追觅 - 2026-01-21

生成时间: 2026−01-21 22:47

分析文章数量: 81

1 Time to Revise Myeloma Diagnostic Criteria? A Decade of Accumulated Evidence on Serum Free Light Chain Ratio ≥100

推荐理由: 该文章对多发性骨髓瘤诊断标准中的重要生物标志物（sFLC比率≥100）的临床意义进行了关键性重新评估，基于真实世界数据揭示了与先前研究差异显著的进展风险，对血液科临床诊断决策具有直接修正价值。

摘要: In 2014, the International Myeloma Working Group (IMWG) expanded multiple myeloma diagnostic criteria to include serum free light chain (sFLC) ratio ≥100 as a standalone myeloma-defining biomarker based on studies suggesting approximately 80% risk of progression to overt myeloma at 2 years. However, subsequent studies demonstrate a substantially lower risk of progression, with a population-based registry data showing 2-year risk as low as 30.4% in this group. Importantly, subsequent data showed…

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2 Case series: a rare dominant form of β-thalassemia successfully treated by luspatercept

推荐理由: 该文章报道了β-地中海贫血中罕见显性遗传新机制，对理解NMD逃逸及截短蛋白的显性负效应具有重要借鉴价值，为血液遗传病机制研究与临床诊断提供了新视角。

摘要: Beta-thalassemia is typically inherited in an autosomal recessive manner and can result from a wide range of mutations affecting all stages of the gene expression pathway. Nonsense and frameshift mutations usually trigger nonsense-mediated mRNA decay (NMD). In rare cases, however, such mutations can lead to dominant β-thalassemia when NMD is bypassed, allowing the synthesis of truncated β-globin chains with dominant-negative effects. We describe a multigenerational family with a novel…

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3 The multifaceted role of post-translational modifications in macrophage polarization: from mechanisms to therapeutic targets

推荐理由: 该综述系统阐明了翻译后修饰调控巨噬细胞极化的分子网络，对理解血液肿瘤、炎症性贫血等疾病的免疫病理机制具有重要借鉴价值，为靶向免疫代谢的治疗策略提供了理论依据。

摘要: Macrophage polarization is central to immune homeostasis and disease pathogenesis. It is achieved through complex regulatory networks mediated by post-translational modifications (PTMs). This review synthesizes the roles of phosphorylation, ubiquitination, methylation, acetylation, and lactylation in shaping polarization outcomes through signal-responsive and metabolism-sensitive molecular networks. We integrate evidence that PTMs form interconnected circuits between signaling, epigenetic, and…

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4 The singularity of IGHV4-34 links infection, autoimmunity, and B-cell tumors

推荐理由: 该文章聚焦于IGHV4-34基因在B细胞功能网络中的核心作用，通过特异性单克隆抗体追踪技术，为血液系统疾病（如自身免疫病与肿瘤）的机制研究与临床转化提供了创新视角。

摘要: B cells expressing the IGHV4-34 gene sit at the centre of a web of B-cell functions, ranging from natural antibodies induced by infection through to autoimmunity and tumors. Tracking via the 9G4 monoclonal antibody (MoAb) specifically directed against the unique flag sequences in the first framework region (FR1) of IGHV4-34, allows insight into the evolving nature and multiple functions of B cells expressing a single IGHV gene. IGHV4-34+ B cells are found early in development, and expansion…

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5 Clusterin maintains hemostatic equilibrium by stabilizing VWF multimers in plasma

推荐理由: 该研究首次明确簇集蛋白作为内皮细胞分泌组与WPB成分，通过稳定VWF多聚体维持凝血平衡，为血栓与出血性疾病的机制研究与潜在治疗靶点提供了重要线索。

摘要: The coagulation-anticoagulation balance is tightly regulated by endothelial-derived factors, which have not been clearly defined. Here, we report that clusterin, a component of Weibel-Palade bodies (WPBs), plays a crucial role in maintaining hemostatic equilibrium by sta bilizing von Willebrand factor (VWF) multimers in plasma. Clusterin was identified by proteomic analysis as a component of endothelial secretome under both chemical and physical conditions and demonstrated as a WPB component via…

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6 Regulation of AP1 adaptor assembly by the bi-handed chaperone MEA1

推荐理由: 该研究首次揭示了未表征

摘要: Bidirectional trafficking between the trans-Golgi network (TGN) and endolysosomal compartments lies at the intersection of biosynthetic and degradative pathways. At the center of this trafficking route is the adaptor protein complex 1 (AP1), a heterotetramer essential for cargo recognition and vesicle budding. Here, we identified Male-Enhanced Antigen 1 (MEA1), a previously uncharacterized protein, as a critical AP1 regulator. Loss of MEA1 resulted in depletion of AP1 subunits and impaired…

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7 Dextran-based T-cell expansion nanoparticles for manufacturing CAR T cells with augmented efficacy

推荐理由: 该研究提出的“T-Expand”纳米颗粒技术针对CAR-T制造中的关键瓶颈——T细胞活化与扩增，通过创新方法可能提升T细胞适应性，对优化白血病/淋巴瘤等血液肿瘤的CAR-T疗法具有直接参考价值。

摘要: Adoptive T cell therapy using chimeric antigen receptor (CAR) engineered T cells is currently being explored in multiple cancer types beyond leukemia/lymphoma. A key step in CAR-T cell manufacturing is the activation and expansion of T cells, which facilitates viral transduction, however, may hamper T cell fitness and reduce in vivo persistence. “T-Expand” is developed for T cell activation and expansion, comprising dextran-based nanoparticles conjugated with anti-CD3 and anti-CD28 antibodies….

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8 DC-SIGN Binding to the Surface Ig Oligomannose-type Glycans Promotes Follicular Lymphoma Cell Adhesion and Survival

推荐理由: 该研究揭示了滤泡性淋巴瘤中一种全新的肿瘤特异性糖基化修饰及其免疫逃逸机制，为开发靶向DC-SIGN的免疫疗法提供了关键理论依据，对血液肿瘤研究具有重要借鉴价值。

摘要: The occupation of the surface immunoglobulin antigen-binding site by oligomannose-type glycans (sIg-Mann) is a tumor-specific post-translational modification of classic follicular lymphoma (FL). SIg-Mann switches binding from antigen to dendritic cell-specific intercellular adhesion molecule 3 grabbing non-integrin (DC-SIGN), known to be expressed on interfollicular macrophages and FL-associated follicular dendritic cells (FDCs). The interaction with DC-SIGN induces reorganization of sIg-Mann in…

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9 Understanding how a highly prevalent GRK5 polymorphism affects platelets and enhances thrombotic risk

推荐理由: 该研究通过GWAS发现GRK5基因变异与血栓性疾病风险的相关性，为血小板功能遗传调控机制提供了新见解，对血栓性疾病的精准预防和临床诊疗具有直接参考价值。

摘要: Inherited genetic variants that modulate platelet function contribute significantly to thrombotic disorders, yet their mechanisms and clinical implications remain underexplored. Two genome-wide association studies identified an AàG variant (rs10886430) in the first intron of G protein-coupled-receptor kinase 5 (GRK5), found in homozygosity in  5 million Americans. The homozygous GRK5 GG genotype has an increased risk of stroke and venous thromboembolism, but the mechanistic link between this…

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10 Plasmin modulates neutrophilic inflammation and alveolar macrophage function, protecting mice from pneumococcal pneumonia

推荐理由: 该研究创新性地拓展了纤溶酶原/纤溶酶系统在炎症消退中的非经典功能，为血液学领域（尤其是凝血与炎症交叉研究）提供了重要的机制借鉴和转化思路。

摘要: Accumulating evidence supports pro-resolving actions of the Plasminogen/Plasmin (Plg/Pla) system during inflammation, beyond its classical role in fibrin degradation. Here, we investigated the role of Plg/Pla on key features of inflammation resolution in a murine model of severe pneumococcal pneumonia. High levels of Plg were observed in the airways following infection, accompanied by increased levels of plasminogen activator inhibitor-1, neutrophil elastase and Plg degradation fragments as…

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11 The multifaceted role of post-translational modifications in macrophage polarization: from mechanisms to therapeutic targets

推荐理由: 该综述系统阐释了翻译后修饰调控巨噬细胞极化的分子网络，为理解血液系统炎症、肿瘤等疾病的免疫机制提供了关键理论借鉴，尤其对造血微环境研究具有重要参考价值。

摘要: Macrophage polarization is central to immune homeostasis and disease pathogenesis. It is achieved through complex regulatory networks mediated by post-translational modifications (PTMs). This review synthesizes the roles of phosphorylation, ubiquitination, methylation, acetylation, and lactylation in shaping polarization outcomes through signal-responsive and metabolism-sensitive molecular networks. We integrate evidence that PTMs form interconnected circuits between signaling, epigenetic, and…

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12 How I treat breakthrough thrombosis in patients with cancer

推荐理由: 该文章针对癌症患者抗凝治疗中突破性血栓形成的临床管理难题提供了实用指导，对血液科医生处理肿瘤相关静脉血栓具有直接的参考价值。

摘要: Cancer patients face an increased risk of venous thromboembolism (VTE), and breakthrough thrombosis despite anticoagulation, with a six-month cumulative incidence of 5-8%. The management of these events is clinically challenging. Confirming suspected breakthrough thrombosis requires imaging review, ideally by comparison with post-index baseline studies, as residual thrombus is common and may mimic recurrence. When true breakthrough thrombosis is confirmed, several potential contributing factors…

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13 The singularity of IGHV4-34 links infection, autoimmunity, and B-cell tumors

推荐理由: 该文章聚焦IGHV4-34基因在B细胞功能中的核心作用，为理解自身免疫病和血液肿瘤的发病机制提供了关键视角，对血液病研究和临床诊疗具有明确的借鉴价值。

摘要: B cells expressing the IGHV4-34 gene sit at the centre of a web of B-cell functions, ranging from natural antibodies induced by infection through to autoimmunity and tumors. Tracking via the 9G4 monoclonal antibody (MoAb) specifically directed against the unique flag sequences in the first framework region (FR1) of IGHV4-34, allows insight into the evolving nature and multiple functions of B cells expressing a single IGHV gene. IGHV4-34+ B cells are found early in development, and expansion…

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14 Clusterin maintains hemostatic equilibrium by stabilizing VWF multimers in plasma

推荐理由: 该研究首次明确簇集素作为内皮细胞Weibel-Palade小体成分对VWF多聚体稳定的关键作用，为出血性与血栓性疾病的机制研究与潜在治疗靶点提供了重要线索。

摘要: The coagulation-anticoagulation balance is tightly regulated by endothelial-derived factors, which have not been clearly defined. Here, we report that clusterin, a component of Weibel-Palade bodies (WPBs), plays a crucial role in maintaining hemostatic equilibrium by sta bilizing von Willebrand factor (VWF) multimers in plasma. Clusterin was identified by proteomic analysis as a component of endothelial secretome under both chemical and physical conditions and demonstrated as a WPB component via…

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15 Prevention, diagnosis and management of community acquired respiratory virus infections including COVID-19 in patients with cancer: 2025 updated evidence-based guideline of the infectious diseases working party (AGIHO) of the German society for hematology and medical oncology (DGHO)

推荐理由: 该文章系统阐述了新发与常见呼吸道病毒对免疫抑制患者（包括血液肿瘤患者）构成的持续威胁及防治策略，其核心观点和临床管理思路对血液科医生处理免疫功能低下患者（如白血病、淋巴瘤、移植后患者）的感染问题具有直接的参考与借鉴价值。

摘要: Community-acquired respiratory viruses (CARV), such as influenza-, parainfluenza- or respiratory syncytial virus, pose a significant threat to immunocompromised patients with cancer. Following the COVID-19 pandemic, SARS-CoV-2 has now joined the ranks of endemic respiratory viruses and continues to be a cause of significant morbidity and mortality in patients with cancer. Strategies to protect this vulnerable patient population both by prevention of infection and by early therapeutic…

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16 Integrating SMRT and Bulk RNA Sequencing With Metabolic Phenotyping to Examine Reduced Skeletal Muscle Mitochondrial Respiration in Type 2 Diabetes

推荐理由: 该研究整合前沿的单分子实时测序与代谢表型分析，方法学创新性强，其剪接异构体精准检测策略对血液肿瘤（如白血病）的转录组变异研究具有重要借鉴价值。

摘要: Recent advances in RNA sequencing (RNA-seq) techniques allow the identification of tissue-specific alternative splicing and can thereby provide new insights into molecular mechanisms of energy metabolism. Full-length transcriptomics based on single-molecule real-time sequencing (SMRT-seq) enable precise detection of isoforms with 99% accuracy in an unbiased manner. In this proof-of-concept study, we integrated SMRT-seq, bulk RNA-seq, and comprehensive metabolic phenotyping to investigate reduced…

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17 The two-step purification method ViREn identifies a single NSUN6-mediated 5-methylcytosine modification promoting dengue virus RNA genome turnover

推荐理由: 该文章提出的RNA修饰检测方法在灵敏度和准确性上有明显改进，对于研究病毒相关血液疾病（如病毒诱导的白血病或RNA异常修饰相关的血液肿瘤）具有重要的技术参考价值。

摘要: Chemical modifications on cellular and viral RNAs are new layers of post-transcriptional regulation of cellular processes, including RNA stability and translation. Although advances in analytical methods have improved the detection of RNA modifications, precise mapping at single-base resolution remains challenging. Requirements for sensitivity and purity limit accuracy and reproducibility, especially for low abundant viral RNAs extracted from infected cells. Here, we report a two-step method,…

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18 Dengue therapeutics consortium 2025: a global collaboration in action

推荐理由: 该文章总结了登革热治疗领域的全球专家共识，不仅涉及当前治疗困境与研发方向，而且其关于宿主导向治疗与临床实验方法的讨论，对研究病毒相关血液疾病（如血小板减少等）具有重要的跨领域借鉴价值。

摘要: Dengue is a global health emergency, with annually increasing case numbers that overwhelm healthcare systems, an ever-expanding range of the mosquito vector, and no antiviral or host-directed treatments proven to alter the course of disease. This article reports on a meeting of the Dengue Therapeutics Consortium, which included attendees from 19 countries with backgrounds in basic science, clinical research, drug development, industry, clinical trial methodology and policy. We summarise the…

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19 Decoding Allosteric Inhibition in MALT1: The Hidden Role of Conformational Plasticity in Metastable States via Biased MD and Deep Learning

推荐理由: 该文章深入探讨了MALT1蛋白在血液肿瘤发生中的关键机制，为血液疾病靶向治疗提供了重要的分子基础，对血液科研究人员具有较高的参考价值。

摘要: The mucosa-associated lymphoid tissue lymphoma-translocation protein 1 (MALT1) is a key protein in the adaptive immune response system in humans. This protein is widely expressed in the human body and is related to nuclear factor-κB (NF-κB) signaling activation in response to T-cell receptors. Due to this, MALT1 is key in the regulation of inflammatory events in a variety of tissues, where its dysregulation is associated with several types of cancer, especially hematological cancers. In this…

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20 Prediction of myeloid malignant cells in Fanconi anemia using machine learning

推荐理由: 该综述系统阐述了范可尼贫血向骨髓增生异常综合征和急性髓系白血病转化的风险与机制，对血液科医生全面认识该遗传性骨髓衰竭综合征的肿瘤转化及临床管理具有重要参考价值。

摘要: Fanconi anemia (FA) is an inherited bone marrow failure syndrome with cancer predisposition. Most FA patients develop aplastic anemia during childhood and have an extremely high cumulative risk to develop cancer during their lifespan. Myeloid malignancy is one of the main neoplastic risks for patients with FA, including high-risk myelodysplastic syndrome (MDS), recently renamed as myelodysplastic neoplasm, and acute myeloid leukemia (AML). Although bone marrow transplantation is the treatment of…

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21 Enhancing link prediction in biomedical knowledge graphs with BioPathNet

推荐理由: 该文章提出的BioPathNet框架通过路径推理增强了生物医学知识图谱的链接预测能力，为血液疾病相关分子网络与病理机制的深入挖掘提供了更强大的方法论工具，具有较高的借鉴价值。

摘要: Understanding complex interactions in biomedical networks is crucial for advancements in biomedicine, but traditional link prediction (LP) methods are limited in capturing this complexity. We present BioPathNet, a graph neural network framework based on the neural Bellman-Ford network (NBFNet), addressing limitations of traditional representation-based learning methods through path-based reasoning for LP in biomedical knowledge graphs. Unlike node-embedding frameworks, BioPathNet learns…

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22 Melanoma causes phenotypic modulations and metabolic switches of iNKT cells influencing clinical outcomes

推荐理由: 该研究深入探讨iNKT细胞在肿瘤免疫逃逸中的功能障碍机制，对血液肿瘤（如淋巴瘤）的免疫治疗研究具有重要借鉴价值，尤其能为血液系统恶性肿瘤的免疫疗法开发提供新思路。

摘要: INTRODUCTION: Invariant NKT (iNKT) cells are crucial effectors in cancer immunosurveillance, due to their immunomodulatory potential through a broad range of effector and regulatory functions. Yet, their use as targets or vectors for cancer immunotherapy in cancer yielded inconsistent outcomes, due to potential tumor immune escape mechanisms. Limited information is available regarding the potential dysfunctions of iNKT cells in melanoma patients, and their clinical significance. A better…

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23 How I treat breakthrough thrombosis in patients with cancer

推荐理由: 该文章聚焦癌症患者抗凝治疗中“突破性血栓”这一临床棘手难题，提出了通过对比基线影像学进行确诊的具体思路，对血液科及肿瘤科医生处理此类复杂并发症具有直接的实践指导价值。

摘要: Cancer patients face an increased risk of venous thromboembolism (VTE), and breakthrough thrombosis despite anticoagulation, with a six-month cumulative incidence of 5-8%. The management of these events is clinically challenging. Confirming suspected breakthrough thrombosis requires imaging review, ideally by comparison with post-index baseline studies, as residual thrombus is common and may mimic recurrence. When true breakthrough thrombosis is confirmed, several potential contributing factors…

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24 DC-SIGN Binding to the Surface Ig Oligomannose-type Glycans Promotes Follicular Lymphoma Cell Adhesion and Survival

推荐理由: 该研究揭示了滤泡性淋巴瘤中一种肿瘤特异性糖基化修饰如何改变表面免疫球蛋白的结合特性，为理解肿瘤免疫逃逸机制和开发靶向治疗提供了新的分子视角。

摘要: The occupation of the surface immunoglobulin antigen-binding site by oligomannose-type glycans (sIg-Mann) is a tumor-specific post-translational modification of classic follicular lymphoma (FL). SIg-Mann switches binding from antigen to dendritic cell-specific intercellular adhesion molecule 3 grabbing non-integrin (DC-SIGN), known to be expressed on interfollicular macrophages and FL-associated follicular dendritic cells (FDCs). The interaction with DC-SIGN induces reorganization of sIg-Mann in…

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25 Time to Revise Myeloma Diagnostic Criteria? A Decade of Accumulated Evidence on Serum Free Light Chain Ratio ≥100

推荐理由: 该文章基于后续真实世界数据，对一项关键骨髓瘤诊断标准的实际预后风险进行了重要修正，强调了避免根据早期研究数据对患者进行过度治疗的必要性，对临床决策具有直接指导价值。

摘要: In 2014, the International Myeloma Working Group (IMWG) expanded multiple myeloma diagnostic criteria to include serum free light chain (sFLC) ratio ≥100 as a standalone myeloma-defining biomarker based on studies suggesting approximately 80% risk of progression to overt myeloma at 2 years. However, subsequent studies demonstrate a substantially lower risk of progression, with a population-based registry data showing 2-year risk as low as 30.4% in this group. Importantly, subsequent data showed…

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26 Plasmin modulates neutrophilic inflammation and alveolar macrophage function, protecting mice from pneumococcal pneumonia

推荐理由: 该研究揭示了纤溶酶原/纤溶酶系统在炎症消退中的非经典功能，为血液学中凝血与炎症交叉领域的研究提供了新视角，尤其对理解感染相关出凝血紊乱具有借鉴价值。

摘要: Accumulating evidence supports pro-resolving actions of the Plasminogen/Plasmin (Plg/Pla) system during inflammation, beyond its classical role in fibrin degradation. Here, we investigated the role of Plg/Pla on key features of inflammation resolution in a murine model of severe pneumococcal pneumonia. High levels of Plg were observed in the airways following infection, accompanied by increased levels of plasminogen activator inhibitor-1, neutrophil elastase and Plg degradation fragments as…

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27 Ligand-controlled regiodivergent and enantioselective C-H cyanation of secondary amines

推荐理由: 该研究在手性铜催化下实现了脂肪胺的区域选择性C-H官能团化突破，方法学创新性强，对药物化学

摘要: Aliphatic amines, such as N,N-dialkyl secondary amines, represent important scaffolds in bioactive molecules, driving significant interest in their regio- and stereoselective C-H functionalisation. While hydrogen atom transfer (HAT) provides a powerful radical-based approach to elaborate such amines, achieving controllable, regio-divergent, and enantioselective functionalisation across different N-alkyl groups remains challenging. Herein, we report a Cu-catalyzed α’/β-regiodivergent and…

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28 Preventing premature deaths through polygenic risk scores

推荐理由: 该研究创新性地将多基因风险评分与现有筛查方案结合建模，方法严谨，对血液病等领域的风险预测模型构建具有重要参考价值。

摘要: Polygenic risk scores (PRS) have demonstrated predictive validity across a range of cohorts and diseases, but quantifying their clinical utility remains a challenge. As PRS can be derived from a single biological sample and remains stable throughout life, we explore the potential of PRS to optimize existing screening programs. Via an integrated modelling approach, we quantify the potential clinical benefits arising from a knowledge of PRS across seven diseases with existing screening programs…

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29 High-entropy alloy Janus artificial enzymes for pH-gated sequential redox therapy of drug-resistant bacterial infection

推荐理由: 该文章提出的一种pH门控的级联催化酶设计策略，其调控炎症微环境的机制对于研究慢性炎症相关的血液疾病（如骨髓炎、造血功能紊乱）具有重要的借鉴价值，尤其在抗氧化与抗菌平衡方面提供了新材料学思路。

摘要: Drug-resistant bacterial infections in chronic wounds remain a critical challenge, particularly under persistent inflammation. Here, we report the de novo design of high-entropy alloy (HEA, PtFeCuCoNi)-based Janus artificial enzymes with pH-gated redox biocatalysis for sequential antibacterial and repair functions. The multi-metal synergy stabilizes the d-band center, allowing acidic oxidase/peroxidase-like activity and neutral antioxidase-like activity. In infection, the enzymes generate…

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30 Targeting the UFL1-AKT cascade suppresses triple-negative breast cancer progression

推荐理由: 该研究揭示了UFL1介导的UFMylation修饰与AKT信号通路在TNBC中的新型互作机制，为肿瘤靶向治疗提供了新思路，其涉及的蛋白质修饰调控原理对血液肿瘤研究具有可借鉴的交叉价值。

摘要: Triple-negative breast cancer (TNBC) is an aggressive and highly lethal disease with limited therapies. While UFL1-mediated UFMylation has been implicated in various diseases, its role in TNBC remains not fully understood. Here, we demonstrate that AKT1 directly interacts with UFL1 and undergoes UFMylation at Lys189/276/297. This modification enhances AKT phosphorylation and activation, promoting tumor growth and chemoresistance in TNBC. In turn, AKT phosphorylates UFL1 at Thr426, establishing a…

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31 TET1 as a master regulator controlling GPX4-dependent and -independent ferroptosis surveillance in acute myeloid leukemia

推荐理由: 该研究通过表观遗传学机制揭示了铁死亡抵抗的关键调控通路，为血液系统肿瘤（如白血病）的治疗提供了新的潜在靶点，具有较高的临床转化借鉴价值。

摘要: Ferroptosis, an iron-dependent, lipid peroxidation-driven programmed cell death, holds substantial promise for cancer therapy, yet its translational potential is hindered by widespread intrinsic resistance. While glutathione peroxidase 4 (GPX4) is a well-established ferroptosis suppressor, the epigenetic circuitry coordinating GPX4-related mechanisms remains elusive. Here, via genome-wide screening, we identify ten-eleven translocation 1 (TET1)-a key mediator of DNA 5-hydroxymethylation-as a…

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32 The UFL1-AKT positive feedback loop promotes breast cancer progression by enhancing lipid synthesis

推荐理由: 该研究深入揭示了UFMylation通过调控AKT活性影响肿瘤代谢的新机制，虽然以乳腺癌为模型，但其揭示的翻译后修饰与脂代谢调控通路对白血病等血液肿瘤的代谢重编程研究具有重要借鉴价值。

摘要: UFMylation, a ubiquitin-like modification, is crucial for cellular processes and is linked to human diseases, including cancer. However, its role in cancer remains unclear. Here, we report that UFL1 promotes breast tumor growth by remodeling lipid metabolism. Mechanistically, UFL1 interacts with and UFMylates AKT, enhancing its localization at the endoplasmic reticulum and phosphorylation by PDK1 and mTORC2, thereby increasing AKT-mediated lipid synthesis. Moreover, AKT phosphorylates UFL1,…

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33 Large-scale serum N-glycomics tracks N-glycosylation dynamics in hepatocellular carcinoma progression and enables early diagnosis

推荐理由: 该

摘要: Hepatocellular carcinoma (HCC) is a leading cause of cancer mortality, yet the role of N-glycosylation in its pathogenesis remains unclear. We applied a multi-center, large-cohort N-glycomics strategy combining isomer-specific glycan profiling with multi-omics integration to characterize disease-associated glycan alterations and develop serum-based diagnostic models. Serum N-glycomes from 1,074 individuals across health, chronic hepatitis B, cirrhosis, and HCC were analyzed using a…

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34 Establishing global standards on wearable technology for measuring mobility in ageing populations: an international consensus exercise

推荐理由: 该研究为老年人群可穿戴设备移动能力监测建立了标准化框架，虽与血液疾病无直接关联，但其严谨的方法学共识对跨学科医学测量研究具有重要参考价值。

摘要: BACKGROUND: Mobility, defined as movement in all its forms, is a hallmark of healthy ageing. As wearable technologies become increasingly integrated into population health surveillance and ageing research, the absence of standardised terminology, measurement protocols and reporting practices presents a major barrier to progress. This consensus exercise aimed to establish minimum standards for measuring mobility with wearable technology in ageing populations and set priorities for future research…

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35 Current Epidemiology and Infection Characteristics of Non-Aspergillus Mold Infections: A Multicenter Study in Australia and New Zealand

推荐理由: 该研究明确了澳大利亚地区血液病患者中除曲霉菌外的主要侵袭性霉菌病原谱，特别是对高死亡率的L. prolificans和毛霉菌的强调，对血液科临床抗感染治疗具有直接参考价值。

摘要: CONCLUSIONS: L. prolificans, Scedosporium spp. and Mucorales are the most frequent non-Aspergillus mold pathogens in Australasia, with other emerging species and mixed infections encountered. Mortality from L. prolificans and Mucorales infections remains high.

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36 Commensal-derived trehalose monocorynomycolate triggers γδ T cell-driven protective ocular barrier immunity

推荐理由: 该研究揭示了特定微生物代谢产物通过γδ T细胞调控IL-17的精确机制，为理解免疫稳态提供了新视角，其免疫调控机制对血液疾病中异常免疫反应的研究具有借鉴价值。

摘要: Commensals shape host physiology through molecular crosstalk with host receptors. Identifying specific microbial factors that causally influence host immunity is key to understanding homeostasis at the host-microbe interface and advancing microbial-based therapeutics. Here, we identified trehalose monocorynomycolate (TMCM) from Corynebacterium mastitidis as a potent stimulator of interleukin 17 (IL-17) production by Vγ4 γδ T cells at the ocular surface. Mechanistically, TMCM-induced IL-17…

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37 Dual genomic localizations and gene regulatory functions of MBD-2 with and without NuRD in Caenorhabditis elegans which lacks DNA methylation

推荐理由: 该研究揭示了在无5mC甲基化的线虫中MBD-2蛋白仍作为NuRD复合物保守组分的现象，为表观遗传调控机制的演化与功能提供了新视角，对研究血液疾病中异常表观遗传调控（如白血病）具有潜在借鉴意义。

摘要: 5-methylcytosine (5mC) DNA methylation is an ancient epigenetic mechanism. Methyl-CpG-binding domain protein 2 or 3 (MBD2/3) is a component of the Nucleosome Remodeling and Deacetylase (NuRD) complex, essential for gene regulation in mammals. The MBD2/3 ortholog is surprisingly preserved even in 5mC-free invertebrates, such as nematodes and flies. We found that Caenorhabditis elegans MBD-2 (Cel-MBD-2), despite without the MBD domain, is a conserved component of the NuRD complex. Cel-MBD-2 null…

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38 Gemcitabine plus selinexor in selective advanced sarcomas: a phase I of the Spanish group for research on sarcoma study

推荐理由: 该研究为探索XPO-1抑制剂联合化疗在晚期肉瘤中的安全性与剂量的早期临床试验，虽然直接血液病相关性有限，但其靶点机制

摘要: Exportin-1 (XPO-1) is related to drug resistance and poor prognosis in solid tumors. Selinexor, an XPO-1 inhibitor, has shown preclinical and clinical activity in sarcomas. This Phase I study explores the combination of gemcitabine and selinexor in a classic 3 + 3 design. Adult patients with selected advanced sarcomas receive gemcitabine and weekly selinexor in 21-day cycles. The main endpoint is to determine the recommended phase 2 dose (RP2D). Secondary end-points include safety, overall…

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39 Bionic Janus hydrogel drives infected Achilles tendon regeneration via mechano-immune spatiotemporal steering

推荐理由: 该文章在仿生材料设计及动态应力调控方面具有显著创新性，虽非直接针对血液疾病，但其在免疫调控与组织修复中的机制研究可为血液系统相关组织工程（如骨髓微环境修复）提供跨学科参考。

摘要: The healing of infected tendons is hindered by mechanical dysfunction, tissue adhesion, bacterial colonization, and immune imbalance. Inspired by the biphasic “adhesion-lubrication” structure of tendon sheaths, we developed a Janus hydrogel, named HAPP@H-EXO, for spatiotemporal repair. The material exhibits antifatigue properties and redistributes mechanical stress through a dynamic network formed by norbornylated PVA and boronic acid-modified hyaluronic acid-PVA. Its high-adhesion side…

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40 Ependymoglial cells are critical for cortex regeneration in axolotls

推荐理由: 该研究在蝾螈中建立的NTR诱导性细胞消融系统技术严谨且具有创新性，虽然不直接针对血液疾病，但其精准靶向消融特定细胞类型的方法对血液学研究（如特定血细胞谱系清除或血液肿瘤模型构建）具有潜在借鉴价值。

摘要: Developing precise targeted cell ablation in the axolotl (Ambystoma mexicanum) is crucial for elucidating the roles or interactions of specific cell types in regeneration and modeling diseases. Here we establish a Nitroreductase (NTR)-based inducible cell ablation system in axolotls. Through generation of Sox2:Cherry-NTR knock-in axolotls, we achieve efficient ablation of ependymoglial cells (EGCs) in the central nervous system. Combined spinal cord and brain transplantation and injury models…

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41 Late Holocene fast-ice dynamics around the Northern Victoria Land coast, Antarctica

推荐理由: 该文章在极地海冰长期动态重建方法上具有显著创新性，但对血液疾病研究无直接关联，仅适合交叉学科方法学参考。

摘要: Fast ice, a consolidated form of sea ice commonly found along the Antarctic margins, plays a critical and multifaceted role in regulating ocean-cryosphere interactions and ecosystem dynamics. While satellite observations and numerical models provide valuable contemporary insights, reconstructing long-term trends and identifying potential environmental drivers requires alternative approaches. In this study, we present a novel method for reconstructing long-term fast-ice dynamics using a…

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42 Endothelin-3 and T-type Ca<sup>2+</sup> channels drive enteric neural crest cell calcium activity, contractility and migration

推荐理由: 该研究通过钙信号机制解析神经嵴细胞迁移的调控，虽非直接血液疾病研究，但其细胞迁移的分子机制对造血干细胞归巢或白血病细胞转移等血液学问题具有重要借鉴价值。

摘要: Enteric neural crest cells (ENCCs) colonize the gut during embryogenesis and migration defects give rise to Hirschsprung disease (HD). Mutations in GDNF/RET and EDN3/EDNRB are known to be causal in HD. Here, we show that migrating ENCCs in mice exhibit endogenous EDN3/EDNRB-gated calcium activity, mediated by chloride channels, T-type Ca^(2+) channels and inositol trisphosphate-sensitive intracellular-store release. We find that inhibiting Ca^(2+) activity results in ENCC migration defects,…

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43 Community benchmarking and evaluation of human unannotated microprotein detection by mass spectrometry based proteomics

推荐理由: 该研究系统评估了大规模质谱数据中未注释微蛋白的鉴定情况，为血液疾病相关新型生物标志物或调控因子的发现提供了可靠的数据筛选框架和可借鉴的分析思路。

摘要: Thousands of short open reading frames (sORFs) are translated outside of annotated coding sequences. Recent studies have pioneered searching for sORF-encoded microproteins in mass spectrometry (MS)-based proteomics and peptidomics datasets. Here, we assessed literature-reported MS-based identifications of unannotated human proteins. We find that studies vary by three orders of magnitude in the number of unannotated proteins they report. Of nearly 10,000 reported sORF-encoded peptides, 96% were…

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44 Biochemical principles of miRNA targeting in flies

推荐理由: 该研究采用前沿的RNA Bind-n-Seq技术系统解析果蝇miRNA结合特性，方法学具有高度可借鉴性，但其结论与哺乳动物或人类血液疾病研究的直接关联较弱，更适合作为分子生物学技术参考。

摘要: MicroRNAs direct Argonaute proteins to repress complementary target mRNAs via mRNA degradation or translational inhibition. While mammalian miRNA targeting has been well studied, the principles by which Drosophila miRNAs bind their target RNAs remain to be fully characterized. Here, we use RNA Bind-n-Seq to systematically identify binding sites and measure their affinities for five highly expressed Drosophila miRNAs. Our results reveal a narrower range of binding site diversity in flies compared…

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45 Near-100% site utilization of single atoms for efficient electrocatalysis

推荐理由: 该文章提出的表面活性剂辅助冷冻铸造策略在单原子催化剂的可及性问题上具有显著方法学创新，虽然不直接涉及血液疾病，但其在纳米材料设计与表征上的思路可能为血液学中药物递送系统或生物传感器开发提供跨学科借鉴。

摘要: Despite that enhancing site utilization (U(site)) of single atoms (SAs) is crucial in electrocatalysis beyond increasing intrinsic activity and site density, numerous SAs are inaccessible during reaction due to the dense micropores and disordered stacking of carbon particles. Here, the enhancement for U(site) of SAs is achieved through a surfactant-assis’ted freeze-casting (SAFC) strategy. The sodium dodecyl sulfate (SDS)-modified Fe-doped zeolitic imidazolate framework-8 (Fe/ZIF-8) particles…

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46 Cryo-electron tomography reveals coupled flavivirus replication, budding and maturation

推荐理由: 本文采用前沿的冷冻电子断层扫描技术，首次在纳米尺度揭示黄病毒复制细胞器的超微结构动态，其方法学创新和细胞器水平的研究思路对血液系统病毒感染（如登革热等出血热病原体）的研究具有重要借鉴价值。

摘要: Flaviviruses replicate their genomes in replication organelles (ROs) formed as bud-like invaginations on the endoplasmic reticulum membrane, which also functions as the site for virion assembly. While this localization is well established, it is not known to what extent viral membrane remodeling, genome replication, virion assembly, and maturation are coordinated. Here, we image tick-borne flavivirus replication in human cells using cryo-electron tomography. We find that the RO membrane bud is…

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47 Intermittent fasting inhibits Tp53-driven glioma through gut microbiota-mediated methionine-m<sup>6</sup>A regulation

推荐理由: 该研究通过多组学分析揭示了间歇性禁食的抗肿瘤效果具有亚型特异性，为血液肿瘤领域探索饮食干预的精准化应用提供了重要的方法学参考。

摘要: Intermittent fasting (IF) has emerged as a potential cancer treatment modality, although its tumor-suppressive effects are limited. Glioblastoma (GBM) can be classified into CDKN2A subtype and TP53 subtype. Here, we discover that the efficacy of IF is correlated with tumor subtypes of GBM. IF significantly inhibite GBM progression in mice with the Tp53 GBM model, whereas its inhibitory effect is not significant in the Cdkn2a GBM model. Multi-omics sequencing is performed in the IF-responsive…

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48 Distinct sympathetic projections to brown fat regulate thermogenesis and glucose tolerance

推荐理由: 该研究虽非直接针对血液疾病，但其揭示的交感神经对血流与代谢的精细调控机制，为研究造血微环境、骨髓血供及血液病相关代谢异常提供了新颖的神经调控视角，具有跨学科借鉴价值。

摘要: Brown adipose tissue (BAT) contributes to thermoregulation and glucose metabolism, but how these functions are coordinated remains unclear. While thermogenesis in the activated BAT typically coincides with increased blood flow and glucose uptake^(1-5), several pathophysiological and nutritional states dissociate these processes^(6,7), suggesting they are governed by distinct sympathetic circuits. Here we identify subpopulations of sympathetic neurons in the stellate ganglion that mediate…

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49 nf-core/proteinfamilies: A scalable pipeline for the generation of protein families

推荐理由: 该文章提出的蛋白质功能注释方法具有跨学科借鉴价值，其序列比对与功能预测策略可应用于血液疾病相关蛋白的功能解析研究。

摘要: The growth of metagenomics-derived amino acid sequence data has transformed our understanding of protein function, microbial diversity, and evolutionary relationships. However, the vast majority of these proteins remain functionally uncharacterized. Grouping the millions of such uncharacterised sequences with the few experimentally characterised ones allows the transfer of annotations, while the inspection of conserved residues with multiple sequence alignments can provide clues to function,…

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50 Deletion of the angiopoietin receptor Tie2 enhances proliferation and sprouting of cardiac endothelial cells

推荐理由: 该研究揭示了Tie1/Tie2信号通路在心脏内皮细胞增殖和发芽中的特异性调控作用，为血管生物学及器官特异性血管疾病研究提供了有价值的实验依据。

摘要: CONCLUSION: Deletion of Tie2 alone or together with Tie1 increases the proliferation and sprouting of cardiac, but not renal or pulmonary ECs, without to neovessel formation in the heart.

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51 BioMark: biomarker analysis tool

推荐理由: 该文章针对高通量组学数据分析的痛点，提出了降低技术门槛的解决方案，对血液病生物标志物研究具有方法学上的可借鉴性，尤其适合缺乏计算背景的血液学研究者参考。

摘要: Biomarkers play a pivotal role in disease diagnosis and prognosis by offering molecular insights into biological states. The rapid growth of high-throughput omics technologies has enabled the generation of large-scale biomarker datasets, yet analyzing these complex, high-dimensional data remains a major challenge-particularly for researchers lacking advanced computational expertise. While numerous tools exist for omics data analysis, many fall short in providing an integrated, user-friendly…

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52 On the fundamental resource for exponential advantage in quantum channel learning

推荐理由: 该研究在量子计算基础资源理论上有重要方法论创新，虽与血液病学无直接关联，但其对“资源量化”的分析框架可为血液学研究中复杂生物标志物的定量解析提供跨学科方法论借鉴。

摘要: Quantum resources enable us to achieve an exponential advantage in learning the properties of unknown physical systems by employing quantum memory. While entanglement with quantum memory is recognized as a necessary qualitative resource, its quantitative role remains less understood. In this work, we distinguish between two fundamental resources provided by quantum memory-entanglement and ancilla qubits-and analyze their separate contributions to the sampling complexity of quantum learning….

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53 Interfacial water regulation on Ru single atoms doped Co<sub>3</sub>O<sub>4</sub> toward efficient electrochemical hydrogenation of quinoxaline

推荐理由: 该文章在单原子催化与电化学氢化界面行为调控方面方法创新、数据可靠，虽然与血液疾病无直接关联，但其在催化机制与材料设计上的方法论对血液病相关药物分子修饰研究具有潜在借鉴价值。

摘要: Electrochemical hydrogenation of quinoxaline presents a promising alternative to traditional methods, yet is suffering from low current density and Faradaic efficiency due to the hampered hydrogenation process. Herein, we develop a cocatalytic system of Ru single atoms doped Co(3)O(4) nanosheet (Ru(SA)/ns-Co(3)O(4)) to optimize the interfacial H(2)O behavior by tuning the Ru single atoms concentration for accelerating the electrochemical hydrogenation of quinoxaline, which enables remarkable…

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54 Upcycling carbon fibre wastes in solid-flames

推荐理由: 该文章在材料升级回收领域提出了创新的“固体火焰”技术，方法严谨，对推动循环经济有较高社会价值；虽不直接涉及血液疾病，但其在碳纤维处理与材料生物相容性方面的思路可为血液学相关生物材料研究提供间接借鉴。

摘要: Hundreds of thousands of tons of epoxy-containing carbon fibre (CF) wastes are generated from the manufacture of CF reinforced epoxy composites to their end-of-use. Today, most recycling strategies of these CF wastes aim at recovering CFs to the ones as virgin as possible, while techniques for efficiently converting CF wastes to materials of higher value, i.e., upcycling of CF wastes, are underexplored. Here, we develop a solid-flames upcycling technique using Mg and CaCO(3) powders as reactants…

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55 De-coherent parallel laser processing of ultradense nanopores for high-density, large-area 3D optical phase encoding

推荐理由: 该研究在超衍射极限激光加工领域方法严谨、创新性强，虽然不直接涉及血液疾病，但其高精度微加工技术可为血液细胞操作、单细胞分析等前沿血液学研究提供潜在工具借鉴。

摘要: Single-beam femtosecond laser pulses can surpass the diffraction limit of conventional focusing systems, enabling deep sub-waveguide single-spot modifications via nonlinear absorption at the focus. However, extending this capability to multi-beam parallel processing has been fundamentally limited by the diffraction limit ( λ/2). Herein, we experimentally and theoretically clarify that this limitation stems from spatial coherence and temporal sequence interference, inducing laser-matter…

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56 Unbiased clustering of acute-on-chronic liver failure patients using machine learning in a real-world ICU cohort

推荐理由: 该研究采用无监督聚类方法对肝衰竭患者进行分层分析，其研究思路和算法模型在血液病复杂亚型分类研究中具有较高的方法论借鉴价值。

摘要: Acute-on-chronic liver failure is a complex condition with varied definitions, complicating risk stratification and targeted management. We apply unsupervised clustering to data from 1,256 patients with acute-on-chronic liver failure as defined by the North American Association for the Study of End-Stage Liver Disease. We systematically evaluate multiple algorithmic models to enable unbiased cohort stratification and to determine key clustering factors and clinical impacts across clusters. The…

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57 Human motion recognition and prediction using loose cloth

推荐理由: 该文章在可穿戴传感与人体运动分析方面方法新颖，虽与血液疾病无直接关联，但其柔性传感技术与生物医学信号监测思路对血液病患者的体征移动监测研究具有间接启发价值。

摘要: Human motion analysis plays a crucial role in fields such as healthcare, human-robot interaction and virtual reality. Conventional approaches typically rely on tightly attached body sensors, which can prove uncomfortable and impractical. Here, we investigate motion recognition and prediction using garments incorporating embedded sensors. We analyse how the movement of loose-fitting clothing can predict body motion in both simulated and real-world scenarios. Results demonstrate that sensors…

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58 Non-traditional fluorescence in quadruple hydrogen bonded supramolecular polymers

推荐理由: 该文章提出基于水母荧光蛋白质子转移机制的仿生发光聚合物策略，在材料设计思路上具有显著创新性，对开发新型生物诊断材料有重要启发，值得材料化学与交叉领域研究者参考。

摘要: Non-traditional luminescent polymers exhibit significant advantages in bio-diagnostics and intelligent materials but suffer from low luminescence efficiency and limited functionality. Inspired by the excited-state proton transfer mechanism mediated by dense hydrogen bonds in jellyfish fluorescent proteins, we propose a strategy using dynamic quadruple hydrogen bonding ureidopyrimidinone motifs to create highly efficient luminescent polymers. By modulating the aggregated structure of the…

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59 Domain adaptation, self-supervision, and generative augmentation enhance GNNs for breast cancer prediction

推荐理由: 该研究提出的多任务图神经网络框架在方法学上具有显著的创新性与集成性，虽然直接面向乳腺癌，但其跨队列泛化、小样本学习和生成增强等策略对血液肿瘤的分子分型与预后建模具有可借鉴的参考价值。

摘要: Breast cancer presents substantial molecular heterogeneity, requiring accurate subtype classification, receptor-status prediction, and survival estimation for precision care. Existing machine-learning models often fail to generalize across cohorts or adapt to rare subtypes. We propose a unified graph neural network (GNN) framework that integrates multi-task learning, domain-adversarial adaptation, contrastive self-supervision, few-shot meta-learning, and generative augmentation. Gene-expression…

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60 Glycine photosynthesis via C-N coupling of waste plastic and nitrate over diatomic Pd-B catalyst

推荐理由: 该研究在双原子催化剂设计和C-N偶联光催化路径控制方面具有显著创新性，虽然不直接涉及血液疾病，但其在氨基酸合成代谢调控方面的思路可为血液学相关代谢研究提供方法学借鉴。

摘要: Photocatalytic C-N coupling offers a promising approach for the sustainable production of amino acids, but the uncontrolled coupling pathway of reaction intermediates limits yield and selectivity. This paper describes a Pd-B diatomic catalyst that can selectively catalyze the photosynthesis of glycine via C-N coupling reaction between waste poly(ethylene terephthalate)-derived ethylene glycol and nitrate, achieving a glycine yield of 2.9 mmol g(cat)^(−1) h^(−1) with a selectivity of 92%….

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61 Low intensity vibration with zoledronate reduces musculoskeletal weakness and adiposity in estrogen deprived female mice

推荐理由: 该研究创新性地探索了非药物性物理干预（低频振动）对雌激素剥夺下骨骼肌肉系统的保护作用，其思路与方法对研究骨髓微环境及造血相关的骨代谢疾病具有潜在借鉴价值。

摘要: Aromatase inhibitors are widely used in the treatment of hormone-sensitive breast cancer, but their suppression of estrogen production accelerates bone loss, increases fracture risk, and negatively impacts muscle and fat metabolism. Here, we demonstrate that daily low intensity vibration, serving as a non-drug mimetic for exercise, protects musculoskeletal health in skeletally immature, female mice under complete estrogen deprivation. Subsequent improvements in vertebral bone density are…

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62 Functional and structural insights into interactions between β-Arrestin 1 and Gαs or Gαi1

推荐理由: 该研究通过MST技术精确量化了G蛋白与β-arrestin1的相互作用亲和力，为GPCR信号转导的分子机制提供了重要细节，虽不直接针对血液疾病，但其揭示的通用信号互作原理对研究血液系统相关GPCR（如趋化因子受体）具有潜在借鉴价值。

摘要: G proteins and arrestins are key transducers for G protein-coupled receptor (GPCR) signaling, mediating distinct downstream pathways. Recent evidence suggests that G proteins and β-arrestins (βarrs) can directly or functionally interact. However, the molecular details and functional consequences of Gα-βarr interactions remain poorly understood. Here, we quantify the binding affinities between βarr1 and Gαs or Gαi1 in various activation states using microscale thermophoresis (MST). βarr1 in the…

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63 Chainmail-inspired conformable and switchable microwave metamaterial absorber

推荐理由: 该文章在柔性微波超材料吸收体的设计与3D打印制备方面具有显著的方法学创新和工程参考价值，但其研究内容与血液疾病无直接关联，主要适用于电磁兼容或隐身技术领域。

摘要: The rigidity of conventional microwave absorbers impedes their reliable integration with complex curved surfaces and deformable components. However, these capabilities remain indispensable for electromagnetic stealth and miniaturized electromagnetic compatibility (EMC) applications that rely on advanced conformal wave-manipulation. To overcome these challenges, we present a chainmail-inspired conformal and switchable microwave metamaterial absorber, conveniently fabricated via 3D printing. The…

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64 Why represcribing instead of deprescribing?

推荐理由: 该文章虽非直接针对血液疾病，但其提出的“合理多重用药”个体化理念对血液科老年共病患者用药管理具有重要借鉴意义，尤其适用于需长期服药的血液肿瘤或抗凝治疗患者。

摘要: CONCLUSION: The goal of age-appropriate drug therapy in geriatric patients should not only be to reduce the number of medications or eliminate polypharmacy, but also to transition from poor polypharmacy to good polypharmacy through individualization and represcribing.

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65 Provider Survey on Burn Care in India

推荐理由: 该研究揭示了印度烧伤护理体系的系统性缺陷和传统就医行为导致的治疗延迟，对公共卫生政策改进具有较高参考价值，但直接与血液疾病的相关性较弱，适合关注全球卫生或感染防控的研究者参阅。

摘要: CONCLUSIONS: The findings reveal significant gaps in staff training, intensive care monitoring, and infection prevention. Many patients initially seek help from traditional healers, often delaying appropriate treatment and worsening outcomes. Enhancing education, implementing standard monitoring practices, and ensuring adherence to clinical protocols are critical steps toward improving burn care outcomes in India.

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66 Sleep as a moderator of adolescent brain development - evidence from a longitudinal MRI study

推荐理由: 该文章聚焦于睡眠对青少年神经发育的影响及干预潜力，虽与血液疾病无直接关联，但对理解发育关键期的健康因素具有普遍参考意义，适合关注脑健康与公共卫生的研究者阅读。

摘要: CONCLUSION: These findings highlight the potential role of sleep in adolescent neurodevelopment and underscore the potential for targeted interventions to support brain health during this critical window.

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67 Patient perspectives on research gaps in cluster headache

推荐理由: 该文章虽非直接针对血液疾病，但通过患者视角揭示了临床需求与治疗缺口，对设计以患者为中心的临床试验（包括新型药物如psilocybin的探索）具有方法学参考价值。

摘要: CONCLUSION: Participants with reported cluster headache highlighted inadequate treatment options, emphasized the need for further research, and expressed interest in future clinical trials, particularly those involving psilocybin or combination therapies.

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68 Insights and emerging perspectives from the 2025 Medaka PI/ERC IndiGene meeting: Heidelberg July 22-24, 2025

推荐理由: 该文章主要总结了日本青鳉作为多学科模式生物的应用价值及学术会议动态，虽在疾病建模方面有通用参考意义，但对血液疾病的直接针对性和可借鉴性有限，适合对模式生物平台发展感兴趣的研究者泛读。

摘要: The Japanese medaka, Oryzias latipes, has become an important vertebrate model organism for addressing research questions across a broad range of disciplines, including developmental and evolutionary biology, stem cells, gene-environment interactions, behavioral neuroscience, disease modeling, and drug discovery. The medaka community took advantage of the successful completion of the ERC Synergy Grant project IndiGene to gather once again in the beautiful Heidelberg (July 22-25, 2025). Building…

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69 Genetic Testing and Imaging in Men with Familial History or Genetic Predisposition of Prostate Cancer-Introducing the Prospective “ProFam-Risk” Study

推荐理由: 该研究在遗传性癌症风险人群的预防门诊模式建立与验证方面方法严谨，具有临床转化潜力，但主要针对前列腺癌，与血液疾病直接相关性较弱，可借鉴其高危人群管理框架。

摘要: Familial and genetic factors influence prostate cancer (PCa) risk, necessitating personalized prevention strategies. This study aims to establish and validate a prevention clinic (ProFam-Risk) for men with a familial or genetic risk of PCa, focusing on genetic testing, multiparametric magnetic resonance imaging (mpMRI), and psychosocial assessment. ProFam-Risk is a prospective registry and outpatient clinic at the University Hospital Düsseldorf, recruiting participants into three groups: healthy…

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70 Massive hepatic necrosis-associated acute liver failure

推荐理由: 该文虽主要聚焦肝病学，但对研究严重全身炎症或凝血功能障碍相关的血液并发症具有参考价值，尤其有助于理解多器官衰竭背景下凝血系统紊乱的机制。

摘要: Massive hepatic necrosis (MHN), characterised by extensive loss of hepatocytes, represents the most severe pathological lesion in acute liver failure (ALF). MHN-associated ALF primarily occurs in patients with acute viral hepatitis A, B or E infections. Additionally, MHN-associated ALF can develop in patients with autoimmune hepatitis or in those taking idiosyncratic drugs. MHN-associated ALF is associated with significantly higher mortality than that caused by other aetiologies. In contrast to…

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71 Risk stratification as a guide to goal-oriented management of patients with fibrotic interstitial lung disease: a registry-based analysis

推荐理由: 虽然该研究直接针对肺纤维化，但其构建基于可干预变量的预后模型的思路，对血液病领域开发类似的精准预后工具具有方法学上的借鉴意义。

摘要: CONCLUSION: This study provides a novel risk model for IPF patients, which may also apply to a broader spectrum of fibrotic ILD. It is based on potentially actionable variables which deserve further evaluation as measurable treatment goals in interventional clinical trials.

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72 Charting the research frontier for viral infections, immunomodulation, and dementia: a perspective on synaptic biomarkers as essential clinical trial endpoints

推荐理由: 该文章虽聚焦神经退行性疾病，但其对病毒-炎症机制的深入探讨可为血液系统炎症性疾病及免疫调节治疗研究提供跨学科思路借鉴。

摘要: The viral-inflammatory hypothesis of Alzheimer’s disease offers a new paradigm, yet interventions like antivirals and vaccination present a paradox that challenge therapeutic development. This perspective examines the critical research gap concerning cerebrospinal fluid (CSF) synaptic biomarkers in immunomodulatory therapy trials. Following decades of partially successful amyloid-centric trials, focus has shifted to upstream triggers including viral infections like Herpes Simplex Virus Type 1,…

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73 Study decision-making to understand how technology will affect behaviour

推荐理由: 由于未提供摘要内容，无法评估研究的创新性、社会影响或血液疾病相关性，建议补充信息后再判断是否值得阅读。

摘要: No abstract

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74 Nickel-catalyzed divergent sulfonations of propargylic carbonate

推荐理由: 该文章在不对称催化合成方法学上具有较高创新性和实用性，但主要面向药物化学与合成化学领域，与血液疾病研究的直接关联较弱，仅可作为背景知识参考。

摘要: Chiral sodium sulfinates serve as crucial synthetic intermediates utilized for rapidly producing a variety of enantioenriched sulfone derivatives that are pervasive in the fields of pharmaceutical chemistry and chemical synthesis. Here we present a practical and highly effective method for the nickel-catalyzed asymmetric sulfonation of propargylic carbonates for the production of essential synthetic building blocks. Notably, sodium 1-methyl 3-sulfinopropanoate (SMOPS), a commercially available…

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75 Intrinsically stretchable 2D MoS<sub>2</sub> transistors

推荐理由: 该研究在可拉伸电子器件领域方法严谨、数据可靠，创新性突出，虽与血液疾病无直接关联，但其在柔性生物电子传感方面的潜在应用可为未来血液检测设备开发提供跨学科思路。

摘要: Intrinsically stretchable electronics is rapidly emerging as a transformative platform for next-generation electronics, offering novel form factors and enhanced capabilities. Herein, we report high-performance intrinsically stretchable thin-film transistors based on two-dimensional semiconducting flakes. Our n-type molybdenum disulfide transistors exhibit a maximum field-effect mobility up to 12.5 cm²V^(−1)s^(−1) (average 8 cm²V^(−1)s^(−1)) and an on/off current ratio above 10⁷, even under 20%…

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76 High-spin state dynamics and quintet-mediated emission in intramolecular singlet fission

推荐理由: 该文章在分子高自旋态的光物理机制研究上具有方法论上的严谨性，但其研究对象与血液疾病的直接关联性较弱，仅对研究血红蛋白氧合过程的自旋化学有边缘参考价值。

摘要: High-spin states in molecular systems hold significant interest for applications ranging from optoelectronics to quantum technologies. Spin states generated in intramolecular singlet fission are of particular relevance, yet the mechanisms controlling triplet-pair formation are not fully understood - especially the involvement of quintet states in luminescence at room temperature remains experimentally elusive. Here, we investigate high-spin state formation and emission in dimers and trimers…

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77 NCOA1 is a gatekeeper of the sexually dimorphic thermogenic activity of white adipose tissue

推荐理由: 该研究在脂肪组织代谢与性别差异机制上有一定创新性，但内容与血液疾病直接关联较弱，对血液学研究的可借鉴性有限。

摘要: Premenopausal women preferentially store fat in subcutaneous depots, which provides protection against cardiometabolic disease. Their white adipose tissue also exhibits a more thermogenic, brown-like profile compared with that of men, yet the mechanisms underlying this sex-specific benefit remain unclear. Here, we show that Nuclear Receptor Coactivator 1 is highly expressed in human subcutaneous fat, with further induction during the conversion of white to beige adipocytes and in response to…

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78 Burden of chronic obstructive pulmonary disease and its attributable risk factors in 204 countries and territories, 1990-2021: results from the Global Burden of Disease Study 2021

推荐理由: 该文章主要关注COPD（慢性阻塞性肺疾病）的全球负担与环境因素，虽然研究方法和公共卫生建议具有参考价值，但与血液疾病领域直接相关性较弱，仅对研究环境因素与全身性疾病的流行病学方法有间接借鉴意义。

摘要: CONCLUSIONS: The study highlights the persistent and evolving global burden of COPD, emphasising the significant impact of environmental factors such as particulate matter pollution. It underscores the need for targeted public health interventions and resource allocation, particularly in low-income and middle-income countries, to mitigate the growing COPD challenge. To enhance COPD management, the recommendations include implementing regional plans to mitigate particulate pollution,…

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79 Dynamic signature of activity-stability tradeoff in lactamase evolution

推荐理由: 该研究在蛋白质进化机制与结构-功能关系上提供了深入的见解，方法严谨，但内容与血液疾病直接关联较弱，主要适用于基础蛋白质研究或酶进化领域，对血液学借鉴价值有限。

摘要: Our ability to understand protein evolution hinges on understanding how evolutionary landscapes are shaped at the fundamental protein level. Using TEM-1 β-lactamase we show that molecular traits related to the statistical ensemble nature of protein structure contribute to broader substrate specificity, active site-scaffold communication, and the selection of stabilizing substitutions. During the evolution of cefotaxime resistance, the initial mutation reorganizes the active site, introducing a…

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80 Morphology-modified contributions of electronic transitions to the optical response of plasmonic nanoporous gold metamaterial

推荐理由: 该文章采用实验与理论结合的方法研究纳米多孔金属的电子性质，方法学具有可借鉴性，但其内容与血液疾病直接关联较弱，更适合材料科学或纳米技术领域的研究者参考。

摘要: Nanoporous metals have emerged as promising functional architectures with tunable optical and electronic properties, high surface areas, and applicability in sensing, catalysis, and biomedicine. While their linear optical behavior and morphological properties have been extensively studied, the electronic properties, and in particular how they are affected by morphology, remain not fully understood. Here we combine experimental and theoretical studies of electronic excitation and relaxation in a…

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81 Enhancing soil citrulline degrading function to mitigate soil-borne Fusarium wilt

推荐理由: 该研究在植物病理学与微生物互作机制方面方法严谨、具有创新性，但内容与血液疾病领域无直接关联，仅其代谢物与病原体相互作用的分析思路可能为血液感染或免疫研究提供间接参考。

摘要: Continuous cropping often exacerbates soil-borne diseases, particularly Fusarium wilt, yet the intricate rhizosphere relationships among phyto-derived metabolites, pathogens, and particular microbial functions remain poorly understood. Here, we observe that citrulline accumulation during continuous cropping is positively correlated with Fusarium wilt severity by enhancing fusaric acid production in Fusarium oxysporum. Metagenomic analyses reveal that citrulline turnover-related functions,…

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