追觅 - 2026-01-28

生成时间: 2026−02-02 14:32

分析文章数量: 56

1 High-Dimensional Spatiotemporal Single-Cell Atlas and 3D imaging of Bone Marrow Microenvironment during CML Progression

推荐理由: 该研究利用高通量CODEX多重成像和3D空间分析，系统描绘了CML进程中骨髓微环境的细胞组成与动态变化，为血液肿瘤微环境机制提供了重要参考，值得血液学研究者阅读。

摘要: The bone marrow microenvironment (BMME) is essential for hematopoiesis and immunity, yet spatiotemporal single-cell analysis during leukemogenesis remains challenging. We characterized the BMME in femurs from wild-type and chronic myeloid leukemia (CML) mice at 7, 14 and 21 days post-induction by highly multiplexed and 3D microscopy. Using a 54-marker CODEX panel, we profiled 2,033,725 cells in 55 regions of interest and identified 41 cell-types. During CML progression, we observed myeloid and…

—

2 Ruxolitinib for Ciltacabtagene Autoleucel-Associated Refractory Diarrhea

推荐理由: 该研究首次探索JAK抑制剂ruxolitinib治疗BCMA CAR‑T后难治性腹泻，创新性强且与多发性骨髓瘤血液治疗直接相关，值得血液科医生关注。

摘要: Intractable diarrhea is a recently described complication following B-cell maturation antigen (BCMA)-targeted chimeric antigen receptor (CAR) T-cell therapy for multiple myeloma (MM) with reported mortality rates of 36-50%. The optimal clinical management is unknown. Here, we report a series of five patients who presented with severe diarrhea after BCMA CAR T-cell treatment. We hypothesized that the Janus kinase (JAK) inhibitor, ruxolitinib, might be an effective therapy based on its success in…

—

3 A Retrospective, Real-World Study of IV Iron Use to Treat Iron deficiency Anemia During Acute Infection

推荐理由: 该研究利用大规模真实世界数据库评估感染期间静脉铁的安全性和疗效，对血液科在贫血合并感染患者的治疗决策具有重要参考价值。

摘要: The administration of intravenous (IV) iron to treat anemia during acute infection remains controversial due to concerns of exacerbating the infection. We conducted a retrospective cohort study using the TriNetX Research Network (2000 to June 2025) to evaluate the safety and efficacy of IV iron administration in adults with iron-deficiency anemia and infection (methicillin-resistant Staphylococcus aureus [MRSA] bacteremia, pneumonia, urinary tract infection [UTI], colitis, or cellulitis)….

—

4 Homeodomain-driven oncogenic diversion to a TCRγδ phenotype in T-cell Acute Lymphoblastic Leukemia

推荐理由: 该研究系统分析了T‑ALL中γδTCR的高表达比例，揭示了γδ谱系在白血病发生中的潜在机制，对血液肿瘤的发病机制和诊疗策略具有重要参考价值。

摘要: T-cell acute lymphoblastic leukemia (T-ALL) results from the malignant transformation of thymocytes blocked in their differentiation. Surface expression of the γδ T-cell receptor (γδTCR) is surprisingly frequent in T-ALLs, questioning the susceptibility of the γδ-lineage to leukemogenesis. Among 1233 T-ALL phenotyped in our center, 33% (n=403) expressed a TCR, of which 47% (n=191 (113 adults, 78 children)) were positive for γδTCR (γδTCR+). By integrating oncogenetic, immunogenetic, phenotypic…

—

5 Distinct trajectory of measurable residual disease in t(11;14) myeloma treated with quadruplet therapy

推荐理由: 该研究聚焦t(11;14)亚型的多发性骨髓瘤，提供了QUAD诱导+自体移植及MRD适应性管理的长期疗效数据，对血液肿瘤临床实践和后续研究具有重要参考价值。

摘要: Quadruplet (QUAD) induction and autologous stem cell transplantation (ASCT) leads to high rates of measurable residual disease (MRD)-negativity with improved outcomes in multiple myeloma (MM). The t(11;14) confers unique biology and different kinetics of treatment response. We analyzed MRD trajectories of patients treated with QUAD/ ASCT and MRD-adapted post ASCT management. Of the 302 patients assessed, 47 (16%) had t(11;14)+. Median follow up was 45.8 months. MRD negativity (10-5) for…

—

6 Exosite-mediated targeting of GSDMB by dimeric granzyme A in lymphocyte pyroptotic killing

推荐理由: 该研究首次阐明了GZMA与GSDMB的高亲和结合机制及其结构基础，为细胞毒性淋巴细胞介导的细胞死亡提供了新视角，对血液肿瘤免疫治疗具有参考价值。

摘要: In cellular immunity, cytotoxic lymphocytes employ granzyme A (GZMA) to cleave and activate the pore-forming protein gasdermin B (GSDMB) for the pyroptotic killing of target cells. How GZMA recognizes and cleaves GSDMB is unknown. Here, we show that human GZMA targets GSDMB via specific, high-affinity binding to its autoinhibitory GSDMB-C domain. This binding requires the dimerization of GZMA, a unique property among human granzymes. A crystal structure of the GZMA-GSDMB-C complex shows a 2:2...

—

7 The C/EBPα-(PU.1-LOUP) regulatory circuit regulates monocyte/macrophage development and immune functions

推荐理由: 该研究首次系统阐明PU.1/C/EBPα对非编码调控RNA的调控网络，对理解髓系恶性疾病的分子机制具有重要借鉴价值，值得血液学研究者阅读。

摘要: The myeloid transcription factors PU.1 and C/EBPα are essential for monocyte/macrophage development, and their dysregulation has been linked to myeloid malignancies and immune disorders. While their binding to enhancers for myeloid coding genes is established, their control of noncoding regulatory RNAs remains poorly understood. Using a comprehensive collection of putative and verified enhancers, we profiled the PU.1 cistrome and transcriptome, identifying a subset of noncoding genes that are…

—

8 Bempedoic acid directly binds and activates PPARα

推荐理由: 该研究首次揭示了降胆固醇药物bempedoic acid直接激活PPARα的机制，方法学严谨、数据可靠，值得血液学研究者了解其在脂质代谢和潜在血液疾病中的启示。

摘要: Bempedoic acid (BA) is a recently approved drug that lowers cholesterol and hepatic lipids, yet its mechanism of action remains incompletely understood. Here, we combine transcriptomic, biochemical, and structural approaches to show that BA directly binds to and activates peroxisome proliferator-activated receptor alpha (PPARα). BA treatment robustly induced PPARα signaling and fatty acid oxidation in primary hepatocytes and mouse liver. Through X-ray crystallography, we uncovered that BA binds…

—

9 A spatially resolved atlas of gastric cancer characterises a lymphocyte-aggregated region

推荐理由: 该研究创新性强，结合单细胞与空间转录组解析胃癌免疫微环境，对免疫治疗机制提供重要线索，值得血液学研究者了解其方法与发现。

摘要: The tumour microenvironment is a focal point in cancer immunotherapy: its cellular composition and spatial organisation can affect the clinical outcomes of cancer patients. By integrating single-cell and spatial transcriptomics, we identify four spatial regions and survey how cellular spatial distribution varies across them in gastric cancer. One region, the Lymphocyte Aggregated Region, consists of lymphocyte aggregates and tertiary lymphoid structures. Within it, we observe associations…

—

10 The functional landscape of alternative splicing in hematopoietic lineage commitment

推荐理由: 该研究系统梳理了多物种胎儿造血器官的可变剪接图谱，为血液发育及相关疾病的分子机制提供了重要参考价值，值得血液学研究者阅读。

摘要: Alternative splicing (AS) is a ubiquitous post-transcriptional regulatory mechanism, that has greatly expanded the transcriptomic and proteomic diversity in vertebrates. While gene regulation of hematopoiesis has been extensively researched in vertebrates, the functions of species- and cell lineage-specific splice variants in vertebrates are largely unknown. Here, we curate transcriptomic data on fetal hematopoietic organ development in six vertebrates and hematopoietic cell differentiation in…

—

11 Lactate and lactylation in macrophage polarization of sepsis

推荐理由: 文章揭示了乳酸在免疫细胞代谢及组蛋白乳酸化中的新机制，对理解败血症及相关血液免疫调节具有启发意义，值得一读。

摘要: Sepsis, which is characterized by potentially fatal multiple organ dysfunction, is caused by an abnormal host response to a major infection. During sepsis, the pathogen stimulates the host to activate resistance mechanisms that enhance immune cells’ oxygen consumption in inflammatory tissues and cells, and promote aerobic glycolysis. Lactate generated by aerobic glycolysis is an essential substrate for the tricarboxylic acid cycle and for post-translational modifications via histone lactylation…

—

12 An adaptive, continuous-learning framework for clinical decision-making from proteome-wide biofluid data

推荐理由: 该文提出的ADAPT‑MS框架在临床蛋白质组学诊断中具备创新性，可为血液疾病的个体化检测提供思路，值得关注。

摘要: Mass spectrometry (MS)-based proteomics provides deep molecular insights from patient samples, but clinical use has been limited by missing values, static biomarker panels, and the need for targeted assay development. We present a framework - Adaptive Diagnostic Architecture for Personalized Testing by Mass Spectrometry (ADAPT-MS) - that enables direct diagnostic and prognostic interpretation of discovery-mode proteomics data at the level of individual samples. ADAPT-MS dynamically retrains…

—

13 Unlocking enzymatic deracemization of structurally diverse allenes by designed photoenzymes

推荐理由: 该文报道了新型光酶实现全反应物的高选择性去旋光，创新性强、方法学严谨，对有机合成和药物化学具有重要参考价值。虽然与血液疾病关联不大，但对探索新型催化剂机制的研究者仍具借鉴意义。

摘要: Precise three-dimensional arrangements of atoms and functional groups govern molecular reactivity and biological function, making stereocontrol a central goal in modern organic and medicinal chemistry. Yet reconciling broad substrate generality with high enantioselectivity remains a core limitation of enantioselective catalysis, motivating the pursuit of privileged chiral catalysts. Here we design a new-to-nature photoenzyme that unlocks enzymatic deracemization of structurally diverse allenes,…

—

14 Ether lipids influence cancer cell fate by modulating iron uptake

推荐理由: 该研究揭示了以太脂质调控膜张力促进癌细胞转移和干性特征的全新机制，创新性强，对肿瘤生物学具有重要参考价值。虽然与血液疾病关联有限，但对理解肿瘤微环境的生物物理学提供了可借鉴的思路。

摘要: Cancer cell fate has been widely ascribed to mutational changes within protein-coding genes associated with tumor suppressors and oncogenes. In contrast, the mechanisms through which the biophysical properties of membrane lipids influence cancer cell survival, dedifferentiation and metastasis have received little scrutiny. Here, we report that cancer cells endowed with high metastatic ability and cancer stem cell-like traits employ ether lipids to maintain low membrane tension and high membrane…

—

15 Structural basis and pathological implications of the dimeric OS9-SEL1L-HRD1 ERAD Core Complex

推荐理由: 该研究提供了哺乳动物ERAD核心复合物的高分辨率结构，对理解细胞内蛋白质质量控制机制具有重要价值，虽与血液疾病关联不直接，但可为相关信号通路的血液学研究提供结构参考。

摘要: The SEL1L-HRD1 complex represents the most conserved branch of endoplasmic reticulum (ER)-associated degradation (ERAD), a critical quality-control pathway that clears misfolded ER proteins. However, the molecular organization and pathogenic mechanisms of mammalian ERAD have remained elusive. Here, we report the cryo-EM structure of the core mammalian ERAD complex, comprising the ER lectin OS9, SEL1L, and the E3 ubiquitin ligase HRD1. The structure, validated by mutagenesis and crosslinking…

—

16 Kynurenine mediates the chemotherapy-induced intestinal toxicity through modulation of gut microbiota

推荐理由: 该研究揭示了IDO1介导的L‑kynurenine升高与化疗肠道毒性之间的关联，创新性强且方法严谨，对理解化疗副作用及其在血液系统（尤其是髓系细胞功能）中的潜在影响具有参考价值。

摘要: Chemotherapy-induced intestinal toxicity is a major dose-limiting complication, but the underlying mechanisms linking systemic metabolism to localized gut damage are poorly understood. Here we show that serum L-kynurenine, a tryptophan metabolite, is elevated in patients with severe oxaliplatin-induced intestinal toxicity. Accumulation of L-kynurenine is driven by IFNγ-mediated induction of indoleamine 2,3-dioxygenase 1 (IDO1) in myeloid cells. Using scRNA-seq and myeloid cell-specific knockout…

—

17 Sensight enables quantitative multivariate engineering of high-performance chemical imaging tools

推荐理由: 该文提出的 Sensight 框架在化学成像探针的设计与优化上具备创新性和较强的预测能力，对血液学中需要高灵敏度细胞成像的研究具有一定借鉴价值。

摘要: Chemical imaging probes enable the visualization of dynamic biology; however, engineering high sensitivity in live cells remains challenging. Here we present Sensight, a quantitative multivariate framework that integrates key photophysical and physicochemical descriptors to predict and optimize probe performance. Using a structurally diverse library, we identify five dominant parameters, define their optimal ranges, and unify them into a radar map representation with strong predictive power and…

—

18 Cryo-EM structures of human ClpXP reveal mechanisms of assembly and proteolytic activation

推荐理由: 该研究通过高分辨率冷冻电镜阐明了人类ClpXP复合体的组装机制，技术创新性强，对理解线粒体蛋白质质量控制具有重要价值，值得血液学研究者了解其潜在的线粒体功能关联。

摘要: The human ClpXP complex (hClpXP) orchestrates mitochondrial protein quality control through targeted degradation of misfolded and unnecessary proteins. While bacterial ClpXP systems are well characterized, the assembly and regulation of human ClpXP remain poorly understood. In this study, we elucidate the complete assembly pathway of hClpXP through high-resolution cryo-electron microscopy (cryo-EM) structures. Our findings confirm that hClpP exists as a single-ring heptamer in isolation and…

—

19 Abiotic sugar enantiomers in the CI carbonaceous chondrite Orgueil

推荐理由: 该研究首次在陨石中同步检测糖类和氨基酸的对映体，创新性强，对生命起源和天体化学具有重要参考价值，值得一读。

摘要: The uneven detection of prebiotic organic compounds in meteorites-where amino acids and nucleobases are commonly identified but sugars remain rare and poorly characterized-limits our understanding of extraterrestrial organic chemistry. This discrepancy is striking given that laboratory simulations of interstellar ice chemistry readily produce complex sugars. Here we report the simultaneous analysis of sugar and amino acid enantiomers in a meteorite sample. Multiple aldoses were detected in the…

—

20 Ammonia oxidizers offset acidification stress via adaptive substrate affinity in aquatic ecosystems

推荐理由: 该研究揭示了酸化条件下氨氧化微生物通过提升底物亲和力的适应机制，创新性强且方法严谨，对环境微生物学和氮循环研究具有重要参考价值。虽然与血液疾病关联度低，但对理解微生物代谢调控的基础科学仍有借鉴意义。

摘要: Ammonia oxidation, a critical nitrogen cycle process, exhibits contradictory responses to aquatic acidification, and the underlying mechanism remains unresolved. Here, through pH manipulation experiments across diverse ecosystems and with a model ammonia-oxidizing archaea species, Nitrosopumilus maritimus strain SCM1, we discover a unifying adaptive mechanism: acidification triggers a compensatory increase in substrate affinity in ammonia-oxidizing microorganisms. This enhancement counteracts…

—

21 The glymphatic system clears amyloid beta and tau from brain to plasma in humans

推荐理由: 该研究首次在人体中通过随机交叉试验展示睡眠对淋巴系统清除AD标志物的影响，方法严谨且对阿尔茨海默病的早期诊断与干预具有重要启示。虽然与血液疾病关联有限，但对神经退行性疾病的机制研究价值突出，值得一读。

摘要: Dysfunction of the glymphatic system has been proposed as a mechanistic link between sleep disruption and Alzheimer’s disease (AD). In animal models, glymphatic impairment alone can drive AD pathology. Whether this system clears amyloid beta (Aβ) and tau in humans remains unknown. In a randomized crossover trial with 39 participants, we found that glymphatic clearance during normal sleep increased morning plasma levels of AD biomarkers compared to sleep deprivation. Participants underwent…

—

22 Engineered VPg saRNA achieves cap-independent, low-immunogenic and precise encoding of therapeutic proteins in vivo

推荐理由: 该文提出的VPg‑saRNA载体在mRNA疫苗与蛋白治疗领域具备创新性，值得血液学研究者关注其潜在的蛋白递送应用。虽然与血液疾病的直接关联有限，但其技术平台可能为血液疾病的基因或蛋白治疗提供新思路。

摘要: Self-amplifying mRNA (saRNA) vectors hold promise for the sustained expression of mRNA vaccines in vivo. However, their inherently high immunogenicity and low-fidelity replication-stemming from the RNA viral genome’s replication mechanisms-limit their efficacy as replacements or adjuncts to protein therapies. Here we report an engineered viral protein genome-linked (VPg) saRNA vector derived from a Norovirus replicon, designed for rapid loading of therapeutic protein mRNAs in vitro. The…

—

23 Mobility-driven synthetic contact matrices as a scalable solution for real-time pandemic response modeling

推荐理由: 该研究系统评估了合成接触矩阵在法国COVID-19期间的表现，对流行病建模和公共卫生决策具有参考价值，但与血液疾病关联度较低。

摘要: Accurately capturing time-varying human behavior remains a major challenge for real-time epidemic modeling and response. During the COVID-19 pandemic, synthetic contact matrices derived from mobility and behavioral data emerged as a scalable alternative to empirical contact surveys, yet their comparative performance remained unclear. Here, we systematically evaluate synthetic and empirical age-stratified contact matrices in France from March 2020 to May 2022, comparing contact patterns and their…

—

24 Lactylation Reprogramming in the Bone Infection Microenvironment Identifies PGK1 K361 as a Potential Therapeutic Target for Osteogenic Dysfunction

推荐理由: 该研究首次揭示赖氨酸乳酸化在骨感染中的异常升高，提供了新的分子机制视角，值得血液学研究者了解跨学科的最新进展。

摘要: Bone infections pose a significant global challenge in orthopedics, often leading to poor bone healing, limb dysfunction, and the need for additional surgeries. Lysine lactylation (Kla) has emerged as a novel post-translational modification, garnering considerable research attention. However, its role in bone infection remains unclear. In this study, results show that Kla levels are significantly higher in the bone tissues of infected patients than in the uninfected controls. Global Kla…

—

25 Shigella flexneri evades septin-mediated cell-autonomous immunity via protein ADP-riboxanation

推荐理由: 该研究揭示了细菌效应子如何逃避宿主的septin笼结构，对细胞自主免疫机制提供了新视角，值得血液免疫学研究者了解其潜在的跨学科启示。

摘要: Cell-autonomous immunity represents evolutionarily conserved defense mechanisms present in both immune and non-immune cells. One of such mechanisms is mediated by cytoskeletal septins that entrap cytosolic bacterial pathogens within cage-like structures. To promote infection, Shigella flexneri delivers effector proteins directly into host cells via a type III secretion system. Here we demonstrate that OspC effectors enable Shigella flexneri to evade septin cage entrapment. Mechanistically, OspC…

—

26 Large-scale capsid-mediated mobilisation of bacterial genomic DNA in the gut microbiome

推荐理由: 该研究创新性强，首次利用纳米孔测序直接解析完整的噬菌体包装DNA，对基因转移机制提供了新工具，虽与血液疾病关联不大，但对微生物与宿主相互作用的基础研究具有参考价值。

摘要: Transducing bacteriophage and gene transfer agents (GTAs) are constrained by the structural limits of their capsids, which determine the maximum length of host DNA they can package. Here, we utilise nanopore sequencing of intact, capsid-packaged DNA molecules to recover full-length reads, thereby enabling the precise identification of encapsidated DNA and its bacterial origin. This approach was validated using well-characterised transducing systems and subsequently applied to faecal viromes from…

—

27 ZFP57 is a regulator of postnatal growth and life-long health

推荐理由: 该研究揭示了ZFP57在哺乳腺中的新功能，拓展了表观遗传调控的认识，对血液疾病直接关联有限，但对理解早期营养与表观遗传的关系具有参考价值。

摘要: Early-life factors, including postnatal nutrition, shape long-term health outcomes with epigenetic effects being implicated but poorly understood in the process. Zinc-finger protein 57 (ZFP57), is an epigenetic regulator of genomic imprinting, a process controlling gene expression based on parental origin with a vital role in prenatal growth. Here, we report an imprinting-independent function of ZFP57 in postnatal resource control via the mammary gland. ZFP57 influences multiple mammary gland…

—

28 Interventional applications of a Stroke Heat Risk Prediction Model produce health benefits

推荐理由: 该研究在高温与卒中死亡的关联建模上具有创新性和较强的公共卫生意义，但与血液疾病的直接关联较弱，适合关注环境因素与脑血管疾病交叉领域的读者。

摘要: Although heat exposure increases stroke risk, targeted individualized interventions remain limited. This study develops and validates a Stroke Heat Risk Grading Prediction Model for precision intervention using 28,116 stroke deaths from 304 Chinese counties. Meteorological and stroke mortality data from 2013-2018 are analyzed with time-series methods, revealing a nonlinear temperature-mortality relationship. Four risk levels are established and validated using 2019-2022 data through…

—

29 Photo-induced selective N-N bond construction via harnessing nitrene release and transfer

推荐理由: 该文提出了创新的N‑N键构建策略，填补了现有方法的空白，对有机合成和药物研发具有潜在价值，值得关注。

摘要: Nitrogen incorporation is fundamental in organic synthesis for functional materials, pharmaceuticals, and agrochemicals. While C-N bond formation has gained great progress, N-N bond construction remains challenging: existing methods rely on prefunctionalized precursors, and direct coupling is hindered by narrow substrate scope and poor reactivity control. Although transition-metal-catalyzed nitrene strategies exhibit high efficacy for intermolecular N-H insertion, nitrene-mediated N-N coupling…

—

30 Jaceosidin Attenuates Sepsis-Induced Myocardial Dysfunction by Promoting SIRT2-Mediated Inhibition of Histone H3K18 Lactylation

推荐理由: 该研究首次探讨黄酮类化合物Jaceosidin对败血症性心肌功能障碍的保护作用，机制新颖，对心血管领域有一定参考价值，但与血液疾病关联度低，社会关注度有限。

摘要: Background: Sepsis-induced myocardial dysfunction (SIMD) is a life-threatening complication with limited therapeutic options. Jaceosidin (JAC), a natural flavonoid from Folium Artemisiae Argyi, shows potential in cardiovascular diseases, but its role and mechanism in SIMD remain unclear. This study aims to investigate the protective effects of JAC against SIMD and explore the underlying molecular mechanisms. Methods: In vitro, AC16 human cardiomyocytes were stimulated with TNF-α and treated with…

—

31 The Lactate Nexus: A Molecular Bridge Linking Physical Activity, Sleep, and Cognitive Enhancement

推荐理由: 该综述提出“乳酸枢纽”概念，对理解运动与睡眠的协同作用具有创新意义，但与血液疾病关联度较低，仅在血液代谢层面提供有限参考。

摘要: Physical activity (PA) and quality sleep are essential for cognitive health, providing synergistic protection against age-related cognitive decline. However, the shared molecular pathways that explain their combined and interactive benefits remain poorly understood. This review suggests that lactate, long dismissed as a metabolic waste product, is a unifying mechanism. We introduce the “Lactate Nexus”, a conceptual framework that proposes lactate functions as a key signalling molecule,…

—

32 Lactate Metabolism in the Intervertebral Disc: Mechanistic Insights and Pathological Implications

推荐理由: 该文揭示了椎间盘细胞代谢的新机制，对理解组织酸性微环境具有创新价值，但与血液疾病关联度低，社会关注度一般，阅读价值中等。

摘要: The intervertebral disc (IVD) is the largest avascular structure in the human body, and its nucleus pulposus (NP) cells predominantly generate large amounts of lactate through glycolysis, accompanied by an acidic microenvironment-features that represent characteristic metabolic traits of disc cells. In recent years, knowledge of the biological roles of lactate has undergone a conceptual shift. On the one hand, lactate can serve as a context-dependent auxiliary biofuel in specific regions of the…

—

33 Tumor-associated macrophages enhance peripheral nerve tumor infiltration and spinal cord repair

推荐理由: 该研究揭示了肿瘤相关巨噬细胞促进肿瘤内神经生长的新机制，创新性强、实验设计严谨，但与血液疾病关联度较低，适合对肿瘤免疫微环境感兴趣的读者参考。

摘要: Tumor-associated macrophages (TAMs) enhance cancer progression by promoting angiogenesis, extracellular matrix remodeling, and immune suppression. Nerve infiltration also contributes to tumor growth. However, the role of TAMs in promoting intratumoral nerve growth remains unclear. In this study, we have shown that TAMs express a distinct neural growth gene signature. TAMs actively enhanced neural growth within tumors and directly promoted in vitro neurite outgrowth. We identified secreted…

—

34 Biomarkers of response to neoadjuvant palbociclib plus anastrozole in endocrine-resistant estrogen receptor-positive/HER2-negative breast cancer: a phase 2 trial

推荐理由: 该研究探索了CDK4/6抑制剂在内分泌耐药乳腺癌中的新组合方案，方法学较为严谨，但与血液疾病关联度低，阅读价值主要限于肿瘤学领域。

摘要: CDK4/6 inhibitors (CDK4/6i) improve outcomes for estrogen receptor (ER) positive/HER2-negative breast cancers (BCs), yet intrinsic and acquired resistance exist. Here, we evaluated anastrozole in combination with palbociclib (ANA/PAL) in the NeoPalAna Endocrine-Resistant cohort (NCT01723774). Thirty-four patients with clinical stage II/III ER + /HER2- BCs resistant to standard neoadjuvant endocrine therapy (on-treatment Ki67 > 10%) received neoadjuvant ANA/PAL, with serial biopsies analyzed. The…

—

35 Near-unity CO<sub>2</sub>-to-ethylene photoconversion over low coordination single-atom catalysts

推荐理由: 该研究在光催化 CO_2 转化领域提出了新颖的单原子催化剂设计，技术创新度高，但与血液疾病关联度低，阅读价值主要在于了解前沿材料化学与可持续能源的交叉进展。

摘要: Photocatalytic conversion of carbon dioxide to value-added chemicals, particularly multi-carbon products, offers a promising route toward carbon-neutral cycles. However, achieving high activity and selectivity remains extremely challenging due to the instability of key reaction intermediates and limited C-C coupling efficiency. Herein, we report a low-coordination manganese single-atom catalyst embedded in zinc sulfide (Mn(1)-ZnS(v)) that enables efficient and selective CO(2)-to-C(2+)…

—

36 Negative electrode degradation induced by two-stage zinc plating and its recovery in zinc batteries

推荐理由: 该文主要探讨锌金属电池的沉积形貌与失活机制，与血液疾病的直接关联性较低，除非对金属沉积在生物体系的类比感兴趣，否则阅读价值有限。

摘要: Controlling the morphology of Zinc (Zn) deposits is an effective strategy to produce stable Zn-metal batteries. However, the degradation of Zn negative electrodes and changes in their morphology remain poorly understood. Here, we show that the Zn plating process has two distinct stages. The first being the formation of relatively dense, lumpy Zn, while the second involves the formation of porous mossy Zn on its protrusions, which changes into electrochemically inactive dead Zn during stripping….

—

37 Synthesis of poly(ester disulfide)s from S<sub>8</sub>-involved step-growth addition polymerization at ambient temperature

推荐理由: 该文提出了利用硫单体合成可降解且具刺激响应性的聚酯二硫键聚合物，方法新颖且原子经济，但与血液疾病的直接关联较弱，阅读价值主要在于为血液药物递送材料提供潜在思路。

摘要: Elemental sulfur (S(8)), an abundant petroleum byproduct, is leveraged as a linchpin monomer in an organobase-catalyzed step-growth addition polymerization with dithiols and diacrylates at ambient temperature. This method enables the scalable synthesis of poly(ester disulfide)s-featuring alternating ester and disulfide linkages-with exceptional atom economy ( > 95% yield), M(n) up to 42.0 kDa, and dual functionality: biodegradable ester units and stimuli-responsive disulfides. Mechanistic…

—

38 Copper-catalysed enantioconvergent N-alkylation of hydrazines with racemic α-haloamides to access enantioenriched hydrazines

推荐理由: 该文在手性水胺的高效不对称合成方面提供了新方法，但与血液疾病的直接关联较弱，适合对有机合成感兴趣的血液学研究者了解最新技术。

摘要: Chiral hydrazines are important building blocks in chiral drug molecules, N-amino peptides, and aza-heterocycles. The catalytic enantioconvergent N-alkylation of readily available hydrazine derivatives with various racemic alkyl halides offers a highly attractive route to chiral hydrazines. However, this process remains challenging due to the lack of efficient asymmetric catalytic systems and the difficulty in achieving regioselectivity at the N^1/N^2 positions of hydrazine derivatives. Herein, we…

—

39 Safeguarding climate-resilient mangroves requires only a moderate increase in the global protected area

推荐理由: 该文在气候适应性保护和成本效益评估方面提供了新方法，对环境政策有参考价值，但与血液疾病关联度极低，仅作跨学科了解即可。

摘要: Climate change and anthropogenic activities threaten biodiversity and ecosystem services. Climate-smart conservation plans address these challenges by ensuring protection of some climate-resilient areas. However, integrating climate change in the design of conservation plans is often deemed too expensive, as it may require larger networks or protecting more costly sites from a conservation perspective. Using mangroves as a case study, we evaluate the efficiency of protecting mangroves in…

—

40 Ion diffusion overestimates figures of merit in polymeric mixed conductors

推荐理由: 该文提出了有机混合离子‑电子导体 µC* 参数的测量误差问题，对材料表征方法有创新，但与血液疾病关联度低，阅读价值主要在于跨学科的技术参考。

摘要: Figures of merit are used to translate science to technology. For organic mixed ionic-electronic conductors (OMIECs), the product of mobility and volumetric capacitance, i.e., the µC* product, is the figure of merit used to guide the development of technologies ranging from bioelectronics to neuromorphics. While organic electrochemical transistors (OECTs) are used extensively to measure the µC* product, if there is a kink in the transistor current, then the µC* product is overestimated. Here, we…

—

41 Beyond Fuel: Exercise-Induced Lactate as a Metabolic-Epigenetic Regulator in Central Nervous System Health and Disease

推荐理由: 该综述系统阐述了乳酸在中枢神经系统的信号功能，虽与血液疾病关联不大，但对理解代谢信号在神经调控中的新机制具有一定参考价值。

摘要: Lactate, as a pivotal metabolite generated by the body, has attracted considerable attention in numerous biological disciplines in recent years. In addition to its role in supplying energy, lactate also functions as a signaling molecule, with the capacity to mediate a diverse array of physiological effects. Within the central nervous system, lactate is involved in the regulation of critical physiological processes, including neurogenesis, synaptic plasticity, mitochondrial biogenesis,…

—

42 The Drosophila proventriculus lacks stem cells but compensates for age-related cell loss via endoreplication-mediated cell growth

推荐理由: 该研究揭示了果蝇前胃中潜在的多能干细胞，对基础干细胞生物学有一定创新价值，但与血液疾病关联度低，公众关注度和政策影响有限。

摘要: The Drosophila proventriculus is a bulb-shaped structure at the juncture of the foregut and the midgut, which plays important roles in ingestion, peritrophic membrane synthesis, and the immune response to oral pathogens. A previous study identified a population of cells in the proventriculus which incorporate bromodeoxyuridine (BrdU), a marker of DNA synthesis, and proposed that these cycling cells are multipotent stem cells that replace dying cells elsewhere in the tissue. Here, we…

—

43 Evolution of manganese low-energy photoredox catalysis from high-energy visible light photocatalysis

推荐理由: 该文在低能光催化领域提出了创新的原位组装策略，方法新颖但与血液疾病关联度低，阅读价值主要限于材料与催化研究者。

摘要: Reducing the energy input of light in photocatalytic reactions is desirable yet challenging, as modifying the light-absorbing or catalytic properties of a photocatalyst typically requires tedious preparation, resulting in a lengthy development process. Here, we overcome this limitation by achieving manganese-based low-energy photoredox catalysis through the in-situ assembly of simple Mn salts with inexpensive coordinating chemicals, thereby bypassing the need for complex pre-preparation….

—

44 Facet-modulated ferroelectric polymers

推荐理由: 该文在铁电聚合物的材料创新与工艺控制方面有一定价值，但与血液疾病关联度极低，且社会影响有限，阅读价值相对一般。

摘要: Ferroelectrics hold significant promise for a wide range of applications owing to their spontaneous polarization characteristics. Despite exhibiting multiple polarization mechanisms that demonstrate significant potential for electromagnetic functional materials, the practical deployment of ferroelectric polymers has been inhibited by the lack of precise control over polymer chains at the atomic scale and the relatively low stability of the polar phase. Here, a procedure of fortifying the…

—

45 Vegetation greening drives long-term dust mitigation in Eastern Asia

推荐理由: 该文主要聚焦干旱地区植被与尘埃的相互作用，虽在环境科学上具一定创新，但与血液疾病关联甚少，血液学研究者阅读价值有限。

摘要: Dryland vegetation dynamics play a fundamental role in dust mitigation. While weaker winds have driven recent dust decline in Eastern Asia, the long-term influence of vegetation remains overlooked. Here, using a physically based modeling approach that partitions the drivers of dust emissions across timescales, we reveal that surface wind dominates interannual variability, negatively correlated with the El Niño-Southern Oscillation, Arctic Oscillation, and Pacific Decadal Oscillation. On a…

—

46 Observation of topological braiding and dynamical criticality in time reflection and refraction

推荐理由: 该文在时变材料的拓扑研究上具有创新性，但与血液疾病关联度极低，阅读价值主要限于物理学或跨学科的基础研究者。

摘要: Time reflection and refraction are among the most canonical phenomena emerging from the burgeoning field of time-varying materials. However, their connection with topology remains largely unexplored. Here, we experimentally report that temporal scattering processes exhibit two distinct topological characteristics: eigenstate topological braiding and dynamical topological phase transition. By developing approaches to implement Schrödinger dynamics and engineer temporal boundaries, various…

—

47 Topological robustness of classical and quantum optical skyrmions in atmospheric turbulence

推荐理由: 该文在光学拓扑结构和量子通信方面具有创新性，但与血液疾病研究关联度极低，阅读价值有限。

摘要: The degradation of classical and quantum structured light induced by complex media, such as atmospheric turbulence, constitutes a critical barrier to its practical implementation in communication, energy transport, imaging and sensing. Here we construct both classical and quantum optical skyrmions and transmit them through experimentally simulated atmospheric turbulence, revealing the embedded topological resilience of their structure. For nonlocal quantum skyrmions, we show that although photon…

—

48 Operationally classical simulation of quantum states

推荐理由: 该文主要探讨量子信息与经典模拟的理论创新，与血液疾病研究关联度极低，除非对跨学科的量子模拟方法有特别兴趣，否则不必阅读。

摘要: A classical state-preparation device cannot generate states in relative superposition. We introduce classical models in which devices that are individually unable to generate states with relative superposition can be stochastically coordinated to simulate sets of quantum states. These models have natural operational interpretation in prepare-and-measure scenarios and they can account for many non-commuting quantum state sets. We develop systematic methods both for classically simulating quantum…

—

49 Ultrafast dynamic stark shift of an exciton-polariton condensate

推荐理由: 该文主要聚焦于量子凝聚态和激子极化子在固态物理中的动态调控，与血液疾病研究关联度极低，除非关注跨学科的物理方法，否则阅读价值有限。

摘要: Time-dependent spatial modulation of a quantum condensate plays a key role in the investigation of the dynamics of collective coherent systems. Cold-atom condensates were already manipulated into forming solitons, vortices and optical lattices via the dynamic Stark effect. In the solid-state framework, semiconductor microcavity exciton-polaritons present an excellent platform for observing nonequilibrium condensate dynamics. Furthermore, the dynamic manipulation of exciton-polariton condensates…

—

50 The frequency response of networks as open systems

推荐理由: 该文主要探讨一般网络与环境的交互机制，虽有一定理论创新，但与血液疾病研究关联度低，阅读价值有限。

摘要: Many biological, technological, and social systems can be effectively described as networks of interacting subsystems. Typically, these networks are not isolated objects, but interact with their environment through both signals and information that are received by specific nodes with an input function or released to the environment by other nodes with an output function. An important question is whether the structure of different networks, together with the particular selection of input and…

—

51 Rejection-based choices discourage people from opting out of voting

推荐理由: 该研究提供了关于选民弃权行为的新解释，方法严谨且数据可靠，但与血液疾病关联度极低，阅读价值主要限于政治行为学领域。

摘要: Representing the will of voters is challenging when many opt out of indicating their preferences. Such opt-out behavior has been explained by voters lacking a preference and/or disliking their options. We provide evidence for a third account: people opt out of choosing between undesirable candidates because bad options are incongruent with their typical goal of selecting the best one. Using a voting task, we show across two lab-based studies that the tendency to opt out of choices between bad…

—

52 Unveiling the environmental impact of earthquakes in Europe

推荐理由: 该文聚焦地震导致的建筑碳排放，对血液疾病研究的直接关联性极低，除非关注环境因素对公共健康的宏观影响，否则阅读价值有限。

摘要: Earthquakes represent a significant but often overlooked environmental burden in the construction sector, driven by post-disaster repairs and reconstruction that generate substantial carbon emissions. Here, we unveil the environmental toll of earthquakes in Europe by presenting a seismic risk map of embodied carbon associated with earthquake damage across residential, commercial, and industrial buildings. We develop a harmonised database of material quantities and carbon factors covering diverse…

—

53 Atomic-scale imaging and charge state manipulation of NV centers by scanning tunneling microscopy

推荐理由: 该文在固态量子比特领域具有创新性，但与血液疾病研究关联度极低，阅读价值对血液学者有限。

摘要: Nitrogen-vacancy (NV) centers in diamond are among the most promising solid-state qubit candidates, owing to their exceptionally long spin coherence times, efficient spin-photon coupling, room-temperature operation, and steadily advancing fabrication and integration techniques. Despite significant progress in the field, atomic-scale characterization and control of individual NV centers have remained elusive. In this work, we utilize a conductive graphene capping layer to enable direct imaging…

—

54 Technological innovations and hafted technology in central China  160,000-72,000 years ago

推荐理由: 该文主要探讨中更新世时期的考古技术创新，与血液疾病研究关联度极低，阅读价值有限。

摘要: Technological innovations in Africa and western Europe in the later part of the Middle Pleistocene signal the behavioural complexity of hominin populations. Yet, at the same time, it has long been believed that hominin technologies in Eastern Asia lack signs of innovation and sophistication. Here, we report on technological innovations occurring at Xigou, in the Danjiangkou Reservoir Region, central China, dating to  160,000-72,000 years ago. Technological, typological, and functional analyses…

—

55 Lactate-lactylation in tumor angiogenesis and progression: mechanisms, biomarker potential, and therapeutic implications

推荐理由: 由于没有提供摘要，无法评估研究创新性、方法严谨性及血液疾病的相关性，信息不足，阅读价值有限。

摘要: No abstract

—

56 Germinal centre IL-4 enforces tissue confinement of IgE memory

推荐理由: 该文缺乏摘要，无法评估研究创新性、方法学严谨性及血液疾病的相关性，阅读价值极低。

摘要: No abstract

—