追觅 - 2026-01-26

生成时间: 2026−01-26 22:33

分析文章数量: 63

1 Pharmacological inhibition of histone Lactylation enhances immunotherapy efficacy in gastrointestinal cancers

推荐理由: 该文揭示了组蛋白乳酸化在肿瘤代谢与免疫抑制中的关键作用，对理解免疫治疗耐药机制具有创新价值，值得血液学研究者关注其潜在的表观遗传调控机制。

摘要: Although immunotherapy has reshaped the treatment landscape for gastrointestinal (GI) malignancies, durable clinical benefit is achieved in only a subset of patients, largely due to the emergence of immune resistance. Accumulating evidence highlights histone lactylation, an epigenetic modification driven by excessive lactate accumulation, as a pivotal mediator linking tumor metabolism to immune suppression. By reprogramming transcriptional networks within the tumor microenvironment, histone…

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2 Reduced methane emissions in transgenic rice genotypes are associated with altered rhizosphere microbial hydrogen cycling

推荐理由: 该研究创新性强，展示了通过植物基因改造显著降低稻田甲烷排放，对气候治理和农业可持续发展具有重要意义，虽与血液疾病关联不大，但在环境与基因工程领域值得一读。

摘要: Rice paddies significantly contribute to atmospheric methane (CH(4)). Here, we show that two independent rice genotypes overexpressing genes for PLANT PEPTIDES CONTAINING SULFATED TYROSINE (PSY) reduce cumulative CH(4) emissions by 38% (PSY1) and 58% (PSY2) over 70 days of growth compared with controls. Genome-resolved metatranscriptomic data from PSY rhizosphere soils reveal lower ratios of gene activities for (mostly hydrogenotrophic) CH(4) production versus consumption, decreased activity of…

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3 The network architecture of general intelligence in the human connectome

推荐理由: 该研究利用大规模人类连接组数据，提出并验证了网络神经科学理论，对理解智力的脑机制具有创新价值，值得关注。

摘要: Advances in network neuroscience challenge the view that general intelligence (g) emerges from a primary brain region or network. Network Neuroscience Theory (NNT) proposes that g arises from coordinated activity across the brain’s global network architecture. We tested predictions from NNT in 831 healthy young adults from the Human Connectome Project. We jointly modeled the brain’s structural topology and intrinsic functional covariation patterns to capture its global topological organization….

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4 Reprogramming Host Histone Modifications by Bacterial Pathogens

推荐理由: 该综述系统阐述了细菌如何通过表观遗传机制调控宿主细胞，对理解感染与免疫调节具有参考价值，但与血液疾病的直接关联较少，适合对感染免疫学感兴趣的血液学研究者阅读。

摘要: Bacterial pathogens have evolved sophisticated strategies to manipulate host cellular processes, ensuring survival, replication, and long-term persistence. Beyond classical immune signaling, emerging evidence highlights the central role of epigenetic regulation in host-pathogen interactions. Pathogens exploit host chromatin through two principal mechanisms: (1) direct modification of histones by bacterial effector proteins with intrinsic enzymatic activities and (2) indirect modulation of host…

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5 Tumour endothelial cells in cancer: Chemo-physical crosstalk and angiogenic signalling in the tumour microenvironment

推荐理由: 该文系统阐述了肿瘤微环境的化学‑机械相互作用，对理解实体瘤的进展有帮助，但与血液疾病的直接关联较少，阅读价值适中。

摘要: The tumour microenvironment (TME) represents a complex, dynamic ecosystem comprising cellular and acellular elements that collectively facilitate tumour progression, invasion, and metastasis through intricate chemo-mechanical interactions. Cancer cells drive TME remodelling by recruiting and reprogramming stromal components, including cancer-associated fibroblasts (CAFs) that alter extracellular matrix (ECM) composition and stiffness, tumour-associated macrophages (TAMs) that promote…

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6 Role of the lipid matrix in the action of local anesthetics

推荐理由: 该研究通过固态核磁共振等高水平技术系统阐明局部麻醉剂与膜的相互作用，方法新颖且数据可靠，对药理学和麻醉剂安全性研究具有参考价值，值得血液学研究者了解其实验思路。

摘要: The binding of local anesthetics (LAs) to cell membranes is required for LAs to reach the target ion channels, but lipid interactions may also play a role in a purely membrane-mediated mode of activity. Here, we used solid-state NMR and further biophysical techniques to characterize the effect of six LAs covering a wide range of structures and properties (benzocaine, bupivacaine, mepivacaine, lidocaine, procaine, QX-314) on membranes. Membrane partitioning log D values (between 2.1 and 3.7)…

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7 Metabolic dysfunction-associated steatotic liver disease and steatohepatitis-associated hepatocarcinoma preclinical models

推荐理由: 该文系统评估了代谢功能障碍相关脂肪性肝病的模型与机制，对肝脏代谢研究有价值，但与血液疾病关联度较低，阅读价值适中。

摘要: Metabolic dysfunction-associated steatotic liver disease (MASLD) encompasses liver steatosis and metabolic dysfunction-associated steatohepatitis (MASH), which can result in fibrosis and/or cirrhosis and increase the risk of hepatocellular carcinoma (HCC). The latest Clinical Practice Guidelines acknowledge the importance of systemic metabolic dysfunction as a driver of hepatic lipid accumulation and disease progression. To ensure translational relevance of preclinical models, they need to…

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8 Von Willebrand Factor Deficiency Impairs Angiogenesis via Angiopoietin-2: Relevance for Gut Angiodysplasia

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摘要: Management of recurrent gastrointestinal (GI) bleeding is a clinical unmet need for patients with Von Willebrand disease (VWD) and is linked to the presence of gut vascular malformations (angiodysplasia). We previously demonstrated that von Willebrand factor (VWF) regulates angiogenesis and vascular integrity. VWF controls the storage of the angiogenesis regulator Angiopoietin-2 (Angpt-2) in endothelial cells (EC), suggesting a candidate for the genesis of angiodysplasia; however, no direct…

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9 Oncogenic SF3B1 mutations alter the splicing of mRNA noncoding regions to induce a novel therapeutic vulnerability

推荐理由: 评分失败，请手动查看

摘要: Oncogenic mutations of SF3B1 are common in myeloid cancers, chronic lymphocytic leukemia (CLL) and select solid tumors. Their mechanistic basis for promoting oncogenesis has been investigated in detail, with the stereotyped missplicing of mRNA protein coding sequences most intensively studied. These changes, in genes such as MAP3K7, BRD9, and ABCB7, typically lead to loss-of-function, thus contributing to cancer pathogenesis.Here we systematically analyzed the impact of mutant SF3B1 on…

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10 Age-associated increases in PAI-1 silenced with siRNA-lipid nanoparticles reduces thrombosis and prolongs lifespan

推荐理由: 评分失败，请手动查看

摘要: Plasminogen activator inhibitor 1 (PAI-1) is an inhibitor of fibrinolysis, thereby promoting blood clot stabilization. PAI-1 contributes to thrombosis, diet-induced obesity, and age-associated diseases such as diabetes, cancer, and Alzheimer’s disease. Circulating PAI-1 increases with age, contributing to the increased thrombotic risk in age-related diseases. In contrast, partial PAI-1 deficiency protects patients from cardiovascular morbidity and extends lifespan. Decreasing circulating PAI-1…

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11 DNA methylation matters: methylation of the γ-globin (HBG) gene promoters is required for postnatal silencing of HbF

推荐理由: 评分失败，请手动查看

摘要: Expression of a sufficient level of fetal hemoglobin (HbF), which is normally silenced after birth, can ameliorate the pathophysiologic basis of both sickle cell disease (SCD) and b-thalassemia postnatally. DNA methylation has been posited for many years to mediate silencing of HbF expression, but its role has been somewhat controversial. Recent publications provide definitive evidence for the critical role of HBG gene promoter methylation in silencing as well as providing insight into the…

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12 Anti-CD4 Antibody-modulated Transplants for GVHD Prevention in Hematopoietic Cell Transplantation

推荐理由: 评分失败，请手动查看

摘要: Graft-versus-host disease (GvHD) remains one of the major complications following allogeneic haematopoietic cell transplantation. Currently, immunosuppressants are used for GvHD prophylaxis and treatment in the majority of transplant recipients. Due to their systemic, non-specific mode of action, this treatment regimen is frequently associated with severe toxic side effects, opportunistic infections as well as cancer relapse when treating haematologic malignancies. By using short-term ex vivo…

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13 GATA1 N-terminus coordinates metabolic reprogramming in erythropoiesis

推荐理由: 评分失败，请手动查看

摘要: Mutations in GATA1 that cause skipping of exon 2, which encodes the N-terminus, are associated with the myeloid leukemia of Down syndrome and Diamond-Blackfan anemia (DBA). To elucidate the molecular function of this N-terminal region, we employed single-cell RNA sequencing (scRNA-seq) on fetal liver cells from Gata1 mutant embryos that express only the short isoform of GATA1 (GATA1s) lacking the N-terminus of full-length GATA1 (GATA1FL). scRNA-seq revealed defects in erythropoiesis and aberrant…

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14 Uncovering the genomic complexity of PAX5 intragenic tandem multiplication via long-read and short-read sequencing

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摘要: By integrating short-read WGS and RNA-seq data with long-read RNA sequencing, we dissect the complex genomic architecture of PAX5 intragenic tandem multiplication (PAX5-ITM), revealing that these complex rearrangements result in in-frame transcripts that likely encode proteins with altered domains.

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15 Heme-induced ITAM signaling exacerbates malaria-associated neuropathogenesis through activation of platelet mTOR

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摘要: Malaria, caused by Plasmodium parasites, accounts for  250 million cases and over 600,000 deaths annually. One leading cause of mortality and morbidity is cerebral malaria (CM). Platelets mediate CM pathogenesis, although the exact mechanisms remain largely unknown. We examined if the mechanistic target of rapamycin (mTOR) pathway in platelets contributes to malaria pathogenesis. Our results demonstrate activation of the mTOR pathway in platelets ex vivo after co-incubation with Plasmodium…

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16 Current treatment decisions in cardiac transthyretin amyloidosis: a multicentre analysis

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摘要: CONCLUSIONS: In this multicentre analysis, treatment with tafamidis was initiated in about 80% of patients with newly diagnosed ATTR-CM. In most centres, treatment decisions were made by an interdisciplinary board, and the reasons for treatment decisions were similar across centres. Due to the lack of consensus criteria, our data may help to standardise decision pathways for ATTR-CM.

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17 Fermion-Selective Tests of New Physics with the Bound-Electron g Factor

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摘要: The use of high-precision measurements of the g factor of single-electron ions is considered as a detailed probe for physics beyond the standard model. The contribution of the exchange of a hypothetical force-carrying scalar boson to the g factor is calculated for the ground state of H-like ions and used to derive bounds on the parameters of that force. Similarly to the isotope shift, we employ the nuclide shift, i.e., the difference for elements with different proton and/or neutron numbers, in…

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18 Time-Dependent Hole States in Multiconfigurational Time-Dependent Hartree-Fock Approaches: A Time-Domain Generalization of Extended Koopmans’ Theorem

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摘要: We introduce a framework for resolving electron-hole dynamics within wave-function-based multiconfigurational time-dependent Hartree-Fock (MCTDHF) theory. Central to this framework is a time-domain generalization of the extended Koopmans’ theorem, which rigorously defines time-dependent hole states through single-electron removal. From this foundation, we prove the existence of exact equations of motion for time-dependent Dyson orbitals, enabling instantaneous construction of photofragments’…

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19 When Does Alzheimer’s Disease Start? Plasma Aβ42/40 Assays Show Steep Changes at Aβ-PET Centiloid 15, Mean Age of 66 Years

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摘要: OBJECTIVE: Sporadic late-onset Alzheimer’s disease (AD) is characterized by a long pre-clinical phase where amyloid-beta (Aβ) and tau begin to accumulate in the brain. The primary objective was to determine the age at which AD starts by finding the average population age when both positron emission tomography (PET) Aβ (Aβ-PET) and plasma Aβ42/40 become abnormal.

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20 Bacteriophage FNU1 negates <em>Fusobacterium nucleatum</em> induced cell growth, migration and chemotherapy resistance in gastrointestinal cancer cells

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摘要: CONCLUSION: Treatments with bacteriophage FNU1, therefore, have the potential to augment existing cancer therapy, and further testing in animal models is warranted.

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21 Gadolinium - Determination of gadolinium and its compounds in workplace air using inductively coupled plasma mass spectrometry (ICP-MS): Air Monitoring Method - Translation of the German version from 2024

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摘要: The working group “Air Analyses” of the German Senate Commission for the Investigation of Health Hazards of Chemical Compounds in the Work Area (MAK Commission) developed and verified the presented analytical method. This analytical method is a validated measurement procedure for the determination of gadolinium [7440-54-2] and its compounds in workplace air in a concentration range of one tenth up to twice of the general dust limit value for the respirable dust fraction in Germany of 1.25 mg/m³….

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22 Blinatumomab in de novo AYA ALL-Results of the Australasian Leukaemia and Lymphoma Group ALL09 “SUBLIME” study

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摘要: Pediatric regimens improve outcomes in adolescent and young adult (AYA) acute lymphoblastic leukemia (ALL) patients. End-consolidation (time point 2 [TP2]) minimal residual disease negativity (MRD^(neg)) is associated with improved survival. In this study, standard consolidation chemotherapy was replaced with blinatumomab to improve TP2 MRD^(neg)-a key survival surrogate in B-lineage ALL. From 2019 to 2022, 55 patients constituted the intention-to-treat (ITT) cohort, median age 25 (range, 16-39)…

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23 Ending HIV transmission in Europe

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摘要: No abstract

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24 Preclinical drug screen identifies WEE1 inhibitor and vinca alkaloid as a combination treatment concept for Li-Fraumeni syndrome medulloblastoma

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摘要: Li-Fraumeni syndrome (LFS) is characterized by constitutional pathogenic TP53 mutation and increased risk of cancer development, including Sonic Hedgehog-activated medulloblastoma (SHH-MB). In LFS patients, radiation and DNA-damaging agents can exhibit lower efficiency and cause secondary malignancies. To identify efficacious, safe chemotherapeutic approaches for LFS-associated SHH-MB, 333 compounds were screened in in vitro TP53^(mut) brain tumor cell lines. The combination of WEE1 inhibitor…

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25 Advanced human organoid-on-chip with physiological cellular complexity reveals bidirectional secretion patterns

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摘要: Intestinal epithelial cells are essential for maintaining gut homeostasis, serving as a physical barrier separating luminal content from the immune compartment. They are crucial for balancing tolerance to commensal and protection from pathogenic bacteria and dietary antigens by the asymmetric secretion of immune regulators. To understand how different epithelial cell types and external stimuli shape this secretion pattern, we established and characterized a human intestinal organoid-on-chip…

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26 1,4-Butanediol - Determination of 1,4-butanediol in workplace air using gas chromatography (GC-FID): Air Monitoring Method - Translation of the German version from 2025

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摘要: The working group “Air Analyses” of the German Senate Commission for the Investigation of Health Hazards of Chemical Compounds in the Work Area (MAK Commission) developed and verified the presented analytical method. It is used to determine the levels of 1,4-butanediol [110-63-4] in workplace air. The method covers concentrations in the range from one hundredth up to twice the current occupational exposure limit value (OELV) of 200 mg/m³. The method is also suitable for monitoring compliance…

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27 Nitrogen dioxide - Determination of nitrogen dioxide in the workplace air using ion chromatography (IC): Air Monitoring Method - Translation of the German version from 2025

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摘要: The working group “Air Analyses” of the German Senate Commission for the Investigation of Health Hazards of Chemical Compounds in the Work Area (MAK Commission) developed and verified the presented analytical method. It is used to determine the levels of nitrogen dioxide [10102-44-2] that occur in the workplace air. The method covers concentrations in the range from one tenth up to twice the current occupational exposure limit value (OELV) of 0.95 mg/m³ (0.5 ml/m³). Samples are collected by…

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28 Cardiac conduction abnormalities in myotonic dystrophy type I: The ongoing value of the ECG

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摘要: No abstract

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29 Spatial Profiling and Prognostic Role of Tumor-Infiltrating CD8+ T and CD20+ B Cells in Metastatic Clear Cell Renal Cell Carcinoma Treated with Sequential Tyrosine Kinase Inhibitors and Nivolumab

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摘要: Background: Tumor-infiltrating lymphocytes (TILs) are known to influence disease progression and treatment response in clear cell renal cell carcinoma. This study aimed at evaluating the prognostic and predictive relevance of T and B cell infiltration patterns in patients with metastatic clear cell renal cell carcinoma (mRCC-cc) treated sequentially with tyrosine kinase inhibitors (TKIs) and the immune checkpoint inhibitor nivolumab. Methods: In this retrospective cohort study, immune cell…

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30 Mainzelliste: Ten years of pseudonymization, record linkage, and informed consent management

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摘要: Record linkage and pseudonymization are crucial tasks in collaborative biomedical research. Data for a patient are rarely stored in one place and therefore often need to be linked and integrated across multiple institutions. Mainzelliste is an open-source software solution designed to solve these challenges by providing a comprehensive and flexible toolkit for pseudonymization, record linkage, and consent management. It supports a variety of pseudonyms, record linkage methods, and modular,…

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31 X-ray contrast-adjustable 3D printing for multimodal fusion of microCT and histology

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摘要: CONCLUSIONS: The novel methodology of using contrast agents and resin in 3D printing enables the generation of customizable, contrast-specific phantoms and reference structures. These can be straightforwardly segmented from the embedding material, significantly simplifying and enhancing the workflow of multimodal imaging processes. In this study, 3D printed conic reference structures were effectively used to automate and streamline the precise multimodal fusion of microCT and histological…

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32 Abdominal-based vs. alternative flaps: Surgical outcomes and quality of life following different techniques of autologous breast reconstruction

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摘要: Abdominal-based flaps are considered the gold standard for autologous breast reconstruction (ABR). With the increasing number of women undergoing mastectomy, however, alternative free flaps from other regions have emerged as valuable alternatives when patients do not qualify for an abdominal-based flap. This single-center cohort study evaluates objective and subjective outcomes in patients who underwent abdominal-based versus alternative flaps for breast reconstruction. Patients who underwent…

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33 Obesity surgery improves metabolic dysfunction-associated steatotic liver disease and type 2 diabetes - MRI and biochemical analysis of liver and pancreas

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摘要: CONCLUSION: Obesity surgery reduced liver volume, type 2 diabetes, fat content of liver and pancreas and improved indicators of MASLD. No significant difference in outcome between operation methods could be established.

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34 Factors Influencing the Inter-Country Movement Intentions of Future Dentists in Ireland: A Cross-Sectional Study

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摘要: CONCLUSION: The majority of international dental students in Ireland are aiming to pursue their dental career in their home countries due to better economic conditions and living standards. These findings suggest that Irish policymakers and educational institutions might need to consider new approaches for the retention of newly graduating dentists.

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35 Integrated treatment-decision algorithms for childhood TB: modelling diagnostic performance and costs

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摘要: CONCLUSION: The TDAs have high sensitivity and can be implemented at PHCs with lower costs than DHs. Improving specificity and reducing treatment costs would enable affordable, large-scale implementation.

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36 Toxic Erythema of Chemotherapy

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摘要: No abstract

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37 The Hypertension Control Paradox - Why Is America Stuck?

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摘要: No abstract

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38 Inheritance

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摘要: No abstract

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39 Medicare’s Role in Fighting Chronic Disease

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摘要: No abstract

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40 Oncogenic SF3B1 mutations alter the splicing of mRNA noncoding regions to induce a novel therapeutic vulnerability

推荐理由: 评分失败，请手动查看

摘要: Oncogenic mutations of SF3B1 are common in myeloid cancers, chronic lymphocytic leukemia (CLL) and select solid tumors. Their mechanistic basis for promoting oncogenesis has been investigated in detail, with the stereotyped missplicing of mRNA protein coding sequences most intensively studied. These changes, in genes such as MAP3K7, BRD9, and ABCB7, typically lead to loss-of-function, thus contributing to cancer pathogenesis.Here we systematically analyzed the impact of mutant SF3B1 on…

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41 Frontiers of cytokine engineering in CAR cell therapy for cancer

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摘要: Chimeric antigen receptor (CAR)-engineered T (CAR-T) cell therapy has revolutionized the treatment of hematologic malignancies, yet its efficacy in solid tumors remains limited by T cell exhaustion, restricted tumor infiltration, and an immunosuppressive tumor microenvironment (TME). Recent advances in cytokine engineering have introduced innovative strategies to overcome these barriers by modulating CAR cell survival, persistence, and cytotoxic function. This review provides a comprehensive…

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42 From innate-like to innate: the next wave of off-the-shelf CAR immunotherapies

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摘要: While autologous CAR T-cell therapies have revolutionized the treatment of hematologic malignancies, their widespread application is hindered by manufacturing complexities, high costs, and limited efficacy against solid tumors due to antigen heterogeneity and the TME. Moreover, the logistical burden of bespoke patient-specific manufacturing restricts global scalability. In response, the immunotherapy landscape is pivoting toward “off-the-shelf” allogeneic therapies derived from innate and…

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43 GATA1 N-terminus coordinates metabolic reprogramming in erythropoiesis

推荐理由: 评分失败，请手动查看

摘要: Mutations in GATA1 that cause skipping of exon 2, which encodes the N-terminus, are associated with the myeloid leukemia of Down syndrome and Diamond-Blackfan anemia (DBA). To elucidate the molecular function of this N-terminal region, we employed single-cell RNA sequencing (scRNA-seq) on fetal liver cells from Gata1 mutant embryos that express only the short isoform of GATA1 (GATA1s) lacking the N-terminus of full-length GATA1 (GATA1FL). scRNA-seq revealed defects in erythropoiesis and aberrant…

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44 Lactylation in post-stroke fatigue: linking metabolic dysregulation to neuroinflammation

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摘要: Lactylation, a recently identified post-translational modification derived from lactate, has emerged as a key immunometabolic regulator in neurological disorders. In the context of ischemic stroke, abnormal lactate accumulation not only reflects energy metabolism dysfunction but also drives protein lactylation, which dynamically influences neuronal survival, glial activation, and neuroinflammatory cascades. Increasing evidence indicates that lactylation modulates transcriptional programs of…

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45 Lactylation in cancer: mechanistic insights, tumor microenvironment, and therapeutic horizons

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摘要: The discovery of lactylation, a post-translational modification derived from lactate, has fundamentally altered the perception of cancer metabolism. Once regarded as a metabolic waste product, lactate is now recognized as a central fuel source, a signaling molecule, and an epigenetic substrate capable of reprogramming gene expression and cellular function. Lactylation integrates metabolic reprogramming, tumor plasticity, and immune suppression, thereby orchestrating cancer initiation,…

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46 Lactylation Plays a Novel Role in the Tumor Microenvironment and its Prognostic Implications for Breast Cancer

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摘要: CONCLUSION: Our findings highlight the potential of lactylation-associated genes, particularly XRCC4, in BC progression and clinical treatment strategies. The development of an XRCC4 inhibitor may be eligible for patent protection and could potentially serve as a novel therapeutic option for BC.

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47 Performance of endoscopic submucosal dissection and submucosal tunneling endoscopic resection for esophageal submucosal tumors: A multicenter retrospective cohort study

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摘要: CONCLUSIONS: ESD and STER are effective and safe for ESTs, with high en bloc resection rates, minimal adverse events and very low recurrence during short-term follow up. These findings support the broader adoption of advanced endoscopic resection, which is transforming the management of ESTs from surgical to endoscopic treatment.

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48 Von Willebrand Factor Deficiency Impairs Angiogenesis via Angiopoietin-2: Relevance for Gut Angiodysplasia

推荐理由: 评分失败，请手动查看

摘要: Management of recurrent gastrointestinal (GI) bleeding is a clinical unmet need for patients with Von Willebrand disease (VWD) and is linked to the presence of gut vascular malformations (angiodysplasia). We previously demonstrated that von Willebrand factor (VWF) regulates angiogenesis and vascular integrity. VWF controls the storage of the angiogenesis regulator Angiopoietin-2 (Angpt-2) in endothelial cells (EC), suggesting a candidate for the genesis of angiodysplasia; however, no direct…

—

49 Oncogenic SF3B1 mutations alter the splicing of mRNA noncoding regions to induce a novel therapeutic vulnerability

推荐理由: 评分失败，请手动查看

摘要: Oncogenic mutations of SF3B1 are common in myeloid cancers, chronic lymphocytic leukemia (CLL) and select solid tumors. Their mechanistic basis for promoting oncogenesis has been investigated in detail, with the stereotyped missplicing of mRNA protein coding sequences most intensively studied. These changes, in genes such as MAP3K7, BRD9, and ABCB7, typically lead to loss-of-function, thus contributing to cancer pathogenesis.Here we systematically analyzed the impact of mutant SF3B1 on…

—

50 Age-associated increases in PAI-1 silenced with siRNA-lipid nanoparticles reduces thrombosis and prolongs lifespan

推荐理由: 评分失败，请手动查看

摘要: Plasminogen activator inhibitor 1 (PAI-1) is an inhibitor of fibrinolysis, thereby promoting blood clot stabilization. PAI-1 contributes to thrombosis, diet-induced obesity, and age-associated diseases such as diabetes, cancer, and Alzheimer’s disease. Circulating PAI-1 increases with age, contributing to the increased thrombotic risk in age-related diseases. In contrast, partial PAI-1 deficiency protects patients from cardiovascular morbidity and extends lifespan. Decreasing circulating PAI-1…

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51 DNA methylation matters: methylation of the γ-globin (HBG) gene promoters is required for postnatal silencing of HbF

推荐理由: 评分失败，请手动查看

摘要: Expression of a sufficient level of fetal hemoglobin (HbF), which is normally silenced after birth, can ameliorate the pathophysiologic basis of both sickle cell disease (SCD) and b-thalassemia postnatally. DNA methylation has been posited for many years to mediate silencing of HbF expression, but its role has been somewhat controversial. Recent publications provide definitive evidence for the critical role of HBG gene promoter methylation in silencing as well as providing insight into the…

—

52 Anti-CD4 Antibody-modulated Transplants for GVHD Prevention in Hematopoietic Cell Transplantation

推荐理由: 评分失败，请手动查看

摘要: Graft-versus-host disease (GvHD) remains one of the major complications following allogeneic haematopoietic cell transplantation. Currently, immunosuppressants are used for GvHD prophylaxis and treatment in the majority of transplant recipients. Due to their systemic, non-specific mode of action, this treatment regimen is frequently associated with severe toxic side effects, opportunistic infections as well as cancer relapse when treating haematologic malignancies. By using short-term ex vivo…

—

53 GATA1 N-terminus coordinates metabolic reprogramming in erythropoiesis

推荐理由: 评分失败，请手动查看

摘要: Mutations in GATA1 that cause skipping of exon 2, which encodes the N-terminus, are associated with the myeloid leukemia of Down syndrome and Diamond-Blackfan anemia (DBA). To elucidate the molecular function of this N-terminal region, we employed single-cell RNA sequencing (scRNA-seq) on fetal liver cells from Gata1 mutant embryos that express only the short isoform of GATA1 (GATA1s) lacking the N-terminus of full-length GATA1 (GATA1FL). scRNA-seq revealed defects in erythropoiesis and aberrant…

—

54 Uncovering the genomic complexity of PAX5 intragenic tandem multiplication via long-read and short-read sequencing

推荐理由: 评分失败，请手动查看

摘要: By integrating short-read WGS and RNA-seq data with long-read RNA sequencing, we dissect the complex genomic architecture of PAX5 intragenic tandem multiplication (PAX5-ITM), revealing that these complex rearrangements result in in-frame transcripts that likely encode proteins with altered domains.

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55 Heme-induced ITAM signaling exacerbates malaria-associated neuropathogenesis through activation of platelet mTOR

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摘要: Malaria, caused by Plasmodium parasites, accounts for  250 million cases and over 600,000 deaths annually. One leading cause of mortality and morbidity is cerebral malaria (CM). Platelets mediate CM pathogenesis, although the exact mechanisms remain largely unknown. We examined if the mechanistic target of rapamycin (mTOR) pathway in platelets contributes to malaria pathogenesis. Our results demonstrate activation of the mTOR pathway in platelets ex vivo after co-incubation with Plasmodium…

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56 GATA1 N-terminus coordinates metabolic reprogramming in erythropoiesis

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摘要: Mutations in GATA1 that cause skipping of exon 2, which encodes the N-terminus, are associated with the myeloid leukemia of Down syndrome and Diamond-Blackfan anemia (DBA). To elucidate the molecular function of this N-terminal region, we employed single-cell RNA sequencing (scRNA-seq) on fetal liver cells from Gata1 mutant embryos that express only the short isoform of GATA1 (GATA1s) lacking the N-terminus of full-length GATA1 (GATA1FL). scRNA-seq revealed defects in erythropoiesis and aberrant…

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57 Lactylation in post-stroke fatigue: linking metabolic dysregulation to neuroinflammation

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摘要: Lactylation, a recently identified post-translational modification derived from lactate, has emerged as a key immunometabolic regulator in neurological disorders. In the context of ischemic stroke, abnormal lactate accumulation not only reflects energy metabolism dysfunction but also drives protein lactylation, which dynamically influences neuronal survival, glial activation, and neuroinflammatory cascades. Increasing evidence indicates that lactylation modulates transcriptional programs of…

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58 Lactylation in cancer: mechanistic insights, tumor microenvironment, and therapeutic horizons

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摘要: The discovery of lactylation, a post-translational modification derived from lactate, has fundamentally altered the perception of cancer metabolism. Once regarded as a metabolic waste product, lactate is now recognized as a central fuel source, a signaling molecule, and an epigenetic substrate capable of reprogramming gene expression and cellular function. Lactylation integrates metabolic reprogramming, tumor plasticity, and immune suppression, thereby orchestrating cancer initiation,…

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59 Lactylation Plays a Novel Role in the Tumor Microenvironment and its Prognostic Implications for Breast Cancer

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摘要: CONCLUSION: Our findings highlight the potential of lactylation-associated genes, particularly XRCC4, in BC progression and clinical treatment strategies. The development of an XRCC4 inhibitor may be eligible for patent protection and could potentially serve as a novel therapeutic option for BC.

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60 A phase I/IIa study of auceliciclib in patients with advanced solid tumours and in combination with temozolomide in patients with recurrent/relapsed high-grade glioma

推荐理由: 该研究聚焦于高等级胶质瘤的CDK抑制剂临床一期试验，与血液疾病关联度低，除非关注跨学科的药物开发，否则阅读价值有限。

摘要: CONCLUSIONS: Auceliciclib was well tolerated, and demonstrated dose-dependent pharmacokinetics and preliminary clinical activity in heavily pretreated patients. Recommended phase II doses are 500 mg twice daily (monotherapy) and 300 mg twice daily with 100 mg temozolomide once daily (combination therapy). These findings support further clinical development of auceliciclib for high-grade glioma and other malignancies.

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61 Suppressing electron-phonon coupling and energy loss in organic solar cells by modulating donor-acceptor penetrated-interface

推荐理由: 该文在有机光伏材料的非辐射能量损失机制上提供了新见解，技术创新度高，但与血液疾病关联度极低，阅读价值主要限于光电材料领域。

摘要: Organic solar cells (OSCs) achieve 21% efficiency, yet non-radiative energy loss (qΔV(nr)) remains a critical barrier to further improve the open-circuit voltage (V(OC)). This loss is primarily governed by the optoelectronic properties of interfacial CT states, yet the precise role of electron-phonon coupling (EPC) is not fully resolved. Through analysis of three all-polymer OSCs and four small molecule acceptor (SMA)-based OSCs, we identify two donor-acceptor (D-A) interfacial mixed phases that…

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62 Rigid ionic-bonding networks boosting organic room temperature phosphorescence

推荐理由: 该文在离子键促进有机磷光材料方面提供了新思路，但与血液疾病关联度极低，阅读价值主要限于材料化学领域的跨学科参考。

摘要: Ionic bonds possess excellent advantages in organic phosphorescence enhancement due to their intense electrostatic interactions, non-directional, and unsaturated characteristics. Nowadays, host-guest doping is the mainstream strategy for synthesizing room-temperature phosphorescent materials. While this strategy may suffer from compatible molecular configurations between host and guest, it needs precise molecular design and synthesis. Herein, ionic alkyl chain molecules are selected as hosts to…

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63 Demonstration of measurement-free universal logical quantum computation

推荐理由: 该文在量子误差纠正与容错逻辑门操作方面提出了新工具箱，技术创新度高，但与血液疾病研究关联度极低，除非关注跨学科的量子技术应用，否则阅读价值有限。

摘要: The ability to perform quantum error correction (QEC) and robust gate operations on encoded qubits opens the door to demonstrations of quantum algorithms. Contemporary QEC schemes typically require mid-circuit measurements with feed-forward control, which are challenging for qubit control, often slow, and susceptible to relatively high error rates. In this work, we propose and experimentally demonstrate a universal toolbox of fault-tolerant logical operations on error-detecting codes without…

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