追觅 - 2026-01-19

生成时间: 2026−01-19 22:31

分析文章数量: 26

1 Impact of Mutational Landscape and Burden on RBC Transfusion Response in Patients With Lower-Risk Myelodysplastic Syndromes (LR-MDS) in the COMMANDS Study

推荐理由: 该研究基于COMMANDS试验数据，深入分析了基因突变谱与输血反应的关系，为骨髓增生异常综合征的精准治疗提供了重要依据，对血液科临床实践和后续研究具有很高的参考价值。

摘要: The COMMANDS trial established luspatercept as a first-line treatment for anemia in transfusion-dependent lower-risk (LR) myelodysplastic syndromes (MDS). Here we report red blood cell (RBC) transfusion response analysis based on somatic mutations profile and disease risk for patients treated with luspatercept or epoetin alfa in the COMMANDS trial. Of 350 evaluable patients, 238 (68.0%) had MDS with multiple lineage dysplasia and ring sideroblasts (RS) according to World Health Organization 2016…

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2 Preanalytical framework for routine clinical use of liquid biopsies: combining EVs and cfDNA

推荐理由: 该研究针对液体活检中细胞外囊泡分离的关键瓶颈——分析前变异进行了标准化探索，对推动血液肿瘤无创诊断技术的临床转化具有直接参考价值。

摘要: Aim: Liquid biopsies hold significant potential for the minimally invasive diagnosis of tumors and other diseases. While the clinical application of cell-free DNA (cfDNA) methodologies is emerging, the implementation of tumor-derived extracellular vesicles (EVs) as validated biomarkers is hindered by substantial preanalytical variations. In this work, we standardized the preanalytical procedures of blood collection for subsequent serial isolation of plasma cfDNA and EVs from a single blood…

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3 Effects of hypothermic oxygenated machine perfusion on bile composition after liver transplantation - Findings from a randomized controlled trial

推荐理由: 该研究首次通过随机试验证实HOPE处理对肝移植后胆汁成分的影响，其提出的胆汁酸毒性保护机制具有创新性，可为血液病领域研究胆汁酸相关代谢或毒性机制提供参考。

摘要: CONCLUSIONS: This is the first randomized study demonstrating effects of HOPE treatment on bile composition following ECD-DBD liver transplantation. Protection from BA toxicity may represent a novel mechanism underlying the effects of HOPE.

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4 Oncolytic adenoviruses encoding bispecific T cell engagers or a novel trispecific T cell engager for dual-targeting of c-MET and EGFR

推荐理由: 该研究提出的双/三特异性T细胞衔接子联合溶瘤病毒的策略，为克服肿瘤免疫逃逸提供了创新思路，其技术平台和免疫治疗原理对血液系统恶性肿瘤（如淋巴瘤、白血病）的免疫疗法研发具有重要借鉴价值。

摘要: This study reports a strategy to overcome immune escape of tumors during viro-immunotherapy due to tumor heterogeneity. We pursued a dual-targeting approach of epidermal growth factor receptor (EGFR) and cellular mesenchymal epithelial transition factor (c-MET) facilitated by two bispecific T cell engagers (TCEs) or one trispecific TCE encoded by oncolytic adenoviruses (oAds). Different bi- and trispecific TCE formats were generated and characterized. We showed efficacy of bispecific TCEs…

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5 Antimeningococcal Protection in Patients Receiving Terminal Complement Inhibitors

推荐理由: 该研究为接受补体抑制剂治疗的血液病患者提供了更优的感染预防策略，直接挑战现行指南，对临床实践有重要指导价值。

摘要: CONCLUSION: Although guidelines recommend vaccination alone, our findings indicate that combined protection offers substantially greater protection against IMD in patients receiving long-term C5i. Continued prospective monitoring will be essential to define the optimal preventive strategies in this high-risk population.

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6 Gilteritinib in an Isolated CNS Recurrence of FLT3-ITD Positive AML

推荐理由: 该文献报道了一例罕见的老年AML患者孤立性中枢神经系统复发案例，对血液科医生具有重要警示意义，提醒在缓解期仍需警惕罕见部位的髓外复发。

摘要: Central nervous system (CNS) involvement in adult acute myeloid leukemia (AML) is uncommon and more frequently observed at relapse than at initial presentation. Typically, CNS relapse coincides with systemic disease, evidenced by detectable blasts in the bone marrow (BM) and/or peripheral blood. We describe a rare case of an 82-year-old patient with a history of AML, diagnosed three and a half years earlier, who developed an isolated CNS relapse while receiving palliative chemotherapy-without…

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7 Generalizable machine learning models for rapid antimicrobial resistance prediction in unseen healthcare settings

推荐理由: 该文章提出的“深度学习+化学/光谱信息”多模态AI方法具有前瞻性，为开发高泛化能力的临床辅助工具提供了清晰的技术路径，对血液病相关的光谱学诊断（如拉曼光谱检测血细胞）研究具有直接的借鉴价值。

摘要: CONCLUSIONS: These results underscore the value of combining deep learning with chemical and spectral information to build generalizable, high-impact clinical AI.

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8 Perioperative laboratory profiles predict complications after extensive head and neck reconstruction: a proof-of-concept study

推荐理由: 该文章探讨了实验室参数作为头颈肿瘤术后并发症预测因子的价值，为血液学指标在围手术期风险评估中的应用提供了临床借鉴思路，有助于拓展血液检测在跨学科外科场景中的实践意义。

摘要: INTRODUCTION: Surgical reconstruction of head and neck defects after oncological resection is a complex procedure often associated with unpredictable postoperative complications. Hence, laboratory parameter profiles are of considerable interest as potential perioperative predictors.

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9 Histone Lactylation Couples FSH-Driven Lactate Metabolism to Mitochondrial Biogenesis by Enhancing HDAC4-Mediated Deacetylation of PGC-1alpha in Granulosa Cells

推荐理由: 该研究揭示了组蛋白乳酸化作为连接代谢重编程与线粒体生物发生的新型表观遗传机制，为代谢-表观遗传交叉调控领域提供了创新视角，对研究能量代谢相关疾病具有潜在借鉴意义。

摘要: Follicle-stimulating hormone (FSH) coordinates ovarian follicle development by aligning mitochondrial biogenesis with increased metabolic demand. Although FSH is known to stimulate glycolysis in granulosa cells (GCs), the mechanism by which glycolytic flux coupled to mitochondrial biogenesis remains unclear. Here, we demonstrate that histone lactylation functions as a lactate-sensitive epigenetic mediator linking FSH-driven metabolic alterations to mitochondrial biogenesis in GCs….

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10 Modeling tissue-specific Drosophila metabolism identifies high sugar diet-induced metabolic dysregulation in muscle at reaction and pathway levels

推荐理由: 该研究通过构建果蝇组织特异性代谢模型，提供了可借鉴的系统生物学方法，对研究血液疾病的代谢异质性及机制有潜在参考价值。

摘要: Individual tissues perform highly specialized metabolic functions to maintain whole-body metabolic homeostasis. Although Drosophila serves as a powerful model for studying human metabolic diseases, modeling tissue-specific metabolism has been limited in this organism. To address this gap, we reconstruct 32 tissue-specific genome-scale metabolic models (GEMs) by integrating a curated Drosophila metabolic network with pseudo-bulk single-nuclei transcriptomics data, revealing distinct metabolic…

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11 Hydrogel with cell-cell adhesion cues enhances neural regeneration

推荐理由: 该研究在仿生材料中创新性地引入细胞间黏附信号机制，方法学严谨，虽然直接针对神经再生，但其揭示的N-cadherin介导的细胞间通讯调控机制对血液系统细胞相互作用（如造血微环境、白血病细胞侵袭）具有重要借鉴价值。

摘要: Cell-cell adhesion is crucial for maintaining cell functions and the integrity of tissue structure in organisms. However, cell-cell adhesion cues have not been effectively replicated in biomaterials and the associated mechanisms that enhance neural regeneration remained largely unexplored. Here, we present a diffusive N-cadherin functionalized hydrogel system, which provided cell-cell adhesion cues to modulate intercellular communications to significantly promote the formation of active neural…

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12 Longitudinal analysis of body weight reveals homeostatic and adaptive traits linked to lifespan in diversity outbred mice

推荐理由: 该研究通过创新建模方法系统分析终生体重动态变化，为血液系统衰老及相关疾病（如贫血、骨髓功能衰退）的研究提供了可借鉴的纵向数据分析框架。

摘要: Dense temporal measurements of physiological health, using simple and consistent assays, are essential to characterize biological processes associated with aging and evaluate the effectiveness of interventions on these processes. We measured body weight in 960 genetically diverse female mice, every 7-10 days over the full course of their lifespan. We used a state space model to characterize the trajectories of body weight throughout life and derived novel traits capturing the dynamics of body…

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13 Dynamont: A comprehensive cross-species comparison of ONT segmentation tools

推荐理由: 该文章系统评估了ONT信号分割工具，为血液病基因组学及转录组学研究中的数据分析提供了方法学参考，有助于提升测序数据处理的准确性与标准化。

摘要: CONCLUSIONS: No tool delivered the best results for all data sets. We recommend a careful choice and normalization of evaluation metrics to select the best segmentation tool as a critical step in the process of ONT signal segmentation. Across nearly all RNA data sets, Dynamont outperforms other segmentation tools in terms of aggregated metric scores. For DNA data sets, however, the performance is more variable, with mixed results observed across tools.

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14 Impact of Preanalytical Sample Preparation on the Recovery Rate of Cryopreserved Allogeneic Hematopoietic Stem Cells

推荐理由: 该文章为冷冻保存的外周血干细胞质量评估提供了可行的CD34⁺细胞复苏率检测方法，对提升造血干细胞移植质量控制具有直接参考价值，尤其适用于遵循GMP规范的实验室标准化实践。

摘要: CONCLUSION: Determination of the CD34^(+) cell recovery rate after thawing is feasible and may be used as an additional parameter for quality control for cryopreserved allogeneic PBSCs. However, the results of currently used viability assays vary considerably, making comparisons between different cell processing units and cryopreservation protocols difficult. Therefore, available protocols should be carefully evaluated based on “good-manufacturing-practice” (GMP) regulations before…

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15 Toll signalling controls intestinal regeneration in Drosophila

推荐理由: 该研究通过果蝇模型揭示先天免疫Toll/NF-κB通路在肠道干细胞增殖中的保守机制，为血液系统干细胞稳态调控及炎症相关血液疾病研究提供了重要的跨器官参考范式。

摘要: The intestinal interphase is where epithelial renewal and tissue maintenance are balanced alongside immunological regulation. How these functions integrate with cellular signalling is under investigation. Here, we studied the role of the evolutionarily conserved innate immune Toll/NF-κB pathway in Drosophila intestinal regeneration. We found that the core components of the canonical Toll pathway were necessary for intestinal stem cell (ISC) mitosis in homeostasis and upon infection. Toll…

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16 Stereotactic Body Radiotherapy vs. Metastasectomy for Soft Tissue and Bone Sarcoma Lung Metastases - A Systematic Review analyzing Safety and Efficacy

推荐理由: 该文章虽主要针对肉瘤肺转移，但其关于立体定向放疗与手术的疗效比较及多学科个体化治疗的理念，对血液系统肿瘤（如淋巴瘤、白血病）转移灶的处理具有重要借鉴意义，尤其强调了以患者为中心的治疗策略。

摘要: CONCLUSION: Evidence indicates SBRT and surgery provide comparable outcomes for sarcoma- PM, with SBRT offering a more favorable toxicity profile. Though heterogeneous indications and incomplete reporting limit comparability, SBRT should not be viewed solely as fallback for surgically ineligible patients. Treatment should be individualized within a multidisciplinary expert team, integrating patient- and modality-specific factors. Well-designed prospective trials are needed to define relative…

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17 Outcomes of total arch replacement and frozen elephant trunk in acute aortic syndrome

推荐理由: 该文章总结了急性主动脉综合征中冷冻象鼻支架植入术的近期疗效，其关于GERAADA评分高估早期死亡率的发现对心血管外科手术风险评估具有直接参考价值，且长期低再手术率的结果值得相关领域临床医生关注。

摘要: CONCLUSIONS: The recent adaptation of frozen elephant trunk implantation in acute aortic syndrome led to an improved outcome. Overprediction trend of early mortality by the GERAADA score and a low rate of aortic redo surgery in the long-term course support this idea.

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18 Assessing the problem of excitation light scattering in high-viscosity jets used in serial crystallography sample delivery

推荐理由: 该研究揭示了时间分辨串行晶体学中光污染问题的机理，为优化光触发反应的结构研究提供了方法学参考，对涉及光敏蛋白（如血液相关光受体蛋白）的血液病机理研究具有潜在技术借鉴价值。

摘要: Serial crystallography for time-resolved structural studies of light-triggered reactions often employs high-viscosity jets to deliver crystals into an X-ray beam. A potential complication is that pump light can scatter within the jet to unintentionally irradiate yet-to-be-probed portions of the jet - a problem known as light contamination. Importantly, by transporting light out of the nominal interaction region, light scattering can reduce the effective irradiation energy density experienced by…

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19 Differences in mortality by donor sex and age in heart transplantation: An individual patient data meta-analysis

推荐理由: 该研究揭示了供体年龄与性别对心脏移植生存率的交互影响，为器官匹配策略提供了新视角，虽非直接血液病研究，但其免疫与匹配机制对移植相关血液学问题（如输血、免疫抑制）有间接参考价值。

摘要: CONCLUSION: Donor age modifies the association between donor sex and survival after heart transplantation. When appropriately size-matched, female donors are associated with similar or lower mortality compared with male donors in both female and male recipients, suggesting a potential survival advantage with female donor hearts.

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20 Federated Knowledge Retrieval Elevates Large Language Model Performance on Biomedical Benchmarks

推荐理由: 该文章提出的BTE-RAG框架在提升大语言模型准确性方面具有创新性，对于生物医学研究的方法学有借鉴意义，但摘要未明确涉及血液疾病的具体应用，可间接为血液学机制探索提供技术参考。

摘要: CONCLUSION: Federated knowledge retrieval provides transparent improvements in accuracy for large language models, establishing BTE-RAG as a valuable and practical tool for mechanistic exploration and translational biomedical research.

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21 Clinical performance of the next generation Elecsys Troponin T high-sensitivity Gen 6 assay in acute coronary syndrome (PERFORM-TSIX): study design

推荐理由: 该研究针对心梗诊断的高敏肌钙蛋白检测进行了大规模全球人群验证，虽然与血液学疾病无直接关联，但其严格的跨国多中心研究方法对提升检验医学标准化具有参考价值。

摘要: CONCLUSION: PERFORM-TSIX will determine the clinical performance of the Troponin T hs Gen 6 assay for the diagnosis of AMI in a large, diverse global population.

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22 Comparative Analysis of Pressure Drop (Δp): Hemodynamic Performance of Three Commercial Oxygenators During Cardiopulmonary Bypass

推荐理由: 该研究对氧合器的压力差性能进行了比较分析，为血液体外循环设备的工程优化提供了参考，但缺乏直接的溶血临床数据，适合器械研发人员而非临床血液病研究者阅读。

摘要: CONCLUSION: The results of the study show that the Inspire has the highest Δp of all the oxygenators examined in this study. In addition to potential influencing factors, the value is also dependent on the internal structure and the surface properties of the oxygenators. However, the present study does not help to clarify the effects of the pressure before and after the oxygenator or the Δp itself on hemolysis and subsequent clinical parameters associated with the use of different commercially…

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23 Histone Lactylation Couples FSH-Driven Lactate Metabolism to Mitochondrial Biogenesis by Enhancing HDAC4-Mediated Deacetylation of PGC-1alpha in Granulosa Cells

推荐理由: 该研究揭示了组蛋白乳酸化作为代谢与表观遗传调控的新机制，虽主要聚焦生殖生物学，但其连接能量代谢与表观遗传的分子框架对研究血液肿瘤代谢重编程具有可借鉴的范式价值。

摘要: Follicle-stimulating hormone (FSH) coordinates ovarian follicle development by aligning mitochondrial biogenesis with increased metabolic demand. Although FSH is known to stimulate glycolysis in granulosa cells (GCs), the mechanism by which glycolytic flux coupled to mitochondrial biogenesis remains unclear. Here, we demonstrate that histone lactylation functions as a lactate-sensitive epigenetic mediator linking FSH-driven metabolic alterations to mitochondrial biogenesis in GCs….

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24 Prevalence and prognosis of multimorbidity in heart failure with mildly reduced ejection fraction

推荐理由: 该研究系统性分析了HFmrEF患者的

摘要: CONCLUSION: In patients hospitalized with HFmrEF, more than 50% had at least 4 comorbidities. Both cardiovascular and non-cardiovascular comorbidities predicted the risk of long-term all-cause mortality in HFmrEF.

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25 An ESTRO-EPTN Delphi consensus on robustness evaluation in proton therapy

推荐理由: 该文章主要针对放疗治疗计划系统的标准化共识，虽非直接血液病研究，但其采用的德尔菲共识方法对血液病领域制定临床指南或技术规范具有方法论上的参考价值。

摘要: CONCLUSIONS: The ESTRO Delphi consensus may serve as practical guidance on points where a clear consensus was achieved. For remaining points, the development of guidelines is recommended to standardize methodologies and reporting. Furthermore, TPS vendors are encouraged to align their developments with the community’s articulated requirements.

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26 Controlled hierarchical self-assembly of hyperbolic paraboloid molecules into two-dimensional superstructures with second-harmonic generation characteristic

推荐理由: 该文章在材料化学领域展示了高创新性与方法学严谨性，但其研究内容与血液疾病无直接关联，对血液学研究的可借鉴性较低，仅适合对超分子结构化学有交叉兴趣的血液学者拓展视野。

摘要: Hyperbolic paraboloid molecules, as systems with remarkable negative Gaussian curvature, have garnered considerable attention in chemistry and materials science due to their unique physicochemical properties. However, controlled organization of these curvature building blocks into well-defined superstructures remains challenging, primarily attributed to the constraints of their inherently contorted structures. Herein, we report the successful formation of hyperbolic-paraboloid-based crystalline…

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