追觅 - 2026-01-29

生成时间: 2026−01-29 22:49

分析文章数量: 113

1 GVHD and GRFS in patients with acute myeloid leukemia undergoing allogeneic HCT with treosulfan- versus reduced-intensity busulfan-based conditioning: a subgroup analysis of a randomized phase 3 trial

推荐理由: 该研究对AML患者的移植前条件方案进行大规模、随机III期试验比较，数据可靠且对临床指南具有重要参考价值，值得血液学研究者阅读。

摘要: Acute myeloid leukemia (AML) is the most common indication for allogeneic hematopoietic cell transplantation (alloHCT), yet graft-versus-host disease (GVHD) remains a major post-transplant complication. Conditioning regimens, particularly reduced-intensity approaches, are critical in optimizing outcomes. This subgroup analysis of the phase 3 MC-FludT.14/L trial compared treosulfan-fludarabine with reduced-intensity busulfan-fludarabine in 352 AML patients (aged 31-70) undergoing alloHCT. The…

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2 Selective lymphodepletion underlies the efficacy of horse anti-thymocyte globulin-based immunosuppressive therapy in aplastic anemia

推荐理由: 该研究首次系统性阐明ATGAM联合环孢素在免疫介导性再生障碍性贫血患者中的药效动力学及免疫重塑，对血液学研究具有重要参考价值，值得阅读。

摘要: Horse-derived anti-thymocyte globulin (ATGAM) in combination with long-term ciclosporin is the first-line treatment for most immune-mediated aplastic anemia (AA) patients. The exact impact of this immunosuppressive therapy (IST) on hematological recovery and the immune landscape, however, remains poorly understood. We report a longitudinal analysis of the pharmacodynamic effects of ATGAM-based IST in a cohort of 44 AA patients. With flow cytometry we quantified plasma levels of…

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3 Male sex adversely impacts survival and myeloid malignancy risk in MGUS: a real-world population-based study

推荐理由: 该研究基于大规模人群队列，系统分析MGUS的临床特征、进展风险及生存情况，对血液肿瘤的流行病学和预后评估具有重要参考价值。

摘要: Monoclonal gammopathy of undetermined significance (MGUS) is a common plasma cell disorder with well described risks of progression to myeloma and lymphoplasmacytic lymphoma. Using data from an established UK population-based cohort of haematological malignancies and premalignancies, we investigated patient and disease characteristics, subsequent haematological malignancy, and survival in 4651 people diagnosed with MGUS 2005-2019. The 5-year net (relative) survival (disease-specific estimate of…

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4 Targeting MCL-1 and MAPK overcomes venetoclax resistance in FLT3-ITD-positive AML cells harbouring activating PTPN11 (SHP-2) mutations

推荐理由: 该研究揭示了VEN耐药AML中PTPN11和FLT3‑ITD突变驱动的MAPK通路激活机制，为克服耐药提供了新靶点，对血液肿瘤研究具有重要参考价值。

摘要: Venetoclax (VEN)-based therapies have improved the treatment of acute myeloid leukaemia (AML); however, the emergence of resistance remains a major limitation. Mutations in protein tyrosine phosphatase (PTP) non-receptor type 11 (PTPN11) and FMS like tyrosine kinase 3 with internal tandem duplication (FLT3-ITD) are common in resistant patients and are linked to activation of mitogen-activated protein kinase (MAPK) signalling and increased expression of anti-apoptotic proteins such as myeloid…

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5 Efficacy and safety of avapritinib in advanced systemic mastocytosis: 4-year follow-up of the PATHFINDER study

推荐理由: 该研究提供了针对KIT D816V突变的高选择性口服抑制剂avapritinib的长期疗效与安全性数据，对系统性肥大细胞增多症及其伴随血液恶性肿瘤的研究具有重要参考价值。

摘要: Advanced systemic mastocytosis (AdvSM), a clonal hematologic neoplasm driven predominantly by D816V-mutant KIT, is often characterized by organ damage. Associated hematologic neoplasms (AHN; usually myeloid) are often present, leading to poor survival. We report on the oral, highly selective, potent KIT D816V inhibitor avapritinib (200-mg once-daily starting dose) with >4 years follow-up from the fully enrolled PATHFINDER (NCT03580655) study. Endpoints included overall response rate (ORR;…

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6 Robust Multimodal Deep Learning for Lymphoma Subtype Classification Using (18)F-FDG PET Maximum Intensity Projection Images and Clinical Data: A Multi-Center Study

推荐理由: 该文提出的多模态深度学习框架能够在不同机构间统一 ^18F‑FDG PET 数据并精准分层分类淋巴瘤亚型，对血液肿瘤的诊断与分型具有重要参考价值，值得阅读。

摘要: Background: Previous attempts to classify lymphoma subtypes based on metabolic features extracted from ^(18)F-FDG PET imaging have been hindered by inconsistencies in imaging protocols, scanner types, and inter-institutional variability. To overcome these limitations, we propose a multimodal deep learning framework that integrates harmonized PET imaging features with structured clinical information. The proposed framework is designed to perform hierarchical classification of clinically…

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7 Demystifying Deep Learning Decisions in Leukemia Diagnostics Using Explainable AI

推荐理由: 该文提出的融合CNN、迁移学习及可解释AI的血液/骨髓诊断流程创新性强，且对血液疾病的影像分析具有较高的参考价值，值得血液学研究者阅读。

摘要: Background/Objectives: Conventional workflows, peripheral blood smears, and bone marrow assessment supplemented by LDI-PCR, molecular cytogenetics, and array-CGH, are expert-driven in the face of biological and imaging variability. Methods: We propose an AI pipeline that integrates convolutional neural networks (CNNs) and transfer learning-based models with two explainable AI (XAI) approaches, LIME and Grad-Cam, to deliver both high diagnostic accuracy and transparent rationale. Seven public…

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8 Metabolic syndrome and risk of monoclonal gammopathy of undetermined significance: a large Korean cohort study

推荐理由: 该研究利用韩国大型健康数据库首次系统评估代谢综合征与MGUS的关联，样本量巨大且与血液肿瘤前驱状态直接相关，值得血液学研究者关注。

摘要: Monoclonal gammopathy of undetermined significance (MGUS) is a premalignant plasma cell disorder with a risk of progression to multiple myeloma. Metabolic syndrome (MetS) is implicated in cancer development, yet its association with MGUS remains unclear. We examined MetS as a risk factor for MGUS in a large Korean cohort. In a retrospective cohort study using the National Health Information Database, we analyzed 4,453,504 adults undergoing health checkups in 2012, followed through 2022. MetS was…

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9 AAVLINK: A potent DNA-recombination method for large cargo delivery in gene therapy

推荐理由: 该研究提出了突破AAV包装容量限制的创新策略（AAVLINK），为血液疾病基因治疗（如血友病、镰状细胞贫血）提供了新的技术路径，值得血液学研究者关注。

摘要: Delivery of therapeutic genes is essential for successful gene therapy. Adeno-associated viruses (AAVs) are a prime vector for carrying gene cargoes. However, the limited packaging capacity of AAVs poses a major challenge for large gene transduction. Here, we devised a strategy termed AAV with translocation linkage (AAVLINK), leveraging Cre/lox-mediated intermolecular DNA recombination to overcome cargo size constraints. This AAVLINK strategy enabled superior gene segmentation flexibility,…

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10 Injured epithelial cell states impact kidney allograft survival after T-cell-mediated rejection

推荐理由: 该研究首次结合单核RNA测序和空间转录组解析急性T细胞介导的肾移植排斥的分子机制，技术创新且数据可靠，对移植免疫学具有重要参考价值。虽然与血液疾病关联有限，但对免疫细胞功能的深入认识仍具一定借鉴意义。

摘要: T-cell-mediated rejection (TCMR) remains a major cause of kidney transplant failure, despite being considered treatable. Its impact reflects a limited understanding of the underlying molecular mechanisms and their clinical consequences. To address this, we induced acute TCMR in mouse kidney transplants and profiled molecular changes using single-nucleus RNA sequencing (snRNA-seq), spatial transcriptomics and immunofluorescence. Results were compared with human snRNA-seq data from TCMR and stable…

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11 Marrow Microenvironmental Pathobiology and Therapeutic Opportunities for <em>TP53</em>-Mutated Myelodysplastic Syndrome/Acute Myeloid Leukemia

推荐理由: 该文深入探讨TP53突变在MDS/AML中的免疫抑制机制，对血液肿瘤的发病机制和潜在治疗靶点具有较高的参考价值，值得血液学研究者阅读。

摘要: Mutations in TP53 inhibit p53 protective behaviors including cell cycle arrest, DNA damage repair protein recruitment, and apoptosis. The ubiquity of p53 in genome-stabilizing functions leads to an aberrant tumor microenvironment in TP53-mutated myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML). Profound immunosuppression mediated by myeloid-derived suppressor cells, the upregulation of cytokines and cell-surface receptors on leukemic cells, the suppression of native immune…

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12 Hypomethylating agents plus venetoclax versus intensive chemotherapy in acute myeloid leukemia with chromosome 5 and 7 abnormalities

推荐理由: 该研究针对染色体5/7异常的AML患者比较强化化疗与HMAs+Venetoclax的疗效，填补了临床决策的关键空白，对血液学研究和临床实践具有重要参考价值。

摘要: Abnormalities in chromosomes 5 and 7 are frequently identified in acute myeloid leukemia (AML), particularly enriched in therapy-and myelodysplasia-related disease, and confer an adverse prognosis. Given the high risk of relapse, allogeneic stem cell transplant (allo-SCT) is typically recommended for patients achieving complete remission (CR) following induction chemotherapy. We currently lack prospective data to decide whether intensive chemotherapy (IC) versus hypomethylating agent+venetoclax…

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13 Clonal hematopoiesis driver mutations: molecular mechanisms and clinical implications - inclusive fitness of pre-leukemic hematopoietic stem and progenitor cells through pro-inflammatory features of their progeny

推荐理由: 该综述从进化学视角阐释克隆性造血的持久机制，对理解CH与血液恶性转化的关系具有重要参考价值，值得血液学研究者阅读。

摘要: Clonal hematopoiesis (CH) is driven by the age-associated expansion of hematopoietic stem and progenitor cells (HSPCs) that harbor somatic driver mutations; however, the mechanisms underlying their long-term persistence remain incompletely understood. This review frames CH through the lens of inclusive fitness, proposing that mutant pre-leukemic HSPCs enhance their evolutionary success not only through intrinsic self-renewal advantages, but also via indirect effects mediated by their…

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14 A triple-node heart-brain neuroimmune loop underlying myocardial infarction

推荐理由: 该研究揭示了心肌梗死后迷走神经感受器的神经免疫机制，方法新颖且数据可靠，对心血管疾病的基础研究具有重要价值，值得阅读。

摘要: Myocardial infarction (MI) triggers adverse cardiac events, immune responses, and nervous system activation, but the neural and neuroimmune mechanisms remain understudied. Using single-cell RNA sequencing (scRNA-seq) and tissue clearing, we identified transient receptor potential vanilloid-1 (TRPV1)-expressing vagal sensory neurons (VSNs) that increase ventricular innervation post MI. Ablating these VSNs mitigated MI pathology, reducing infarct size, abnormal electrocardiograms, cardiac…

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15 Task-specific pre-training for molecular property prediction

推荐理由: 该文提出的任务特定预训练方法在小样本分子属性预测上表现突出，对药物研发（包括血液疾病相关药物）提供了新思路，值得一读。

摘要: Molecular property prediction is a critical task in computational chemistry and drug discovery. While deep learning has advanced this field, the increasing complexity of models contrasts with the scarcity of labeled data, leading to severe overfitting and limited generalization. In this paper, we propose TasProp, a task-specific pre-training strategy for molecular property prediction, particularly for the scenarios with small labeled datasets. To learn a robust molecular representation, TasProp…

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16 Hypomethylating agents plus venetoclax versus intensive chemotherapy in acute myeloid leukemia with chromosome 5 and 7 abnormalities

推荐理由: 该研究针对染色体5/7异常的AML患者比较强化化疗与HMA+Venetoclax的疗效，对血液学临床决策和移植前治疗方案具有重要参考价值。

摘要: Abnormalities in chromosomes 5 and 7 are frequently identified in acute myeloid leukemia (AML), particularly enriched in therapy-and myelodysplasia-related disease, and confer an adverse prognosis. Given the high risk of relapse, allogeneic stem cell transplant (allo-SCT) is typically recommended for patients achieving complete remission (CR) following induction chemotherapy. We currently lack prospective data to decide whether intensive chemotherapy (IC) versus hypomethylating agent+venetoclax…

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17 Epigenetic silencing and pharmacological inhibition of EIF5A2 foster venetoclax sensitivity in acute myeloid leukaemia

推荐理由: 该研究揭示了EIF5A2失活可增强AML对venetoclax的敏感性，为靶向治疗提供了新思路，值得血液学研究者关注。

摘要: We show how the loss of activity of the translation initiation factor EIF5A2-either through gene hypermethylation or pharmacologic inhibition of its highly specific hypusine post-translational modification-induces venetoclax sensitivity in acute myeloid leukaemia (AML) cells.

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18 Injured epithelial cell states impact kidney allograft survival after T-cell-mediated rejection

推荐理由: 该研究首次结合单核RNA测序和空间转录组揭示TCMR的分子机制，对移植免疫学具有创新价值，虽与血液疾病关联有限，但对免疫细胞功能的深入解析仍具参考意义。

摘要: T-cell-mediated rejection (TCMR) remains a major cause of kidney transplant failure, despite being considered treatable. Its impact reflects a limited understanding of the underlying molecular mechanisms and their clinical consequences. To address this, we induced acute TCMR in mouse kidney transplants and profiled molecular changes using single-nucleus RNA sequencing (snRNA-seq), spatial transcriptomics and immunofluorescence. Results were compared with human snRNA-seq data from TCMR and stable…

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19 Ab initio detection of multiple epitranscriptomic modifications from Oxford nanopore technology direct RNA sequencing data

推荐理由: 该文提出的多修饰检测模型 NanoSpeech 在直接RNA测序领域创新性强，方法可靠，可为血液疾病中RNA修饰研究提供新工具和思路，值得血液学研究者关注。

摘要: Charting the eukaryotic epitranscriptome by direct RNA sequencing is promising but still very challenging, as current bioinformatics tools are based on modification-unaware software and require multiple modification-specific learning steps. Here, we introduce NanoSpeech, a modification-aware basecaller for the ab initio simultaneous detection of multiple modified bases using a transformer model, and NanoListener, which implements a simulated randomers strategy for robust training datasets and a…

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20 Predictive value of seizure onset for gross motor dysfunction in individuals with pathogenic GABRB2 and GABRB3 variants

推荐理由: 该研究首次区分GABRB2/3基因的功能增益与缺失突变对运动功能的影响，并构建预测模型，对神经遗传学有重要参考价值，值得一读。

摘要: OBJECTIVE: Pathogenic variants in γ-aminobutyric acid type A (GABA(A)) receptor genes have been associated with a wide spectrum of neurological disorders. We aimed to delineate the clinical trajectories associated with gain-of-function (GoF) and loss-of-function (LoF) variants in GABRB2 and GABRB3, and to develop a risk-prediction model for gross motor dysfunction based on age at seizure onset.

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21 Lactylation and tumor immune regulation: insights from recent studies

推荐理由: 该文阐述乳酸酰化作为新型翻译后修饰在肿瘤免疫抑制中的作用，创新性强且与血液肿瘤的代谢调控有潜在关联，值得血液学研究者了解。

摘要: Lactate, a major product of glycolysis, accumulates abundantly in the tumor microenvironment (TME), serving not only as a hallmark of metabolic dysregulation but also as a key driver of immunosuppression. In recent years, lysine lactylation (Kla), a novel post-translational modification (PTM), has been identified, linking lactate metabolism closely with epigenetic regulation. Current studies indicate that lactylation modulates gene transcription and metabolic pathways in tumor cells while…

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22 MPHGNN: metapath-guided heterogeneous graph neural network for miRNA-drug resistance association prediction

推荐理由: 该文提出了创新的计算框架用于预测miRNA与药物耐药的关联，方法新颖且可为精准用药提供思路，值得血液肿瘤领域的研究者参考。

摘要: Aberrant expression of microRNAs (miRNAs) is closely associated with the pathogenesis and progression of various diseases, particularly cancer, as well as therapeutic responses. Identification of miRNA-drug resistance associations is critical for drug screening and precision medicine. However, conventional experimental approaches remain time-consuming and labor-intensive, while existing computational methods often face challenge in capturing higher-order semantic inference from sparse prior…

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23 BiGvCL: bipartite graph-based cross-domain contrastive learning model for the predicting drug-gene interactions

推荐理由: 该文提出的仅基于图对比学习的DGIs预测框架在精准用药领域具备创新性，方法与数据可为血液疾病药物研发提供思路，值得一读。

摘要: Drug-gene interactions (DGIs) influence the toxicity or ineffectiveness of the drug therapy and play an important role in elucidating drug mechanisms, predicting potential adverse effects, and facilitating precision medicine. Existing computational methods typically rely on chemical or genetic sequence features of drugs and genes, limiting their effectiveness for novel entities lacking explicit annotations. To address this, we propose BiGvCL, a framework that predicts DGIs exclusively based on…

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24 A Murine Database of Structural Variants Identifies A Candidate Gene for a Spontaneous Murine Lymphoma Model

推荐理由: 该研究提供了40株近交小鼠的高质量长读长测序及结构变异图谱，为构建血液疾病小鼠模型提供了重要的基因资源，值得血液学研究者参考。

摘要: A more complete map of the pattern of genetic variation among inbred mouse strains is essential for characterizing the genetic architecture of the many available mouse genetic models of important biomedical traits. Although structural variants (SVs) are a major component of genetic variation, they have not been adequately characterized among inbred strains due to methodological limitations. To address this, we generate high-quality long-read sequencing data for 40 inbred strains; and design a…

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25 Advances in scCUT&amp;Tag and computational analysis for single-cell gene regulatory element mapping

推荐理由: 该文介绍的单细胞CUT&Tag技术在表观遗传研究中具备创新性和高分辨率，对血液系统的基因调控机制研究具有参考价值，值得血液学研究者阅读。

摘要: Histone modifications (HMs) and transcription factors (TFs) are central to chromatin dynamics and transcriptional regulation. Conventional bulk approaches like ChIP-seq require large cell populations, limiting applicability to heterogeneous studies and tissue samples. In contrast, single-cell cleavage under targets and tagmentation (scCUT&amp;Tag) and its variants have enabled high-resolution profiling of HMs and TFs for investigating gene regulatory mechanisms in individual cells, transformatively…

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26 MPHGNN: metapath-guided heterogeneous graph neural network for miRNA-drug resistance association prediction

推荐理由: 该文提出了创新的计算框架用于预测miRNA‑药物耐药关联，方法严谨且数据可靠，对癌症等疾病的精准用药具有参考价值，值得血液学研究者了解其思路与技术。

摘要: Aberrant expression of microRNAs (miRNAs) is closely associated with the pathogenesis and progression of various diseases, particularly cancer, as well as therapeutic responses. Identification of miRNA-drug resistance associations is critical for drug screening and precision medicine. However, conventional experimental approaches remain time-consuming and labor-intensive, while existing computational methods often face challenge in capturing higher-order semantic inference from sparse prior…

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27 Microvascular endothelial metabolic dysfunction drives cerebral edema through bioenergetic failure after ischemia-reperfusion

推荐理由: 该研究揭示了缺血性卒中后微血管能量崩溃的代谢‑表观遗传机制，创新性强且对临床治疗有重要启示，值得血液学研究者了解其跨学科的潜在借鉴价值。

摘要: Aim: Despite major advances in recanalization therapy, poor functional outcomes after ischemic stroke remain common. The central challenge is not only restoring blood flow but also overcoming the bioenergetic failure that can persist during reperfusion. This study aims to identify the missing link by defining how a metabolic-epigenetic cascade drives microvascular energetic collapse, thereby elucidating mechanisms underlying sustained cerebral edema and the no-reflow phenomenon following…

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28 Lactylation and tumor immune regulation: insights from recent studies

推荐理由: 该文阐述了乳酸及其新型翻译后修饰——赖氨酸乳酰化在肿瘤免疫抑制中的机制，创新性强且对肿瘤免疫代谢研究具有重要参考价值，值得血液肿瘤及免疫学研究者阅读。

摘要: Lactate, a major product of glycolysis, accumulates abundantly in the tumor microenvironment (TME), serving not only as a hallmark of metabolic dysregulation but also as a key driver of immunosuppression. In recent years, lysine lactylation (Kla), a novel post-translational modification (PTM), has been identified, linking lactate metabolism closely with epigenetic regulation. Current studies indicate that lactylation modulates gene transcription and metabolic pathways in tumor cells while…

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29 Metabolically regulated proteasome supramolecular organization in situ

推荐理由: 该研究利用原位冷冻电子断层成像揭示了酵母蛋白酶体储存颗粒的形成机制，技术创新且方法严谨，对理解蛋白酶体在细胞应激中的调控具有重要参考价值，值得血液学研究者关注。

摘要: Many proteins localize in membraneless organelles. However, understanding the steps along membraneless organelle formation-and the structural impact on granule constituents-has been hindered by limited resolution of intracellular data. We address these challenges through in situ cryo-electron tomography (cryo-ET) along with formation of yeast proteasome storage granules (PSGs). During the transition from proliferation to quiescence, doubly capped 26S proteasomes arrested in an inactive state…

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30 Bridge helix of Cas12a is an allosteric regulator of R-loop formation and RuvC activation

推荐理由: 该研究通过结构功能解析提升了Cas12a的特异性，为基因编辑在血液疾病治疗中的安全性改进提供了重要思路，值得血液学研究者关注。

摘要: CRISPR-Cas12a, an RNA-based DNA targeting system, is widely used for genome editing and biomarker detection. To mitigate the off-target DNA cleavage of Cas12a, we previously developed a Francisella novicida Cas12a variant (FnoCas12a^(KD2P)) by introducing double proline substitutions (K969P/D970P) in a conserved arginine-rich helix called the bridge helix (BH). In this work, we use a combinatorial approach to understand the molecular mechanisms of BH-mediated activation of Cas12a for DNA…

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31 Endothelial PDLIM5 promotes tip cell filopodia formation and tumor angiogenesis by regulating ACTN1/ACTN4-dependent actin bundling

推荐理由: 该研究揭示了PDLIM5在肿瘤血管内皮细胞中的关键作用，提供了血管生成新机制，对血管相关血液疾病的研究具有一定借鉴价值。

摘要: Filopodia formation by tumor endothelial cells (TECs) is critical for tip cell-guided sprouting angiogenesis and tumor growth. However, the cytoskeletal organization that underlies this process remains elusive. Here, we demonstrates that TECs highly express actin-binding genes, with PDZ and LIM domain 5 (PDLIM5), a cytoskeletal protein, significantly upregulated in TECs and correlated with poor patient survival. Endothelial-specific deletion of Pdlim5 inhibits sprouting angiogenesis by…

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32 Leveraging glucan-induced trained immunity for the epigenetic and metabolic rewiring of macrophages to enhance colorectal cancer vaccine response

推荐理由: 该研究揭示了β‑葡聚糖诱导的训练性免疫通过表观遗传和代谢重塑提升癌症疫苗效应，创新性强且对免疫学、肿瘤学具有重要参考价值。对血液学的直接关联有限，但其关于巨噬细胞功能调控的机制可为血液疾病的免疫研究提供思路。

摘要: Colorectal cancer (CRC) remains refractory to most immunotherapies, with cancer vaccines failing due to an immunosuppressive tumor microenvironment. Here, we show that β-glucan-induced trained immunity overcomes these barriers by reprogramming macrophages through H3K4me3-dependent epigenetic modifications and metabolic rewiring. In female mice vaccinated with peptide-coated adenovirus-based vaccine PeptiCrad, training enhances glycolysis with creatine metabolism sustaining CXCL9/10 production,…

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33 A versatile platform for sequential glyco-, phospho-, and proteomics with multi-PTMs integration

推荐理由: 该文提出的MuPPE平台在多层次PTM同步分析上具备创新性和技术突破，可为血液疾病的蛋白组学研究提供新工具，值得血液学研究者关注。

摘要: Serial multi-omic analysis of proteome, phosphoproteome, and glycoproteome is pivotal for elucidating drug mechanisms, discovering biomarkers, and identifying therapeutic targets. However, simultaneous multi-level post-translational modifications (PTMs) analysis via parallel processing is hampered by laborious, time-consuming procedures and inconsistent reproducibility. We present an integrated Multi-level PTMs-Proteomic Enrichment platform (MuPPE), enabling sequential glycoproteome,…

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34 Field-effect-informed urine liquid biopsy for bladder cancer

推荐理由: 该研究提出了提升尿液肿瘤DNA检测特异性的创新方法，对膀胱癌精准治疗具有重要价值，值得血液学研究者了解其液体活检技术的最新进展。

摘要: Only some non-muscle-invasive bladder cancer (NMIBC) patients benefit from intravesical Bacillus Calmette-Guérin (BCG), and predictive biomarkers remain lacking. While urine tumor DNA (utDNA) analysis is promising, mutations in tumor-adjacent normal urothelium, namely the field effect, limit specificity. Here, we show that the prevalence of somatic mutations in the urine increases with age. We introduce an improved utDNA minimal residual disease (MRD) approach that increases specificity by…

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35 Expression-Driven Genetic Dependency Reveals Targets for Precision Oncology

推荐理由: 该研究提出了基于表达依赖性的精准肿瘤靶点筛选方法，创新性强且数据整合度高，对癌症精准治疗具有重要参考价值，值得血液肿瘤研究者了解其思路与资源。

摘要: CONCLUSIONS: Our approach provides a systematic method to identify precision oncology targets based on expression-driven dependency patterns. By integrating multi-omics data with genetic dependency screens, we’ve created a comprehensive catalog of potential therapeutic targets that may expand treatment options for cancer patients lacking druggable mutations. This resource offers new opportunities for precision oncology target discovery beyond mutation-based approaches.

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36 Lamin A/C-regulated cysteine catabolic flux modulates stem cell fate through epigenome reprogramming

推荐理由: 该研究揭示了核层蛋白A/C在胱氨酸代谢及细胞命运中的新机制，虽与血液疾病关联不直接，但为代谢调控在干细胞和潜在血细胞分化中的研究提供了新思路，值得血液学研究者关注。

摘要: Spatiotemporal changes in the nuclear lamina and cell metabolism shape cell fate, yet their interplay is poorly understood. Here we identify lamin A/C as a key regulator of cysteine catabolic flux essential for proper cell fate and longevity. Its loss in naive mouse pluripotent stem cells leads to upregulation of the cysteine-generating and catabolizing enzymes, cystathionine γ-lyase (CTH) and cystathionine β-synthase (CBS), thereby promoting de novo cysteine synthesis. Increased cysteine flux…

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37 Curcumol Induces Necroptosis of Hepatic Stellate Cells by Targeting KAT8 to Suppress HK2 Lactylation and Promote HUWE1-Dependent Ubiquitination

推荐理由: 该研究揭示了天然化合物 Curcumol 通过代谢重编程选择性清除活化的肝星状细胞，为肝纤维化治疗提供了新思路，值得血液学研究者了解其代谢调控机制的潜在借鉴价值。

摘要: Liver fibrosis is a pathological outcome of chronic liver injury and is primarily driven by the continuous activation of hepatic stellate cells (HSCs). During activation, HSCs depend on aerobic glycolysis to maintain their fibrogenic characteristics, suggesting that metabolic reprogramming could serve as an effective therapeutic approach. In this study, we demonstrate that Curcumol, a natural compound derived from plants in the Zingiberaceae family, selectively removes activated HSCs by…

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38 Microvascular endothelial metabolic dysfunction drives cerebral edema through bioenergetic failure after ischemia-reperfusion

推荐理由: 该研究揭示了缺血性卒中后微血管能量崩溃的代谢‑表观遗传机制，创新性强且对公共健康和临床治疗具有重要启示，值得血液学研究者了解其血管微环境的最新进展。

摘要: Aim: Despite major advances in recanalization therapy, poor functional outcomes after ischemic stroke remain common. The central challenge is not only restoring blood flow but also overcoming the bioenergetic failure that can persist during reperfusion. This study aims to identify the missing link by defining how a metabolic-epigenetic cascade drives microvascular energetic collapse, thereby elucidating mechanisms underlying sustained cerebral edema and the no-reflow phenomenon following…

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39 Ferroplasticity drives social isolation-induced anxiety via a ventral hippocampal iron-α-synuclein axis

推荐理由: 该研究提出了“铁可塑性”新概念，揭示了社会隔离与铁代谢、α‑突触核蛋白之间的神经机制，对理解精神疾病的生物学基础具有重要价值。虽然与血液疾病关联有限，但其在铁代谢和应激反应方面的发现可为血液学研究提供一定的参考。

摘要: Social isolation is a major environmental driver of anxiety disorders, yet its neurobiological underpinnings remain elusive. We report here that social isolation triggers “ferroplasticity”-a novel form of experience-dependent synaptic remodeling-in ventral hippocampus (vHip) pyramidal neurons via a glucocorticoid-initiated iron-α-synuclein (α-Syn) axis. Psychosocial stress specifically engages this pathway. Mechanistically, isolation-induced glucocorticoid receptor activation upregulates…

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40 Cycling molecular assemblies for Golgi imaging and disruption

推荐理由: 该文提出的循环分子组装技术为快速、细胞特异性的高尔基体成像与干扰提供了新工具，创新性强，方法学严谨，但与血液疾病的直接关联较少，社会影响和政策关联度亦有限。

摘要: The Golgi apparatus is a central hub for protein trafficking and signaling, yet its rapid imaging and cell-selective disruption remain challenging. Here, we report cycling molecular assemblies (CyMA) for fast Golgi imaging and cell-selective interference. CyMA precursors are acetylated amphiphilic thiopeptides that traverse plasma membrane and are deacetylated by intracellular thioesterases. This exposes thiols that undergo palmitoylation by Golgi-resident palmitoyl acyltransferases utilizing…

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41 Cefiderocol resistance genes identified in environmental samples using functional metagenomics

推荐理由: 该文揭示了新型抗生素 cefiderocol 的耐药机制，对抗菌治疗和公共卫生政策具有重要参考价值，虽与血液疾病关联有限，但对血液科免疫抑制患者的感染管理仍具借鉴意义。

摘要: Antibiotic resistance poses a global public health threat, which can originate from the transfer of environmental antibiotic resistance genes to pathogenic bacteria, as highlighted by the “One Health” framework. Cefiderocol is a siderophore cephalosporin recently introduced in clinical practice which displays a “Trojan Horse” mechanism, utilizing bacterial iron transportation systems for cell entry. Although it is only used as a last-line antibiotic, resistance has already been observed in…

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42 Scalable embedding fusion with protein language models: insights from benchmarking text-integrated representations

推荐理由: 该文提出的蛋白质语言模型新方法对提升序列特征表示具有创新意义，虽与血液疾病关联度不高，但对血液相关蛋白功能预测和变异分析提供了潜在技术参考，值得血液学研究者了解。

摘要: Protein language models (pLMs) have become essential tools in computational biology, powering diverse applications from variant effect prediction to protein engineering. Central to their success is the use of pretrained embeddings-contextualized representations of amino acid sequences-which enable effective transfer learning, especially in data-scarce settings. However, recent studies have revealed that standard masked language modeling objectives used to train these models often produce…

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43 Targeting Metabolic Pathways in AML Cell Lines: Impact of Hypoxia-Inducible Factor-1alpha (HIF-1alpha) and Lactate Dehydrogenase-A (LDH-A) Inhibition

推荐理由: 该研究揭示了HIF‑1α和LDH‑A抑制剂在AML细胞代谢调控中的新作用，对血液肿瘤代谢治疗具有一定参考价值，值得血液学研究者关注。

摘要: CONCLUSION: Our findings show that HIF-1α and LDH-A inhibitors not only serve as cytotoxic drugs but also regulate the expression of lactate transporter and interfere with the metabolism-related mechanisms in AML cells.

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44 Potential-dependent polaron formation activates TiO<sub>2</sub> for the hydrogen evolution reaction

推荐理由: 该研究提出了在电极上通过外加电位可逆调控极化子的新方法，创新性强且对半导体电催化机制有重要启示，值得跨学科的科研人员阅读。

摘要: Polarons play a crucial role in determining the (photo)electrocatalytic activity of semiconductors. Traditionally, polarons are introduced ex situ and irreversibly during catalyst synthesis, but herein we present a fundamentally different approach of introducing polarons in situ in a reversible manner using the external electrode potential. We study the potential-dependent polaron formation and its impact on electrocatalysis on a prototypical TiO(2) semiconductor electrode for the acidic…

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45 A comprehensive tandem repeat catalog of the human genome

推荐理由: 该研究利用长读长测序和新算法在全基因组层面系统描绘串联重复，方法创新且数据可靠，对基因组学和潜在疾病机制研究具有参考价值。虽然与血液疾病直接关联有限，但对理解重复扩增相关的遗传病仍有借鉴意义。

摘要: With the increasing availability of long-read sequencing data, high-quality human genome assemblies, and software for fully characterizing tandem repeats, genome-wide genotyping of tandem repeat loci on a population scale is becoming more feasible. Such efforts not only expand our knowledge of the tandem repeat landscape in the human genome but also enhance our ability to differentiate pathogenic tandem repeat mutations from benign polymorphisms. To this end, we analyze genome datasets from 272…

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46 BiGvCL: bipartite graph-based cross-domain contrastive learning model for the predicting drug-gene interactions

推荐理由: 该文提出的仅基于图对比学习的药物‑基因相互作用预测框架在方法创新上具备一定价值，可为血液疾病药物靶点筛选提供思路，但与血液病的直接关联较弱，阅读价值适中。

摘要: Drug-gene interactions (DGIs) influence the toxicity or ineffectiveness of the drug therapy and play an important role in elucidating drug mechanisms, predicting potential adverse effects, and facilitating precision medicine. Existing computational methods typically rely on chemical or genetic sequence features of drugs and genes, limiting their effectiveness for novel entities lacking explicit annotations. To address this, we propose BiGvCL, a framework that predicts DGIs exclusively based on…

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47 Rubber-like DNA hydrogel enabled by fast-shrinking-induced entanglement

推荐理由: 该文提出的快速收缩诱导纠缠（FaSIE）制备全DNA橡胶水凝胶方法新颖，机械性能优异，对材料科学和生物医学载体研发具有参考价值，值得一读。

摘要: Biomass DNA holds immense potential as a sustainable material, but the scalable production of robust DNA materials with sufficient mechanical strength remains an essential challenge. Herein, we report a Fast-Shrinking-Induced Entanglement (FaSIE) process to achieve rubber-like hydrogels solely composed of DNA (stiffness >800 kPa, toughness >5 MJ/m³, and stretchability > 1000%). Fast shrinking kinetic restricts the chain relaxation, while the ultra-long chain feature of biomass DNA further…

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48 Empagliflozin in Heart Failure and Previous Coronary Revascularization: Insights From EMPEROR-Pooled

推荐理由: 该研究提供了关于 empagliflozin 在心衰患者中（无论是否既往血运重建）疗效与安全性的高质量证据，对心血管领域有重要参考价值，但与血液疾病关联有限。

摘要: CONCLUSIONS: In this large HF trial program, revascularized patients with HF exhibited similar rates of HF and ischemic events as those without prior revascularization. The efficacy and safety of empagliflozin in HF were consistent in those with and without a revascularization history.

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49 Dihydrotestosterone and Finasteride Effects on Alcohol Cue-Elicited Brain Activity in Males With Heavy Episodic Drinking

推荐理由: 该研究首次探讨5α‑还原酶抑制降低二氢睾酮对酒精提示诱发的大脑活动和渴求的影响，创新性强且对酒精依赖的干预具有潜在公共卫生意义。虽然与血液疾病关联有限，但对跨学科的酒精成瘾机制研究仍具参考价值。

摘要: Preliminary animal and human studies have shown that blood dihydrotestosterone concentrations are increased in males with alcohol use disorder, and 5α-reductase inhibitors, which decrease dihydrotestosterone concentrations, reduce alcohol consumption. To gain mechanistic insight, we studied the effects of reduced dihydrotestosterone concentrations following pharmacological 5α-reductase inhibition on alcohol cue-elicited brain activity and alcohol craving in males with problematic alcohol use. To…

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50 SpaLLM: a general framework for spatial domain identification with large language models

推荐理由: 该文提出了将大语言模型嵌入用于空间转录组域识别的创新框架，方法新颖且具备跨组织的通用性，值得血液学研究者了解以拓展空间组学在血液疾病中的潜在应用。

摘要: Spatial transcriptomics (ST) technologies enable the profiling of gene expression while preserving spatial context, offering unprecedented insights into tissue organization. However, traditional spatial domain identification methods primarily rely on gene expression matrices and spatial coordinates while overlooking the rich biological knowledge encoded in gene functional descriptions. Here, we propose SpaLLM, a general framework that integrates large language model (LLM) embeddings of gene…

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51 Training tactile sensors to learn force sensing from each other

推荐理由: 该文提出的跨传感器力感知框架在仿生机器人领域具备创新性，对血液学研究的直接帮助有限，但对跨学科的生物启发式技术有一定参考价值。

摘要: Humans achieve stable and dexterous object manipulation by coordinating grasp forces across multiple fingers and palms, facilitated by a unified tactile memory system in the somatosensory cortex. This system encodes and stores tactile experiences across skin regions, enabling the flexible reuse and transfer of touch information. Inspired by this biological capability, we present GenForce, the first framework that enables transferable force sensing across diverse tactile sensors in robotic hands….

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52 Multi-platform integration of brain and CSF proteomes reveals biomarker panels for Alzheimer’s disease

推荐理由: 该研究提供了大规模蛋白质组数据，对阿尔茨海默病的生物标志物发现具有创新价值，但与血液疾病的直接关联较弱，阅读价值主要在于方法学借鉴。

摘要: Alzheimer’s disease (AD) is the leading cause of dementia and represents a progressive, irreversible neurodegenerative disorder. Given the complexity and heterogeneity of AD, which involves numerous interrelated molecular pathways, large-scale proteomics datasets are essential for robust biomarker discovery. Comprehensive proteomic profiling enables the unbiased identification of novel biomarkers across diverse biological processes, thereby increasing the likelihood of finding sensitive and…

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53 Cost-effectiveness of a smart pillbox intervention for adherence to oral HIV pre-exposure prophylaxis

推荐理由: 该研究创新性地评估了数字化干预提升PrEP依从性的成本效益，对公共卫生政策具有重要参考价值，但与血液疾病关联度较低，仅在血液学研究中可作方法学借鉴。

摘要: Despite proven oral pre-exposure prophylaxis (PrEP) efficacy, adherence barriers among men who have sex with men (MSM) persist. Economic viability of digital adherence tools in low- and middle-income countries (LMICs) requires validation. We assessed the 6-month within-trial cost-effectiveness of a digital intervention for real-time enhancement of oral PrEP adherence (DIRECT-PrEP) in China, from health system, multipayer, and societal perspectives. Costs were derived from hospital records, and…

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54 High Yield Branched Puromycin Linker Design Enables Efficient cDNA Display and Chemical Modification of Peptides

推荐理由: 该文提出的SPAAC链接策略在肽类药物合成中显著提升产率，方法创新且实验数据可靠，值得在化学药物研发领域阅读，但与血液疾病的直接关联较少。

摘要: Peptide chemical modification is a valuable technique for improving peptide stability and bioactivity, particularly in drug discovery applications. Here, we report the development of a novel linker junction strategy using strain-promoted azide-alkyne cycloaddition (SPAAC) that enables the efficient formation of branched puromycin linkers with an average yield of 97%. This approach represents an improvement over traditional Michael-Addition methods, which typically yield  15%-20%. The high yield…

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55 A systems view on DNA damage response kinetics in <em>Tetrahymena</em>

推荐理由: 该研究提供了大规模的转录组‑蛋白组时间序列数据，对DNA损伤响应机制具有创新性和方法学价值，但与血液疾病关联度低，社会关注度有限，适合对基础DNA修复机制感兴趣的研究者参考。

摘要: A tightly regulated DNA damage response is critical to the overall integrity of the genome. Here, we combine transcriptomics and proteomics to study DNA damage response kinetics across well-established treatments in the ciliate Tetrahymena thermophila This extensive data set containing 6 conditions (HU, MMS, IR, HP, cisplatin, and UV) and 7 time points (from 0 to 8 hours) integrates over 250 paired transcriptome and proteome measurements. We observe upregulation of known DNA repair proteins as…

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56 Predicting protein-carbohydrate binding sites: a deep learning approach integrating protein language model embeddings and structural features

推荐理由: 该文提出了利用深度学习预测蛋白-碳水化合物非共价结合位点的计算方法，创新性和技术价值较高，但与血液疾病的直接关联有限，阅读价值一般。

摘要: Protein-carbohydrate interactions play an important role in many biological processes and functions, like inflammation, signal transduction, and cell adhesion. In our work, we will study non-covalent carbohydrate binding sites. In this paper, we aim to build a deep-learning model to predict non-covalent protein-carbohydrate binding sites. We were motivated by the fact that experimental approaches for predicting these sites are expensive. So, computational tools are necessary for identifying…

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57 Curcumol Induces Necroptosis of Hepatic Stellate Cells by Targeting KAT8 to Suppress HK2 Lactylation and Promote HUWE1-Dependent Ubiquitination

推荐理由: 该文揭示了天然化合物 Curcumol 通过代谢重编程选择性清除活化的肝星状细胞，为肝纤维化治疗提供新思路，虽与血液疾病关联不大，但对了解细胞代谢与纤维化的机制具有参考价值。

摘要: Liver fibrosis is a pathological outcome of chronic liver injury and is primarily driven by the continuous activation of hepatic stellate cells (HSCs). During activation, HSCs depend on aerobic glycolysis to maintain their fibrogenic characteristics, suggesting that metabolic reprogramming could serve as an effective therapeutic approach. In this study, we demonstrate that Curcumol, a natural compound derived from plants in the Zingiberaceae family, selectively removes activated HSCs by…

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58 Dalpicilib combined with cetuximab in patients with HPV-negative, anti-PD-1-resistant recurrent or metastatic head and neck squamous cell carcinoma: A phase II trial

推荐理由: 该研究探索CDK4/6抑制剂与抗EGFR药物联合治疗HPV阴性头颈癌，创新性突出，但对血液疾病的直接借鉴价值有限，阅读价值主要在于了解肿

摘要: Human papillomavirus (HPV)-negative head and neck squamous cell carcinoma (HNSCC) is characterised by hyperactivation of the cyclin-dependent kinase 4/6 (CDK4/6) pathway. As immunotherapy has become the first-line treatment for HNSCC, resistance to anti-programmed death-1 (PD-1) agents has emerged as a pivotal challenge. This prospective, single arm, phase II study (NCT05721443) evaluated the efficacy and safety of dalpiciclib, a CDK4/6 inhibitor, combined with cetuximab in patients with…

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59 Photo-initiated solvent-mediated depolymerization of consumer poly(methyl methacrylate) without chlorinated reagents

推荐理由: 该文在低温光催化回收PMMA方面提出了创新方法，实验数据可靠，适合关注材料循环与环境治理的科研人员阅读，但与血液疾病研究关联度极低。

摘要: The chemical recycling of commodity acrylic polymers, such as the transparent thermoplastic polymethyl methacrylate (PMMA), typically requires temperatures of 350-400°C. Herein, we report chemical recycling back to monomers for PMMA between 120-180°C, through UV illumination under oxygen-free conditions. We have achieved gram-scale degradation of consumer plastic with >95% conversion, yielding >70% monomer, which can be readily repolymerized. The process proceeds even at high concentrations (>1...

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60 Neuroimaging evaluation of high dose methotrexate-induced neurotoxicity in pediatric and young adults: a PET/MRI study

推荐理由: 该研究首次利用 18F‑FDG PET/MRI 评估高剂量甲氨蝶呤后脑代谢变化，对血液系统恶性肿瘤患者的神经毒性监测具有一定参考价值。

摘要: INTRODUCTION: High-dose Methotrexate (HDMTX) can induce neurotoxicity, yet its impact on brain metabolism remains underexplored. This study aimed to assess short- and long-term brain metabolic changes post-HDMTX on 18F-FDG PET/MRI relative to baseline (pre-HDMTX) scans.

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61 Morphologic and immunophenotypic characterization of lymphocytosis following BCMAtargeted CAR-T cell therapy in relapsed/refractory multiple myeloma

推荐理由: 评分失败，请手动查看

摘要: Not available.

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62 GVHD and GRFS in patients with acute myeloid leukemia undergoing allogeneic HCT with treosulfan- versus reduced-intensity busulfan-based conditioning: a subgroup analysis of a randomized phase 3 trial

推荐理由: 评分失败，请手动查看

摘要: Acute myeloid leukemia (AML) is the most common indication for allogeneic hematopoietic cell transplantation (alloHCT), yet graft-versus-host disease (GVHD) remains a major post-transplant complication. Conditioning regimens, particularly reduced-intensity approaches, are critical in optimizing outcomes. This subgroup analysis of the phase 3 MC-FludT.14/L trial compared treosulfan-fludarabine with reduced-intensity busulfan-fludarabine in 352 AML patients (aged 31-70) undergoing alloHCT. The…

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63 Chill out: freezing temperatures produced by letting a stressed alloy relax

推荐理由: 评分失败，请手动查看

摘要: No abstract

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64 An organ-conformal, kirigami-structured bioelectronic patch for precise intracellular delivery

推荐理由: 评分失败，请手动查看

摘要: Efficient and precise delivery of therapeutics toward target loci of organs is crucial for effective disease therapy. However, conventional devices face remarkable challenges to achieve clinically desirable conformality, spatial controllability, and efficiency, especially to organs with complex anatomies, due to a lack of appropriate mechanical and/or material properties. Here, we report a bioelectronic patch for organ-conformal, kirigami-structured electro-transfection (POCKET) that features…

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65 A GPCR-G protein-β-arrestin megacomplex enabled by a versatile allosteric modulator

推荐理由: 评分失败，请手动查看

摘要: Approximately one-third of clinical drugs mediate their therapeutic effects through G protein-coupled receptors (GPCRs), highlighting their immense therapeutic relevance. Novel approaches to modulate GPCR activity have the potential to yield unique pharmacological profiles. Conventionally, the G protein and β-arrestin signaling pathways downstream of GPCRs have been viewed as mutually exclusive. Using the in-house developed survival pressure selection (SPS) method, a high-throughput platform for…

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66 Proteomic profiling of UV damage repair patches uncovers histone chaperones with central functions in chromatin repair

推荐理由: 评分失败，请手动查看

摘要: DNA damage compromises not only genome stability but also chromatin integrity, which plays a central role in controlling cell identity. Chromatin repair entails the deposition of new histones at sites of DNA damage. How this is coordinated with parental histone dynamics for the maintenance of chromatin states is unknown. To bridge this knowledge gap, here we devise a novel proteomic strategy to characterize dynamic changes in the chromatin landscape during the repair of UV-induced DNA lesions in…

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67 Natural variation in Phosphatidylinositol 4-Kinase OsPI4Kγ7 and its interaction with OsLIC balance rice yield and latitudinal adaptation

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摘要: High yield and wide adaptation of rice are crucial for grain supply and food security. Here, we report a type II phosphatidylinositol 4-kinase, OsPI4Kγ7, which positively regulates rice yield and confers wide adaptation of rice. We show that OsPI4Kγ7 interacts with the transcription factor, OsLIC, and promotes its stability and nuclear translocation via phosphorylation, thereby increasing yield. Meanwhile, the natural variation of OsPI4Kγ7 alters its expression level by modulating OsTb2 binding….

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68 Lipid Nanoparticle Database towards structure-function modeling and data-driven design for nucleic acid delivery

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摘要: Lipid nanoparticles (LNPs) are the leading nonviral nucleic acid delivery technology, but LNP structure-function data remains fragmented and nonstandardized. Unlike protein engineering which is anchored by the centralized Protein Data Bank, the LNP field lacks a unified repository for systematic analysis. To address this, we develop Lipid Nanoparticle Database (LNPDB) (https://lnpdb.molcube.com), an integrated database and web tool that consolidates structural and functional data for 19,528…

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69 Impaired stem cell migration and divisions in Duchenne muscular dystrophy revealed by live imaging

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摘要: Dysregulation of stem cell properties is a hallmark of many pathologies, but the dynamic behaviour of stem cells in their microenvironment during disease progression remains poorly understood. Using the mdx mouse model of Duchenne Muscular Dystrophy, we developed innovative live imaging of muscle stem cells (MuSCs) in vivo, and ex vivo on isolated myofibres. We show that mdx MuSCs have impaired migration and precocious differentiation through unbalanced symmetric divisions, driven by p38 and…

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70 Prenatal Zika virus exposure disrupts social-emotional development and cortical visual function in infant macaques

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摘要: Prenatal Zika virus (ZIKV) exposure can result in outcomes ranging from severe birth defects to subtle developmental delays, yet the underlying mechanisms remain unclear. Using a translational rhesus macaque model, we assess visual, auditory, and neurodevelopmental outcomes through 12 months of age following first-trimester ZIKV inoculation. Pregnant macaques, either flavivirus-naive or with prior dengue virus (DENV) exposure, are inoculated with Asian or African ZIKV lineages. Maternal viremia…

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71 Labor Market Outcomes of People with HIV Pre- and Post-Diagnosis in the Netherlands

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摘要: In the current era of effective antiretroviral therapy, HIV has become a manageable chronic condition. Little is known about the consequences of HIV on individuals’ labor market outcomes. We study the impact of an HIV diagnosis using linked clinical data (the Dutch ATHENA cohort) and administrative data. A causal effect is estimated by comparing outcomes of people with HIV diagnosed between 2010 and 2022 (n = 5960) to a matched control group (n = 59,600) in a difference-in-difference design. We…

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72 An uORF-encoded mobile peptide sparks systemic stomatal immunity

推荐理由: 该研究揭示了植物系统性气孔免疫的新机制，创新性强，但与血液疾病关联度低，阅读价值主要在于提供跨学科的信号传导思路。

摘要: Higher organisms spread external stimuli from the perceptive tissues to the whole body to achieve systemic responses. In plants, guard cells sense pathogens and close stomata to prevent their entry. We observed that pathogen-infected local leaves transmit the danger status to uninfected distal systemic leaves and trigger their stomatal closure as a global defense termed systemic stomatal immunity (SSIM). The underlying mobile signals remain unknown. Here, we report that an upstream open reading…

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73 Bioinspired spiking architecture enables energy constrained touch encoding

推荐理由: 该文在触觉传感技术方面有一定创新和方法学价值，但与血液疾病关联度极低，阅读价值对血液学研究有限。

摘要: The sense of touch is essential for safe interactions with the external world, enabling humans to rapidly detect and localize physical stimuli. Biological systems achieve these abilities through hundreds of thousands of mechanoreceptors distributed across the skin and efficiently processing vast streams of tactile information. Replicating these affordances in autonomous systems is crucial for advancing robotics. However, current tactile sensing solutions face critical challenges, including…

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74 Machine perfusion ameliorates non-anastomotic strictures after liver transplantation: A systematic review and meta-analysis of randomized controlled trials

推荐理由: 该文章系统评估了机器灌注对肝移植胆道并发症的影响，方法学较为严谨，但与血液疾病关联度低，阅读价值有限。

摘要: INTRODUCTION: Machine perfusion (MP) technology may reduce the incidence of biliary complications (BCs) by reducing ischemia-reperfusion injury (IRI). This meta-analysis aims to compare the effects of MP and static cold storage (SCS) on the incidence of BCs, non-anastomotic stricture (NAS), and anastomotic stenosis (AS) after liver transplantation (LT).

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75 From nontargeted to precision oncology: predictive biomarkers and targeted therapies in advanced urothelial carcinoma

推荐理由: 该文主要聚焦于转移性尿路上皮癌的免疫检查点抑制剂及新型靶向药物，对血液疾病的直接借鉴价值有限，阅读价值相对一般。

摘要: For many decades, the treatment of metastatic urothelial carcinoma (mUC) was dominated by platinum-based chemotherapy. However, the introduction of immune checkpoint inhibitors in combination with modern antibody-drug conjugates (ADCs) and FGFR3 inhibitors has replaced this “old” standard due to significantly better efficacy. Although these therapies are targeted therapies, biomarker-driven therapy decisions are rarely used to date. The currently available biomarkers are also only helpful in…

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76 Coherent Ising machine based on polarization symmetry breaking in a driven Kerr resonator

推荐理由: 该文在光学模拟与优化算法方面具有创新性，但与血液疾病研究关联度极低，除非关注跨学科硬件平台，否则阅读价值有限。

摘要: Time-multiplexed networks of degenerate optical parametric oscillators have demonstrated remarkable success in simulating coupled Ising spins, thus providing a promising route to solving complex combinatorial optimization problems. In these systems, referred to as coherent Ising machines, spins are encoded in the oscillator phases, and measured at the system output using phase-sensitive techniques, making intricate phase stabilization necessary. Here, we introduce an optical Ising machine based…

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77 Localized 2D/3D heterojunction enhances photovoltage for perovskite-organic tandem solar cells

推荐理由: 该文在宽禁带钙钛矿太阳能电池的界面工程方面提出了新颖的Lewis酸碱相互作用策略，技术创新度较高，但与血液疾病关联度极低，阅读价值主要限于材料与能源领域的研究者。

摘要: Wide-bandgap perovskite solar cells are essential for constructing multi-junction solar cells; nevertheless, their achievable photovoltage is often limited by non-radiative recombination losses caused by defect states, mismatched energy levels, and poor contact at interfaces, resulting in a photovoltage plateau beyond 1.68 eV. Here, we explore intricate Lewis acid-base interactions between hole-selective self-assembled monolayer and ammonium ligands to engineer a localized 2D/3D perovskite…

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78 Ablation provides key macronutrients (nitrogen and phosphorous) to glacier ice algae in NW Greenland

推荐理由: 该研究提出了低浓度磷检测的新方法，对理解格陵兰冰盖藻类生长及其对冰面融化的影响具有重要意义，但与血液疾病关联有限，主要适合关注环境与气候变化的

摘要: Dissolved phosphorus (P) is thought to limit the growth of glacier ice algae, which darken the surface of the Greenland Ice Sheet (GrIS) and enhance surface melt. This contention is largely based on the low-level of P concentrations, which are often below the limit of detection of conventional methods. Here, we propose that low-level nutrient analysis is essential to understand the macronutrient limitation of glacier algal growth on the GrIS. We sample surface (≤5 cm) and shallow (5-10 and…

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79 AACRNL evolved from virulence factor to epigenetic parasite driving genome expansion in free-living eukaryotes

推荐理由: 该研究揭示了Crinkler效应子在非病原真核生物中的全新功能，提供了进化与表观遗传学交叉的前沿视角，值得血液学研究者了解其潜在的跨学科启示。

摘要: Crinkler effectors are iconic toxins deployed by pathogens to suppress host immunity, a function long thought exclusive to pathogenic species. Here, we uncover a striking evolutionary twist: an ADP-ribosyltransferase-associated Crinkler-like protein that has repurposed its toxin-derived activity to function as an epigenetic parasite in free-living eukaryotes, challenging the paradigm that Crinkler effectors are exclusively pathogen-restricted virulence factors. The…

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80 Collaborative and Cooperative Hospital “In-House” Medical Device Development and Implementation in the AI Age: The European Responsible AI Development (EURAID) Framework Compatible With European Values

推荐理由: 该文聚焦AI在医院的整体转型与实施挑战，虽对血液学直接贡献有限，但对了解医疗系统中技术落地的障碍具有一定参考价值。

摘要: The last years have seen an acceleration in the development and uptake of artificial intelligence (AI) systems by “early adopter” hospitals, caught between the pressures to “perform” and “transform” in a struggling health care system. This transformation has raised concerns among health care providers as their voices and location-specific workflows have often been overlooked, resulting in technologies that fail to integrate meaningfully into routine care and worsen rather than improve care…

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81 Performing chest compressions during the initial phase of out-of-hospital cardiac arrest: continuous vs. alternating (CALM) - a study protocol for prospective, randomised, monocentric, non-blinded, mannequin study with German emergency medical service personnel

推荐理由: 该研究聚焦于心肺复苏胸部按压的技术细节，与血液疾病关联度较低，虽对急救实践有一定公共健康价值，但对血液学研究的借鉴意义有限。

摘要: INTRODUCTION: Effective chest compressions are a core element of cardiopulmonary resuscitation (CPR). Current guidelines recommend exchanging the person performing chest compressions every two minutes to ensure high-quality chest compressions. However, this can lead to several task interruptions, which could result in a prolonged delay until other relevant tasks, such as securing the airway or administering adrenaline, are completed. Some studies have shown that a rescuer can perform sufficient…

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82 Revascularization Treatment of Basilar Artery Occlusion in Patients with Mild-to-Moderate Severe Stroke

推荐理由: 该研究涉及基底动脉闭塞的血管介入治疗，虽与血液疾病关联不大，但对急性脑卒中治疗策略具有一定的临床参考价值。若关注卒中治疗的最新证据，可略作阅读。

摘要: CONCLUSIONS: In this multicenter observational cohort study, EVT(±IVT) in patients with basilar artery occlusion with mild-to-moderate stroke, was not associated with improved clinical outcome but higher mortality compared with IVT-treatment. Our findings underscore equipoise and the need for prospective trials in this population.

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83 Harnessing Toluene Solvent as a Reactant: Regioselective Benzyl Radical Addition to Multi-π 1,5-Enynes in a Copper-Catalyzed Cascade to Indenes

推荐理由: 该文在有机合成方法上具有创新性，但与血液疾病关联度极低，且社会影响和政策价值有限，阅读价值一般。

摘要: C─H activation of toluene generates a benzyl radical that undergoes C─C coupling, converting an abundant solvent into carbon building blocks. A major challenge, however, is to direct the highly reactive benzyl radical to add regioselectively to a multi-π system in a way that initiates a cascade leading to complex products. Here, we achieved this goal for the first time, to our knowledge, and demonstrated that polysubstituted indene derivatives can be efficiently obtained through a…

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84 Stepwise hydrogen spillover-engineered synergistic sites enable near-quantitative conversion of waste PET to p-xylene

推荐理由: 该文在塑料废弃物高效转化方面提出了创新的催化剂体系，虽与血液疾病关联度低，但对了解跨学科的先进材料技术及其环境政策影响仍有一定参考价值。

摘要: The valorization of plastic waste represents a major challenge of the 21st century due to its severe environmental impact. Here, we report a stepwise hydrogen spillover-constructed CuCo/CoO(x) catalyst that enables near-quantitative conversion of waste polyethylene terephthalate to p-xylene (>99.9%), significantly outperforming the performance of various Cu- and Co-based catalysts as well as previously reported noble metal catalysts. The stepwise hydrogen spillover induces the formation of…

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85 External Validation of the Martini-Klinik Nomogram Predicting the Indication for Adjuvant Radiation Therapy According to EAU Guidelines Among Patients With High-Risk Prostate Cancer After Radical Prostatectomy

推荐理由: 该研究仅涉及前列腺癌的放疗指征预测，对血液疾病的直接启示有限，血液学研究者阅读价值不高。

摘要: CONCLUSIONS: This external validation within a contemporary tertiary-care cohort confirmed the ability of the Martini-Klinik nomogram to predict the indication for adjuvant radiation therapy after radical prostatectomy according to current EAU guideline recommendations in high-risk prostate cancer patients. The present nomogram may support clinicians in preoperative patient counseling about the risk for adjuvant treatment.

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86 Behavioral Risk Factors and Seroprevalence for Human Papillomavirus in Sinonasal Carcinoma: A Multi-Institutional Case-Control Study

推荐理由: 该研究揭示了HPV相关鼻窦癌的血清学特征及扁桃体切除的保护作用，对鼻窦癌的病因学有一定创新价值，但与血液疾病关联度低，阅读价值一般。

摘要: CONCLUSIONS AND RELEVANCE: HPV-SNC exhibits distinct serologic features without clear behavioral risk factors. The protective association of tonsillectomy suggests lymphoid tissue may play a role in HPV-associated sinonasal oncogenesis. In contrast, the absence of identifiable risk factors for HPV-independent SNC highlights the need for further etiologic studies.

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87 Holographic Whole-Object Photopolymerization Preserving Director Alignment in Liquid Crystalline Actuators

推荐理由: 该文在软体机器人材料方面具备创新性，但与血液疾病研究关联度极低，阅读价值对血液学者有限。

摘要: Liquid crystalline (LC) crosslinked polymeric structures are promising for soft robotic applications, as their actuation profile is intrinsically encoded and results from the structure’s shape and the LC molecular orientation (director). However, it remains challenging to fabricate 3D objects and at the same time control the director orientation within the 3D structure. Liquid crystalline molecules are commonly aligned using modified surfaces or electric/magnetic fields. However, additive…

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88 Disentangling multiple gas kinematic drivers in the Perseus galaxy cluster

推荐理由: 该文在星系团气体动力学的高分辨率X射线光谱研究上具备创新性，但与血液疾病关联度极低，阅读价值对血液学研究者有限。

摘要: Galaxy clusters, the Universe’s largest halo structures, are filled with an X-ray-emitting gas with a temperature between 10 million and 100 million degrees. Their evolution is shaped by energetic processes such as feedback from supermassive black holes (SMBHs) and mergers with other cosmic structures^(1-3). The imprints of these processes on gas kinematics remain largely unknown, restricting our understanding of energy conversion within clusters⁴. High-resolution spectral mapping with the X-Ray…

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89 The Ocean Equity Index

推荐理由: 该文提出的海洋公平指数在治理与政策评估方面具创新性，社会影响大，但与血液疾病研究关联度极低，血液学研究者阅读价值有限。

摘要: The ocean is essential for humanity^(1-3). Yet, inequity in ocean-based activities is widespread and accelerating^(4-8). Addressing this requires governance approaches that can systematically measure equity and track progress⁹. Here we present the Ocean Equity Index (OEI)-a framework for assessing and improving equity in ocean initiatives, projects and policies. We apply the index, which scores twelve criteria, to case studies at local, national and global scales. We show that the OEI can…

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90 The climate opportunities and risks of contrail avoidance

推荐理由: 该文提供了航空凝结尾迹规避对全球变暖的量化评估，方法严谨但与血液疾病研究关联度极低，阅读价值有限。

摘要: Navigational contrail avoidance presents an opportunity for rapid reduction in aviation-attributable warming. Here, we use the Aviation Climate and Air Quality Impacts model to evaluate the global temperature changes associated with contrail avoidance towards 2050. If no avoidance is adopted, aviation is projected to contribute 0.040 K of CO(2) warming and 0.054 K of contrail warming by 2050. The combined warming from aviation CO(2) and contrails is 19% of the difference between current…

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91 Allylrhodanine-processed all-small-molecule organic solar cell achieves an 18.43% efficiency breakthrough

推荐理由: 该文提出了新型固体添加剂 3‑AR 在全小分子有机太阳能电池中的形貌调控机制，创新性突出，但与血液疾病关联度极低，阅读价值主要限于材料科学领域。

摘要: Solid additives (SAs) improve organic solar cells (OSCs) morphology and performance, yet, their efficiency in all-small-molecule (ASM) OSCs is limited by strong donor-acceptor crystallinity, and the underlying mechanisms remain unclear. Herein, structurally resembling the MPhS-C2 donor, 3-allylrhodanine (3-AR) as a SA enables precise control over the active layer morphology. Interesting, combined theoretical calculations and thin-film morphology analyses reveal 3-AR preferentially interacts with…

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92 Ultralong-range exciton transport in submillimeter-scale spherulite film of π-conjugated polymers

推荐理由: 该研究在有机半导体的激子输运方面提供了新方法和实验数据，但与血液疾病关联度极低，阅读价值对血液学研究者有限。

摘要: Long-range exciton transport in organic semiconductors is essential for the performance of optoelectronic devices. However, solution-processed π-conjugated polymers films typically exhibit short exciton diffusion lengths (<20 nm) due to local imperfections or variations in interchain packing. Here, large-area submillimeter-scale spherulites are achieved by treating the spin-coated polydiarylfluorene film under solvent vapor annealing. The exciton diffusion length, visualized using transient…

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93 The representation of omitted sounds in the mouse auditory cortex

推荐理由: 该研究在听觉皮层预测机制上提供了新颖的成像方法和数据，对血液疾病研究的直接借鉴价值有限，阅读价值不高。

摘要: Humans and animals use predictions to optimize their behavior, however, the underlying neuronal implementation remains elusive. We address this using omitted sounds on the macro- and microscale of the auditory cortex of female, normal hearing mice using high-speed imaging. Neuronal responses to the omission of expected sounds were time-locked to expected stimulus onset, localized to layer 1-4 of higher auditory area (Temporal Association Area, TeA), and continued to rise until the following…

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94 A universal all-dry microfabrication method for sensitive electronic materials via an inorganic molecular lithographic mediator

推荐理由: 该文虽在微纳加工技术上有创新，但与血液疾病研究关联度极低，阅读价值对血液学研究者有限。

摘要: Lithography is pivotal in fabricating micro/nanoscale patterns and processing materials for electronic microdevices. However, conventional organic polymeric resists inevitably entail the use of various chemical solutions or solvents, which especially compromise fragile electronic materials featuring atomic-level surfaces. Here, we introduce inorganic selenium molecules as a lithographic mediator for sensitive electronic material processing without direct exposure to solutions or solvents….

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95 Green chemical process for continuous production of high-purity 2,5-furandicarboxylic acid in anion exchange membrane flow electrolyzer

推荐理由: 该文在生物质电氧化工艺上具有创新性，但与血液疾病研究关联度极低，血液学研究者阅读价值有限。

摘要: The electrooxidation of biomass platform molecules to produce highly value-added chemicals represents a promising technology for biomass utilization and carbon emission reduction. However, low production capacity and the lack of well-established engineering paradigms have constrained the practical application of this technology. Here, a green chemical process for the anion-exchange membrane (AEM) electrocatalytic 5-hydroxymethylfurfural oxidation (AEM-HMFOR) is proposed and applied to…

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96 Synergistic MOF-based composite enabling significant solar-to-water generation enhancement in climate-resilient AWH

推荐理由: 该文在太阳能驱动的空气水收集技术上提出了新型复合吸附剂，创新性突出，但与血液疾病研究关联度极低，阅读价值对血液学者有限。

摘要: Solar-driven atmospheric water harvesting (SAWH) holds significant promise for decentralized water supply. However, its widespread application is hindered by two critical limitations: underutilization of high-humidity adsorption windows during nighttime and insufficient desorption during daytime due to the high desorption temperature requirement of conventional sorbents. To overcome these challenges, this study proposes a composite sorbent strategy by synergistically combining the low enthalpy…

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97 A water-soluble copolymer for storage and electron conversion in photocatalytic on-demand hydrogen evolution

推荐理由: 该文虽在光伏储能材料方面有创新，但与血液疾病研究关联度极低，血液学研究者阅读价值有限。

摘要: Cost- and energy-efficient long-term storage of excess solar energy remains a major bottleneck in the transition to a sustainable society. Here, we present a water-soluble redox-active copolymer containing viologen moieties that can be charged with electrons upon visible light irradiation using a tris[4,4′-bis(tert-butyl)−2,2′-bipyridine]ruthenium(II) complex as chromophore. In the presence of a sacrificial donor, the system achieves charging efficiencies above 80% and fully maintains this state…

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98 Scaling crossover in droplet impact force on elastic substrates

推荐理由: 该文主要探讨液滴在弹性基底上的冲击力尺度转换，与血液疾病研究关联度极低，除非关注生物打印等交叉领域，否则阅读价值有限。

摘要: Droplet impacts are fundamental to fluid-structure interactions, shaping processes from erosion to bioprinting. While previous scaling laws have provided insights into droplet dynamics, force scaling laws remain insufficiently understood, particularly for soft substrates where both the droplet and substrate deform significantly. Here, we show that droplet impacts on elastic substrates exhibit a scaling crossover in maximum impact force, transitioning from inertial force scaling, typical for…

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99 Polarization-modulated programmable photovoltaic performance of a designed ferroelectric heterojunction

推荐理由: 该研究聚焦于新型光伏材料和异质结效应，与血液疾病关联度极低，除非专门研究跨学科材料在医学仪器中的潜在应用，否则不值得优先阅读。

摘要: Conventional photovoltaic devices based on PN or Schottky junctions are inherently constrained by the material band gap, resulting in limited photoelectric conversion efficiency. The van der Waals ferroelectric material CuInP(2)S(6) offers strong potential for efficient photocurrent generation via bulk photovoltaic effect, while heterostructure engineering provides additional degrees of freedom for performance modulation. Yet, the specificity in asymmetric CuInP(2)S(6) heterojunctions remains…

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100 Critical social media posts linked to retractions of scientific papers

推荐理由: 该文缺乏摘要，无法判断研究内容、创新性及对血液疾病的关联性，阅读价值有限。

摘要: No abstract

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101 Renal function during tenofovir‑based antiretroviral therapy among people living with HIV in Lilongwe, Malawi: findings from the prospective LighTen cohort study

推荐理由: 由于缺乏摘要和具体信息，无法评估该研究的创新性、方法学严谨性及其对血液疾病的相关性，阅读价值有限。

摘要: No abstract

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102 Aggressive Lymphoma after CD19 CAR T-Cell Therapy

推荐理由: 由于缺乏摘要内容，无法评估该研究的创新性、方法学严谨性及其对血液疾病的相关性，建议暂不阅读。

摘要: No abstract

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103 A Naturally Occurring Gain-of-Function Mutation in Factor VIII

推荐理由: 由于缺乏摘要和具体信息，无法评估该研究的创新性、方法学严谨性或对血液疾病的相关性，阅读价值极低。

摘要: No abstract

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104 Popeye Sign in Transthyretin Amyloidosis

推荐理由: 由于缺乏摘要和具体信息，无法评估该研究的创新性、方法学严谨性及其对血液疾病的相关性，阅读价值极低。

摘要: No abstract

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105 Educational Strategies to Prepare Trainees for Clinical Uncertainty. Reply

推荐理由: 由于没有提供摘要或任何内容信息，无法评估该研究的创新性、方法学严谨性或对血液疾病的相关性，阅读价值极低。

摘要: No abstract

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106 Educational Strategies to Prepare Trainees for Clinical Uncertainty

推荐理由: 由于缺乏摘要和具体信息，无法评估创新性、方法学严谨性及对血液疾病的相关性，阅读价值有限。

摘要: No abstract

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107 Educational Strategies to Prepare Trainees for Clinical Uncertainty

推荐理由: 由于缺乏摘要和具体信息，无法评估该研究的创新性、方法学严谨性或对血液疾病的相关性，阅读价值极低。

摘要: No abstract

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108 Aspirin in Patients Receiving Oral Anticoagulation. Reply

推荐理由: 由于缺乏摘要和具体信息，无法评估该研究的创新性、方法学严谨性或对血液疾病的相关性，阅读价值极低。

摘要: No abstract

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109 Aspirin in Patients Receiving Oral Anticoagulation

推荐理由: 由于没有提供摘要或任何内容，无法评估该研究的创新性、方法学严谨性或对血液疾病的相关性，故不推荐阅读。

摘要: No abstract

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110 Aspirin in Patients Receiving Oral Anticoagulation

推荐理由: 由于缺乏摘要和具体信息，无法评估该研究的创新性、方法学严谨性或对血液疾病的相关性，阅读价值极低。

摘要: No abstract

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111 Correction: Brentuximab vedotin plus chemotherapy for the treatment of front-line systemic anaplastic large cell lymphoma: subgroup analysis of the ECHELON-2 study at 5 years’ follow-up

推荐理由: 由于缺乏摘要内容，无法评估该研究的创新性、方法学严谨性及其对血液疾病的实际价值，故不推荐阅读。

摘要: No abstract

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112 MIMI: Molecular Isotope Mass Identifier for stable isotope-labeled Fourier transform ultra-high mass resolution data analysis

推荐理由: 由于缺乏摘要和具体信息，无法评估该研究的创新性、方法学严谨性及其对血液疾病的相关性，阅读价值有限。

摘要: No abstract

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113 Deep-sea robots will search for source of mysterious ‘dark oxygen’

推荐理由: 由于缺乏摘要和具体内容，无法评估该研究的创新性、方法学严谨性及其对血液疾病的相关性，阅读价值有限。

摘要: No abstract

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