追觅 - 2026-01-18

生成时间: 2026−01-18 22:33

分析文章数量: 41

1 Af-CUT&Tag: a sensitive and antibody-free chromatin profiling method using genetically encoded tags and high-affinity binders fused to Tn5

推荐理由: 该文章提出的Af-CUT&Tag技术突破了染色质分析中抗体依赖的限制，为血液病中稀有细胞群体的表观遗传研究提供了高灵敏度、高特异性的新方法，对血液肿瘤机制研究具有重要借鉴价值。

摘要: Conventional chromatin profiling techniques are often limited by antibody availability and performance. Here, we introduce Af-CUT&Tag, a target antibody-free method that overcomes these limitations by using CRISPR-integrated peptide tags (HiBiT/ALFA-tag) recognized by engineered binders (LgBiT/NbALFA) fused to a Tn5 transposase. Af-CUT&Tag eliminates dependence on traditional target antibodies, achieving robust specificity and sensitivity with as few as 500 cells. It provides high-quality…

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2 Multimodal supramolecular targeting chimeras enable spatiotemporally resolved protein degradation in vivo

推荐理由: 该文章提出的SupTACs平台实现了组织特异性和时序可控的蛋白降解技术突破，对血液肿瘤靶向治疗具有重要的方法学借鉴价值。

摘要: Targeted protein degradation (TPD) has transformed strategies for modulating protein function in both basic biology and therapeutic development. However, current strategies often lack the spatial and temporal precision required for in vivo applications. Herein, we report supramolecular targeting chimeras (SupTACs), a modular and programmable platform that enables tissue-specific and temporally controlled protein degradation in vivo. SupTACs self-assemble into supramolecular nanoparticles (SNPs)…

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3 Molecular determinants of Smc5/6 association with DNA junctions

推荐理由: 该研究通过单分子技术深入揭示Smc5/6复合物在DNA损伤修复中的机制，为血液系统疾病（如骨髓增生异常综合征、白血病）的基因组不稳定性研究提供了重要的分子水平借鉴。

摘要: Smc5/6 is an essential genome maintenance complex that interacts with double-stranded (ds) DNA, single-stranded (ss) DNA, and ss-dsDNA junctions. DNA association underlies Smc5/6′s functions in managing intermediates generated during genome replication and repair. However, the mechanisms of this activity are not fully understood. Here, we report a single-molecule study examining Smc5/6 association with a dsDNA substrate containing a ssDNA gap with defined 3′ and 5′ junctions. We found that…

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4 Robust characterization and interpretation of rare pathogenic cell populations from spatial omics using GARDEN

推荐理由: 该研究提出的GARDEN框架能精准识别空间组学中的稀有病理细胞群体，对于探索血液疾病的发病机制和靶向治疗具有直接借鉴价值。

摘要: Spatial omics links molecular measurements to their positions in tissue, revealing cellular organization and interactions. Yet most computational tools highlight common cell types and overlook rare populations that can drive disease. Here we show GARDEN, a computational framework that identifies and characterizes these pathogenic cells or regions in spatial omics by embedding graph-based dynamic attention into a spatially-aware graph fusion contrastive model. GARDEN works consistently across…

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5 A small molecule VDAC ligand inhibits ERAD and induces selective cancer cell death via disruption of calcium homeostasis

推荐理由: 该文章发现了调控ERAD通路的新型小分子工具，该通路与多发性骨髓瘤等血液系统肿瘤的发生、耐药及蛋白酶体抑制剂疗效密切相关，为血液疾病的机制研究和潜在治疗靶点开发提供了

摘要: Endoplasmic reticulum-associated degradation (ERAD) is a critical protein quality control mechanism that also regulates lipid metabolism and calcium homeostasis. Dysregulation of ERAD and unfolded protein response underlies diseases including cancer, neurodegenerative disorders, and metabolic syndromes. Small molecule modulators of ERAD could enable mechanistic discovery and therapeutic intervention, but few have been identified. Using a high-content screening, we discovered several…

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6 Coiled-coil heterodimer-mediated split base editing systems enable flexible and robust nucleotide substitutions

推荐理由: 该研究通过创新的拆分式碱基编辑器设计克服了AAV递送限制，为血液遗传病的基因治疗提供了更高效的体内编辑工具，对血红蛋白病等血液疾病的研究具有重要借鉴价值。

摘要: Base editors (BEs) enable precise base substitutions, but their size exceeds the packaging capacity of adeno-associated virus (AAV), impeding in vivo applications. Here we design a split BE system that recruits deaminases to Cas9 nickase via coiled-coil heterodimers, resulting in various coiled-coil heterodimers-mediated base editors (CC-BEs), including cytidine base editor (CC-CBE), adenine base editor (CC-ABE), and their derivatives. We reveal that CC-BEs maintain and even improve the editing…

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7 PTMA safeguards mitochondrial integrity to sustain metabolic function and antitumor activity of CD8 T cells

推荐理由: 该研究揭示了T细胞衰竭过程中的关键调控轴TCF1-PTMA，为改善免疫治疗效果提供了新靶点，对淋巴瘤等血液肿瘤的免疫治疗研究具有重要借鉴意义。

摘要: Immune checkpoint blockade (ICB) has transformed cancer treatment, yet its efficacy is often limited by the progressive exhaustion of tumor-reactive CD8 T cells. By analyzing transcriptomes of CD8 T cells from patients treated with ICB across cancer types, we found that prothymosin alpha (PTMA) is highly expressed in progenitor exhausted T (T(PEX)) cells and is associated with treatment response. PTMA expression was directly controlled by T cell factor 1 (TCF1), a central regulator of T(PEX)…

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8 AI-guided CAR designs and targeted pathway modulation to enhance multi-antigen CAR T cell durability and overcome antigen escape

推荐理由: 该文章结合AI引导设计与靶向蛋白降解技术，创新性地提出了解决CAR-T细胞治疗中持久性和抗原逃逸问题的新策略，对血液肿瘤的临床及基础研究具有较高的参考价值。

摘要: The persistence of CAR T cells and antigen escape remain major barriers to durable therapeutic success in hematologic malignancies. Our study integrates AI-guided design with targeted protein degradation to overcome these challenges. Utilizing an in-silico library of CAR constructs followed by an in vitro screening, we developed a predictive model, CARMSeD, which forecasts constructs prone to self-activation and dysfunction. Optimized bispecific CD20/CD19 CAR T cells demonstrate superior…

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9 The differential impact of three different NAD<sup>+</sup> boosters on circulatory NAD and microbial metabolism in humans

推荐理由: 该文章系统阐述了NAD+代谢在血液细胞功能和疾病中的核心作用，对理解贫血、白血病等血液疾病的代谢重编程及开发靶向干预策略具有重要参考价值。

摘要: Nicotinamide adenine dinucleotide (NAD(H)) and its phosphorylated form NADP(H) are vitamin B(3)-derived redox cofactors essential for numerous metabolic reactions and protein modifications. Various health conditions are associated with disturbances in NAD^(+) homeostasis. To restore NAD^(+) levels, the main biosynthetic pathways have been targeted, with nicotinamide (Nam), nicotinamide riboside (NR) and nicotinamide mononucleotide (NMN) being the most prominent boosters. However, while many…

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10 RNA-binding proteins and ribonucleoproteins as determinants of immunity

推荐理由: 该文章深入探讨RNA结合蛋白在感染免疫应答中的调控机制，对理解血液系统免疫细胞的转录与翻译动态具有重要参考价值，为血液疾病如免疫缺陷或炎症相关血液病的研究提供了新的分子视角。

摘要: Infection triggers one of the most dramatic systemic responses in the body, and the coordinated activation and function of immune cells requires a dynamic regulation of transcriptomes and proteomes. This is achieved by RNA-binding proteins, which, together with RNA, form ribonucleoproteins. These proteins expand the information content of the genome and determine the lifespan, localization and function of RNA. Moreover, they control when, where and how much protein is produced. They can also…

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11 Continuum architecture dynamics of vesicle tethering in exocytosis

推荐理由: 该研究采用了前沿的多技术整合方法解析了ExHOS的动态构象连续谱，为细胞囊泡运输机制提供了全新视角，其方法论和发现对研究血细胞分泌过程（如血小板或免疫细胞囊泡释放）具有潜在借鉴价值。

摘要: Essential for eukaryotes, multiple copies of the exocyst complex tether each secretory vesicle to the plasma membrane (PM) in constitutive exocytosis. The exocyst higher-order structure (ExHOS) that coordinates the action of these multiple exocysts remains unexplored. We integrated particle tracking, super-resolution microscopy, and cryo-electron tomography to time-resolve the continuum conformational landscape of the ExHOS and to functionally annotate its different conformations. We found that…

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12 Human genetics guides the discovery of CARD9 inhibitors with anti-inflammatory activity

推荐理由: 该研究通过结构生物学方法探索CARD9蛋白的可成药位点，为先天免疫相关疾病的靶向治疗提供了创新思路，对血液系统自身免疫或炎症性疾病的研究具有跨学科借鉴价值。

摘要: Human genetic association studies highlight key genes involved in disease pathology, yet targets identified by these analyses often fall outside the traditional definitions of druggability. A rare truncated variant of the scaffold protein CARD9 is linked with protection from Crohn’s disease, prompting us to pursue the development of inhibitors that might similarly modulate innate inflammatory responses. Using a phased approach, we first identified a ligandable site on CARD9 using a structurally…

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13 Nanoparticles hijack calvarial immune cells for CNS drug delivery and stroke therapy

推荐理由: 该研究创新性地利用颅骨免疫细胞作为纳米药物载体穿越颅骨-脑膜微通道，为中枢神经系统药物递送提供了新策略；其免疫细胞工程化方法对血液病研究中细胞疗法与靶向递送具有重要借鉴意义。

摘要: The rapid accessibility of calvarial immune cells to the brain, in principle, may offer transformative opportunities for overcoming drug delivery barriers in central nervous system (CNS) disorders. Here, we hijacked calvarial immune cells using drug-loaded nanoparticles (NPs) and leveraged their unique migration mechanism through skull-meninges microchannels to bypass the blood-brain barrier (BBB) for CNS drug delivery. We constructed NP-loaded immune cells in situ via intracalvariosseous (ICO)…

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14 Weight-independent effects of dietary carbohydrate-to-fat ratio on metabolomic profiles: secondary outcomes of a 5-month randomized controlled feeding trial

推荐理由: 该研究采用随机对照喂养试验和代谢组学分析，方法严谨可靠，其代谢适应机制的研究结果对探讨营养干预与血液代谢相关疾病（如贫血、代谢性血液病）具有潜在借鉴价值。

摘要: Diet plays a crucial role in health, with low-carbohydrate diets often proposed to exert metabolic benefits. We aim to investigate metabolomic adaptations in 164 adults with overweight or obesity who were randomly assigned to high- (n = 54), moderate- (n = 53), or low-carbohydrate (n = 57) diets during a 20-week weight-loss maintenance phase of the Framingham State Food Study [(FS)2], a controlled, parallel feeding trial (ClinicalTrials.gov: NCT02068885). We measure fasting plasma metabolites by…

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15 Intranasal blood-brain barrier bypass enables sequential mitochondria-targeted bioengineered nanolamellar system for ischemic stroke therapy

推荐理由: 该研究通过构建仿生纳米层状系统突破血脑屏障，其线粒体靶向和细胞表型调控策略对研究血源性疾病中细胞器特异性干预和屏障穿透技术具有重要借鉴意义。

摘要: Mitochondrial damage constitutes the central pathological mechanism of cerebral ischemia-reperfusion (I/R) injury. Targeted delivery of antioxidants to mitochondria and the phenotype polarization of glial cells holds great promise for effective treatment. However, the blood-brain barrier (BBB) remains a major obstacle, causing insufficient drug accumulation in neuronal mitochondria. Here, we develop a bioengineered nanolamellar system (MM@BPPF) by coating microglia-mitochondria hybrid…

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16 Engineering energy-efficient Saccharomyces cerevisiae for methanol and CO<sub>2</sub> assimilation

推荐理由: 该研究通过能量代谢工程策略显著提升酵母甲醇利用效率，其能量（ATP/NAD(P)H）调控机制对红细胞代谢异常等血液疾病研究具有重要借鉴价值。

摘要: Methanol is a promising one-carbon (C1) feedstock for microbial bioconversion; however, engineered Saccharomyces cerevisiae often faces energetic constrains during its assimilation. Here, we develop SC-AOX(25), an energy-efficient methylotrophic S. cerevisiae, through engineering of heterologous methanol-formaldehyde-formate (MFF) oxidation pathways coupled with adaptive laboratory evolution. SC-AOX(25) efficiently generates adenosine triphosphate (ATP) and nicotinamide adenine dinucleotide…

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17 Intestinal epithelial TLR5 signaling promotes barrier-supportive macrophages

推荐理由: 该研究揭示了肠道菌群通过调控单核细胞招募影响巨噬细胞稳态的新机制，对理解血液系统中单核/巨噬细胞分化与迁移具有重要借鉴价值。

摘要: Intestinal macrophages are essential for epithelial barrier repair. In homeostasis, macrophages are continuously replenished by recruitment of circulating C-C chemokine receptor 2 (CCR2)^(+) monocytes into the intestinal lamina propria (LP), a process that requires the commensal microbiota. The specific microbial factors and downstream host pathways that coordinate macrophage replenishment are inadequately understood. Here, we show that colonization with an Escherichia coli isolate increased…

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18 Structural variation tunes apoptotic responses to drive immune escape in melanoma

推荐理由: 该研究通过拷贝数变异调控凋亡基因剂量的机制揭示了免疫治疗获得性耐药的新途径，其研究思路与方法对血液肿瘤（如淋巴瘤、白血病）的耐药机制研究具有重要借鉴价值。

摘要: Copy-number variation reshapes apoptotic gene dosage to drive acquired immunotherapy resistance in melanoma.

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19 Variant-resolved prediction of context-specific isoform variation with a graph-based attention model

推荐理由: 该研究提出的Otari框架在转录异构体调控分析上具有方法学创新，可为血液疾病中基因剪接异常及遗传变异的功能研究提供新的计算工具借鉴。

摘要: In eukaryotes, most genes produce multiple transcript isoforms that diversify the transcriptome and proteome, serving as a key mechanism of functional regulation. Genetic variation can disrupt the RNA processing signals that shape isoform structure and abundance, yet modeling these effects at full-length isoform resolution remains challenging due to the complexity of transcript regulation. Here, we introduce Otari, an attention-based graph neural network framework trained on the human genomic…

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20 Continuum architecture dynamics of vesicle tethering in exocytosis

推荐理由: 该研究采用前沿的多模态成像技术解析了外囊泡复合体高阶结构的动态构象，方法学具有高度创新性，为细胞膜运输机制提供了新见解，对研究血细胞分泌或膜蛋白运输相关血液疾病有潜在借鉴价值。

摘要: Essential for eukaryotes, multiple copies of the exocyst complex tether each secretory vesicle to the plasma membrane (PM) in constitutive exocytosis. The exocyst higher-order structure (ExHOS) that coordinates the action of these multiple exocysts remains unexplored. We integrated particle tracking, super-resolution microscopy, and cryo-electron tomography to time-resolve the continuum conformational landscape of the ExHOS and to functionally annotate its different conformations. We found that…

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21 Lactylation-driven gene signatures define breast cancer prognosis: a predictive model and insights into immune microenvironment dynamics

推荐理由: 该研究将组蛋白乳酸化修饰与肿瘤预后模型创新结合，其构建生物标志物模型的方法学对血液肿瘤预后研究具有可借鉴意义。

摘要: CONCLUSION: We successfully developed a lactylation-based prognostic model that can assess breast cancer prognosis and potentially guide personalized treatment strategies.

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22 Effects of preoperative recombinant Interleukin 2-based immunomodulation on outcome after gastrointestinal cancer surgery: a systematic review and meta-analysis

推荐理由: 该研究显示rIL-2术前免疫调节能有效预防术后免疫抑制且副作用可控，为血液肿瘤免疫治疗及围术期管理提供了有借鉴意义的临床思路。

摘要: CONCLUSION: Preoperative rIL2-based immunomodulation prevents postoperative immunosuppression while the occurrence of severe side effects does not seem to be relevant.

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23 Functional remodeling of iNKT cells by sulfatide-reactive type II NKT cells reprograms alveolar macrophages to alleviate lung ischemia-reperfusion injury

推荐理由: 该研究揭示了II型NKT细胞通过调控肺泡巨噬细胞M2极化减轻肺缺血再灌注损伤的新机制，为血液系统疾病中免疫细胞与组织损伤互作的研究提供了可借鉴的思路。

摘要: Lung ischemia-reperfusion injury (LIRI) is a serious complication in critical clinical situations. Despite its importance, the specific role of type II natural killer T (NKT) cells in LIRI remains unclear. In this study, we establish a LIRI mouse model and demonstrate that sulfatide-reactive type II NKT cells promote M2 polarization of alveolar macrophages (AMs) and alleviate LIRI through AMs-mediated mechanisms. This protective effect is absent in Jα18^(-/-) mice, indicating the essential role…

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24 Spectroelectrochemical insight into copper cobalt catalysts for CO<sub>2</sub> and nitrite co-electroreduction to urea

推荐理由: 该研究虽聚焦电化学尿素合成，但其涉及的质子平衡机制和串联催化原理对血液疾病中代谢废物（如尿素）清除及相关治疗技术具有间接参考价值。

摘要: Electrochemical CO(2) and nitrite co-reduction provides a sustainable urea synthesis route but remains limited by low selectivity and an undecided C-N coupling mechanism. Here, we report co-sputtered bimetallic Cu-Co catalysts that facilitate urea formation via a tandem relay mechanism. The optimal Cu:Co ratio of 1:1 achieves a urea yield rate of 61 ± 6 mmol h⁻¹g(cat)⁻¹ at −1.2 V vs. RHE under neutral pH, emphasizing the importance of proton balance in sustaining proton-coupled electron…

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25 Multilayer oxide protection layer with multiple tunnelling paths for efficient and durable Si-based photocathode

推荐理由: 该研究在材料科学领域提出了一种突破性的通用方法，通过多载流子隧穿路径解决了氧化物保护层效率与耐久性的传统矛盾，具有显著的方法学创新性和工程参考价值。

摘要: Constructing a low-resistance oxide protection layer is challenging but highly beneficial for realizing a practical photoelectrochemical device. The thickness of oxide layer strongly influences its behaviors of carrier transport and corrosion resistance, generally leading to a trade-off between efficiency and durability. Different from the previous methods, here we propose and demonstrate a universal approach to decouple the trade-off of oxide layer by multiple carrier-tunnelling paths. This…

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26 Breast composition and dose deposition to fat and fibroglandular tissues are associated with breast side effects after radiation therapy

推荐理由: 该研究为乳腺癌放疗剂量优化与毒性关联提供了新视角，对肿瘤放射治疗临床实践具有直接参考价值，尤其在剂量均匀性规划方面。

摘要: CONCLUSION: Breast characterisation offers new insight into the link between dose and toxicity. Breast density and dose parameters from different substructures were associated with different breast toxicity. These findings further support the importance of dose homogeneity of breast RT planning.

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27 ZIP3 is essential for the encephalitogenic function of pTh17 cells by regulating intracellular zinc levels

推荐理由: 该研究揭示了ZIP3通过调控锌离子水平影响致病性Th17细胞功能的新机制，为自身免疫疾病的细胞代谢研究提供了可借鉴的思路，虽非直接血液病研究，但对免疫相关血液疾病机制有间接参考价值。

摘要: CONCLUSIONS: ZIP3 is essential for the encephalitogenic function of pTh17 cells and promoting EAE, likely by regulating cytosolic Zn^(2+) levels.

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28 MAGED: Multimodal Attentive Graph learning with Gene Expression Dynamics on Knowledge Graphs for TCM Target Prediction

推荐理由: 该研究创新性地整合传统知识与现代分子证据，提供了可解释的草药靶点预测框架，对于天然药物作用机制研究具有方法学上的借鉴价值。

摘要: CONCLUSION: MAGED provides an accurate and interpretable framework for predicting herb-target interactions, effectively integrating traditional knowledge with modern molecular evidence. This approach shows strong potential to facilitate the discovery of herbal mechanisms and the identification of novel therapeutic targets.

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29 Macrocycle-assembled membranes for high-salinity organic wastewater treatment

推荐理由: 该文章在膜材料分子设计上具有显著创新性，其大环化合物修饰思路对血液病靶向药物载体或血液净化材料研发有跨学科启发价值。

摘要: Membrane processes offer a promising pathway for selectively separating organics and salts to enable water reuse and resource recovery. While polymeric membranes incorporating macrocyclic molecules that feature amphiphilic nature and tunable cavities are well suited for this purpose, traditional macrocycles with limited reactive sites and uncontrolled diffusion are challenging to be assembled into highly interconnected membranes. Here, we introduce tetra-aldehyde appended calixarene (TACA), a…

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30 Intrinsic connectivity patterns of striatal subfields predict individual dimensions of psychopathology and are associated with cholinergic and serotonergic neurotransmission in schizophrenia

推荐理由: 该研究在方法学上严谨，采用多站点验证与独立数据集，对精神分裂症症状维度与神经连接关联提供了可靠分析，但内容与血液疾病领域无直接关联，仅可作为神经科学方法学参考。

摘要: Symptoms of schizophrenia may reflect different pathophysiological processes in the striatum, but the links between striatal subfield connectivity, symptom dimensions, and molecular architectures remain unclear. Using connectivity profiles from 12 striatal subfields to predict negative, positive, affective, and cognitive symptoms in schizophrenia, we identified consistent connectivity features through cross-validations and validated with leave-one-site-out analysis and an independent dataset….

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31 Recruitment of the multiple sclerosis cohort within the European Mobilise-D clinical validation study-lessons learnt, baseline demographics and clinical characteristics

推荐理由: 该研究在数字健康评估方法学上具有较高严谨性和创新性，可为血液病领域（如患者体能状态监测）提供方法学借鉴，但直接相关性有限。

摘要: CONCLUSIONS: The longitudinal collection of clinical and unsupervised mobility assessments will provide a comprehensive dataset, allowing for the determination of digital mobility assessments’ construct validity, predictive capacity, responsiveness, and clinical meaningfulness. Novel insights into real-world mobility that describe both walking activity and gait outcomes will be gained.

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32 Building climate-resilient primary care: A convergent mixed-methods climate vulnerability and capacity assessment in the Cederberg subdistrict, South Africa

推荐理由: 该研究为非洲基层医疗的气候韧性规划提供了可推广的评估框架，虽非直接针对血液疾病，但其系统性风险评估方法对公共卫生领域的适应性研究具有借鉴意义。

摘要: CONCLUSIONS: This study demonstrated that facility-level VCA assessments can successfully guide climate resilience planning in African primary care settings. The VCA process identified context-specific hazards, risks and feasible adaptation options across key domains of health system function. The approach provides an adaptable framework for other African settings seeking to strengthen primary care resilience to climate impacts. Transitioning from assessment to implementation will require local…

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33 Lactylation-driven gene signatures define breast cancer prognosis: a predictive model and insights into immune microenvironment dynamics

推荐理由: 该研究在组蛋白乳酸化修饰领域构建了可靠的预后模型，方法学具有参考价值；虽然直接关联血液疾病有限，但其表观遗传学分析思路对血液肿瘤研究有潜在借鉴意义。

摘要: CONCLUSION: We successfully developed a lactylation-based prognostic model that can assess breast cancer prognosis and potentially guide personalized treatment strategies.

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34 Corrigendum to “Impact of estimated dose of radiation to immune cells (EDRIC) in locally advanced non-small-cell lung cancer: A secondary analysis of the multicenter randomized PET-Plan trial” [Radiother. Oncol. 208 (2025) 110907]

推荐理由: 由于摘要缺失，无法评估文章的具体内容与价值，建议获取全文后再判断是否值得阅读。

摘要: No abstract

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35 Segmented filamentous bacteria in the gut protect against secondary bacterial infections in the lung

推荐理由: 由于未提供摘要内容，无法对文章进行具体评估。建议补充摘要信息，以便从血液病学角度判断其研究创新性、数据可靠性及临床借鉴价值。

摘要: No abstract

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36 Aperiodic 1/f noise drives ripple activity in humans

推荐理由: 该研究在神经科学方法学上具有较高严谨性和创新性，对信号检测与噪声分析有重要参考价值，但直接与血液疾病研究的相关性较弱，适合关注交叉学科方法学的学者借鉴。

摘要: Sharp-wave ripples (SWR) are central for cognition and hallmark sleep in the rodent hippocampus. Recently, ripple-like activity was also observed in the human hippocampus and neocortex during wakefulness and sleep. However, ripple detection across brain states and cortical regions remains challenging. We demonstrate that putative ripples largely index noise originating from region-, state-, and demand-dependent modulation of cortical background activity. We establish the noise sensitivity for…

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37 Complex Interactions Between Stress, Nutrition, Gut Microbiota, and Infectious Diseases and Their Impact on Health in Global Conflicts: A Narrative Review

推荐理由: 该文章从肠-脑轴角度探讨冲突与压力关联，具有跨学科视野和公共卫生意义，但对血液疾病缺乏直接关联，血液学可借鉴性较低。

摘要: Following the global recovery from the COVID-19 pandemic, wars and conflicts have escalated to levels unseen since the Cold War. It is well known that conflict is accompanied not only by significant losses among both military personnel and civilians but also by rising levels of stress and stress-related disorders within the general population. Stress is bidirectionally connected with the state of the gut microbiota through the gut-brain axis. Dietary factors and eating behaviours also play…

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38 Multiple hydrogen bonding enables large-area doped phosphorescent glasses with robust stability and high-temperature afterglow

推荐理由: 该文章在材料科学领域展示了创新性的分子室温磷光设计思路，具有方法学参考价值，但与血液疾病研究直接关联性较弱，仅适合关注交叉学科材料应用的研究者泛读。

摘要: Molecular room-temperature phosphorescence (RTP) materials with compact and ordered structures organized by intermolecular interactions have proven to be a newly-emerged strategy for high-performance luminescence. However, typical crystalline materials exhibit intrinsic brittleness and compromised optical transparency due to their highly ordered packing, thereby restricting their applicability in diverse functional systems. Herein, a universal non-conjugated molecule (1,2,3,4-butane…

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39 Migrant blackbirds (Turdus merula) on stopover have higher plasma PYY compared to residents: A validation and proof-of-concept

推荐理由: 该文章主要聚焦于鸟类迁徙能量调节的激素机制，与血液疾病直接关联较弱，但其中关于肽YY（PYY）食欲调控的内容对血液肿瘤患者食欲障碍研究或有间接参考价值。

摘要: Migratory birds expend substantial energy during flight and often rely on stopovers to refuel. Foraging behavior during stopover might vary with fuel loss and food availability though likely involves higher food intake rates than in non-migratory (resident) individuals. In mammals, hormones such as leptin signal information about energy balance and satiety. In contrast the gut hormone peptide YY (PYY), which rises rapidly after feeding and suppresses appetite in mammals, might serve a similar…

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40 Exciton-polariton photodiodes

推荐理由: 该文章主要关注光电子半导体材料，与血液疾病研究无直接关联，对血液学领域的借鉴价值有限，仅适合对交叉学科材料技术有广泛兴趣的研究者参考。

摘要: Photodiodes are central to high-speed communication, sensing and light-harvesting devices. While silicon and other inorganic semiconductor-based photodiodes have been widely integrated into commercial technologies, photodiodes from excitonic semiconductors continue to maintain high interest in research. Excitonic semiconductors are superior in terms of absorption as compared to silicon and III-V semiconductors, but have always suffered from poor charge transport and narrow band absorption due to…

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41 Molecular heterogeneity of the non-human primate cochlea

推荐理由: 该研究在非人灵长类耳蜗单细胞测序方面具有方法学上的创新与严谨性，为理解复杂器官的细胞组成提供了高级技术范例；但其研究内容与血液疾病领域无直接关联，可借鉴性主要局限于广义的细胞生物学或组学研究思路。

摘要: Unraveling the intricate composition and function of the cochlea is paramount to comprehending the mechanisms underlying sound perception and the pathogenesis of auditory disorders. The mammalian cochlea displays a highly organized structure, which contributes to the diversity and complexity of auditory processing. However, the cellular intricacies in non-human primates remain largely unexplored. In the present study, we employed high-throughput transcriptomic sequencing to profile over 36,701…

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