追觅 - 2026-01-31

生成时间: 2026−02-02 14:36

分析文章数量: 82

1 Multidimensional Characterization of Tumor-Immune Architecture Reveals Clinically Relevant Classic Hodgkin Lymphoma Subtypes

推荐理由: 该研究通过多模态系统水平解析CHL肿瘤微环境，揭示了疾病异质性和潜在分子亚型，对血液肿瘤尤其是霍奇金淋巴瘤的机制研究和临床分型具有重要参考价值。

摘要: The tissue architecture of classic Hodgkin Lymphoma (CHL) is unique among cancers and characterized by rare malignant Hodgkin and Reed-Sternberg cells that co-evolve with a complex ecosystem of immune cells in the tumor microenvironment (TME). The lack of a comprehensive systems-level interrogation has hindered the description of disease heterogeneity and clinically relevant molecular subtypes. Here, we employed an integrative, multimodal approach to characterize CHL tumors using malignant cell…

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2 Dual targeting of SLC25A51 and succinate dehydrogenase selectively depletes mitochondrial NAD<sup>+</sup> to eradicate KRAS-driven AML

推荐理由: 该研究揭示了KRAS突变在AML中的关键驱动作用并提供了针对性化合物，创新性强且对血液肿瘤研究具有重要借鉴价值。

摘要: Acute myeloid leukemia (AML) arises from diverse mutations, yet its most aggressive drivers remain elusive. Here, we show that Kirsten rat sarcoma viral oncogene homolog (KRAS) mutations drive hyperproliferative and therapy-/glucose stress-resistant AML, whereas existing inhibitors lack sufficient cytotoxicity. Dual physiological/glucose-deprived screening identified compound 615 selectively eliminating KRAS-mutant cells through concurrently inhibiting succinate dehydrogenase (SDH) and the…

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3 Antiapoptotic BCL2 family proteins BCL-XL and MCL1 as factors predicting resistance against venetoclax plus azacitidine for patients with newly diagnosed acute myelogenous leukemia

推荐理由: 该研究探讨了VEN+AZA治疗AML耐药的分子机制，对血液肿瘤领域的治疗策略具有重要参考价值，值得阅读。

摘要: The combination of Venetoclax (VEN), a BCL2 inhibitor, and Azacitidine (AZA), a hypomethylating agent, is the standard treatment for acute myelogenous leukemia (AML) in patients older than 65 years who are not eligible for intensive chemotherapy. While high response rates for this treatment have been noted, it has been also reported that the anti-apoptotic BCL2 family proteins BCL-XL and MCL1 may be involved in VEN resistance. However, no study has heretofore been conducted to investigate the…

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4 Engineered internal architecture of core-shell lipid nanoparticles promotes efficient mRNA endosomal release

推荐理由: 该文提出的 LNP 结构创新显著提升 mRNA 递送效率，对基因治疗和疫苗研发具有重要参考价值，值得血液学研究者了解其潜在的应用前景。

摘要: Messenger RNA (mRNA) therapeutics rely on lipid nanoparticles (LNPs) for delivery, yet inefficient endosomal escape remains a major bottleneck, with only a small fraction of internalized cargo reaching the cytoplasm. Conventional LNPs encapsulate mRNA in amorphous lipid cores, where partial charge neutralization and lack of structural order limit protonation-driven membrane disruption. Here, we present an architectural strategy that engineers LNP internal structure using ionizable lipid-coated…

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5 Multistep receptor binding of the hepatitis B virus preS1 domain

推荐理由: 该研究揭示了HBV/HDV前S1区的无序结构如何实现高亲和受体结合，创新性强且方法严谨，对病毒感染机制和潜在抗病毒策略具有重要参考价值。对血液学研究虽非直接聚焦，但在病毒血源传播及相关血液安全防控方面提供

摘要: The preS1 domain present on hepatitis B and D virus particles is an intrinsically disordered peptide (IDP) essential for recognizing the host receptor, sodium taurocholate co-transporting polypeptide (NTCP). However, it remains poorly understood how the disordered preS1 peptide achieves high-affinity binding through its conformational change. Here, we reveal a stepwise binding process through which multiple regions within preS1 cooperate to establish the stable binding to NTCP. By combining…

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6 Lymph node colonization induces tissue remodeling via immunosuppressive fibroblast-myeloid cell niches supporting metastatic tolerance

推荐理由: 该研究采用空间组学和动物模型揭示淋巴结转移对全身免疫抑制的机制，创新性强且方法严谨，对肿瘤免疫学和转移研究具有重要参考价值。虽然与血液疾病的直接关联有限，但其对免疫微环境的洞察可为血液系统免疫调控提供间接启示，值得阅读。

摘要: Lymph node (LN) colonization in cancer is linked to poor prognosis. Evidence suggests that LN colonization induces systemic immunosuppression, facilitating distant metastasis. We investigated LN-mediated immunosuppression in patients with head-and-neck cancer using spatial proteomics, spatial transcriptomics, and an in vivo model of melanoma LN metastasis. Both primary tumors and paired LNs of nodal-positive patients exhibit enhanced interferon-γ signaling and an enrichment of immunosuppressive…

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7 Sympathetic-epithelial crosstalk governs tissue-resident memory T cell immunosurveillance in the skin

推荐理由: 该研究揭示了交感神经通过角质形成细胞调控皮肤驻留记忆 CD8^+ T 细胞的机制，为癌症免疫监视提供新视角，值得血液免疫学研究者参考。

摘要: Effective host defense and immunosurveillance at barrier tissues require coordinated functions of multiple cell types. Here, we show that in the skin, sympathetic nerves engage with epidermal keratinocytes to regulate the local density of tissue-resident memory CD8^(+) T (T(RM)) cells, thereby influencing regional cancer immunosurveillance. Sympathetic nerves do not communicate directly with CD8^(+) T(RM) cells. Instead, they form synapse-like structures near basal keratinocytes and dynamically…

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8 Impact of Kidney Histology and Choice of Treatment on Survival in Patients with Multiple Myeloma

推荐理由: 该研究揭示了骨髓瘤患者肾组织学特征与预后及透析可逆性的关联，对血液科临床决策和后续研究具有较高参考价值。

摘要: CONCLUSIONS: Kidney histology determines distinct clinical trajectories in MM patients, with CN showing potential for dialysis reversibility. Modern combination therapies significantly improve renal outcomes. The requirement for ongoing KRT, was the primary predictor of overall survival.

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9 From inhibition to regulation: serpins in health and disease

推荐理由: 该

摘要: This issue of the Biomedical Journal highlights regulatory mechanisms that shape aging, disease progression, and biological complexity across molecular, cellular, and systems levels. A central theme is plasminogen activator inhibitor-1 (PAI-1) as a multifunctional regulator linking fibrinolysis, cellular senescence, stem cell dynamics, fibrosis, and tumor biology. Contributions examine structure-guided development of small-molecule PAI-1 inhibitors and their therapeutic potential across…

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10 A type I interferon-mitochondrial axis regulates efferocytosis and interferon-stimulated gene induction in macrophages

推荐理由: 该研究揭示了IFN‑I信号通过ISG15介导的线粒体蛋白ISGylation调控巨噬细胞代谢，为血液免疫细胞功能及相关血液疾病的机制研究提供了新思路，值得一读。

摘要: Macrophage metabolism is intricately linked to cellular function. Contrasting with Toll-like receptor (TLR) stimulation, cytosolic nucleic acid sensing induced a decrease in mitochondrial membrane potential (MMP) while maintaining mitochondrial respiration. Interferon α/β (IFN-I) receptor (IFNAR) signaling was necessary and sufficient for this metabolic response. IFNAR signaling induced interferon-stimulated gene 15 (ISG15) expression and ISGylation of mitochondrial proteins, including subunits…

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11 Cancer cachexia in STK11/LKB1-mutated non-small cell lung cancer is dependent on tumor-secreted GDF15

推荐理由: 该研究揭示了STK11/LKB1突变驱动

摘要: Cachexia is a wasting syndrome involving adipose, muscle, and body weight loss in cancer patients. Tumor loss-of-function mutations in STK11/LKB1, a regulator of AMP-activated protein kinase, induce cancer cachexia (CC) in preclinical models and are linked to weight loss in non-small cell lung cancer (NSCLC) patients. This study examines the role of the integrated stress response (ISR) cytokine growth differentiation factor 15 (GDF15) in regulating cachexia using patient-derived and engineered…

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12 Emerging landscape of KRAS inhibitors in cancer treatment

推荐理由: 该文介绍了新型KRAS抑制剂及其克服耐药的机制，对肿瘤研究前沿具有创新价值，且其中涉及的RAS通路在部分血液肿瘤中亦有重要作用，值得血液学研究者参考。

摘要: Alterations in KRAS, NRAS, and HRAS occur in roughly 20% of patients with cancer, making RAS one of the most intensively studied oncogenic targets. The discovery of mutant-selective KRAS^(G12C) inhibitors has provided a proof-of-concept for RAS-directed therapies, heralding a new era in the treatment of RAS-driven cancers. Yet, the efficacy of first-generation KRAS^(G12C) inhibitors is limited by the rapid emergence of resistance. Novel classes of (K)RAS inhibitors with distinct mechanisms of…

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13 Lymph node colonization induces tissue remodeling via immunosuppressive fibroblast-myeloid cell niches supporting metastatic tolerance

推荐理由: 该研究采用空间组学和动物模型揭示淋巴结转移导致的系统性免疫抑制机制，创新性强且方法严谨，对肿瘤免疫学有重要参考价值。虽然与血液疾病关联有限，但对免疫微环境的理解可为血液肿瘤免疫治疗提供思路，值得一读。

摘要: Lymph node (LN) colonization in cancer is linked to poor prognosis. Evidence suggests that LN colonization induces systemic immunosuppression, facilitating distant metastasis. We investigated LN-mediated immunosuppression in patients with head-and-neck cancer using spatial proteomics, spatial transcriptomics, and an in vivo model of melanoma LN metastasis. Both primary tumors and paired LNs of nodal-positive patients exhibit enhanced interferon-γ signaling and an enrichment of immunosuppressive…

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14 Promiscuous stimulation of HSP70 ATPase activity by parasite-derived J-domains

推荐理由: 该研究揭示了疟原虫导出J‑域蛋白与宿主HSP70的相互作用机制，对理解疟疾在血液中的致病过程具有一定参考价值，值得血液学研究者关注。

摘要: The malaria parasite P. falciparum exports a large number of proteins to the human host cell, including members of the J-domain protein (JDP) family. In other systems, JDPs stimulate the ATPase activity of HSP70 and direct client protein interactions. Three exported PfJDP are highly homologous yet appear to have divergent roles. We examined the ability of isolated J-domains from these proteins to stimulate the ATPase activity of PfHSP70-X and human HsHSP70 and HsHSC70. In vitro assays…

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15 KAT5 and KAT8 lactylate GPX4 Facilitates Ferroptosis and Inflammation in Diabetic Retinopathy

推荐理由: 该研究揭示了高糖诱导的GPX4乳酸化促进铁死亡和炎症的全新机制，对代谢调控和细胞死亡研究具有创新价值，值得血液学研究者了解其跨学科启示。

摘要: Diabetes-induced hyperglycemia promotes retinal capillary endothelial cell dysfunction, contributing to diabetic retinopathy. In this study, we reveal that high glucose (HG) drives ferroptosis and inflammation through lactate-mediated GPX4 lactylation. HG conditions enhance glycolysis and lactate production, leading to increased lactylation of GPX4, a process mediated by the acetyltransferases KAT5 and KAT8. GPX4 lactylation reduces its antioxidant function, promoting lipid peroxidation,…

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16 Scalable TCR synthesis and screening enable antigen reactivity mapping in vitiligo

推荐理由: 该文提出的TCRAFT技术可大规模快速构建功能性TCR，对免疫治疗及血液肿瘤的T细胞疗法研发具有重要参考价值，值得阅读。

摘要: T cells initiate targeted immune responses using T cell receptors (TCRs) to recognize specific antigens. Mapping TCRs to antigens at scale remains a major challenge. Here, we developed an approach to synthesize and functionally screen tens of thousands of TCRs simultaneously. TCR rapid assembly for functional testing (TCRAFT) uses a modular strategy to rapidly and inexpensively construct large pools of TCRs from sequences while maintaining TCRα/β pairing. We applied TCRAFT to reconstruct over…

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17 Supercharging-enhanced nDIA-MS enables global profiling of drug-induced proteome solubility shifts

推荐理由: 该文提出了在窄窗口DIA质谱中使用DMSO提升信号强度的创新方法，对提升血液蛋白组学检测灵敏度具有参考价值，值得血液学研究者了解。

摘要: Mass spectrometry (MS) is indispensable for high-throughput quantitation of protein expression. But protein function is regulated by factors beyond abundance alone. Here, we evaluate two supercharging reagents, dimethyl sulfoxide (DMSO) and m-nitrobenzyl alcohol (mNBA), in narrow-window data-independent acquisition (nDIA)-MS. DMSO markedly enhances MS signal and protein identification, whereas mNBA primarily increases peptide identifications. Optimizating nDIA-MS with 3% DMSO boosts signal…

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18 Insights into the structure and modulation of human TWIK-2

推荐理由: 该研究首次解析了TWIK-2的高分辨率结构，为理解其在肺动脉高压等疾病中的调控机制提供了重要基础，值得血液/血管相关研究者参考。

摘要: The Tandem of pore domain in a Weak Inward Rectifying K^(+) channel 2 (TWIK-2; KCNK6) is a member of the Two-Pore Domain K^(+) (K(2P)) channel family, which is associated with pulmonary hypertension, lung injury, and inflammation. Despite its physiological relevance, the structure, regulatory mechanisms, and selective modulators of TWIK-2 remain largely unknown. Here, we present a 3.7 Å single particle cryo-electron microscopy structure of human TWIK-2 and highlight its conserved and distinctive…

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19 Clonal expansion of cytotoxic CD8^+ T cells in lecanemab-associated ARIA

推荐理由: 该研究首次通过多组学手段揭示 ARIA 与外周 CD8^+ T 细胞重编程的关联，创新性强且与阿尔茨海默病的公共健康关注度高，值得血液免疫学研究者参考。

摘要: Amyloid-related imaging abnormalities (ARIA) are the principal safety concern limiting anti-amyloid therapies for Alzheimer’s disease, yet their biology remains unclear. Here we show, through multi-omic profiling of peripheral blood from three ARIA+ patients and matched controls, that ARIA is associated with coordinated reprogramming of CD8 + T cells. CD8+ effector memory (TEM) and terminally differentiated (TEMRA) subsets were expanded, clonally enriched, and transcriptionally primed for…

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20 TMEM63 proteins act as mechanically activated cholesterol modulated lipid scramblases contributing to membrane mechano-resilience

推荐理由: 该研究揭示了OSCA/TMEM63通道可能具备机械激活的脂质翻转酶功能，创新性强且实验方法严谨，对细胞机械感知机制有重要参考价值，值得血液学研究者了解其潜在的跨学科启示。

摘要: OSCA/TMEM63 mechanosensitive ion channels play critical physiological roles in plants and animals. These channels bear structural homology to the dual functional TMEM16 family, and OSCA1.2 was recently shown to form a lipid-lined ion conduction pathway in the open state. This raised the question of whether members of the OSCA/TMEM63 family may also function as mechanically activated lipid scramblases. Using a combination of in vitro and cellular assays with computational techniques, we show that…

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21 Dual promoter-enhancer activities reflect a unified regulatory logic

推荐理由: 该研究推出的高通量双报告系统为解析基因调控元件的双重功能提供了创新工具，对血液系统基因调控研究具有一定借鉴价值，值得血液学研究者关注。

摘要: Accumulating evidence indicates that both putative promoters and enhancers can exert dual promoter and enhancer functions. However, how these activities are related within individual elements and what determines this dual functionality remain poorly understood. We developed a massively parallel dual reporter assay that enables simultaneous assessment of the intrinsic promoter and enhancer potential exerted by the same sequence. Parallel quantification for thousands of elements reveals that…

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22 Mosaic partial epidermal reprogramming remodels neighbors and niches to refine skin homeostasis and repair

推荐理由: 该研究揭示了上皮干细胞的可逆去分化在组织修复中的新机制，创新性强且实验设计严谨，对再生医学有重要启示，值得血液学研究者了解其原理以拓展跨组织的干细胞调控思路。

摘要: Adult stem cells and their niches communicate intricately for tissue maintenance and regeneration. However, effectively coordinating these complex interactions is challenging. Here, we demonstrate that transient dedifferentiation of a fraction of epithelial stem cell progenies orchestrates beneficial changes within the entire skin’s cellular networks to favor repair. We achieved this by inducing a mosaic and reversible expression of reprogramming factors (Oct-4, Sox2, Klf4, and c-Myc) in the…

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23 Inhibiting H3K18 Lactylation in Microglia Aggravates White Matter Injury after Intracerebral Hemorrhage in Mice

推荐理由: 该研究揭示了乳酸‑H3K18乳酸化在脑出血后微胶质细胞介导的髓鞘再生中的关键作用，创新性强且对血液出血相关的神经修复具有参考价值，值得一读。

摘要: CONCLUSION: These results demonstrated that lactate-derived H3K18 lactylation (H3K18la), orchestrated by p300/CBP-mediated epigenetic reprogramming, serves as a critical endogenous neuroprotective axis of WMI following ICH. Microglia emerge as the cellular executors of this pathway. This lactate-p300/CBP-H3K18la axis thus represents a therapeutically targetable mechanism for enhancing post-hemorrhagic brain repair through microglia-guided myelin regeneration.

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24 Inhibiting H3K18 Lactylation in Microglia Aggravates White Matter Injury after Intracerebral Hemorrhage in Mice

推荐理由: 该研究揭示了乳酸‑H3K18乳酸化在脑出血后微胶质细胞介导的髓鞘再生中的关键作用，创新性强且对血液‑脑相互作用的机制研究具有一定参考价值，值得一读。

摘要: CONCLUSION: These results demonstrated that lactate-derived H3K18 lactylation (H3K18la), orchestrated by p300/CBP-mediated epigenetic reprogramming, serves as a critical endogenous neuroprotective axis of WMI following ICH. Microglia emerge as the cellular executors of this pathway. This lactate-p300/CBP-H3K18la axis thus represents a therapeutically targetable mechanism for enhancing post-hemorrhagic brain repair through microglia-guided myelin regeneration.

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25 Commensal-myeloid crosstalk in neonatal skin regulates interleukin-1 signaling and cutaneous type 17 inflammation

推荐理由: 该研究揭示了早期共生菌与单核细胞在皮肤屏障发育中的相互作用，对理解单核细胞的组织分布和功能具有一定的血液学借鉴价值，值得血液学研究者关注。

摘要: Early-life microbe-immune interactions at barrier surfaces have lasting impacts on the trajectory toward health versus disease. Monocytes, macrophages, and dendritic cells are primary sentinels in barrier tissues, yet the salient contributions of commensal-myeloid crosstalk during tissue development remain poorly understood. Here, we identify that commensal microbes facilitate accumulation of a population of monocytes in neonatal skin. Transient post-natal depletion of these monocytes resulted…

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26 Tumor-associated macrophages display differential protein cargo sorting in extracellular vesicles associated with poor survival in ovarian cancer

推荐理由: 该文揭示了卵巢癌腹水中巨噬细胞来源的外泌体在肿瘤微环境中的作用，对免疫细胞与肿瘤互作的机制提供

摘要: Ovarian cancer (OC) progression and metastasis are promoted by ascites, which constitutes a central part of the tumor microenvironment (TME). In this fluid, tumor-associated macrophages (TAMs) represent a prominent immune cell type. In addition to tumor and other host cells such as TAMs, ascites is highly enriched in soluble factors as well as extracellular vesicles (EVs). How TAMs contribute to the EV compartment of the OC TME remains, however, underexplored. In this work peripheral blood…

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27 Molecular features of human pathological tau distinguish tauopathy-associated dementias

推荐理由: 该研究通过创新的FLEXITau质谱平台深度解析阿尔茨海默病中tau蛋白的修饰谱，对神经退行性疾病机制具有重要参考价值，但与血液疾病关联有限。

摘要: In Alzheimer’s disease (AD), pathological tau protein shows a progressive accumulation of post-translational modifications (PTMs), reflecting disease severity, progression, and prion-like activity. Although many neurodegenerative diseases with dementia display tau aggregates, the pathological proteoforms of tau protein from each disease type remain unknown. Here, using a quantitative mass spectrometry-based proteomics platform, FLEXITau, deep characterization of pathological tau protein isolated…

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28 How I Approach Clinical Ethics Consultation in Hematology

推荐理由: 文章通过血液学案例阐释临床伦理咨询的四个阶段，对血液疾病患者的伦理决策提供了实用参考，值得血液科医生和伦理学者阅读。

摘要: Caring for individuals with hematological disorders is increasingly complex, and with medical complexity often comes ethical complexity. Prognostic uncertainty, stakeholder conflicts, and myriad other ethical challenges often contribute to situations that can benefit from ethics support. Through the presentation of three vignettes focusing on ethical dilemmas arising from hematology cases, we review the four phases of clinical ethics consultation: consult triage; ethics consult intake;…

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29 Mechanically heterogeneous hydrogel with cell-programmed network restructuring promotes tissue regeneration by mechano-epigenetic modulation

推荐理由: 该文提出的可自适应收缩水凝胶为研究干细胞与基质相互作用提供了新工具，对血液系统尤其是骨髓微环境的模拟具有潜在借鉴价值，值得血液学研究者关注。

摘要: Stem cell differentiation dynamically remodels and stiffens the extracellular matrix (ECM), generating stage-specific biomechanical cues that guide tissue development. However, conventional biomaterials, designed to mimic mature ECM stiffness, neglect its spatiotemporal heterogeneity due to their static, non-evolvable nature. Herein, we develop a cell-programmed adaptative contraction (CPAC) hydrogel that enables mesenchymal stem cells (MSCs) to actively remodel their microenvironment through…

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30 External quality assessment in antimicrobial susceptibility testing (EUCAST disc diffusion methodology) of five anaerobic strains - performance of 35 laboratories in Germany and Austria, 2024

推荐理由: 该研究通过多中心比对评估厌氧菌药敏检测的准确性，对实验室质量控制和临床抗感染治疗具有参考价值，但与血液疾病的直接关联较弱。

摘要: This study evaluated the performance of antimicrobial susceptibility testing (AST) for anaerobic bacteria among 35 clinical microbiology laboratories in Germany and Austria through an interlaboratory comparison (ILC) challenge. A panel of five anaerobic bacterial strains (two Bacteroides fragilis, and one each of Phocaeicola vulgatus, Clostridium perfringens and Fusobacterium necrophorum) was tested by the participating laboratories against a panel of antibiotics (piperacillin-tazobactam,…

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31 Observation of B_c^+→Dh^+h^- Decays

推荐理由: 该研究首次观测到多种 B_c^+ → D h^+h^- 衰变，展示了高能实验的创新与严谨方法，虽与血液疾病关联不大，但对基础粒子物理研究具有参考价值。

摘要: Searches are presented for B_c^+→Dh^+h^- decays, where D is a charmed meson and h^± is a charged pion or kaon, using pp collision data collected by the LHCb experiment corresponding to an integrated luminosity of 9 fb^-1. The decays B_c^+→D^+K^+π^-, B_c^+→D^*+K^+π^-, and B_c^+→D_s^+K^+K^- are observed for the first time. Their branching fractions, expressed as ratios relative to that of the B_c^+→B_s^0π^+ decay, are determined to be…

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32 P300 enhances glycolysis and dox resistance in DLBCL by upregulating HK2 expression through histone lactylation

推荐理由: 该研究揭示了P300介导的糖酵解在

摘要: CONCLUSION: Dox resistance in DLBCL was mediated by P300-facilitated glycolysis.

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33 Lactate transmission from hypoxic tumor cells promotes macrophage senescence and M2 polarization via the DNMT1-NHE7 axis to accelerate endometrial cancer progression

推荐理由: 该研究揭示了缺氧‑乳酸代谢轴在子宫内膜癌中的新机制，对肿瘤免疫微环境有重要启示，值得血液学研究者了解其在巨噬细胞调控中的潜在借鉴价值。

摘要: Although hypoxia is a well-known key driver of metabolic reprogramming in endometrial cancer (EC), its role in lactate-mediated macrophage activation remains unclear. This study investigates whether hypoxia-mediated lactate metabolism reprogramming facilitated EC progression via macrophages. Our data demonstrated that hypoxia-inducible factor 1 subunit alpha (HIF1A) drives a lactate-regulated metabolic cascade, elevating glycolytic genes and monocarboxylate transporter 3 (MCT3) in EC cells to…

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34 KAT5 and KAT8 lactylate GPX4 Facilitates Ferroptosis and Inflammation in Diabetic Retinopathy

推荐理由: 该研究揭示了高糖诱导的GPX4乳酸化导致铁死亡和炎症的新机制，创新性强，但与血液疾病关联度较低，阅读价值适中。

摘要: Diabetes-induced hyperglycemia promotes retinal capillary endothelial cell dysfunction, contributing to diabetic retinopathy. In this study, we reveal that high glucose (HG) drives ferroptosis and inflammation through lactate-mediated GPX4 lactylation. HG conditions enhance glycolysis and lactate production, leading to increased lactylation of GPX4, a process mediated by the acetyltransferases KAT5 and KAT8. GPX4 lactylation reduces its antioxidant function, promoting lipid peroxidation,…

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35 Bio-based oxalic acid production in Issatchenkia orientalis enables sustainable rare earth recovery

推荐理由: 该研究在微生物合成草酸及稀土回收方面具备创新性和一定的工业应用前景，但与血液疾病关联度低，阅读价值主要在于跨学科的代谢工程思路。

摘要: The growing demand for rare earth elements (REEs) in clean energy and high-tech industries underscores the need for sustainable recovery methods and a reliable supply of processing chemicals. Here, we establish a microbial platform using the acid-tolerant yeast Issatchenkia orientalis SD108 to produce bio-oxalic acid for REE recovery. By introducing an oxaloacetate cleavage pathway and applying metabolic engineering, the engineered strain produces 39.53 g·L^(−1) oxalic acid at pH 4.0 in…

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36 Tenascin C<sup>+</sup> myofibroblasts exacerbate vascular neointimal hyperplasia by propagation of nerve-macrophage interactions in mice

推荐理由: 该研究揭示了TNC‑驱动的成纤维细胞向肌成纤维细胞转化机制，对血管损伤和再狭窄的基础研究具有创新价值，但与血液疾病关联度较低，阅读价值主要在于了解血管重塑的分子机制。

摘要: Neointimal hyperplasia (NIH) is a major pathological feature of vascular injury, yet its cellular and molecular drivers remain elusive. Here, using a mouse model of ligation-induced carotid artery NIH, we identify a population of Tenascin C-expressing (Tnc^+) myofibroblasts (MF). We demonstrate a TNC-driven transition of adventitial fibroblasts (AF) into Tnc^+ MFs via integrin αvβ1, initiating a positive feedback loop that sustains MF accumulation. In vitro, Tnc^+ MFs enhance neurite outgrowth, and…

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37 Structural basis of pausing during transcription initiation in mycobacterium tuberculosis

推荐理由: 该研究提供了结核分枝杆菌转录起始复合物的高分辨率结构，对理解细菌转录调控具有重要创新价值，但与血液疾病关联度较低，阅读价值主要在于分子机制和抗结核药物研发的启示。

摘要: In bacteria, RNA polymerase (RNAP) often pauses during the early stages of transcription initiation. The structural basis for these transient pauses remains unclear. Here, we present cryo-electron microscopy (cryo-EM) structures of the paused initiation complex (PIC) and initiation complex (IC) of Mycobacterium tuberculosis (Mtb), which include the RNAP core enzyme, the ECF σ factor σ^(E), transcription factor CarD, promoter DNA, and nascent RNA. Our structures with pre-melted scaffolds reveal…

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38 Phased-assembly-driven pangenome graphs for structural variant genotyping and complex trait mapping in dairy cattle

推荐理由: 该研究在结构变异检测和全基因组图谱构建方面方法创新、技术成熟，但与血液疾病关联度较低，适合关注基因组结构多样性的研究者阅读。

摘要: Structural variants are an underexplored source of genetic diversity. As part of the FarmGTEx Project, here we report a Holstein breed-specific pangenome graph (H20D) using Minigraph-Cactus and 40 phased haploid assemblies from 20 cows. H20D outperforms both assembly- and read-based long-read callers, and far exceeds short-read approaches, identifying over 10,000 additional structural variants per sample. It also significantly improves structural variant detection and genotyping relative to…

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39 AI for cancer treatment information: Can academia stay in the game?

推荐理由: 该文展示了检索增强大模型在癌症治疗信息提供中的创新应用，虽与血液疾病关联有限，但对了解AI在肿瘤医学中的潜力与风险具有参考价值。

摘要: In this issue of Cancer Cell, Jun et al. developed a retrieval-augmented large language model linked to an academia-led molecular knowledge database, demonstrating how AI may deliver cancer treatment information without hallucination. It must compete for adoption amid a fast-paced, industry-led transformation in the flow of clinical information to patients.

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40 How I Approach Clinical Ethics Consultation in Hematology

推荐理由: 该文通过血液科案例阐释临床伦理咨询流程，对血液疾病临床管理中的伦理困境具有一定借鉴价值，值得血液科医师了解。

摘要: Caring for individuals with hematological disorders is increasingly complex, and with medical complexity often comes ethical complexity. Prognostic uncertainty, stakeholder conflicts, and myriad other ethical challenges often contribute to situations that can benefit from ethics support. Through the presentation of three vignettes focusing on ethical dilemmas arising from hematology cases, we review the four phases of clinical ethics consultation: consult triage; ethics consult intake;…

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41 Transplatformer: translating toxicogenomic profiles between generations of platforms

推荐理由: 该文提出跨平台转录组数据翻译的计算方法，对提升历史基因表达数据的利用价值具有创新意义，但与血液疾病的直接关联较弱，阅读价值适中。

摘要: BACKGROUND: Transcriptomic profiling technologies have advanced the analysis of biological and toxicological responses. However, substantial differences in probe design, dynamic range, gene coverage, and preprocessing pipelines across platforms introduce artifacts that limit cross-study integration and hinder the reuse of historical datasets. We aim to develop computational methods for accurate cross-platform translation to maximize the value of legacy resources.

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42 SRSF2 mutations drive daunorubicin resistance in acute myeloid leukemia via THBS1 stabilization

推荐理由: 该研究揭示了SRSF2突变在白血病药物耐药中的作用，对血液肿瘤机制具有一定参考价值，但因实验细节和临床数据不足，阅读价值一般。

摘要: CONCLUSIONS: SRSF2 mutations promoted DNR resistance through multiple mechanisms, and targeted combination therapy with PDGFB pathway inhibitors may represent a novel strategy to improve therapeutic outcomes in patients with mutations.

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43 Human orbitofrontal neural activity is linked to obsessive-compulsive behavioral dynamics

推荐理由: 本文在OFC低γ功率与OCD症状动态的关联上提供了高分辨率的神经生理证据，方法创新但与血液疾病关联性极低，若关注跨学科神经精神研究可适度阅读。

摘要: Biomarkers of obsessive-compulsive disorder (OCD) symptom dynamics and related behavior could advance personalized interventions. Aberrant activity in the orbitofrontal cortex (OFC) has been implicated in symptom exacerbation in OCD. We conducted an intracranial monitoring assay to identify high-resolution neurophysiologic correlates of OCD symptoms in the human OFC. We found that low-gamma power in the anteromedial OFC was consistently elevated during high symptom states in a symptom…

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44 Hallmarks of cancer-Then and now, and beyond

推荐理由: 该文对癌症机制进行宏观概念梳理，创新性和方法学价值一般，但对血液肿瘤的直接启示有限，阅读价值中等。

摘要: Cancer presents a remarkably instructive perturbation of mechanisms manifesting in our biology that have gone awry, eliciting a malady that is inexorably increasing in incidence and societal burden concomitant with healthier aging. The wealth of knowledge and data forthcoming from decades of cancer research can be organized into conceptually distinct but interconnected parametric dimensions that define the mechanistic foundation of the disease: aberrantly acquired functional capabilities (the…

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45 Lactylation of SLC26A3 in the acidic tumor microenvironment promotes malignant progression of colorectal carcinoma

推荐理由: 该文揭示了SLC26A3在结直肠癌中的新机制，对肿瘤代谢研究具有创新价值，但与血液疾病关联有限，阅读价值一般。

摘要: The acidic tumor microenvironment provides the energy that drives the development of malignant tumors. High concentrations of lactic acid and H^(+) are key features of the acidic tumor microenvironment, and lactylation has gradually been shown to play a significant role in tumor progression. The expression of solute carrier family 26 member 3 (SLC26A3) is closely related to the occurrence and development of colorectal cancer (CRC), but the specific molecular mechanisms remain unclear. We…

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46 Lactate transmission from hypoxic tumor cells promotes macrophage senescence and M2 polarization via the DNMT1-NHE7 axis to accelerate endometrial cancer progression

推荐理由: 该研究揭示了缺氧‑乳酸代谢在子宫内膜癌中的新机制，对肿瘤免疫微环境有重要启示，值得血液学研究者了解其在巨噬细胞调控中的潜在借鉴价值。

摘要: Although hypoxia is a well-known key driver of metabolic reprogramming in endometrial cancer (EC), its role in lactate-mediated macrophage activation remains unclear. This study investigates whether hypoxia-mediated lactate metabolism reprogramming facilitated EC progression via macrophages. Our data demonstrated that hypoxia-inducible factor 1 subunit alpha (HIF1A) drives a lactate-regulated metabolic cascade, elevating glycolytic genes and monocarboxylate transporter 3 (MCT3) in EC cells to…

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47 Dynamic stretching beyond electron transfer in a homointerpenetrated metal‒organic framework for enhanced Fenton-like reactions

推荐理由: 该文在金属有机框架的结构调控与Fenton类催化方面具有创新性，但与血液疾病的直接关联较弱，适合对材料催化感兴趣的研究者了解。

摘要: While extensive efforts have been devoted to enhancing electron transfer efficiency through metal valence cycling in heterogeneous Fenton-like reactions, the potential catalytic improvement induced by dynamic structural stretching remain unexplored. Here, we introduce a homointerpenetrated Fe-based metal‒organic framework (BUC-95) featuring a dynamic stretchable structure that significantly boosts the heterogeneous Fenton-like catalytic performance. BUC-95′s unique stretchable structure achieved…

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48 Evolutionary repurposing of a metabolic thiolase complex enables antibiotic biosynthesis

推荐理由: 该研究揭示了口腔链球菌中酶复合体的全新功能，对天然产物合成机制具有创新意义，但与血液疾病关联度低，阅读价值主要在于酶学和微生物代谢领域的参考。

摘要: The functional diversification of biosynthetic enzymes underlies the chemical richness of natural products, yet how primary metabolic enzymes evolve to acquire specialized functions in secondary metabolism remains elusive. Here, we report a tripartite enzyme complex from oral Streptococcus species-comprising 3-hydroxy-3-methylglutaryl (HMG)-CoA synthase (HMGS), acetyl-CoA acetyltransferase (ACAT), and a DUF35 protein-that catalyzes an unusual Friedel-Crafts C-acetylation on a…

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49 A radiolabeled dendrimer non-invasively identifies and tracks innate immune cell activation in a mouse model of experimental autoimmune encephalomyelitis

推荐理由: 评分失败，请手动查看

摘要: Multiple sclerosis (MS) is a chronic neurodegenerative disease driven by infiltration of activated innate immune cells into the central nervous system (CNS). Current imaging approaches for diagnosing and monitoring disease progression rely on structural lesions and cannot directly assess innate immune activity. Here, we describe a dendrimer positron emission tomography (PET) tracer, ^(18)F-flurimedrimer (^(18)F-FMD), for non-invasive, longitudinal tracking of activated myeloid cells. In an…

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50 A Proposed Unified, Scalable Platform for Integrative Research on Venomous Species

推荐理由: 该文提出的 VenomsBase 平台在多组学数据整合方面具有创新性，可为药物发现提供新资源，但与血液疾病的直接关联较少，阅读价值主要在于了解潜在的生物活性分子来源。

摘要: Venomous animal research is hampered by fragmented, specialized, and non-interoperable databases (isolated genomic, proteomic, and ecological data). Despite the immense promise of venomous organisms to yield novel bioactive compounds for pharmacological and evolutionary applications, the informatics landscape for such taxa has remained patchy, lacking macro-scale integration across species. We present VenomsBase, an integrated, modular resource that synthesizes multi-omics data, ecological…

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51 The biological role of local and global fMRI BOLD signal variability in multiscale human brain organization

推荐理由: 该文揭示了宏观脑信号变异性的特征，对神经科学研究具有一定创新价值，但与血液疾病关联度低，阅读价值相对有限。

摘要: Variability drives the organization and behavior of complex systems, including the human brain. Understanding the variability of brain signals is thus necessary to broaden our window into brain function and behavior. Few empirical investigations of macroscale brain signal variability have been undertaken, given the difficulty in separating biological sources of variance from artefactual noise. Here, we characterize the temporal variability of the most predominant macroscale brain signal, the…

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52 Covalent modification of a glutamic acid inspired by HaloTag technology

推荐理由: 该文提出了针对低活性 Asp/Glu 的新型共价修饰策略，方法创新度高，但与血液疾病关联度有限，适合对化学生物学或药物设计感兴趣的读者参考。

摘要: For targeted covalent protein modification at low-reactivity aspartates and glutamates, new methods are in high demand. We report a technique inspired by the HaloTag technology, which employs nucleophilic substitution at chloroalkane-functionalised ligands by a specific aspartate residue. Embedding of alkyl bromide warheads into non-covalent inhibitors enables covalent modification of a glutamate in the lipoprotein binding chaperone - phosphodiesterase of retinal rod subunit delta (PDEδ), which…

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53 High-throughput methods leveraging robotics and computer vision for the development of therapeutic phage cocktails

推荐理由: 该文介绍的高通量噬菌体筛选平台在方法学上具备创新性，可为血液感染及相关血液病的噬菌体治疗提供技术参考，值得一读。

摘要: We present the high-throughput automated screening techniques that are being used to develop bacteriophage-based therapeutic products currently under investigation in human clinical trials to combat urinary tract infections^1. By integrating modern liquid handling robotics, standardized phenotypic assays, and computer vision-based enumeration, we established a platform capable of reproducibly screening large collections of phages against clinically derived bacterial strain panels. This approach…

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54 Trustworthy prediction of enzyme commission numbers using a hierarchical interpretable transformer

推荐理由: 该文提出的层次可解释Transformer模型在酶功能预测上具创新性，但与血液疾病关联有限，阅读价值主要

摘要: Accurate and trustworthy prediction of Enzyme Commission (EC) numbers is critical for understanding enzyme functions and their roles in biological processes. Despite the success of recently proposed deep learning-based models, there remain limitations, such as low performance in underrepresented EC numbers, lack of learning strategy with incomplete annotations, and limited interpretability. To address these challenges, we propose a hierarchical interpretable transformer model, HIT-EC, for…

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55 On-surface synthesis platform for highly branched oligomers based on sequential C-C coupling and C-H activation of carbenes

推荐理由: 该文在表面合成与卡宾化学方面具有创新性和技术价值，但与血液疾病研究关联度极低，阅读价值主要在于拓展跨学科思路。

摘要: On-surface synthesis is an emerging field for fabricating low-dimensional nanostructures. While carbenes are versatile reactive intermediates in solution-phase organic synthesis, they have rarely been explored in on-surface synthesis. Here, we demonstrate the versatility of carbenes in synthesizing highly branched zero-dimensional oligomers with distinct structures on a metal surface by combining bond-resolved scanning tunneling microscopy imaging, manipulation, X-ray photoelectron spectroscopy,…

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56 Lifetime Physical Activity Moderates the Neural Effects of Childhood Adversity on Resting State Functional Connectivity

推荐理由: 该研究揭示了体力活动在早期逆境后神经适应中的调节作用，对神经科学和公共健康有一定启示，但与血液疾病关联度低，血液学研究者可酌情阅读。

摘要: CONCLUSIONS: LPA moderated the association between ACE and rs-FC within emotion- and sensorimotor-related networks. Higher activity levels were linked to connectivity profiles consistent with potential neural resilience to early adversity. These findings highlight physical activity as a modifiable lifestyle factor associated with neurobiological adaptation following early adversity.

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57 First Results on the Search for Lepton Number Violating Neutrinoless Double-β Decay with the LEGEND-200 Experiment

推荐理由: 该研究在低背景液氩环境下的高纯锗探测技术具有前沿创新性，但与血液疾病关联度较低，主要适用于基础粒子物理领域。若关注血液学的研究者，可略作了解其技术潜在的跨学科应用。

摘要: The LEGEND Collaboration is searching for neutrinoless double-beta (0νββ) decay by operating high-purity germanium detectors enriched in ^76Ge in a low-background liquid argon environment. Building on key technological innovations from the GERmanium Detector Array (GERDA) experiment and the MAJORANA DEMONSTRATOR experiment, LEGEND-200 has performed a first 0νββ decay search based on 61.0 kg yr of data. Over half of this exposure comes from our highest performing detectors, including newly…

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58 PLETHORA-autophagy axis activates organ regeneration through ROS modulation

推荐理由: 该研究阐明了自噬在植物伤口修复中的新机制，对血液疾病的直接启示有限，但可为细胞稳态调控提供思路，值得有兴趣的研究者了解。

摘要: Injury-induced disruption of cellular homeostasis leads to accumulation of stress at sites adjacent to a wound. How do these cells mitigate wound-induced stress and restore cellular homeostasis to promote regeneration? To address this question, we examined the role of autophagy-a conserved quality control pathway that recycles defective cellular components to sustain cellular homeostasis-in facilitating wound repair in plants. We demonstrate that transcriptional activation of autophagy-related…

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59 Engineered alcohol oxidases catalyse transesterification in aqueous media without competing hydrolysis

推荐理由: 该研究展示了通过突变获得的无水酯化酶活性，创新性强，但与血液疾病关联度低，阅读价值主要在于酶工程和有机合成领域。

摘要: Transesterification reactions are fundamental transformations in organic chemistry, yet performing them in aqueous media is challenging because of the competing hydrolysis reaction. In this study, we describe a mutant of alcohol oxidase from Phanerochaete chrysosporium (PcAOx-VPN) that also exhibits transesterification activity. Moreover, PcAOx-VPN displays no detectable hydrolytic activity, owing to its hydrophobic active site, which effectively excludes water. These characteristics make…

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60 Understanding alkali metal promotion in hydrogenation catalysis through Strong Metal-Base Interaction

推荐理由: 该文阐明了碱金属在金属催化剂中的促进机制，对催化科学有一定创新价值，但与血液疾病关联度极低，阅读价值相对有限。

摘要: Alkali metals have been widely used as promoters in heterogeneous metal catalysts to improve activity, product selectivity, and stability. Despite their prevalence, the precise role remains not fully uncovered due to the complex interplay between catalytic components and reactants involving dynamic structural changes. Herein, we elucidate the promotional effect of alkali metal in hydrogenation reactions from a unified perspective. Using Na-doped Rh/TiO(2) as a representative system, we…

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61 A neutral cyclic aluminium (I) trimer

推荐理由: 该文首次报道中性三聚体铝配合物的结构与反应机制，对金属还原化学具有创新意义，但与血液疾病关联度极低，社会关注度和政策影响也有限，阅读价值主要在于基础化学研究。

摘要: As part of the quest to develop metal-based redox chemistry beyond the d-block, low oxidation state aluminium complexes have gained wide recognition as discrete and versatile 2-electron reductants. Despite reports of monomeric, dimeric and tetrameric neutral structures, as well as a range of charged aluminyl compounds, neutral trimeric structures have remained notably absent. Furthermore, trimeric nuclearity has previously not been considered when investigating reaction mechanisms. Here, we…

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62 Crowdsourced biodiversity monitoring fills gaps in global plant trait mapping

推荐理由: 该文展示了多源数据与遥感结合的创新方法，对生态与气候研究有价值，但与血液疾病关联度低，血液学研究者阅读价值有限。

摘要: Plant functional traits are fundamental to ecosystem dynamics and Earth system processes, but their global characterization is limited by available field surveys and trait measurements. Recent expansions in biodiversity data aggregation-including vegetation surveys, citizen science observations, and trait measurements-offer new opportunities to overcome these constraints. Here we demonstrate that combining these diverse data sources with high-resolution Earth observation data enables accurate…

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63 Sex-specific neural responses to smartphone cues in young adults

推荐理由: 该研究聚焦于智能手机使用与大脑功能的性别差异，虽具一定创新性和社会关注度，但与血液疾病关联甚少，血液学研究者阅读价值

摘要: Problematic smartphone use has been associated with altered reward and executive control network activity, yet potential sex differences in the underlying neural mechanisms remain insufficiently understood. We investigated sex-specific neural correlates of smartphone cue reactivity (CR) in 69 healthy young adult smartphone users (age range 18-30 years, female/male n = 45/24). Participants completed the Smartphone Addiction Inventory (SPAI) and underwent functional MRI during a smartphone CR…

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64 Breathing control training as a treatment for functional seizures (BREATHS trial): a multicentre, assessor-blinded, randomised controlled efficacy and acceptability trial study protocol

推荐理由: 该研究聚焦功能性癫痫发作的呼吸干预，虽具一定创新性，但方法学局限明显，对血液疾病的关联和参考价值极低，阅读价值有限。

摘要: INTRODUCTION: Functional seizures (FS) are events that resemble epileptic seizures, but are not attributed to brain pathology and are instead thought to be due to psychological factors. A small, multisite, open-label, single-arm, pilot trial of a breathing intervention known as breathing control training (BCT) found it to be safe and effective in reducing seizure frequency in FS. We propose a protocol for a study to confirm these results.

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65 First Observation of CP Violation and Measurement of Polarization in B^+→ρ(770)^0K^*(892)^+ Decays

推荐理由: 该文首次观测到 B^+→ρ^0K*^+ 的 CP 破坏，实验方法严谨、数据量大，对粒子物理学前沿有重要价值，但与血液疾病关联度极低，血液学研究者可酌情阅读。

摘要: An amplitude analysis of the B^+→(π^+π^-)(K_S^0π^+) decay is performed in the mass regions 0.30<1.10 GeV/c^2 and 0.75<1.20 GeV/c^2, using pp collision data recorded with the LHCb detector corresponding to an integrated luminosity of 9 fb^-1. The polarization fractions and CP asymmetries for B^+→ρ(770)^0K^*(892)^+ decays are measured. Violation of the CP symmetry in the decay B^+→ρ(770)^0K^*(892)^+ is observed for the first time,…

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66 Lactate promotes cuproptosis in acute kidney injury by activating H3K18 lactylation-dependent upregulation of HSPA6 expression

推荐理由: 该研究揭示了乳酸诱导的组蛋白乳酰化在肾缺

摘要: AIMS: The present study aims to investigate the role and mechanism of lactate-induced histone lactylation in regulating cuproptosis during renal IRI.

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67 P300 enhances glycolysis and dox resistance in DLBCL by upregulating HK2 expression through histone lactylation

推荐理由: 该研究揭示了P300介导的糖酵解在弥散性大B细胞淋巴瘤对阿霉素耐药中的作用，对血液肿瘤耐药机制有一定参考价值，但信息量有限，适合对该方向有兴趣的研究者快速了解。

摘要: CONCLUSION: Dox resistance in DLBCL was mediated by P300-facilitated glycolysis.

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68 Harmonic non-Hermitian skin effect

推荐理由: 该文提出并实验验证了“谐波非厄米皮肤效应”，在物理学前沿具有创新性，但与血液疾病研究关联度极低，血液学研究者阅读价值有限。

摘要: The non-Hermitian skin effect (NHSE), an exotic phenomenon of localization at the boundary, has recently drawn extensive attention and Floquet engineering offers a powerful approach to expanding its scope. The fundamental role of harmonic response in Floquet systems has nonetheless yet to be elucidated. Here, we introduce the concept of harmonic NHSE and demonstrate it experimentally in an acoustic platform. Within our theoretical framework, we demonstrate that incorporating dynamic couplings…

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69 Diversity and ecological roles of hidden viral players in groundwater microbiomes

推荐理由: 该研究在地下水病毒多样性方面提供了大规模、创新的宏基因组数据，对环境微生物学有重要价值，但与血液疾病关联度低，血液学研究者阅读价值有限。

摘要: Groundwater ecosystems harbor diverse microbial communities adapted to energy-limited, light-deprived conditions, yet the role of viruses in these environments remains poorly understood. Here, we analyzed 1.24 terabases of metagenomic and metatranscriptomic data from seven wells in the Hainich Critical Zone Exploratory (CZE) to characterize groundwater viromes. We identified 257,252 viral operational taxonomic units (vOTUs) (≥ 5 kb), with 99% novel at order, family and genus levels against…

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70 Hand-like autonomous flying robot for airborne grasping and interaction

推荐理由: 该文虽在仿生航空机器人领域具创新性，但与血液疾病研究关联度极低，阅读价值主要限于跨学科的技术启发。

摘要: Birds’ extraordinary aerial agility and environmental interaction enable complex tasks such as mid-air hunting, perching, and nest-building, inspiring the development of advanced aerial robots with similar manipulation capabilities. However, existing platforms often face challenges such as large size, heavy payloads, end-effector torque interference, and limited functionality, severely restricting their practical deployment. Drawing inspiration from the biological, structural, and actuation…

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71 Global metagenomics reveals plastid diversity and unexplored algal lineages

推荐理由: 该文阐述光合作用细胞器的进化机制，对血液疾病研究的直接帮助有限，但对理解细胞共生与基因组演化的基础生物学仍有一定参考价值。

摘要: Photosynthetic organelles in eukaryotes originated through primary endosymbiosis with a cyanobacterium, an event that profoundly shaped the evolutionary landscape of the eukaryotic tree of life. Primary plastids in Archaeplastida, especially in cultivable plants and algae, contribute most to known plastid diversity. Secondary and higher-order endosymbiosis, involving eukaryotic hosts and algal endosymbionts, further spread photosynthesis among protists within the CASH lineages (Cryptophyta,…

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72 Twist engineering induced spin-orbit coupling for photosynthesis of ethane from carbon dioxide and water

推荐理由: 该研究在光催化乙烷合成方面具有创新性，但与血液疾病关联度极低，阅读价值主要限于材料化学领域，对血液学研究帮助不大。

摘要: Harnessing sunlight, carbon dioxide, and water to produce two-carbon products is promising but constrained by sluggish kinetics and high carbon-carbon coupling barriers. Here, we report Ni single-atom anchored twisted SnS(2) (Ni-TSnS(2)) for ethane (C(2)H(6)) photosynthesis. In-situ electron paramagnetic resonance was developed to observe spin-orbit coupling in Ni-TSnS(2). Spontaneous long-range spin-momentum locking originated from spin-orbit coupling enables magnetic-field-free long-range spin…

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73 Ectopic cambia in wisteria vines are associated with the expression of conserved KNOX genes

推荐理由: 该研究在植物二次维管生长机制上提供了新颖的比较转录组和进化分析，对血液疾病研究的直接借鉴价值有限，但对跨学科的发育生物学研究者仍有一定参考意义。

摘要: Secondary vascular growth is a conserved mechanism that gives rise to vascular tissues produced via a single vascular cambium. Molecular mechanisms underlying this process are characterized mainly in model species with typical vascular architectures, while the genetics underlying ecologically-important atypical vascular architectures remain unexplored. We use developmental anatomy, comparative transcriptomics, molecular evolutionary analyses, and heterologous gene expression to address this…

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74 RECOAT study - Retrospective evaluation of surface-modified and coated flow diverters for the treatment of unruptured intracranial aneurysms

推荐理由: 该文仅给出结论性描述，缺乏实验设计、数据和血液疾病相关的具体信息，阅读价值有限。

摘要: CONCLUSION: The present study demonstrates high safety and efficacy for coated or surface-modified FDs. Whether the surface modifications confer a clinical benefit needs to be addressed in comparative studies.

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75 Lactate promotes cuproptosis in acute kidney injury by activating H3K18 lactylation-dependent upregulation of HSPA6 expression

推荐理由: 该研究探讨乳酸诱导的组蛋白乳酰化与铜死亡在肾缺血再灌注中的关系，创新性有限且与血液疾病关联不强，阅读价值一般。

摘要: AIMS: The present study aims to investigate the role and mechanism of lactate-induced histone lactylation in regulating cuproptosis during renal IRI.

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76 Association of a diffuse phenotype on MRI with shorter overall survival in patients with astrocytoma CNS WHO grades 2 and 3

推荐理由: 该研究聚焦于脑胶质瘤的MRI表型与预后关系，与血液疾病关联度极低，阅读价值有限。

摘要: CONCLUSIONS: A diffuse phenotype on MRI seems to be associated with shorter survival times in patients with CNS WHO grade 2 and 3 astrocytomas. These findings warrant further investigation in prospective data sets.

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77 Governing black soils for food and climate security

推荐理由: 由于缺乏摘要，无法判断该研究的创新性、方法学严谨性及其对血液疾病的实际价值，阅读价值有限。

摘要: No abstract

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78 Predicting suicide attempts in a high-risk clinical cohort of adolescents using machine-learning

推荐理由: 该文缺乏摘要，无法了解研究内容、创新性及对血液疾病的关联，信息不足，阅读价值有限。

摘要: No abstract

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79 This robot hand detaches and walks by itself

推荐理由: 该文缺乏摘要，无法判断研究内容、创新性及对血液疾病的关联性，信息不足，阅读价值有限。

摘要: No abstract

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80 China is betting on ‘optical’ computer chips - will they power AI?

推荐理由: 由于未提供摘要，无法评估该研究的创新性、方法学严谨性及其对血液疾病的相关性，建议先获取完整文献后再决定是否阅读。

摘要: No abstract

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81 Can academia handle my religious faith?

推荐理由: 由于缺乏摘要和具体信息，无法评估创新性、方法学严谨性及对血液疾病的关联性，阅读价值有限。

摘要: No abstract

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82 Light-powered bacteria become living chemical factories

推荐理由: 由于缺乏摘要，无法判断研究创新性、方法严谨性及血液疾病的相关性，信息不足，阅读价值有限。

摘要: No abstract

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