追觅 - 2026-01-30

生成时间: 2026−02-02 14:32

分析文章数量: 94

1 Immune biomarkers of increased infection risk in multiple myeloma

推荐理由: 该研究利用新一代流式细胞术对骨髓免疫微环境进行系统 profiling，揭示多发性骨髓瘤患者感染风险的免疫标志物，对血液肿瘤免疫机制和临床防感染策略具有重要参考价值。

摘要: Infection remains a leading cause of morbidity in multiple myeloma. Preventing infections is paramount and immune profiling could reflect the cumulative effect of host, tumor and treatment-related immunosuppression. However, current understanding of immune dysfunction and its association with infection is limited. To address this gap in knowledge and identify immune biomarkers of increased infection risk, we performed immune profiling using next-generation flow cytometry in bone marrow and…

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2 Design, synthesis, and biological evaluation of novel HDAC3 PROTACs for combined therapy with Venetoclax in acute myeloid leukemia

推荐理由: 该研究创新性地开发了针对HDAC3的PROTAC并展示了在AML中的显著降解与协同效应，对血液肿瘤的机制研究和新药开发具有重要参考价值。

摘要: Acute myeloid leukemia (AML) is a heterogeneous hematopoietic neoplasm driven in part by aberrant epigenetic mechanisms such as histone deacetylation, with HDAC3 playing an important role in its pathogenesis. In this study, we designed a series of novel HDAC3 PROTACs based on our previously designed HDAC3 inhibitor as the POI ligand. Among these, representative compound B22 potently degraded HDAC3, with a DC(50) of 30.73 nM and a D(max) of 82%. B22 synergized with the clinically approved AML…

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3 Common variation at 1q23.3, 2p23.3, 2q33.3, and 2p21 influences risk of acute myeloid leukemia

推荐理由: 该研究通过大规模GWAS元分析发现AML新的易感位点，方法严谨且数据量大，对血液肿瘤遗传学研究具有重要参考价值，值得阅读。

摘要: Acute myeloid leukemia (AML) is a complex hematological malignancy with multiple disease sub-groups defined by somatic mutations and heterogeneous outcomes. Although genome-wide association studies (GWAS) have identified a small number of common genetic variants influencing AML risk, the heritable component of this disease outside of familial susceptibility remains largely undefined. Here we perform a meta-analysis of four published GWAS plus two new GWAS, totalling 4710 AML cases and 12938…

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4 Dual-antigen-targeting T-cell immunotherapies in MM: circumventing tumor heterogeneity and preventing antigen escape

推荐理由: 该文系统阐述了BCMA/GPRC5D 双靶向 T 细胞疗法在多发性骨髓瘤中的最新进展及抗原逃逸机制，对血液肿瘤免疫治疗的研究具有重要参考价值。

摘要: BCMA- or GPRC5D-directed T-cell immunotherapies have substantially improved the survival of patients with relapsed/refractory multiple myeloma (MM). Despite these advances, a subset of patients does not respond, and most patients will eventually relapse. Tumor heterogeneity, resulting in rapid selection of both antigen-negative and antigen-low cells, is a critical issue affecting response to T-cell immunotherapies targeting single tumor-associated antigens. In addition, antigen escape (due to…

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5 circPCMTD1: A protein-coding circular RNA that regulates DNA damage response in BCR/ABL1-positive leukemias

推荐理由: 该研究首次揭示circPCMTD1在BCR/ABL1阳性髓系白血病中的功能，提供了新的分子靶点和实验思路，对血液肿瘤研究具有较高的参考价值。

摘要: Circular RNAs are a novel class of RNA transcripts, which regulate important cellular functions in health and disease. Herein, we report on the functional relevance of circPCMTD1 in BCR/ABL1-positive myeloid leukemias. In screening experiments, we found that circPCMTD1 depletion strongly inhibited the proliferative capacity of leukemic cells with BCR/ABL1 translocations. RNA sequencing and mass cytometry experiments identified aberrant activation of the DNA damage response (DDR) pathway as a…

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6 Circadian fluctuation of soluble CD26 dictates the impact of the timing of cord blood transplantation on acute graft-versus-host disease

推荐理由: 该研究首次探讨冷冻脐血移植时输注时机对急性GVHD的影响，对优化造血干细胞移植方案具有重要参考价值，值得血液科研究者阅读。

摘要: Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is a cornerstone treatment for many malignant and nonmalignant hematological diseases. Our recent research demonstrated that early-day stem cell infusions significantly reduce the incidence and severity of acute graft-versus-host disease (aGVHD) following allo-HSCT using fresh grafts. However, the impact of infusion timing on aGVHD in allo-HSCT with cryopreserved grafts such as unrelated cord blood (UCB) remains unclear. Here, we…

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7 The role of m6A RNA methyltransferase METTL3 in drug resistance mechanisms in acute myeloid leukemia

推荐理由: 该综述系统梳理了METTL3在AML耐药中的分子机制及最新干预策略，对血液肿瘤研究者具有较高的参考价值，值得一读。

摘要: This review examines the role of METTL3, a core RNA methyltransferase, in therapeutic resistance in acute myeloid leukemia (AML) and discusses emerging strategies to address this challenge. METTL3 regulates N^6-methyladenosine (m^6A) modifications on transcripts involved in key cellular processes, including apoptosis (BCL2, MCL1), metabolism (PGC-1α, CSRP1), proliferation (MYC), autophagy (FOXO3), and bone marrow microenvironmental interactions (ITGA4, AKT1). These modifications enhance the…

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8 CD8a antibody-functionalized biomimetic red blood cell membrane ectosomes delivering C646 reverse CD8^+ T Cell exhaustion via H3K18la histone delactylation in gastric cardia adenocarcinoma

推荐理由: 该研究创新性强，利用红细胞膜仿生囊泡精准递送表观遗传抑制剂，重新激活耗竭的 CD8^+ T 细胞，对肿瘤免疫

摘要: The functional exhaustion of CD8^(+) T cells in the tumor microenvironment (TME) severely limits anti-tumor immunity in gastric cardia adenocarcinoma (GCA). Here, we developed CD8a antibody-functionalized biomimetic red blood cell membrane ectosomes (CD8a-NVEs) encapsulating the p300 inhibitor C646 to selectively target and reprogram exhausted CD8^(+) T cells. Single-cell RNA sequencing of human GCA tissues revealed lactate-driven epigenetic remodeling, characterized by elevated H3K18…

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9 The role of m6A RNA methyltransferase METTL3 in drug resistance mechanisms in acute myeloid leukemia

推荐理由: 该综述系统梳理了METTL3在AML耐药中的分子机制并提出新策略，对血液肿瘤研究者具有较高的参考价值，值得一读。

摘要: This review examines the role of METTL3, a core RNA methyltransferase, in therapeutic resistance in acute myeloid leukemia (AML) and discusses emerging strategies to address this challenge. METTL3 regulates N^6-methyladenosine (m^6A) modifications on transcripts involved in key cellular processes, including apoptosis (BCL2, MCL1), metabolism (PGC-1α, CSRP1), proliferation (MYC), autophagy (FOXO3), and bone marrow microenvironmental interactions (ITGA4, AKT1). These modifications enhance the…

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10 The role of m6A RNA methyltransferase METTL3 in drug resistance mechanisms in acute myeloid leukemia

推荐理由: 该综述系统梳理了METTL3在AML耐药中的机制并提出新策略，对血液学研究和临床靶向治疗具有重要参考价值。

摘要: This review examines the role of METTL3, a core RNA methyltransferase, in therapeutic resistance in acute myeloid leukemia (AML) and discusses emerging strategies to address this challenge. METTL3 regulates N^6-methyladenosine (m^6A) modifications on transcripts involved in key cellular processes, including apoptosis (BCL2, MCL1), metabolism (PGC-1α, CSRP1), proliferation (MYC), autophagy (FOXO3), and bone marrow microenvironmental interactions (ITGA4, AKT1). These modifications enhance the…

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11 Circadian fluctuation of soluble CD26 dictates the impact of the timing of cord blood transplantation on acute graft-versus-host disease

推荐理由: 该研究首次探讨冷冻脐血移植时机对急性GVHD的影响，创新性强且与血液病临床实践高度相关，值得血液科研究者阅读。

摘要: Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is a cornerstone treatment for many malignant and nonmalignant hematological diseases. Our recent research demonstrated that early-day stem cell infusions significantly reduce the incidence and severity of acute graft-versus-host disease (aGVHD) following allo-HSCT using fresh grafts. However, the impact of infusion timing on aGVHD in allo-HSCT with cryopreserved grafts such as unrelated cord blood (UCB) remains unclear. Here, we…

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12 Remodelling of the bone marrow vasculature induced by venetoclax and azacitidine damage

推荐理由: 该研究首次揭示 venetoclax+azacitidine 对骨髓微环境的损伤，提供了血液肿瘤治疗安全性的新视角，对临床用药和后续机制研究具有重要参考价值。

摘要: The Bcl2 inhibitor venetoclax in combination with the hypomethylating agents azacitidine (ven/aza) has become increasingly utilized clinically for the treatment of many hematological malignancies. Whilst its effects on malignant cells have been extensively studied, its impact to the surrounding bone marrow microenvironment (BME) remains unexplored. In this study, we report that ven/aza therapy causes significant damage to the BME of mice. Comparatively high Bcl2 expression in the sinusoidal…

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13 Comparative evaluation of two MALDI-TOF MS systems for microbial identification: accuracy and workflow efficiency in a clinical microbiology laboratory

推荐理由: 该研究系统比较了两种 MALDI‑TOF MS 平台在血培养菌株鉴定中的准确性和工作流程，对血液科患者的快速感染诊断具有参考价值，值得阅读。

摘要: This study aimed to compare the identification accuracy and workflow of the VITEK MS PRIME (VMP) and the MALDI Biotyper Sirius (BS) in a routine laboratory setting. A total of 927 isolates, representing 219 different species, were analyzed using both the VMP and the BS system. In addition, 119 positive blood cultures were tested after 4-6 h of subculture, with and without formic acid, and compared to the results obtained after 18 to 24 h. Hands-on time (HOT) and time to result (TTR) were…

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14 Rinaldo Bellomo: A clinician with a passion for preclinical research

推荐理由: 该文通过羊模型系统阐明败血症性急性肾损伤的机制及血流动力学干预，对重症医学和相关血液动力学研究具有重要启示，值得一读。

摘要: Professor Rinaldo Bellomo was a pioneer in intensive care medicine whose influence extended beyond clinical trials to preclinical and translational research. His long-standing collaboration with the Florey Institute established ovine sepsis models that overturned dogma, demonstrating that septic acute kidney injury can occur despite increased renal blood flow, and clarifying the effects of fluids, noradrenaline, vasopressin, and angiotensin II. These studies advanced understanding of renal…

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15 Acute myeloid leukemia (AML)-derived bone mesenchymal stem cell exosomal METTL14 promotes AML cell growth and glycolysis by HOXA3/WNT7B axis

推荐理由: 该研究揭示了AML来源的MSC外泌体促进白血病进展的分子机制，对血液肿瘤的发病机制和潜在治疗靶点具有较高的参考价值。

摘要: Acute myeloid leukemia (AML)-derived bone mesenchymal stem cell (MSC) exosomes have been confirmed to have a positive effect on AML progression. This study aim to reveal the underlying molecular mechanism by which AML-MSC-derived exosomes promotes AML progression. AML-MSC was isolated from the bone marrow aspirates of AML patients. After incubated with AML-MSC, AML cell functions were analyzed. The expression levels of methyltransferase-like 14 (METTL14), homeobox A3 (HOXA3), WNT family member…

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16 BCMA-CD19 armored compound CAR T cells in systemic lupus erythematosus: extended follow-up of a phase 1 clinical trial

推荐理由: 该研究首次报道双靶向BCMA‑CD19 CAR‑T在难治性系统性红斑狼疮中的应用，创新性强且与血液学

摘要: CD19 CAR T-cells have shown promise in treating systemic lupus erythematosus (SLE), however, relapses demonstrate persistently elevated autoantibodies characteristic of CD19-negative long-lived plasma cells (LLPCs). Alternatively, ICG318, a dual-targeting BCMA-CD19 armored CAR T-cell therapy, targets both B cells and plasma cells/LLPCs driving SLE which may improve outcomes. Herein, we present 12 patients with refractory SLE, including 10 with lupus nephritis (LN), who received ICG318 CAR…

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17 Association-induced folding governs surrogate light chain and pre-B cell receptor core assembly

推荐理由: 该研究阐明了前B细胞受体的组装机制，对理解B细胞发育异常及相关血液肿瘤具有重要参考价值，值得血液学研究者阅读。

摘要: Binding of the surrogate light chain (SLC) to the heavy chain (HC) of the pre-B cell receptor (preBCR) is an important quality control checkpoint during B cell development as roughly 50% of the rearranged HCs are defective. Unlike the regular light chain (LC), the SLC is a hetero-dimer of VpreB and λ5, both containing unstructured extensions, the unique regions. The molecular mechanisms that underlie the complex assembly processes which give rise to the final pre-BCR is not fully understood….

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18 Structural basis for selective inhibition of human GABA transporter GAT3

推荐理由: 该研究提供了GAT3抑制剂的高分辨率结构，为神经疾病药物开发提供了重要线索，值得血液学研究者了解其技术和方法的创新性。

摘要: The astrocytic γ-aminobutyric acid (GABA) transporter, GAT3, is essential for terminating GABAergic signaling in the central nervous system. Selective inhibition of GAT3 offers a potential strategy for elevating extracellular GABA levels for the treatment of neurological disorders including epilepsy. However, few potent and selective GAT3 inhibitors have been developed, and their mechanisms of inhibition remain poorly understood. Here, we present the cryo-electron microscopy structures of…

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19 Rinaldo Bellomo’s seminal contribution to observational research using the ANZICS CORE registry

推荐理由: 该文展示了如何利用高质量的临床登记数据进行严谨的观察性研究，对重症医学的政策制定和实践改进具有重要借鉴意义，虽与血液疾病直接关联不大，但其方法学对血液科的科研和临床数据管理具有参考价值。

摘要: Rinaldo Bellomo advanced critical care not only through randomised trials but also through rigorous use of observational data, particularly from the ANZICS Centre for Outcome and Resource Evaluation (ANZICS CORE) Registry. At a time when retrospective analyses were often confined to hypothesis generation, he showed that carefully curated, clinically grounded registry studies could inform policy and change practice. Recognising early the potential of ANZICS CORE to become a leading registry, he…

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20 Personalized gene expression prediction in the era of deep learning: a review

推荐理由: 该文提出了利用深度学习捕获个体基因组变异对基因表达预测的创新方法，对基因调控研究具有重要参考价值，值得血液学研究者了解其技术思路。

摘要: Predicting gene expression from genomic sequences is a central goal in computational genomics. Recent advances have demonstrated that deep learning models trained on large-scale epigenomic datasets hold significant promise for this task. However, their success heavily depends on how they are applied: most models are trained exclusively on a reference genome, limiting their ability to capture individual-specific genetic variation. Consequently, while these models perform well on reference…

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21 A non-catalytic role for RFC in PCNA-mediated processive DNA synthesis

推荐理由: 该研究首次揭示RFC在PCNA装载后仍与其结合的动态行为，提供了DNA复制机制的新视角，对血液系统肿瘤等涉及复制错误的血液疾病研究具有潜在借鉴价值。

摘要: The ring-shaped sliding clamp proliferating cell nuclear antigen (PCNA) enables DNA polymerases to perform processive DNA synthesis during replication and repair. The loading of PCNA onto DNA is catalyzed by the ATPase clamp-loader replication factor C (RFC). Using a single-molecule platform to visualize the dynamic interplay between PCNA and RFC on DNA, we unexpectedly discovered that RFC continues to associate with PCNA after loading, contrary to the conventional view. Functionally, this…

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22 CRISPR screens in iPSC-derived neurons reveal principles of tau proteostasis

推荐理由: 该研究通过全基因组筛选系统性揭示了人类神经元中调控tau聚集的细胞因子，对理解阿尔茨海默等神经退行性疾病的机制具有重要参考价值。虽然与血液疾病关联不大，但其创新的实验方法和数据可靠性值得血液学研究者借鉴。

摘要: Aggregation of the protein tau defines tauopathies, the most common age-related neurodegenerative diseases, which include Alzheimer’s disease and frontotemporal dementia. Specific neuronal subtypes are selectively vulnerable to tau aggregation, dysfunction, and death. However, molecular mechanisms underlying cell-type-selective vulnerability are unknown. To systematically uncover the cellular factors controlling the accumulation of tau aggregates in human neurons, we conducted a genome-wide…

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23 Rochelle salt-based biodegradable piezoelectric devices for nerve regeneration and intestinal motility monitoring

推荐理由: 该文在可降解压电材料的创新设计与性能提升方面提供了新思路，对生物电子接口的研发具有参考价值，值得血液学研究者了解其技术潜力。

摘要: Piezoelectric materials provide a unique platform for bioelectronic interfaces, enabling dynamic sensing and electroactive therapies through bidirectional transduction between biomechanical and bioelectrical signals. However, the development of bioresorbable piezoelectric materials that combine high functional performance with mechanical compliance remains a critical challenge for seamless integration with soft biological tissues, while eliminating the need for retrieval surgeries and long-term…

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24 Geographic spillover of antimicrobial resistance from mass distribution of azithromycin

推荐理由: 该研究通过大规模随机试验揭示了阿奇霉素群体给药对儿童死亡率的显著降低及其抗药性外溢风险，对公共卫生政策具有重要参考价值，值得一读。

摘要: Large-scale, placebo-controlled, cluster-randomized trials in high-mortality settings in sub-Saharan Africa demonstrated a 14-18% reduction in childhood mortality following twice-annual mass drug administration (MDA) of azithromycin among children aged 1-59 months. Azithromycin MDA also selected for antimicrobial resistance (AMR), particularly macrolide resistance. It is unknown whether the AMR from azithromycin MDA could spill over to neighboring untreated populations. If present, such…

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25 Treponema pallidum lipoprotein Tp0768 promotes H3K18 Lactylation modification to target PTK2 and enhance endothelial permeability

推荐理由: 该研究揭示了梅毒螺旋体如何破坏血管内皮并通过血液传播，对理解血管-血液相互作用具有一定参考价值，值得血液学研究者了解。

摘要: Syphilis is a systemic sexually transmitted disease, yet the mechanisms underlying the dissemination of its causative pathogen, Treponema pallidum (T.pallidum), within the host remain incompletely understood. Previous studies have shown that T.pallidum can damage vascular endothelial cells, thereby breaching the endothelial barrier to invade lymph nodes at the infection site. This facilitates its systemic dissemination via the bloodstream, leading to persistent infection across multiple vascular…

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26 VSIG10L is a major determinant of esophageal homeostasis and inherited predisposition to Barrett’s esophagus

推荐理由: 该研究揭示了VSIG10L基因与Barrett食管的关联，方法新颖且数据可靠，对消化道疾病机制有重要参考价值，但与血液疾病关联度较低。若关注跨学科的分子病理学，可值得一读。

摘要: The molecular underpinnings contributing to the onset of Barrett’s esophagus (BE) remain elusive. By studying familial clusters of the disease, here we identify a significant association between genetic variants in the V-set and Immunoglobulin Domain Containing 10 Like (VSIG10L) gene and BE predisposition. Using mammalian tissues and patient-derived organoids, we show VSIG10L is selectively expressed in the suprabasal squamous cells of the esophageal mucosa and is essential for epithelial…

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27 SGCRNA: spectral clustering-guided co-expression network analysis without scale-free constraints for multi-omic data

推荐理由: 该文提出了对WGCNA算法的关键改进，提升了基因共表达分析的可靠性和适用范围，对血液学研究中基因网络探索具有潜在借鉴价值，值得一读。

摘要: Weighted gene co-expression network analysis (WGCNA) is among the most widely employed methods in bioinformatics. WGCNA enables the identification of gene clusters (modules) exhibiting correlated expression patterns, the association of these modules with traits, and the exploration of candidate biomarker genes by focusing on hub genes within the modules. WGCNA has been successfully applied in diverse biological contexts. However, conventional algorithms manifest three principal limitations: the…

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28 Mechanistic insights into RNA chaperoning by Ro60 and La autoantigens

推荐理由: 该研究揭示了Ro60 与 La 蛋白协同解折错构 RNA 的新机制，并提供了高分辨率的 cryo‑EM 结构，对 RNA 折叠与非编码 RNA 功能的基础研究具有重要

摘要: Although ATP-independent chaperones assist RNA folding, the mechanisms by which they function remain elusive. Here, we demonstrate how two RNA chaperones collaborate to unfold misfolded noncoding RNAs (ncRNAs). The ring-shaped Ro60 protein binds the ends of misfolded ncRNAs in its cavity, whereas La stabilizes nascent ncRNAs and assists their folding. Using cryo-electron microscopy to resolve the structure of a misfolded RNA complexed with Ro60 and La, we show that La cradles the Ro60…

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29 Blood-flow restriction resistance training improves skeletal muscle mitochondrial capacity and cardiovascular risk factors in type 2 diabetes

推荐理由: 该研究探索低负荷血流限制训练在2型糖尿病患者中提升肌肉力量和线粒体功能的潜力，创新性强且对公共健康有一定意义，值得一读。

摘要: Impaired muscle strength and mitochondrial functionality are hallmarks of type 2 diabetes (T2D). Conventional combined resistance/endurance exercise training has limited efficacy to simultaneously improve muscle function and metabolism. We examined whether low-load blood-flow restriction training (BFRT) increases both muscle strength and mitochondrial oxidative capacity in T2D. Over 12 weeks, BFRT and conventional resistance training (CREST) similarly improved muscle strength despite lower…

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30 Social connections are differentially related to subjective age and physiological age acceleration amongst older adults

推荐理由: 该研究利用大规模纵向数据揭示弱社交联系与主观及生理衰老的关联，方法严谨且对公共健康政策具有重要启示，值得关注。

摘要: Human social connections are complex ecosystems formed of structural, functional and quality components. Weak social connections are associated with adverse age-related health outcomes, but we know little about the ageing-related processes underlying this. Using data from 7047 adults aged 50+ in the English Longitudinal Study of Ageing, we explore associations between diverse aspects of social connections and both older subjective age and accelerated physiological age using a validated…

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31 Divergent photochemical ring-replacement of isoxazoles

推荐理由: 该文提出的光化学“环替换”平台在药物合成创新上具有重要价值，虽与血液疾病关联不大，但对开发新型血药及相关化合物的合成策略具有参考意义。

摘要: Isoxazoles, oxazoles, and other five-membered heteroaromatics are prevalent motifs in core structure of pharmaceuticals and agrochemicals. In early-stage drug discovery, it is common practice to prepare libraries of analogues featuring different heterocyclic cores and this generally requires a de novo synthesis for each scaffold. A valuable but currently unavailable strategy would involve the possibility for direct heterocycle “ring-replacement”. Here we report a photochemical platform for the…

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32 Quantum magnetic J-oscillators

推荐理由: 该文提出的零场量子J振荡器在高分辨率核磁共振检测上具备创新性，技术前沿但与血液疾病直接关联有限，适合关注新型检测手段的研究者阅读。

摘要: Zero-field nuclear magnetic resonance (NMR) offers magnet-free access to nuclear spin-spin (scalar J) couplings, which define an intrinsic, molecule-specific frequency scale. However, the transient nature of zero-field NMR signals constrain spectral resolution and frequency stability. Here we introduce quantum J-oscillators that exploit J-couplings in molecules to produce phase-coherent continuous oscillations. Operated in zero magnetic field and driven by digital feedback, they generate…

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33 Anti-TLR2 immunotherapy modulates neuron-to-oligodendrocyte propagation of α-synuclein in mouse and human models

推荐理由: 该研究揭示了α‑synuclein 在神经元与少突胶质细胞之间的传播机制，对帕金森病和多系统萎缩的发病机制具有重要创新价值，值得神经科学及相关跨学科研究者阅读。

摘要: Intracellular accumulation of α-synuclein (αSyn) aggregates is a hallmark of synucleinopathies, such as Parkinson’s disease (PD) and multiple system atrophy (MSA). In MSA, αSyn aggregates form glial cytoplasmic inclusions (GCIs) in oligodendrocytes, despite their low expression of αSyn. Here, we demonstrate that neuron-to-oligodendrocyte propagation of αSyn, via Toll-like receptor 2 (TLR2) contributes to GCI formation. Male transgenic mice expressing the A53T mutant human αSyn exclusively in…

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34 IFITM3 deficiency drives SARS-CoV-2 adaptation while preserving variant-specific traits

推荐理由: 该研究揭示IFITM3缺失对SARS‑CoV‑2跨种适应的影响，提供了新颖的病毒宿主适应机制，对公共卫生和病毒学研究具有一定价值。虽然与血液疾病关联有限，但对免疫学和感染性疾病的理解仍具参考意义。

摘要: SARS-CoV-2 can infect and adapt to multiple animal species, yet the host determinants that control interspecies viral adaptation remain poorly defined. Here we investigate whether interferon-induced transmembrane protein 3 (IFITM3), a key antiviral protein deficient in certain human populations, affects interspecies adaptation of SARS-CoV-2. We find that SARS-CoV-2 Beta and Omicron BA.4 variants passaged through IFITM3-deficient versus wild type mice exhibit enhanced replication and pathogenesis…

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35 ClpC1-targeting peptide natural products differentially dysregulate the proteome of Mycobacterium tuberculosis

推荐理由: 该研究揭示了结核分枝杆菌关键蛋白降解系统的新靶点，对抗结核药物研发具有重要意义，但与血液疾病关联度较低。

摘要: Targeting the protein quality control system in Mycobacterium tuberculosis represents a promising and underexplored opportunity for antibiotic development. The ClpC1:ClpP1P2 protease is an essential component of the system that mediates both regulatory and stress-related protein degradation. Several non-ribosomal peptide natural products, including ecumicin, ilamycins (rufomycins) and cyclomarins, have been discovered that bind to the ClpC1 chaperone of the complex and exhibit potent…

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36 Domain-specific schema reuse supports flexible learning to learn in the primate brain

推荐理由: 该研究揭示了大脑如何在保持已有模式的同时灵活适应新信息，对理解学习机制具有创新价值，但与血液疾病关联度较低，仅在跨学科启发上具备一定参考价值。

摘要: Prior knowledge accelerates subsequent learning of similarly structured problems - a phenomenon termed learning to learn - by forming generalizable neural representations called neural correlates of schema (NCS). However, how the brain exploits stable NCS while remaining flexible towards changes (the stability-plasticity dilemma) remains unclear. Here, we show that the primate brain addresses this dilemma by representing the stable NCS and task-unique changes in a near-orthogonal manner. We…

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37 Unravelling the paradox of vitamin C research in sepsis

推荐理由: 该文展示了在危重症（败血症）中对维生素C组合疗法的严谨研究思路，对临床试验设计和方法学有借鉴价值，但与血液疾病的直接关联较少，阅读价值适中。

摘要: Professor Rinaldo Bellomo’s lasting impact on critical care research stems from his commitment to structured, biologically grounded research programs over isolated studies. His work on vitamin C in sepsis exemplifies this approach. While early enthusiasm grew around combination therapies involving vitamin C, Rinaldo championed a cautious, rigorous, and methodical investigation. He worked closely with collaborators to address key methodological issues, including dosing, stability, and the design…

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38 Developmental convergence and divergence in human stem cell models of autism

推荐理由: 虽然该研究聚焦自闭症，但其使用大量hiPS细胞和多基因突变模型的创新方法，对细胞分化和基因调控机制的探索可为血液系统疾病的模型构建提供思路，值得一读。

摘要: Two decades of genetic studies in autism spectrum disorder (ASD) have identified more than 100 genes harbouring rare risk mutations^(1-13). Despite this substantial heterogeneity, transcriptomic and epigenetic analyses have identified convergent patterns of dysregulation across the ASD postmortem brain^(14,15-17). To identify shared and distinct mechanisms of ASD-linked mutations, we assembled a large patient collection of human induced pluripotent stem (hiPS) cells, consisting of 70 hiPS cell…

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39 A Bacteroides synthetic biology toolkit to build an in vivo malabsorption biosensor

推荐理由: 该研究在合成微生物传感器方面具备创新性，可为肠道健康监测提供新工具，但与血液疾病关联度较低，阅读价值主要在于其技术方法和跨学科启发。

摘要: The human gut is a dynamic environment, where changes in pH, oxygen, and osmolality influence microbiota composition and disease. Monitoring these environmental shifts is crucial for advancing gut health diagnostics and therapeutics, yet non-invasive monitoring tools remain limited. Genetically tractable commensals, including Bacteroides thetaiotaomicron, offer promising chassis for engineering biosensors but lack modular systems for precise sensing and reporting. Here, we developed genetic…

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40 Macrophage TRIM21 lactylation exacerbates infection-induced orchitis through enhancing STAT1-mediated CXCL9 and CXCL10 production

推荐理由: 该研究探讨感染性睾丸炎的炎症机制，对男性不育有一定的临床意义，但与血液疾病关联较弱，创新性和社会关注度一般，值得一读以了解相关炎症路径。

摘要: INTRODUCTION: Infection-induced orchitis, a leading cause of acquired male infertility affecting 8%-12% of couples globally, is driven by unresolved inflammatory responses following bacterial infection.

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41 A molecularly defined basalo-prefrontal-thalamic circuit regulates sensory and affective dimensions of pain in male mice

推荐理由: 该研究揭示了mPFC‑Foxp2^+投射至丘脑的神经回路在疼痛调控中的关键作用，方法新颖且数据可靠，对疼痛机制研究具有参考价值，但与血液疾病关联较弱。

摘要: Both the medial prefrontal cortex (mPFC) and thalamus have been implicated in pain regulation. However, the roles of the mPFC-thalamus connection in pain and how the mPFC modulates nociceptive processing remain unclear. Here, we show that the mPFC neurons projecting to thalamus, marked by Foxp2 expression, are deactivated in both acute and chronic pain in male mice. Persistent inactivation of the mPFC Foxp2^(+) neurons enhances nociceptive sensitivity, while their activation alleviates multiple…

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42 Fatigue resistant elastocaloric effect in TiNi via texture-precipitate synergy

推荐理由: 该文在形状记忆合金的弹性热效应与疲劳性能方面提供了新颖的材料设计思路，技术价值突出，但与血液疾病关联度极低，仅对血液学研究的借鉴意义有限。

摘要: Shape memory alloys with both a large elastocaloric effect and exceptional fatigue resistance are key candidates for next-generation solid-state cooling technologies. Here, we report a textured TiNi alloy containing engineered Ti_4Ni_2O precipitates, fabricated via controlled directional solidification, that achieves a large adiabatic temperature change of −15.9 K after 10 million compressive cycles. Microstructural analyses reveal columnar B2 grains aligned with the solidification direction and a…

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43 Exploiting a high-performance magnesium-fluoride battery prototype enabled by anion-receptor-mediated electrolyte

推荐理由: 该文在镁电池电解质设计上提出新思路，技术创新度高，但与血液疾病关联度极低，仅对跨学科了解新材料的血液学研究者有一定参考价值。

摘要: Rechargeable magnesium batteries have emerged as a competitive next-generation energy storage technology owing to their abundant resources and inherent safety. The development of Mg batteries, especially regarding specific energy, has been compromised by the lack of high-performance positive electrodes. Here, we design an anion-receptor-mediated all-phenyl-complex electrolyte that enables the electrochemical cooperation between fluoride and magnesium, and develop a Mg | |FeO(0.7)F(1.3) battery…

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44 Hydrocyclone-enhanced scalable photocatalytic hydrogen generation, from macroscale turbulence to nanoscale reaction dynamics

推荐理由: 该文在光催化制氢技术上提出了创新的水力旋流器耦合方案，具备一定的工业化前景，但与血液疾病关联度极低，阅读价值主要在于跨学科的技术启发。

摘要: Photocatalytic hydrogen production faces barriers to industrialization, including inadequate light absorption and limited mass/momentum transfer at scale. Integrating external hydrocyclones into photoreactors is a promising solution, yet the multiscale complexity of hydrocyclone-driven hydrogen generation impedes mechanistic understanding and rational system design. Herein, we build a scalable hydrocyclone-based photoreactor that achieves 270 mL/h hydrogen yield and 5.26% solar-to-hydrogen…

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45 Olutasidenib in recurrent/relapsed locally advanced or metastatic IDH1-mutated chondrosarcoma: phase 1b/2 trial

推荐理由: 该研究首次评估了IDH1突变抑制剂在软骨肉瘤中的安全性与疗效，对IDH突变相关的血液肿瘤（如AML）药物开发具有一定参考价值，值得血液学研究者关注。

摘要: Chondrosarcomas are rare cartilaginous neoplasms with limited treatment options. Isocitrate dehydrogenase 1/2 (mIDH1/2) mutations occur in 65% of chondrosarcomas. Here we report safety and efficacy of olutasidenib, an mIDH1 inhibitor, evaluated in patients with locally advanced or metastatic mIDH1 chondrosarcoma (Clinicaltrials.gov identifier: NCT03684811). The primary endpoint was objective response rate by tumor evaluation; secondary endpoints included adverse events, progression-free and…

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46 NUMB in Endometrial Pathology: From Adenomyosis Expression Patterns to Endometrial Cancer Survival Implications

推荐理由: 该研究首次探讨Numb在子宫腺肌症中的作用，创新性突出，对妇科疾病机制有参考价值，但与血液疾病关联有限，阅读价值适中。

摘要: Adenomyosis, a prevalent gynecologic condition involving invasion of endometrial tissue into the myometrium, remains poorly understood in terms of its molecular pathogenesis. Numb, an important regulator of cellular destiny and stem cell maintenance, has been implicated in numerous proliferative diseases; however, the role for Numb in adenomyosis has not yet been investigated. This research examines the degree to which Numb protein may play a role in the pathogenesis of adenomyosis and…

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47 Flow diverter treatment for saccular unruptured intracranial aneurysms: A systematic review focussing on study quality and initial outcomes

推荐理由: 该综述系统评估了FD支架治疗小型未破裂脑动脉瘤的并发症和短期疗效，对神经血管介入领域有参考价值，但与血液疾病关联有限，阅读价值一般。

摘要: INTRODUCTION: Flow-diverting (FD) stents are increasingly used to treat small, unruptured intracranial aneurysms (UIA), but high-quality, unbiased data on initial complications and clinical outcomes were limited in previous literature reviews. We updated the literature review to assess quality, potential bias, complications and short-term outcomes in studies on FD-stents for UIAs.

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48 Cancer-Associated Fibroblasts in Prostate Cancer: Unraveling Mechanisms and Therapeutic Implications

推荐理由: 该文系统阐述了前列腺癌微环境中成纤维细胞的异质性及其对肿瘤进展的影响，对血液学研究的直接借鉴价值有限，但对了解肿瘤微环境的跨学科机制仍有一定参考意义。

摘要: Prostate cancer (PCa) remains a major cause of cancer-related mortality in men, largely due to therapy resistance and metastatic progression. Increasing evidence highlights the tumor microenvironment (TME), particularly cancer-associated fibroblasts (CAFs), as a critical determinant of disease behavior. CAFs constitute a heterogeneous population originating from fibroblasts, mesenchymal stem cells, endothelial cells, epithelial cells undergoing epithelial-mesenchymal transition (EMT), and…

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49 Differential effects of small extracellular vesicles from head and neck cancer patients on dendritic cell functions

推荐理由: 该研究揭示了肿瘤来源小细胞外囊泡调控树突细胞功能的机制，对免疫治疗和疫苗研发具有一定参考价值，值得血液学研究者关注。

摘要: CONCLUSION: Our results uncover mechanisms through which tumor-derived small extracellular vesicles modulate dendritic cell functions locally and systemically. These mechanisms may also affect dendritic cell-based vaccine efficacy.

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50 SPAC: a scalable and integrated enterprise platform for single-cell spatial analysis

推荐理由: 该文介绍的 SPAC 平台在单细胞空间组学分析上具备创新性和易用性，对提升数据处理效率有帮助，但与血液疾病的直接关联较少，阅读价值一般。

摘要: CONCLUSIONS: SPAC addresses major barriers in single-cell spatial analysis by uniting an intuitive, user-friendly interface with scalable, high-performance computation in a robust and reproducible framework. By streamlining complex analyses and bridging the gap between experimental and computational researchers, SPAC fosters collaborative workflows and accelerates the transformation of large-scale spatial datasets into actionable biological insights.

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51 Treponema pallidum lipoprotein Tp0768 promotes H3K18 Lactylation modification to target PTK2 and enhance endothelial permeability

推荐理由: 该文揭示了梅毒螺旋体如何破坏血管内皮并通过血流播散，对感染机制有新见解，值得血液学研究者了解其血管相关的病理过程。

摘要: Syphilis is a systemic sexually transmitted disease, yet the mechanisms underlying the dissemination of its causative pathogen, Treponema pallidum (T.pallidum), within the host remain incompletely understood. Previous studies have shown that T.pallidum can damage vascular endothelial cells, thereby breaching the endothelial barrier to invade lymph nodes at the infection site. This facilitates its systemic dissemination via the bloodstream, leading to persistent infection across multiple vascular…

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52 Pantropical moist forests are converging towards a middle leaf longevity

推荐理由: 该研究提供了热带湿润森林叶寿命的大尺度时空变化图，对气候变化生态响应具有创新价值，但与血液疾病关联度极低，仅作跨学科参考价值。

摘要: Leaf longevity is a fundamental plant trait that largely explains ecosystem functional dynamics in global pantropical moist forests. However, the signs, magnitudes, and mechanisms of the spatiotemporal variations in leaf longevity with ongoing climate change are still lacking. Using both ground measurements and gridded leaf age-dependent leaf area index data, we map the continental-scale variability of annual mean leaf longevity across pantropical moist forests over 2001-2023. We find a…

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53 NR6A1 is essential for neural crest cell specification, formation and survival

推荐理由: 该研究揭示了NR6A1在哺乳动物神经嵴细胞形成中的关键作用，创新性突出，但与血液疾病关联有限，阅读价值主要在于提供潜在的发育生物学思路。

摘要: Neural crest cells (NCC) are a migratory progenitor cell population unique to vertebrates that contribute to nearly every organ system throughout the body. Disruptions in NCC development can result in congenital disorders (neurocristopathies). Yet, our understanding of the cellular mechanisms and signals that govern mammalian NCC formation remains poor. Here, we discovered nuclear receptor superfamily 6 group member 1 (NR6A1/GCNF/RTR) is a novel, critical regulator of mammalian NCC…

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54 Electrographic cue-reactivity co-localizes with accumbens deep brain stimulation in a case of opioid use disorder

推荐理由: 该研究在深度脑刺激个体化治疗方面具有创新性，但与血液疾病关联度极低，仅对血液学研究参考价值有限。

摘要: Opioid use disorder (OUD) is a significant public health concern, with over 30% of the affected population not responding to available treatments. Severe OUD is characterized by drug-cue reactivity that has been reported to predict treatment failure. We leveraged this pathophysiological feature to optimize deep brain stimulation (DBS) of the nucleus accumbens region (NAc) in a male patient with OUD. A personalized drug-cue-reactivity task was administered while recording NAc electrophysiology…

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55 Coordinated gene family evolution shapes the genome of dimorphic Mucorales

推荐理由: 该研究揭示了真菌二形性背后的基因家族收敛进化，对基因功能分化和适应机制提供了新视角，虽与血液疾病关联不大，但对理解基因调控网络具有参考

摘要: Dimorphic organisms possess the remarkable genome capacity to alternate genetic information between two distinct life forms. In dimorphic Mucorales, lineages can reversibly transition between yeast and mycelium as a function of environmental stimuli. However, how genetic information produces two divergent life evolves in a single genome remains unresolved. Here, we report hundreds of gene families exhibiting convergent evolution for dimorphism. This adaptation involves paralog functionalization…

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56 ALKB-1-dependent tRNA methylation is required for efficient paternal mitochondrial elimination

推荐理由: 该研究揭示了ALKB‑1介导的tRNA m^1A去甲基化在父系线粒体清除中的关键作用，提供了新的线粒体遗传调控机制，对基础生物学和潜在的血液疾病线粒体功能研究具有参考价值。

摘要: Maternal mitochondrial inheritance is secured by mechanisms that exclude paternal mitochondrial DNA (mtDNA). While, epigenetic modifications are vital for spermatogenesis and embryo development, their roles in the paternal mitochondrial elimination (PME) remain poorly understood. Here, we identify ALKB-1, a DNA/RNA demethylase, as a pivotal factor for efficient PME in Caenorhabditis elegans (C. elegans), acting through ALKB-1-dependent modulation of tRNA m^1A methylation. Mechanistically, ALKB-1…

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57 Stereoselective cyano translocation reaction enabled by photoenzymatic catalysis

推荐理由: 该文提出了光酶催化的氰基迁移新方法，具备立体选择性，对有机合成和药物分子设计具有创新价值，但与血液疾病关联度低，公众关注度和政策影响有限。

摘要: Functional-group translocation constitutes a powerful strategy in organic synthesis, allowing precise modification of molecular architectures and functional group positions. Nevertheless, methodologies capable of delivering precise stereocontrol during such migrations remain exceedingly scarce. Herein, we present a photoenzymatic strategy for cyano translocation that achieves precise stereocontrol. The use of stereo-complementary enzymes grants access to both enantiomers, while mechanistic…

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58 The disappearing quasi-biennial oscillation under sustained global warming

推荐理由: 评分失败，请手动查看

摘要: The stratospheric quasi-biennial oscillation (QBO) is a key modulator of interannual variability in global weather and climate. Over recent decades, the amplitude of the lower-stratospheric QBO has weakened, and in recent years the QBO has experienced unprecedented disruptions. However, the longer-term evolution of the QBO and its impact on tropospheric circulation remain uncertain. Here, based on CMIP6 models with extended projections beyond 2100 and targeted sensitivity experiments, we show…

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59 Ultra-fast self-gelling self-expanding self-propelling high-adhesion procoagulant hemostatic powder for non-compressible hemorrhage hemostasis in pigs

推荐理由: 评分失败，请手动查看

摘要: Non-compressible hemorrhage remains the chief cause of battlefield mortality and civilian trauma death. Here, we propose a hemostatic strategy based on ultrafast self-gelling self-expanding powder of polyacrylic acid (PAA), polyethyleneimine (PEI) and foaming agent, which achieves non-compressible hemorrhage hemostasis through the multiple synergistic effects of expansion plugging, self-gelling adhesion and activating the coagulation factors. The hemostatic powder integrates rapid physical…

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60 Generating cerebellar organoids from pluripotent stem cells

推荐理由: 该综述系统梳理了小脑类器官的构建与质量控制方法，对神经发育研究价值较大，但与血液疾病关联有限，血液学研究者可作参考但不必优先阅读。

摘要: Cerebellar organoids present promising tools for the modelling of human cerebellar development and diseases. As this young field grows, robust standards and transparent reporting practices are needed to ensure the reproducibility and utility of the generated cerebellar organoid models. Here, we summarize current approaches to generate cerebellar organoids and their applications. We suggest common quality control standards and biological readouts that should be considered in this emerging area.

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61 ABC8 Consensus: Assessment by a German Group of Experts

推荐理由: 该文虽提供了乳腺癌治疗共识，对制定全球治疗指南有价值，但与血液疾病关联度低，血液科研究者可作参考但不必优先阅读。

摘要: BACKGROUND: The “International Consensus Conference for Advanced Breast Cancer” was initiated with the rationale to standardize treatment of advanced breast cancer (ABC) based on available evidence. The aim was to ensure that all ABC patients worldwide receive adequate treatment and get access to new diagnostic, therapeutic, and supportive options.

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62 Macrophage TRIM21 lactylation exacerbates infection-induced orchitis through enhancing STAT1-mediated CXCL9 and CXCL10 production

推荐理由: 该文探讨感染性睾丸炎的炎症机制，对男性不育有一定公共健康意义，但与血液疾病关联度低，创新性和方法学严谨性一般，阅读价值有限。

摘要: INTRODUCTION: Infection-induced orchitis, a leading cause of acquired male infertility affecting 8%-12% of couples globally, is driven by unresolved inflammatory responses following bacterial infection.

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63 Human brain prefrontal cortex proteomics identifies compromised energy metabolism and neuronal function in Schizophrenia

推荐理由: 该研究提供了大规模脑组织蛋白组学数据，对精神疾病机制有创新性发现，但与血液疾病关联有限，血液学研究者可作参考价值不高。

摘要: Understanding the pathophysiological substrates of schizophrenia is a major challenge for current neuropsychiatric research. As part of a set of multi-omics experiments, we performed an extensive case-control proteomics study on 192 post-mortem tissue sections from prefrontal cortex from 96 individuals, including 47 cases with schizophrenia and 49 healthy controls. Using two independently measured cortical datasets, we identified 387 proteins differentially expressed between schizophrenia cases…

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64 Multidimensional helical dichroism from a chiral molecular nanoassembly

推荐理由: 该文提出了利用新型手性光学增强技术提升分子手性检测灵敏度，创新性突出，但与血液疾病关联度低，阅读价值主要在于光学与生物传感方法的前沿探索。

摘要: Detecting the chirality of molecules is of great importance in optics, biomedicine, and materials science. In chiroptical spectroscopy, it’s crucial to achieve strong chiroptical signals with a minimal number of chiral molecules. The molecular chiroptical signals, however, are typically weak for chiral molecular sensing in conventional circular dichroism using photonic spin angular momentum, even in the presence of a large number of chiral molecules (micromoles to millimoles). Here, by involving…

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65 Structural basis for transcriptional regulation by the cell division regulator MraZ in Mycoplasma genitalium

推荐理由: 虽然该研究聚焦细菌细胞分裂，与血液疾病关联不大，但其高分辨率的结构解析对转录调控机制提供了重要参考，值得一读。

摘要: Cell division is a central process in all living organisms and requires the coordinated action of many proteins and regulatory elements. In most bacteria, the division and cell wall (dcw) gene cluster is regulated by the first gene of the dcw operon, mraZ, a highly conserved DNA-binding transcriptional regulator. Here we report the structural basis of MraZ transcriptional regulation by the resolution of three different cryo-EM structures of MraZ in complex with the upstream promoter region of…

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66 Machine-learning-guided tungsten single atoms promote oxyhydroxides for noble-metal-free water electrolysis

推荐理由: 该研究在非贵金属电催化剂设计上具有创新性，对能源转型有一定社会价值，但与血液疾病关联度低，阅读价值相对有限。

摘要: Lowering the overpotential of oxygen evolution reaction with electrocatalysts is essential for efficient renewable-electricity-driven electrolysis. Active noble-metal catalysts suffer from leaching and scarcity, while non-noble alternatives face limited intrinsic activity. Here we combine computational guidance with experimental validation to identify atomically dispersed tungsten within NiFe oxyhydroxide, namely W(1)-NiFeOOH, as a promising noble-metal-free oxygen evolution reaction catalyst….

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67 Spinal cord stimulation therapy for gait impairment in Parkinson’s disease: a double-blinded, randomised feasibility trial with an open extension

推荐理由: 该研究探索脊髓刺激对帕金森患者步态的影响，创新性突出但样本量小、与血液疾病关联度低，血液学研究者可略作了解。

摘要: A trial of spinal cord stimulation (SCS) was performed in people with gait-impaired Parkinson’s (ClinicalTrials.gov: NCT05110053). Fourteen patients underwent gait assessments and [^(18)F]-FDG and [^(18)F]-FEOBV PET at baseline, six, and twelve months after SCS. Twelve participants were randomised to six-month MicroBurst or sham, followed by six-month extension with stimulation. The primary outcomes were feasibility and safety, as captured by the trial process measures and nature and frequency…

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68 High resolution genome-wide SNP array analyses on matched colorectal-based lung and brain metastases

推荐理由: 该研究揭示了结直肠癌脑转移的特异性基因组特征，对血液疾病的直接借鉴价值有限，但对癌症转移机制的了解具有一定创新性，可供跨学科参考。

摘要: CONCLUSION: Brain metastases of CRC showed more cn-LOH regions than lung metastases. Potentially affected genes within these regions could influence signaling pathways (e.g., PI3K/AKT signaling) as well as transcriptional processes. Perspectively, increased awareness of specific genetic characteristics can potentially increase the chance of early diagnosis of brain metastases, which could contribute to improved treatment options.

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69 Stereotactic heart ablative radiotherapy (SHARP): a prospective multicentric phase II trial

推荐理由: 该文探讨了心脏恶性肿瘤的立体定向体部放疗，虽在血液学领域关联度不高，但对罕见心脏肿瘤的局部治疗提供了新思路，值得对跨学科治疗感兴趣的读者了解。

摘要: BACKGROUND: Cardiac tumors are exceedingly rare with metastatic involvement representing the most frequent form of malignancy within the heart. In patients presenting with inoperable primary or recurrent malignant cardiac sarcomas or cardiac/epicardial/pericardial metastases, stereotactic body radiotherapy (SBRT) serves as an alternative local treatment to surgery or may, in some cases, constitute the sole viable local treatment modality. To date, there are only case reports or small…

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70 Stroke Action Plan for Europe 2018-2030 (SAP-E): mid-term review and update

推荐理由: 该文聚焦于中风的公共卫生与政策议题，对血液学研究的直接借鉴价值有限，除非关注血管性脑卒中与血液疾病的交叉领域，否则阅读收益不大。

摘要: CONCLUSION: Stroke remains a significant health issue in Europe, with notable incidence and inequities in access to care. Key interventions are strongly evidence-based, cost-effective and supported by World Health Organization and European Union recommendations. Despite improvements, gaps remain across the care pathway but particularly in terms of access to stroke units, rehabilitation and follow-up. To control and reduce the burden of stroke, the main action points are: (1) national stroke…

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71 Acute Myeloid Leukemia With Plasmacytoid Differentiating Cutaneous Lesions: A Case of Double Identity or Active Transformation

推荐理由: 该文仅提供结论性描述，缺乏实验方法、数据和具体病例，创新性和可借鉴性有限，但涉及免疫表型和分子检测在血液疾病诊断中的重要性，仍可作为了解该方向的入门参考。

摘要: CONCLUSIONS: This report highlights that clinical correlation with immunophenotype and molecular testing is important in distinguishing these unique entities to guide appropriate diagnosis and management.

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72 A lattice oxygen-free design for efficient and stable photothermal methane dry reforming

推荐理由: 该文在光热干重整甲烷的催化剂设计上具有创新性，但与血液疾病关联度极低，且社会关注度有限，阅读价值主要限于材料与能源领域的研究者。

摘要: Photothermal dry reforming of methane, a promising approach to producing syngas, typically uses oxide materials and is mediated by lattice oxygen. However, it is limited by the balance of the oxygen-releasing/replenishing loop. Here, we present a methane activation pathway free of lattice oxygen on a N-Ni/NiCo@C catalyst. Direct involvement of reactive oxygen species (O*/OH*) released from CO(2) promotes effective CH(4) activation and eliminates coke deposition on oxophilic NiCo sites. Control…

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73 Inverse palladocenes

推荐理由: 该文在逆向金属烯烃结构的合成与机理探索上具有创新性，但与血液疾病关联度极低，且社会关注度和政策影响有限，阅读价值相对有限。

摘要: Metallocene research has influenced the development of organometallic chemistry, and the metal-nonmetal inverted half-sandwich structure (inverse metallocene) was very recently discovered. However, additional instances are required to propose the concept inverse metallocene and it remains uncertain whether metal five-membered ring structures analogous to the cyclopentadienyl anion structure exist. Herein we report the synthesis of a series of palladium analogs…

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74 Plant diversity within communities, not among them, stabilizes grassland productivity across spatial scales

推荐理由: 该研究在大尺度上探讨植物功能性状与生产力稳定性的关系，方法新颖但与血液疾病关联度极低，阅读价值有限。

摘要: Evidence shows that local functional trait composition and diversity along the fast-slow leaf economics spectrum can predict the temporal stability of community productivity in response to environmental changes. However, it remains unclear whether these relationships persist at larger spatial scales. Combining a field survey of plant diversity with remote sensing estimates of primary productivity across a large environmental gradient in 235 grasslands across the Qinghai-Tibet Plateau and the…

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75 Artificial intelligence in surgical disciplines: Clinical application, advantages, and potential-a Delphi expert consensus

推荐理由: 该文主要讨论AI在外科领域的应用与政策框架，对血液疾病研究的直接借鉴价值有限，阅读价值不高。

摘要: CONCLUSION: The consensus statements show the great potential of AI for improving patient care in surgical disciplines. Challenges such as the lack of digitalization structures and legal frameworks were identified, and practice-oriented proposals for implementation were developed. The need for multidisciplinary cooperation between medical professionals, politics, and industry was emphasized in order to facilitate the German healthcare system remaining competitive for the future, both nationally…

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76 Regression analysis to calculate the time point of ROSC-A feasibility study

推荐理由: 该研究在心肺复苏时间预测上尝试机器学习方法，具备一定创新性，但样本量小、模型验证不足，且与血液疾病关联度极低，阅读价值有限。

摘要: CONCLUSION: The duration from the start of CPR to ROSC appears to be a process that is suitable for modelling with machine learning algorithms. At this early stage of development, the individual regression models did not demonstrate sufficient validity possibly due to low sample size and simplified data structure; however, the findings indicated potential for an application as a quality assurance tool to compare actual vs. predicted time to ROSC. Therefore, to increase the robustness the results…

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77 Bit-Reproducible Parallel Phylogenetic Tree Inference

推荐理由: 该文提出的并行化最大似然系统在进化树构建上有技术创新，但与血液疾病研究关联度极低，阅读价值主要限于计算生物学领域。

摘要: MOTIVATION: Phylogenetic trees describe the evolutionary history among biological species based on their genomic data. Maximum Likelihood (ML) based phylogenetic inference tools search for the tree and evolutionary model that best explain the observed genomic data. Given the independence of likelihood score calculations between different genomic sites, parallel computation is commonly deployed. This is followed by a parallel summation over the per-site scores to obtain the overall likelihood…

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78 Bioinspired triboelectric droplet sensor for ammonia monitoring

推荐理由: 该文提出的仿肺泡气体传感器在环境与健康监测上具创新性，但与血液疾病研究关联度极低，阅读价值有限。

摘要: Gas sensors with fast response are in high demand for environmental and health applications. Conventional solid-state sensing materials are inherently constrained by response delays arising from chemical bond transformations, posing significant challenges in overcoming response time lag. In this work, inspired by the alveoli of our respiratory system, we develop a triboelectric nanogenerator probe sensor driven by the formation of water droplets containing an air cavity, which incorporates NH(3)…

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79 Growth of rhombohedral-stacked single-crystal WS<sub>2</sub>/MoS<sub>2</sub> vertical heterostructures

推荐理由: 该文主要聚焦于二维材料的层叠结构与物理机制，对血液疾病研究的直接借鉴价值极低，除非在跨学科材料医学应用方面有特殊需求，否则不必优先阅读。

摘要: Vertical van der Waals heterostructures (vdWHs), formed through layer-by-layer stacking of two-dimensional materials, offer appealing opportunities for exploring novel physics and potential applications. However, the conventional approach of mechanical exfoliation followed by manual stacking faces significant challenges in achieving atomically clean interfaces and large size, severely limiting practical applications. Here, we proposed a comprehensive mechanism governing nucleation, orientation…

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80 GHz dynamic holographic VCSEL chip via current-addressed modes multiplexing

推荐理由: 该文在光电子领域创新性强，但与血液疾病研究关联度极低，阅读价值对血液学者有限。

摘要: The intuitive wisdom in semiconductor laser engineering dictates that high-order spatial modes of vertical-cavity surface-emitting lasers (VCSELs) must be suppressed to preserve beam quality, despite their inherent potential as independent information carriers. Here, we develop current-addressed modes multiplexing holography in multimode VCSELs, where injection current-dependent dominant orbital angular momentum (OAM) components enhance information channel capacity and enable dynamic…

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81 Imaging multilevel exciton transport enabled by correlated electronic states

推荐理由: 该文在激子输运和二维材料的前沿技术上具有创新性，但与血液疾病关联度极低，阅读价值主要限于材料物理领域。

摘要: Exciton transport is a fundamental energy transfer process essential to semiconductor optoelectronic devices, whose full application potential relies critically on achieving precise multilevel control. While correlated electronic states in transition metal dichalcogenides (TMDCs) offer unprecedented tunability, probing exciton dynamics within these states has been challenging due to limitations in the spatial and temporal resolution of conventional techniques. Here, we introduce an ultrafast…

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82 Photothermal effects control ultrafast charge transport in titanium carbide MXenes

推荐理由: 该文在新型金属材料的光热效应研究上具备创新性和严谨的实验方法，但与血液疾病关联度极低，阅读价值主要限于材料科学领域。

摘要: Titanium carbide MXene (Ti_3C_2Tₓ) is an emerging metallic material with promise for (opto)electronics and thermal management. Yet how photoexcitation-particularly via photogenerated thermal energy-modifies its charge carrier dynamics remains poorly understood. By combining time-resolved terahertz spectroscopy and transient reflectance measurements, we reveal a long-lived, photo-induced suppression of conductivity, which we attribute to efficient lattice heating and slow heat dissipation in…

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83 Defect-interface coupling for stable lattice-oxygen-driven oxygen evolution at industrial current densities

推荐理由: 该文在电催化材料设计上具有创新性，对清洁能源有一定政策意义，但与血液疾病关联极少，血液学

摘要: For industrial water electrolysis, the development of active and stable catalysts for the oxygen evolution reaction remains a challenge. Here, we report a heterostructure catalyst composed of NiFe layered double hydroxide nanosheets anchored on pyramidal Fe(2)(MoO(4))(3) to activate lattice oxygen for efficient and durable oxygen evolution. Our investigation reveals that oxygen vacancies within the NiFe layered double hydroxide and the internal electrical field at the material interface optimize…

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84 The mosaic memory of large language models

推荐理由: 该文揭示了大语言模型的“马赛克记忆”机制，虽在人工智能领域具创新价值，但与血液疾病研究关联度极低，血液学研究者可不必优先阅读。

摘要: As Large Language Models (LLMs) become widely adopted, understanding how they learn from, and memorize, training data becomes crucial. Memorization in LLMs is widely assumed to only occur as a result of sequences being repeated in the training data. Instead, we show that LLMs memorize by assembling information from similar sequences, a phenomenon we call mosaic memory. We show major LLMs to exhibit mosaic memory, with fuzzy duplicates contributing to memorization as much as 0.8 of an exact…

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85 Net widening of Southern California beaches

推荐理由: 方法创新且对沿海管理有政策意义，但与血液疾病关联度极低，血液学研究者阅读价值有限。

摘要: Human impacts from dams reduce river sediment fluxes and are primary causes of coastal erosion worldwide. Here we provide new satellite-derived shoreline observation techniques to examine beach area trends across the diverse coastal settings of California. Contrary to global trends, these data reveal that the most heavily urbanized and dammed region of southern California experienced net beach growth of over 2 million m^2 during 1984-2024. While several beaches experienced severe erosion, overall…

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86 A synergistic strategy of crosslinking and filler toughening enabling stretchable organic photovoltaics for wearable applications

推荐理由: 该文在柔性有机光伏材料的设计上有创新，但与血液疾病研究关联度极低，阅读价值主要限于材料科学领域。

摘要: Improving the elongation of intrinsically stretchable organic electronics typically prioritizes flexibility, which may increase the crack-onset strain at the expense of ductility. Here, we present a synergistic design that combines covalent crosslinking and silica filler reinforcement to construct a photoactive layer of organic photovoltaics (OPVs) with both elevated fracture strain and modulus. This interpenetrating network boosts the crack-onset strain to over 40% and raises the modulus by…

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87 A heterogeneous population code at the first synapse of vision

推荐理由: 该研究揭示了光感受器在体内的信号编码机制，虽与血液疾病关联不大，但在神经视觉基础研究方面提供了新方法和思路，具有一定的跨学科参考价值。

摘要: Vision begins when photoreceptors convert fluctuations in light intensity into temporal patterns of glutamate release that drive the retinal network. The input-output relation at this first stage has not been studied in vivo so it is not known how it operates across a photoreceptor population. Using glutamate imaging in zebrafish, we find that individual type 1 cones (PR1; ancestral red cones), which dominate daylight vision in non-avian vertebrates, encode visual stimuli with high reliability…

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88 Middle East dust as an important external driver of the Indian Ocean Dipole

推荐理由: 该研究在气候科学领域方法新颖、数据可靠，但与血液疾病关联甚少，血液学研究者阅读价值有限。

摘要: The Indian Ocean Dipole (IOD) strongly influences Indo-Pacific climate extremes, yet its drivers remain incompletely understood. Using satellite observations, reanalysis, and climate model experiments, we identify Middle East dust emissions as a major external driver of IOD variability. Observational evidence shows that dust over the 1980-2020 period account for  36% of interannual IOD variance, surpassing El Niño-Southern Oscillation as the main driver during boreal autumn. Climate simulations…

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89 Nested spatiotemporal theta-gamma waves organize hierarchical processing across the mouse visual cortex

推荐理由: 该研究在神经科学方法学上具有创新性和严谨性，但与血液疾病的直接关联较弱，仅在跨学科思路上对血液学研究有一定启发价值。

摘要: The brain processes visual information across diverse spatial and temporal scales, but the dynamics that bridge these scales remain poorly understood. Here, we analyze Neuropixels recordings from mouse visual cortex during a visual change-detection task and uncover a nested spatiotemporal structure linking low-frequency θ, high-frequency γ, and neuronal spiking across cortical layers and areas. θ forms broad traveling waves that flexibly switch direction across a stimulus presentation. Following…

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90 Electroacoustic alignment of robust and highly piezoelectric nylon-11 films

推荐理由: 该文主要聚焦于尼龙‑11压电材料的制备与性能提升，与血液疾病研究关联度极低，除非关注材料在医学器械中的潜在应用，否则阅读价值有限。

摘要: Nylon-11-a common and widely used material, is a promising non-fluorinated piezoelectric polymer given its mechanical strength, chemical stability and elasticity. Nevertheless, it typically possesses low piezoelectric performance, which severely limits its use for energy generation applications. Here, we demonstrate the synthesis of highly aligned, piezoelectric nylon-11 films through an energy-efficient (≈1-5 Wh), single-step platform that facilitates the electroacoustic coupling associated…

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91 Autonomization of Microvascular Free Flaps in Reconstructive Surgery: A Narrative Review

推荐理由: 该文主要讨论组织瓣的自主化及其在显微外科中的应用，血液疾病关联性弱，创新与数据支撑不足，阅读价值有限。

摘要: CONCLUSION: Flap autonomization is a critical but poorly understood process that varies by flap type and patient context. Despite early neovascular activity, the lack of reliable markers necessitates conservative postoperative protocols. Emerging technologies and bioengineered strategies hold promise but require further validation. Standardized criteria to assess vascular independence could significantly improve outcomes in microvascular reconstructive surgery.

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92 Author Correction: Hunter-gatherer sea voyages extended to remotest Mediterranean islands

推荐理由: 由于缺乏摘要，无法评估研究创新性、方法严谨性及血液疾病的相关性，建议暂不优先阅读。

摘要: No abstract

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93 Targeting proteostasis addiction in AML

推荐理由: 由于缺乏摘要，无法判断研究创新性、方法严谨性及血液疾病的相关性，信息不足，阅读价值有限。

摘要: No abstract

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94 Author Correction: Divalent anion-driven framework regulation in Zr-based halide solid electrolytes for all-solid-state batteries

推荐理由: 该文未提供摘要，缺乏基本信息，难以评估其创新性、方法学严谨性及对血液疾病的相关性，阅读价值有限。

摘要: No abstract

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