of clonal populations of the same species to display distinct phenotypes despite experiencing the same environment. Bacteria exhibit phenotypic heterogeneity across diverse cellular processes, which can provide competitive fitness advantages both within the host and against surrounding microbiota. However, visualizing phenotypic heterogeneity at single-cell resolution within dense microbial communities is technically challenging. Here, we present a…

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64 Regulating zinc nucleation and growth with low-surface-tension electrolytes for practical aqueous zinc metal batteries

推荐理由: 该研究在电化学储能领域提出了创新的低表面张力电解液策略，其关于界面稳定性和无枝晶生长的研究方法对血液病中细胞界面修饰或金属离子代谢相关研究具有潜在的方法学借鉴价值。

摘要: Rechargeable zinc metal batteries are promising for large-scale energy storage due to their low cost and high safety, but their development is seriously hindered by the dendritic growth and side reactions of zinc metal anodes. To address this challenge, we report here that rational design of low-surface-tension electrolytes can enable dense nucleation and fine-grained growth of zinc. This low-surface-tension strategy leads to high stability of the solid-electrolyte interface, dendrite-free…

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65 EGFR inhibitor-resistant lung cancers exhibit collateral sensitivity to a covalent, cysteine-independent KEAP1 oligomerizing molecular bridge

推荐理由: 该研究在揭示靶向治疗耐药机制及发现潜在克服策略方面方法严谨、数据系统，具有较高科学创新性，但其直接聚焦于实体瘤（非小细胞肺癌），对血液肿瘤的借鉴价值较为间接。

摘要: Targeted therapies have revolutionized cancer care. Unfortunately, most patients develop refractory, multifocal resistance to these therapies within a matter of months. Here, we demonstrate that the evolution of resistance to EGFR inhibitors in EGFR-mutant non-small cell lung cancer endows cells with hypersensitivity to a PAINS-like small molecule, MCB-613. Systematic proteomic, functional genomic, and biochemical studies revealed that MCB-613 binds KEAP1 in a covalent, cysteine-independent…

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66 Growth of non-layered 2D transition metal nitrides enabled by transient chloride templates

推荐理由: 该文章报道了一种合成二维过渡金属氮化物的通用新方法，在材料合成领域具有显著创新性，对于从事纳米材料或相关基础研究的人员具有较高参考价值，但与血液疾病研究的直接关联较弱。

摘要: 2D transition metal nitrides (TMNs) have attracted significant attention due to their magnetic, electrical, and chemical properties at atomic thickness. However, the synthesis of 2D TMNs is still challenging, due to their strong isotropic metal-nitrogen bonding networks. Here, we report a universal synthesis of non-layered 2D TMN family by using corresponding metastable metal chlorides as transient templates. This approach takes advantage of the layered structures and low conversion energy…

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67 Changing microbiology and outcomes of PD-associated peritonitis over four decades

推荐理由: 该研究基于四十年的长期数据，揭示了腹膜透析相关腹膜炎病原谱的变迁及预后关键因素，对临床抗感染实践具有明确的指导意义；其关于微生物流行病学监测和抗生素管理的核心结论，对血液科处理免疫抑制患者感染有间接的借鉴价值。

摘要: CONCLUSION: Our findings show temporal changes of microbiological spectrum of PD-associated peritonitis over four decades. Polymicrobial and Gram-negative peritonitis were associated with poorer outcomes, emphasizing the need for ongoing microbiological surveillance and antibiotic stewardship to optimize PD care.

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68 Coherent nonlinear X-ray four-photon interaction with core-shell electrons

推荐理由: 该研究在X射线非线性光谱学方法上具有显著创新性和技术前瞻性，虽不直接涉及血液疾病，但其高时空分辨的相干测量方法可为血液学超快动力学研究提供潜在技术借鉴。

摘要: Coherent nonlinear light-matter interaction with X-rays gives access to a regime in ultrafast spectroscopy in which atomic resolution meets femtosecond and attosecond timescales^(1,2). Particularly, X-ray four-wave mixing, involving several resonant transitions in a single coherent nonlinear process, has the potential to provide information on the electronic states coupling, coherent electron motion, correlation and dynamics, with state and site selectivity^(3-5). Here we demonstrate coherent,…

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69 Granulomatosis with Polyangiitis

推荐理由: 由于未提供摘要内容，无法评估文章的具体价值；建议补充摘要信息以便进行准确评价。

摘要: No abstract

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70 2024-2025 Covid-19 Vaccine Outcomes in U.S. Veterans

推荐理由: 由于未提供摘要内容，无法评估文章的具体价值；建议补充摘要信息以便进行准确评价和推荐。

摘要: No abstract

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71 Clinical and sociodemographic predictors of intensive care unit admission following chemotherapy in acute myeloid leukemia

推荐理由: 本文暂无摘要可供评估，若实际内容涉及血液病学前沿研究或临床实践创新，则可能对领域发展具有参考意义。建议获取完整内容后重新评估。

摘要: Not available.

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72 Author Correction: Revisiting the soil carbon saturation concept to inform a risk index in European agricultural soils

推荐理由: 由于未提供摘要内容，无法评估文章的具体价值，建议先获取摘要信息以判断其是否值得阅读。

摘要: No abstract

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73 Quantum suppression of cold reactions far from the s-wave energy limit

推荐理由: 该研究在量子干涉抑制化学反应方面提供了突破性实验证据，方法论严谨，对基础科学有重要价值，但与血液疾病研究直接关联较弱，适合量子化学或原子物理领域的研究者参考。

摘要: Quantum effects in chemical reactions are most pronounced at ultracold temperatures, where only a few partial waves contribute. While interference among many partial waves is theoretically expected to persist at higher temperatures, direct evidence for such quantum effects in reactive processes has been lacking. Here, we report signatures of quantum interference suppressing a chemical reaction in the multi-partial-wave regime: resonant charge exchange between a single ^(87)Rb^(+) ion and its…

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74 Publisher Correction: Realization of a Dirac-vortex topological photonic crystal fiber

推荐理由: 由于未提供摘要，无法评估文章的具体内容、创新性或社会价值，建议补充摘要后再进行详细评价。

摘要: No abstract

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75 Change and flow

推荐理由: 由于摘要缺失，无法对文章内容进行实质性评估；建议先获取完整摘要或全文，再根据其研究内容判断是否值得血液病领域研究者深入阅读。

摘要: No abstract

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76 Phase-controlled growth of 2D crystals of the MB<sub>2</sub>T<sub>4</sub> family via a flux-assisted method

推荐理由: 该文章在二维三元材料生长方法上具有显著创新性和技术参考价值，但内容与血液疾病研究无直接关联，仅适合从事交叉学科材料开发的血液学研究者在方法学上间接借鉴。

摘要: Van der Waals materials of the MB(2)T(4) family (M = transition metal or rare-earth metal, B = Bi or Sb, T = Te, Se, or S) have attracted wide interest for their exotic topological and magnetic properties, as well as potential spintronic applications. However, the direct growth of 2D ternary MB(2)T(4) remains challenging due to multiple competing phases and complex atomic arrangements. Here, we report a flux-assisted, phase-controlled growth strategy to directly grow six distinct 2D MB(2)T(4)…

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77 Solvent-mediated partial ionicity enhances mechanical nanosizing effect of Mg-based hydrogen storage alloys

推荐理由: 本文主要涉及镁合金的机械球磨纳米化工艺机制研究，属于材料科学领域，与血液疾病的直接关联性较弱；但其中关于溶剂介导表面性质改变的方法可能为其他生物材料的纳米化处理提供有限参考。

摘要: The high ductility of Mg has posed major challenges for nanofabrication utilizing mechanical ball-milling. While the addition of organic solvents is effective, it has been unclear how they improve the ball-milling effect by modifying the material’s surface properties. Herein, we report that the solvent-mediated partial ionicity plays an important role in enhancing the nanosizing effect of Mg(87.5)Ni(5.5)Y(7) alloy. This approach enables the Mg(87.5)Ni(5.5)Y(7) particles to be 88 times smaller…

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