追觅 - 2026-01-25

生成时间: 2026−01-25 22:31

分析文章数量: 43

1 The Monash learning health system maturity matrix: codesign of a tool to measure and guide improvement in complex health system behaviour

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摘要: No abstract

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2 Local metastatic expansion versus secondary intra-organ dissemination: two causes of neurological death explained by fundamentally different metastatic colonization patterns

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摘要: CONCLUSIONS: This study identifies the HGP as a potential surrogate for predicting the underlying cause of organ failure in brain metastases. Additionally, it highlights the significant role of secondary dissemination and recolonization in brain metastasis, processes that have been largely overlooked in clinical practice. These findings address a critical knowledge gap and may inform future treatment strategies.

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3 Prognostic value of deep learning-based coronary artery calcium score and quantitative pneumonia burden in patients hospitalized with COVID-19

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摘要: No abstract

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4 The impacts of COVID-19 on routine immunization for children in Rwanda

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摘要: No abstract

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5 ProteoBoostR: an interactive framework for supervised machine learning in clinical proteomics

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摘要: CONCLUSIONS: ProteoBoostR is an open-source application that empowers proteomics researchers to perform advanced ML classification. It can be readily applied to other proteomic datasets and disease contexts, promoting reproducible ML analyses in proteomics and accelerating the translation of omics-based classifiers into clinical research.

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6 Exploring translational relevance of baseline and longitudinal metabolic profiling in the blood of ovarian cancer patients

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摘要: We conducted blood-based metabolomic profiling in ovarian cancer and determined its clinical relevance. NMR spectroscopy was performed on a total of n = 760 longitudinal plasma samples from n = 292 ovarian cancer patients, probing for n = 39 metabolites. At primary diagnosis, we revealed two distinguishable signatures, representing blood-based surrogates for a continuum of two metabolic states in ovarian cancer. These signatures shaped two subgroups of patients with differential surgical outcome…

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7 Modulation of Nudt21 levels reveals dose-dependent roles of alternative polyadenylation in tissue regeneration

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摘要: Stem cells continually self-renew and differentiate to sustain tissue homeostasis, yet the role of post-transcriptional mechanisms in guiding these processes remains incompletely understood. Here, we demonstrate that the regulation of 3′UTR length via alternative mRNA polyadenylation (APA) is essential for stem cell function across diverse tissues. Modulating the APA regulator Nudt21 reveals that stem cell self-renewal and differentiation depend on distinct dosage thresholds and thus can be…

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8 Behaviour of female mice defeated in an inter-female aggression protocol predicts resilience to cocaine-induced conditioned place preference

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摘要: Several studies have demonstrated that exposure to different protocols of social defeat induces anxiety- and depression-like symptoms in male and female mice. Moreover, male mice exposed to an intermittent social defeat (ISD) show increased vulnerability to the rewarding effects of cocaine, although several behavioural traits have been found to confer resilience against this effect. However, the effects of ISD on the vulnerability to drugs of abuse in female mice have not been studied. Thus, our…

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9 Burden of chronic respiratory disease in Asia, 1990-2023: a systematic analysis for the Global Burden of Disease Study 2023

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摘要: BACKGROUND: Chronic respiratory diseases are an important global issue, particularly in Asia, where burden patterns vary widely across countries. With more than half the world’s population living in Asia, understanding the national and regional burden of chronic respiratory diseases is essential; however, research on this area remains inadequate. We aimed to investigate the burden of chronic respiratory diseases in Asia at national and regional levels, and to identify key risk factors.

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10 Making the invisible visible: Exploring women’s and maternity care providers’ views on an antenatal screening tool to identify women with previous traumatic birth experience and or a current fear of birth in a subsequent pregnancy

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摘要: CONCLUSION: Women found the screening tool acceptable and valued acknowledgment of their experiences and current feelings, which made the invisible visible. Clinicians confirmed the SPST’s acceptability and feasibility in antenatal settings.

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11 Machine learning for enzyme catalytic activity: current progress and future horizons

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摘要: Enzyme catalysis, with its advantages in environmental sustainability and efficiency, is gaining traction across diverse industrial applications, such as waste utilization and pharmaceutical biomanufacturing. However, optimizing enzyme catalytic activity remains a significant challenge. To facilitate enzyme mining and engineering, machine learning (ML) models have emerged to predict enzyme substrate specificity, enzyme turnover number, and enzyme catalytic optimum. This review endeavored to…

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12 GeNePi: a graphics processing unit enhanced next-generation bioinformatics pipeline for whole-genome sequencing analysis

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摘要: Next-generation sequencing (NGS) has revolutionized genome biology by enabling rapid whole-genome sequencing (WGS) and driving its adoption in research and clinical settings. However, the high-throughput nature of NGS and the complexity of downstream analyses demand robust computational solutions. We present GeNePi, a modular bioinformatic pipeline for efficient and accurate analysis of WGS short paired-end reads. GeNePi is a genomics analysis pipeline built on the Nextflow framework,…

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13 EDEN: multiscale expected density of nucleotide encoding for enhanced DNA sequence classification with hybrid deep learning

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摘要: CONCLUSIONS: EDEN provides an efficient, biologically informed, and interpretable multiscale representation for genomic sequence classification. Its favorable parameter-performance ratio and robust consistency across tasks underscore its practicality for large-scale genomic applications.

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14 mspms: an R package and GUI for multiplex substrate profiling by mass spectrometry

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摘要: CONCLUSIONS: mspms is the first publicly available, comprehensive platform for MSP-MS data analysis downstream of peptide identification and quantification. It integrates preprocessing, normalization, statistical testing, and visualization into a single, transparent, and user-friendly framework, making it a valuable resource for the protease research community. The package is distributed via Bioconductor, and a graphical interface is available online for interactive use.

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15 Can H5N1 avian influenza in dairy cattle be contained in the US?

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摘要: The emergence and sustained spread of H5N1 in US dairy cattle since 2024 have demonstrated that highly pathogenic avian influenza (HPAI) is capable of establishing long-term transmission in livestock. Genomic surveillance has clarified national patterns of spatial diffusion, interspecies transmission, and viral evolution, but critical data gaps remain that impede efforts to track virus movements in real time, identify modes of transmission, and inform control efforts.

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16 Comprehensive analysis of proteomics and lactylation proteomics in ovarian granulosa cells of patients with polycystic ovary syndrome

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摘要: CONCLUSIONS: This study provides a comprehensive quantitative overview of proteomic and lactylation-modified proteomic expression profiles in granulosa cells from patients with PCOS, offering novel insights into PCOS research. Further research is needed to clarify the specific roles of protein lactylation in PCOS pathogenesis.

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17 RBM15/IGF2BP3 promotes immune escape in bladder cancer by enhancing m6A modification of PFKFB4

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摘要: The role of N6-methyladenosine (m6A) in shaping the tumor microenvironment remains incompletely understood. Here, we investigated the function of the m6A writer RBM15 in bladder cancer (BC). Single-cell sequencing and spatial transcriptomics demonstrated that RBM15 is predominantly expressed in malignant epithelial cells and exerts oncogenic effects. Integrated m6A-seq and lactylation proteomics analyses indicated that RBM15 could regulate both glycolysis and immunity through m6A modification…

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18 Pregnenolone promotes immune evasion through blocking endogenous retrovirus expression

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摘要: Research into steroid hormones shaping tumor biology has gained increasing attention. Using multiple mouse tumor models, we show that pregnenolone promoted tumor progression and reduced sensitivity to immunotherapy. Pregnenolone levels were markedly elevated in maternal mice experiencing mating deficiency. Mechanistically, pregnenolone directly binds Kap1 and inhibits Trim39-mediated ubiquitination at K750, leading to Kap1 stabilization and repression of endogenous retrovirus (ERV) expression…

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19 Printing technologies for monitoring crop health

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摘要: Agricultural production requires low-cost sensors capable of delivering reliable, high-resolution data across large areas. Rising food demand, limited arable land, and severe soil degradation have accelerated the adoption of precision agriculture, which relies on real-time monitoring of soil, plant, and environmental conditions. Central to this shift is the development of scalable sensor technologies enabled by advances in materials science. Printing techniques, including inkjet, screen, aerosol…

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20 Curvature programmed inkjet printing enables adaptive deposition for Gaussian sintering lasers

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摘要: The inherent Gaussian intensity distribution of laser beams causes critical issues such as ablation, spattering, and porosity during laser sintering and melting. Although modulating the intensity distribution by a beam shaper can alleviate these problems, it suffers from high cost, limited durability, and significant energy loss. To address these challenges, we propose a thickness-matching strategy that aligns film geometry with the laser intensity profile. Mathematical analysis provides the…

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21 Essential role of NONO-HOXA1-Wnt axis in cardiomyocyte differentiation

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摘要: NONO is recognized as a critical molecular scaffold involved in both transcriptional and posttranscriptional regulation. Mutations in NONO are frequently linked to congenital heart diseases (CHDs) in humans. However, the mechanisms by which NONO regulates cardiac development remain elusive. Here, we identified NONO as a pivotal dual-function regulator of cardiomyocyte differentiation in human induced pluripotent stem cells (hiPSCs). NONO deficiency in hiPSCs results in a distinct defect in early…

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22 Potential and challenges for sustainable progress in human longevity

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摘要: Decelerating gains in life expectancy (e(0)) in high-income countries have raised concerns about the future of human longevity. To enhance our understanding of these developments, we examine subnational (N = 450) mortality trends in Western Europe in the period 1992-2019. Between 1992 and 2005, gains in life expectancy were both substantial and widespread. Laggard regions experienced the fastest improvements, yielding rapid regional convergence. Between 2005 and 2019, however, gains in these…

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23 A stabilized tandem antigen chimera that elicits potent malaria transmission-reducing activity

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摘要: Malaria parasite transmission remains a barrier to elimination since asymptomatic individuals sustain the infectious reservoir. Transmission-blocking vaccine (TBV) candidates targeting Plasmodium falciparum (Pf) gametocyte surface proteins Pfs230 and Pfs48/45 have shown promise in clinical trials. Several vaccine candidates have been developed for these antigens, yet it is unclear which elicit the most robust and durable transmission-blocking responses. From structure-function relationships of…

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24 Recreating viable YY<sup>h</sup> genotype uncovers the role of CpYYL underlying YY lethality in papaya

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摘要: Papaya is a trioecious species with XX females, XY males, and XY^(h) hermaphrodites. Any combination of Y and Y^(h) chromosomes is lethal. The gene underlying YY lethality is pivotal in the transition from stage 2 to stage 3 in sex chromosome evolution. Here, we identify and functionally validate the YY lethality gene in papaya, CpYYL. Loss of CpYYL function accelerates glycolysis and reduces sucrose accumulation in embryo, causing embryo abortion. CpYYL interacts with CpAKRP and overexpression…

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25 Modulation of Nudt21 levels reveals dose-dependent roles of alternative polyadenylation in tissue regeneration

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摘要: Stem cells continually self-renew and differentiate to sustain tissue homeostasis, yet the role of post-transcriptional mechanisms in guiding these processes remains incompletely understood. Here, we demonstrate that the regulation of 3′UTR length via alternative mRNA polyadenylation (APA) is essential for stem cell function across diverse tissues. Modulating the APA regulator Nudt21 reveals that stem cell self-renewal and differentiation depend on distinct dosage thresholds and thus can be…

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26 Comprehensive benchmarking single and multi ancestry polygenic score methods with the PGS-hub platform

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摘要: Polygenic scores (PGS) quantify genetic contributions to complex traits, yet existing single- and multi-ancestry methods lack multi-dimensional evaluation within a unified framework. Here, we benchmarked 13 state-of-the-art PGS methods across 36 traits in UK Biobank European and African samples. The prediction performance, computational efficiency, the number of variants, and the impact of different linkage disequilibrium (LD) reference sizes were thoroughly assessed for each method. Results of…

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27 Molecular recognition of thyroglobulin by sortilin

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摘要: Sortilin is a ubiquitous membrane receptor mediating trafficking of protein cargoes. In the thyroid, sortilin binds thyroglobulin (TG) during its endocytosis, a key process in thyroid homeostasis. Although sortilin has been proposed to recognise highly iodinated TG, the molecular details of this interaction remain unknown. In this work, using an integrative structural biology approach, we reveal that sortilin binds an unstructured TG C-terminal peptide and exhibits a strong preference for the…

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28 BiG-SCAPE 2.0 and BiG-SLiCE 2.0: scalable, accurate and interactive sequence clustering of metabolic gene clusters

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摘要: Microbial metabolic gene clusters encode the biosynthesis or catabolism of metabolites that facilitate ecological specialization, mediate microbiome interactions and constitute a major source of medicines and crop protection agents. Here, we present BiG-SCAPE and BiG-SLiCE 2.0, next-generation methods that facilitate scalable, accurate and interactive gene cluster analyses. BiG-SCAPE 2.0 updates its classification, alignment methods, and visualizations, enabling more accurate analysis, up to 8x…

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29 An open decoupled cell design achieving electricity generation and amplification through waste-to-energy conversion

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摘要: Conventional closed batteries are constrained by the electrical energy efficiency of 100%, inevitably leading to the reduction of electricity storage. In contrast, open decoupled batteries offer the possibility to break this limitation, but remain unexplored. Here, we develop a highly efficient and sustainable open decoupled battery through a three-electrodynamic-potential (3E) design, simultaneously realizing waste-to-energy conversion, power generation and energy storage. For decoupled…

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30 Bernoulli’s principle-mediated Cl<sub>2</sub> electrosynthesis

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摘要: Existing technologies for chlorine (Cl(2)) synthesis are generally suffered from low productivity or high production cost. Guided by Bernoulli’s principle, here we report an efficient yet cost-effective electrochemical system for Cl(2) electrosynthesis, which is composed of anodic chlorine evolution reaction (CER) connected to gas chamber by triple-phase gas diffusion layer. The key is to modulate gas diffusion layer by Bernoulli’s principle, wherein the pressure difference at triple-phase…

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31 Click-based determination of accumulation of molecules in Escherichia coli

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摘要: Gram-negative bacterial pathogens pose a significant challenge in drug development because their outer membranes hinder the permeation of small molecules. The lack of widely adoptable methods for measuring the cytosolic accumulation of compounds in bacterial cells further hinders drug discovery efforts. To address this challenge, we report the development of the Chloroalkane Azide Membrane Permeability (CHAMP) assay, which we designed specifically to assess molecule accumulation in the cytosol…

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32 A tidal disruption event from an intermediate-mass black hole revealed by comprehensive multi-wavelength observations

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摘要: Tidal disruption events (TDEs) occur when a star crosses the tidal radius of a black hole (BH) and is ripped apart, providing a powerful way to probe dormant BHs over a wide mass range. In this study, we present our late-time observations and comprehensive multi-wavelength analyses of AT 2018cqh, a TDE at the center of a dwarf galaxy that exhibited successive flares in the optical, X-ray, and radio bands. We discovered an unexpected high-state X-ray plateau phase following the peak until the…

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33 Interaction and functional specialization across a distributed neural circuit for flexible task control in macaques

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摘要: Reversal tasks have been regarded as probes of behavioural inhibition and linked to prefrontal and specifically orbitofrontal cortex. The centrality of behavioural inhibition to reversal task performance and the task’s dependence on particular prefrontal sub-regions have, however, been questioned in primates. Using a combination of whole brain recording, transient ultrasonic disruption, two types of reversal task, and a task model emphasizing identification of transitions between latent states,…

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34 Entanglement-inspired frequency-agile rangefinding

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摘要: Entanglement, a key feature of quantum mechanics, is recognized for its non-classical correlations which have been shown to provide significant noise resistance in single-photon rangefinding and communications. Drawing inspiration from the advantage given by energy-time entanglement, we developed an energy-time correlated source based on a classical laser that preserves the substantial noise reduction typical of quantum illumination while surpassing the quantum brightness limitation by over six…

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35 Bradyzoite subtypes rule the crossroads of Toxoplasma development

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摘要: Toxoplasmosis is a major risk to chronically infected individuals, especially those who become immunocompromised. Although one-third of the globe is infected with Toxoplasma, no treatments prevent or eliminate cysts in part due to limited understanding of bradyzoite biology. The cyst is central to Toxoplasmosis, as transition from bradyzoites to tachyzoites drive pathology. In this study, we aim to understand the biology of bradyzoites prior to recrudescence and the developmental pathways they…

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36 Duration of super-emitting oil and gas methane sources

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摘要: The duration of super-emitting events (>100 kg h^(−1)) in oil and gas basins remains insufficiently understood but is key for reporting programs and mitigation strategies. Carbon Mapper conducted aerial surveys from April 30 to May 17, 2024, over the New Mexico Permian Basin, covering 276,000 wells, 1100 compressor stations, 175 gas processing plants, and 27,000 km of pipeline. We find over 500 super-emitting sources with 300 of these sources observed repeatedly across multiple days. We quantify…

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37 Atroposelective interrupted CuAAC reaction using cyclic diaryliodoniums

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摘要: Copper-catalyzed azide-alkyne cycloaddition (CuAAC) is a pivotal strategy for joining two fragments, including bioactive moieties under mild conditions. In recent years, “interrupted” CuAAC reaction has emerged by intercepting copper triazolide intermediates, thereby significantly broadening the scope of these transformations. However, asymmetric transformations based on the interruption of copper triazolide intermediates have remained elusive. In this work, we present an efficient and mild…

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38 TREM2 expression level is critical for microglial state, metabolic capacity and efficacy of TREM2 agonism

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摘要: Triggering receptor expressed on myeloid cells 2 (TREM2) is a central regulator of microglial activity and loss-of-function coding variants are major risk factors for late onset Alzheimer’s disease (LOAD). To better understand the molecular and functional changes associated with TREM2 signalling in microglia, we generated a TREM2 reporter mouse. In APP transgenic animals, bulk RNA-sequencing of isolated microglia sorted based on reporter expression highlighted TREM2 level-related changes in…

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39 Functional variants at 1p36.23 confer risk of schizophrenia through modulating RERE

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摘要: Genome-wide association studies have identified 1p36.23 as a schizophrenia risk locus. However, the functional variants and genes driving the association remain unknown. Here, we identified two functional variants (i.e., rs159961 and rs301792) at the 1p36.23 risk locus. Both variants reside introns of RERE and exhibit allele-specific enhancer activity. Risk alleles of rs159961 and rs301792 increase enhancer activity by altering REST and POLR2A binding, leading to RERE upregulation. Consistently,…

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40 Giant near-field nonlinear electrophotonic effects in an angstrom-scale plasmonic junction

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摘要: Plasmons facilitate a strong confinement and enhancement of near-field light, offering exciting opportunities to enhance nonlinear optical responses at the nanoscale. However, despite significant advancements, the electrically tunable range of the nonlinear optical responses at nanometer-scale plasmonic structures remains limited to a few percents per volt. Here, we transcend the limitation of the nanometer regime by expanding the concept of electrophotonics into angstrom-scale platform,…

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41 Beyond suppression: the paradox of JAK inhibitors as amplifiers of cancer immunotherapy

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摘要: JAK inhibitors target a large group of cytokines that signal through the JAK-STAT pathway and are typically used clinically as immunosuppressive agents. However, recent work has demonstrated the paradoxical ability of JAK inhibitors to enhance antitumour and antiviral immune responses and established their synergy with immune checkpoint inhibitors in early-stage clinical trials. In this Perspective, we consider why JAK inhibitors, which are typically used as immunosuppressive drugs, can have…

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42 Epidermal growth factor receptor controls sex differences in lung type 2 responses to inhaled allergen

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摘要: Hormonal disruptions are associated with poor asthma control in females, yet how these phenomena are linked remains unknown. Here, we investigated distinct allergen-induced immune responses between the sexes during maturation. By 6 weeks of life, female mice exposed to the aeroallergen house dust mite (HDM) from postnatal day 7 exhibited stronger type 2 (T2) immune responses and higher lung interleukin-33 (IL-33) than males. IL-33 administration to HDM-sensitized males was sufficient to augment…

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43 Transient disruption of T cell help impairs germinal center dynamics and memory responses

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摘要: T follicular helper (T(FH)) cells are essential for germinal center (GC) formation and long-lived humoral immunity. Here, we used an Il21 fate mapping (Il21-fm) strategy to remove T(FH) cells from established GCs to disentangle their function from that of other T cells in a temporal manner. We confirm their role in driving proliferation and positive selection of GC B cells but show that GCs can survive the transient absence of T(FH) cells. After ablation of T(FH) cells, both the GC response and…

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