追觅 - 2026-02-01

生成时间: 2026−02-01 22:37

分析文章数量: 57

1 MER57E3 transposable elements regulate gene expression in a human cell model of neural development

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摘要: CONCLUSIONS: Our data indicate that members of the MER57E3 TE subfamily regulate the expression of critical neurogenesis genes during neural progenitor cell (NPC) development. Moreover, this study emphasizes the importance of investigating TEs, offering new insights into how their epigenetic dysregulation may contribute to pathogenesis of neurodevelopmental disorders.

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2 Validity and reliability of simulation-based assessment tools for European Training Requirement-defined competencies in anaesthesiology: a two-centre observational pilot study

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摘要: Despite ongoing efforts to harmonise postgraduate anaesthesiology training across Europe, significant variability persists among national programmes, and a unified certification process is lacking. Simulation is widely used in postgraduate anaesthesiology training, and several validated tools are available to assess both technical and nontechnical skills. However, use of such tools for summative assessments in specialist certification has not yet been established. This prospective, observational…

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3 In vitro generation of human CD14<sup>+</sup> MDSC-like cells from normal human monocytes

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摘要: Myeloid-derived suppressor cells (MDSC) are heterogenous group of immature and mature myeloid cells that accumulate in chronic inflammatory conditions and contribute to the immune suppression. Their ability to inhibit immune responses makes them critical targets for therapeutic interventions. However, working with patient-derived MDSC poses challenges. Variability in cell yields and the complexity of their isolation procedures significantly hinder the conduct of in vitro experiments aimed at…

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4 Rethinking Insecticide Toxicology for the 21st Century

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摘要: Insecticides remain indispensable for crop protection and food security, yet their widespread use may contribute to the global decline of beneficial insect populations. Efforts to mitigate these impacts are hampered by a fragmented understanding of how insects metabolise insecticides and how sublethal exposures affect physiology, behaviour, and fitness. Here, we synthesise current understanding of metabolic detoxification and highlight critical gaps: the tissue- and time-dependent dynamics of…

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5 Seasonal Community-Acquired Respiratory Virus Infections in Patients with Cancer - Epidemiological and Clinical Overview, an Analysis of the Multicenter OncoReVir Registry

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摘要: CONCLUSION: CARV epidemiology in patients with cancer changed substantially across pandemic phases, while clinical severity and infection-related mortality remained largely unchanged.

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6 A brief history of ependymoma

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摘要: Ependymoma represents a biologically and clinically heterogeneous group of glial tumours that arise throughout the whole neuroaxis and in all age groups. Whereas intracranial ependymoma is usually found in children, adults suffer mostly from spinal cord ependymoma. In comparison to other neuro-oncological tumour entities, ependymoma has been largely understudied for decades. However, the recent years resulted in unprecedented progress with regard to the understanding of the biological…

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7 Structural correlates of auditory verbal hallucinations in patients with borderline personality disorder

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摘要: CONCLUSIONS: These findings reveal structural correlates of AVH in BPD, implicating sensorimotor, executive, and affective networks. The overlap with SZ-associated cortical patterns suggests transdiagnostic neural mechanisms and shared pathophysiological substrates of AVH.

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8 A genome-wide association meta-analysis of cholesterol synthesis intermediates identifies three associations for lanosterol

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摘要: BACKGROUND: Cholesterol is a main contributor to coronary artery disease (CAD). Although the genetic basis of blood cholesterol concentration is well studied, there is currently a lack of studies investigating the genetics of its precursors from de novo biosynthesis.

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9 Double Graph Attention Network for predicting non-alcoholic fatty liver disease in patients with type 2 diabetes

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摘要: Type 2 diabetes mellitus (T2DM) is a chronic metabolic disease, while non-alcoholic fatty liver disease (NAFLD) is the most prevalent chronic liver disease, which can progress to more severe liver diseases such as liver fibrosis, cirrhosis and hepatocellular carcinoma. Approximately 50%-70% of T2DM patients also have NAFLD. Traditional diagnostic methods like liver biopsy have limitations, making large-scale screening difficult. In the past decade, machine learning have emerged as crucial tools…

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10 S2potAE: multimodal spatial spot autoencoder integrating image and transcriptomic features for deconvolution

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摘要: Spatial transcriptomics (ST) technologies have significantly advanced our ability to discern gene expression patterns within intact tissue structures, enabling unprecedented insights into cellular heterogeneity and tissue architecture. However, accurately determining cell-type proportions within spatially aggregated transcriptomic spots remains challenging due to inherent granularity discrepancies, batch effects, and spatial heterogeneity. To address these challenges, we introduce S$^{2}$potAE,…

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11 Advances and challenges in single-cell RNA sequencing data analysis: a comprehensive review

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摘要: Single-cell RNA sequencing (scRNA-seq) has transformed the resolution of cellular heterogeneity, offering insights into dynamic biological processes from tumor evolution to immune regulation. However, its clinical translation is limited by challenges such as data sparsity, batch effects (differences caused by technical variation rather than biology), and the absence of standardized benchmarks for core pipelines like Seurat and Scanpy. This review outlines emerging computational strategies that…

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12 S2potAE: multimodal spatial spot autoencoder integrating image and transcriptomic features for deconvolution

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摘要: Spatial transcriptomics (ST) technologies have significantly advanced our ability to discern gene expression patterns within intact tissue structures, enabling unprecedented insights into cellular heterogeneity and tissue architecture. However, accurately determining cell-type proportions within spatially aggregated transcriptomic spots remains challenging due to inherent granularity discrepancies, batch effects, and spatial heterogeneity. To address these challenges, we introduce S$^{2}$potAE,…

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13 plmmr: an R package to fit penalized linear mixed models for genome-wide association data with complex correlation structure

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摘要: Correlation among the observations in high-dimensional regression modeling can be a major source of confounding. We present a new open-source package, plmmr, to implement penalized linear mixed models in R. This R package estimates correlation among observations in high-dimensional data and uses those estimates to improve prediction with the best linear unbiased predictor. The package uses memory mapping so that genome-scale data can be analyzed on ordinary machines even if the size of data…

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14 piRAT: piRNA Annotation Tool for annotating, analyzing, and visualizing piRNAs

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摘要: No abstract

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15 Sample size requirements for machine learning classification of binary outcomes in bulk RNA-Seq data

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摘要: No abstract

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16 Coniferyl aldehyde in ginger-Eucommiae Cortex enhances osteoarthritis treatment by modulating ALDOA and H3K23la histone lactylation

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摘要: CONCLUSIONS: This study identified the basis for the synergistic effect of ginger juice on EC and supported the scientific rationale for G-EC processing. In this study, CFA improved OA by affecting glycolysis and modulating lactylation at the H3K23la site of H3 histones, highlighting the critical role of CFA in its anti-OA effects. A non-invasive diagnostic model for OA was developed, which facilitated the rapid prediction of OA risk in patients, and interpretable machine-learning methodologies…

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17 Coniferyl aldehyde in ginger-Eucommiae Cortex enhances osteoarthritis treatment by modulating ALDOA and H3K23la histone lactylation

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摘要: CONCLUSIONS: This study identified the basis for the synergistic effect of ginger juice on EC and supported the scientific rationale for G-EC processing. In this study, CFA improved OA by affecting glycolysis and modulating lactylation at the H3K23la site of H3 histones, highlighting the critical role of CFA in its anti-OA effects. A non-invasive diagnostic model for OA was developed, which facilitated the rapid prediction of OA risk in patients, and interpretable machine-learning methodologies…

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18 Pre-existing neutralizing antibodies against cattle-transmitted influenza A virus H5N1 are detectable in unexposed individuals

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摘要: The transmission of influenza A virus H5N1 clade 2.3.4.4b from cattle to humans highlights the risk of an H5N1 pandemic. Pre-existing immunity strongly impacts the course and severity of viral infections, making detailed knowledge of antibodies against the spilled-over strain crucial. Here, we assessed humoral immunity against H5N1 A/Texas/37/2024 in H5N1-naive individuals. We performed complementary binding and neutralization assays on 66 individuals and ranked activities among a panel of 76…

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19 Targeting immune cells in the aged brain reveals that engineered cytokine IL-10 enhances neurogenesis and improves cognition

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摘要: The immune system could play an important role in the age-related decline in brain function, yet specific immune-based strategies to enhance brain resilience in older individuals are lacking. Here, we combined engineered proteins and direct brain delivery to target immune cell populations within the old brain. We detected T cells with an exhaustion signature in the old brain and targeted them with a potent engineered checkpoint inhibitor (RIPR-PD1). This led to T cell expansion and strong…

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20 Stepwise epigenetic signal integration drives adaptive programming of cytotoxic lymphocytes

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摘要: Lymphocyte differentiation during infection depends on the integration of antigen and cytokine signals, yet how the timing and sequence of these cues program cell fate remains unclear. We found that interleukin-12 (IL-12) plays a context-dependent role in immune memory formation. Without prior antigen-receptor signaling, IL-12 drove cytotoxic lymphocytes toward terminal effector differentiation. In contrast, antigen signaling redirected IL-12-STAT4 activity through cooperation with AP-1…

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21 B cell-intrinsic IL-2 signaling regulates inflammation by promoting IL-10 expression in CD25<sup>+</sup> age-associated B cells

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摘要: Interleukin (IL)−2 can impact both plasma cell (PC) differentiation and the generation of IL-10^(pos) B cells. We generated mice bearing a B cell-specific deletion of Il2rb (Il2rb^(ΔB)) to define the B cell-intrinsic role of IL-2. Il2rb^(ΔB) mice displayed normal B cell development and homeostasis but increased extrafollicular PC responses upon immunization. In vitro, IL-2 sustained both PC differentiation and expression of a regulatory program. In vivo, IL-2 signaling defined a PDCA-1^(pos)…

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22 Meningeal B cells: Emerging players at the brain border

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摘要: The meninges, long viewed as passive protective membranes, are now recognized as active immunological interfaces harboring diverse immune populations. Among them, B cells have emerged as dynamic participants in central nervous system (CNS) homeostasis and disorders. Recent studies have identified distinct B cell subsets in the meninges at different developmental and activation stages, including precursors supported by skull marrow-derived progenitors and immunoglobulin A (IgA)⁺ plasma cells…

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23 Room-temperature polariton condensate in a quasi-2D hybrid perovskite

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摘要: Quasi-2D halide perovskites are chemically synthesized realizations of quantum well stacks with giant exciton oscillator strengths, tunable emission spectra, and very large exciton binding energies. While these features render quasi-2D halide perovskites a promising platform for room-temperature polaritonics, bosonic condensation and polariton lasing in quasi-2D perovskites have so far remained elusive at ambient conditions. Here, we demonstrate room-temperature cavity exciton-polariton…

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24 Molecular signatures of resilience to Alzheimer’s disease in neocortical layer 4 neurons

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摘要: Selective neuronal vulnerability is a hallmark of Alzheimer’s disease (AD), yet the molecular basis of resilience remains poorly understood. Using single-nucleus and spatial transcriptomics to compare neocortical regions affected early (prefrontal cortex, precuneus) or late (primary visual cortex) in AD, we identified a resilient excitatory population in layer 4 of the primary visual cortex expressing RORB, CUX2, and EYA4. Layer 4 neurons in association neocortex shared molecular signatures of…

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25 Architectural and evolutionary features of TE-derived TSSs shape tissue-specific promoter activity in the human genome

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摘要: Transposable elements are abundant in the human genome and have been increasingly recognized as sources of alternative promoters. Yet, the extent of their transcriptional activity in human tissues and the features that govern their regulatory potential remain unclear. Here, we integrated high-resolution RAMPAGE data from 115 human biosamples to construct a comprehensive atlas of 26,056 transcription start sites derived from transposable elements. These sites contribute to tissue-specific gene…

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26 Fluorescence mapping of atropisomer populations enabled by through-space conjugation

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摘要: Multi-axis atropisomers are ubiquitous in nature, and their intricate stereoconformations not only deepen stereochemical understanding but also elucidate fundamental principles of molecular atropisomeric dynamics. Nevertheless, insights into multi-axis atropisomerism remain limited. This work presents a systematic investigation of three classes of LaPlente-type biaxial atropisomers based on naphthalene rotors and phenyl linkers. Thermodynamically and kinetically controlled interconversion of…

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27 Probing the molecular structure at graphite-water interfaces by correlating 3D-AFM and SHINERS

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摘要: Water at solid surfaces is key for many processes ranging from biological signal transduction to membrane separation and renewable energy conversion. However, under realistic conditions, which often include environmental and surface charge variations, the interfacial water structure remains elusive. Here we overcome this limit by combining three-dimensional atomic force microscopy (3D-AFM) and interface-sensitive shell-isolated nanoparticle enhanced Raman spectroscopy (SHINERS) to characterize…

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28 Plasma proteome mediates the associations between air pollution exposure and disease risk

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摘要: Air pollution has been increasingly linked to a wide range of diseases, yet the underlying biological mechanisms remain poorly understood. Here, we systematically investigate how circulating proteins mediate the health effects of multiple air pollutants and quantify individual susceptibility. Using large-scale data from the UK Biobank, we identify 30 diseases significantly associated with air pollution exposure. We uncover 1,089 pollutant-associated proteins enriched in immune pathways, among…

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29 Bioinspired charge reservoir enables efficient CO<sub>2</sub> photoreduction with H<sub>2</sub>O via tungsten valence oscillation

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摘要: Solar-driven conversion of CO(2) and H(2)O into chemicals is a promising strategy, while achieving simultaneous and efficient CO(2) reduction and H(2)O oxidation remains challenging. Here, inspired by the role of plastoquinone in temporarily storing electrons during natural photosynthesis, we design a silver-modified tungsten trioxide (Ag/WO(3)) that functions as a charge reservoir through reversible W^(6+)/W^(5+) transitions under irradiation. When coupled with various active components,…

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30 DNA diamond formulates a decomposable composite letter constellation model for DNA data storage

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摘要: Oligonucleotide multiplicity is an inherent property of current DNA synthesis technology. Composite letter DNA storage exploits this property to improve logical density and reduce costs. However, letter indistinguishability and high molecular diversity pose challenges for reliable recovery. Here, we formulate a composite letter constellation model, named DNA diamond, consisting of 15 decomposable points. Inspired by set partitioning in telecommunications, we propose a two-stage letter detection…

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31 Vertical chiral emission from an intrinsically achiral metasurface enabled with anisotropic continuum

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摘要: Manipulating emission polarization is crucial for advanced applications such as polarized fluorescence and lasing, thermal radiation control, stereochemistry and spintronics. Existing approaches for generating circularly polarized emission primarily rely on nanostructures with true chirality, where the far-field polarization at the Γ point is believed to require out-of-plane symmetry breaking. This raises a question: can an intrinsically achiral metasurface that preserves out-of-plane symmetry…

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32 Neoadjuvant modified FOLFIRINOX plus nivolumab in borderline-resectable pancreatic ductal adenocarcinoma: a pilot phase 1 trial

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摘要: Chemotherapy and immune checkpoint inhibitor combinations have failed to improve survival in pancreatic ductal adenocarcinoma (PDAC), except in rare microsatellite instability-high cases; most studies focused on advanced disease. Here, we present clinical and translational results from a single-arm, prospective phase 1b/2 investigator-initiated study (NCT03970252) evaluating neoadjuvant modified FOLFIRINOX (mFFX) plus nivolumab in patients with borderline-resectable PDAC. The co-primary…

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33 Microbiota-induced EI24 improves homeostasis but impedes function of alveolar macrophages via metabolic regulation

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摘要: Lung microenvironment controls the homeostasis and function of alveolar macrophages (AMs), the major regulators of lung immunity, but the underlying mechanisms, particularly the role of microbiota, remain unclear. Here, with Lyz2^(cre)Ei24^(fl/fl) mice, we report that EI24 deficiency in macrophages disrupts AMs homeostasis but enhances their phagocytosis and inflammatory responses via metabolic rewiring. Consequently, Lyz2^(cre)Ei24^(fl/fl) mice exhibit resistance to viral infection and tumor…

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34 Developments and challenges in hit progression within fragment-based drug discovery

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摘要: Fragment-based Drug Discovery (FBDD) is a proven methodology for the discovery of new therapeutics. After the identification of small molecular fragments, subsequent steps are guided by the “Design, Make, Test” (DMT) cycle. During the “Design” phase, chemical modifications are proposed that generate Structure-Activity Relationship information, improve interaction profiles and physicochemical properties. In the “Make” phase, designs are synthesised into viable compounds, with an emphasis on…

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35 Modulating thermo-diffusion/galvanic coupling via ion speciation engineering enables high-performance ionic thermoelectric cells

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摘要: Ionic thermoelectric (i-TE) materials have demonstrated a high thermopower in harvesting low-grade heat, emerging as superior candidates for self-powered electronics. However, coupling two i-TE effects in n-type materials is scarce, which restricts the development of high-performance systems. Herein, we uncover an overlooked thermogalvanic redox reaction between Cu^(2+) and Cu^(+) stabilized by Cl⁻ and quantitatively track the progressive reaction process by operando characterization. In binary…

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36 Ultra-coherent meta-emitter tailors arbitrary thermal wavefront

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摘要: Conventional coherent light-field manipulation techniques inherently conflict with the spatiotemporal incoherence of thermal radiation sources. While recent advances in thermophotonics have facilitated directional thermal emission, arbitrary thermal wavefront control-a cornerstone for advanced functionalities like focusing and holography-remains an unaddressed challenge. Here, we report a generalized recipe of designing meta-emitters with lossy and lossless outer boundaries, that enables thermal…

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37 Printed origami thermoelectric generator achieves &gt; 20 Wm<sup>-</sup>² from low-grade heat via material and process design

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摘要: Printing facilitates low-cost thermoelectric generators to power battery-free internet-of-things devices, wearables, and Industry 4.0 systems. However, scaling up requires printable thermoelectric materials with good mechanical properties and high performance. Here, we report a high-performance Ag(2)(Se(1-x)S(x))(1.05)-based n-type printed thermoelectric film through a combination of engineering non-stoichiometric defects and sulfur substitution. An optimal sulfur substitution of 2 at. %…

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38 Early detection of aberrant cell fate and repair using circulating progenitor cells in patients with heterotopic ossification

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摘要: Heterotopic ossification (HO), the abnormal formation of bone in soft tissues, is a debilitating complication that occurs after severe burns, trauma, and joint replacement surgery. Current diagnostic methods detect HO only after substantial progression, limiting opportunities for early intervention. In this study, we show that circulating mesenchymal progenitor cells (cMPCs), isolated using a microfluidic iChip from patients undergoing hip replacement and a mouse model of traumatic HO, exhibit…

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39 Repurposing nuclear receptors for ligand-responsive liquid condensate formation and gene regulation

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摘要: Cells regulate processes through protein interaction networks. Most chemically induced dimerization (CID) systems respond to exogenous molecules, limiting integration with endogenous signaling. Here, we repurpose nuclear receptor (NR) ligand-binding domains (LBDs) and coactivators to develop hormone- or clinically approved drug-responsive CIDs. Using the LBDs of TRβ, VDR, RARγ, ERβ, and GR2 with a TIF2 coactivator peptide, we constructed CIDs responsive to triiodothyronine, vitamin D, retinoic…

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40 Reliable repurposing of the antibody interactome inside the cell

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摘要: Eighty-five percent of the human proteome has at least one interacting monoclonal antibody. These molecules penetrate the cytoplasm poorly and are very often non-functional within the cell. Analysis of antibody variable domains and characterisation of forty-five single-chain variable fragment (scFv) intrabodies expressed in human cells indicated charge to have the greatest impact on solubility. We created new interdomain linkers, optimised scFv domain orientation and found an optimisable charge…

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41 Computational single-neuron mechanisms of visual object coding in the human temporal lobe

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摘要: Understanding how the human brain encodes visual objects involves deciphering the neural computations and circuits in the temporal lobe. Here, we recorded intracranial EEG from the human ventral temporal cortex (VTC) and medial temporal lobe (MTL), as well as single-neuron activity in the MTL, to investigate the computational mechanisms of neural object coding. The VTC exhibited axis-based feature coding, and a neural feature space could be constructed using VTC neural axes, within which visual…

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42 Covalent inhibitor design confers activity against both GDP- and GTP-bound forms of KRAS G12C

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摘要: The discovery of KRAS G12C inactive state inhibitors represented a significant advancement in the field of precision oncology. While inactive state inhibition shows promise in patients, Switch II (SWII)-binding inhibitors targeting both inactive and active states remain an underdeveloped therapeutic modality. Here, we describe the discovery of such KRAS G12C dual inhibitors that bind the SWII allosteric site using a chemically differentiated warhead to covalently modify both the KRAS G12C…

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43 Transition to bio-based plastic packaging reveals complex climate-biodiversity trade-offs

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摘要: Plastics are a major contributor to global greenhouse gas emissions and biodiversity loss, with packaging accounting for around 40% of European plastic production. Bio-based plastics are often promoted as a climate-friendly alternative, yet their broader environmental implications remain unclear. Here, we conduct a harmonized life cycle assessment of fossil- and bio-based plastic packaging, integrating end-of-life fate and plastic leakage. We find that while bio-based plastics reduce greenhouse…

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44 Multicomponent synergistic immobilization via in-situ and dynamic exchange strategies for constructing hierarchical biopharmaceuticals

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摘要: Hierarchical immobilization of multicomponent biomacromolecules has been demonstrated to be a favorable protocol for constructing advanced biopharmaceuticals, but still with formidable challenges. Herein, we innovate a multicomponent synergistic immobilization approach combining an in-situ method with a structural-transformation-promoted dynamic exchange method in a flexible zeolitic pyrimidine framework (ZPF) platform to construct multicomponent biopharmaceuticals. In-depth mechanism…

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45 Tunable chiral and nematic states in the triple-Q antiferromagnet Co<sub>1/3</sub>TaS<sub>2</sub>

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摘要: Complex spin configurations in magnetic materials, ranging from collinear single-Q to non-coplanar multi-Q states, exhibit rich symmetry and chiral properties. However, their detailed characterization is often hindered by the limited spatial resolution of neutron diffraction techniques. Here we employ magnetic circular dichroism and magnetic linear dichroism to investigate the triangular lattice antiferromagnet Co(1/3)TaS(2), revealing three-state (Z(3)) nematicity and also spin chirality across…

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46 Recurrent connections facilitate occluded object recognition by explaining-away

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摘要: Despite the ubiquity of recurrent connections in the brain, their role in visual processing is less understood than that of feedforward connections. Occluded object recognition, an important cognitive capacity, is thought to rely on recurrent processing of visual information, but it remains unclear whether and how recurrent processing improves recognition of occluded objects. Using convolutional models of the visual system, we demonstrate how a distinct form of computation arises in…

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47 Tomato antiviral ubiquitin-proteasome system recognizes viral 59 kDa protein to confer tomato chlorosis virus resistance

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摘要: Viral diseases critically impact crop yields, necessitating insights into plant-pathogen recognition and resistance. In tomato (Solanum lycopersicum), tomato chlorosis virus (ToCV) employs 59 kDa protein (p59) to facilitate movement and degrade the host Catalase1 (SlCAT1), disrupting redox homeostasis. Importantly, tomato has evolved an antiviral ubiquitin-proteasome system (UPS) featuring the Antiviral E2 ubiquitin-conjugating enzyme (SlAVE2) and Antiviral E3 ubiquitin ligase (SlAVE3) pair,…

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48 Nanotwin architecture and ultra-high valley degeneracy lead to high thermoelectric performance in GeTe-based thermoelectric materials

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摘要: Here, we achieve a high peak ZT of 2.5 as well as an exceptional average ZT of 1.9 through nanotwin architecture and inducing ultra-high valley degeneracy. We find that nanotwins, ordered vacancy arrays and point defects serve as intense phonon scattering centers for enhancing wide-frequency phonon scattering, resulting in ultralow lattice thermal conductivity in GeTe. Interestingly, density-functional theory calculations reveal that CuBiS(2) alloying realizes refined valence band alignment in…

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49 Saturation of space weathering in shaping lunar regolith particle morphology

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摘要: The lunar mare regolith preserves tripartite records of volcanism, impacting, and space weathering. However, previous studies based on limited soil particle numbers were hindered by issues of sample representativeness. Here we conduct micro-CT scans of bulk soil samples from Chang’e-5 (nearside) and Chang’e-6 (farside), and develop machine learning-based image segmentation and classification methods to identify a vast number of basalt, agglutinate, breccia, and monomineralic particles. The…

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50 Ultralow CNT-reinforced phase-change fibers for scalable wearable thermoregulation

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摘要: Phase-change materials (PCMs) demonstrate transformative potential for wearable thermal management systems; however, their practical implementation faces challenges due to trade-offs among energy storage density, mechanical robustness, and phase-change stability. Here, we present a nanotechnology-directed strategy that integrates ultralow carbon nanotubes (CNT, 0.1 wt.%) scaffolds with three-dimensional (3D) interpenetrating polymer networks (IPNs), achieving remarkable synergy between…

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51 Strain-invariant omnidirectional stretchable MXetronics

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摘要: Titanium carbide MXene flakes hold great promise for system-level MXene-based electronics (MXetronics) due to their outstanding electrical conductivity and diverse functional properties. However, the weak MXene interlayer bonding often causes film fracturing under mechanical strain, ultimately leading to device failure, manifested as unstable operation, inaccurate data transmission, and potential electrical disconnection. Here, we present strain-invariant, omnidirectionally stretchable…

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52 Enhanced methane chlorination via RuO<sub>2</sub>-gas convection electrode with in-situ generated dynamical three-phase boundaries

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摘要: Chloromethane (CH(3)Cl) is a crucial chemical intermediate conventionally synthesized under harsh conditions. Electrocatalytic methane (CH(4)) chlorination enables a sustainable alternative by utilizing abundant CH(4) and chlor-alkali feedstocks under ambient conditions. However, the high stability and low solubility of CH(4) limit CH(3)Cl’s production. To address these issues, we develop a hierarchical system integrating catalyst and electrode designs. RuO(2) catalyst is applied for surface…

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53 A spatiotemporal atlas of cerebrovascular development in zebrafish

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摘要: The vertebrate brain requires precisely patterned vasculature, yet the molecular and cellular dynamics of cerebrovascular development remain incompletely understood. While single-cell studies have profiled brain vasculature, integrating these data across molecular, cellular, and architectural scales remains challenging. We combine in situ sequencing, single-cell transcriptomics, and 3D vascular reconstruction to map zebrafish brain endothelial development (3-11 dpf). Quantitative 3D analysis…

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54 Safety and biologic activity of a bispecific T cell receptor targeting HIV Gag in males living with HIV: a first-in-human trial

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摘要: HIV persistence in reservoirs despite antiretroviral therapy (ART) is a barrier to a permanent cure. We present the affinity-enhanced TCR bispecific IMC-M113V as a potential therapeutic for targeted HIV reservoir elimination. Preclinical studies demonstrate that IMC-M113V redirects T cells towards cells expressing the variable viral peptide, Gag(77-85,) presented by HLA-A*02:01 at low copy number, without binding to HIV-negative cells. Here, we conduct a first-in-human, open-label single…

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55 Experimental realization of dice-lattice flat band at the Fermi level in layered electride YCl

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摘要: Flat electronic bands, where interactions among electrons overwhelm their kinetic energies, hold the promise for exotic correlation physics. The dice lattice has long been theorized as a host of flat bands with intriguing band topology. However, to date, no material has ever been found to host the characteristic flat bands of a dice lattice. Here, using angle-resolved photoemission spectroscopy (ARPES), we discover a dice-lattice flat band at E(F) in the van der Waals (vdW) electride [YCl]^(2+):…

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56 Discover the maze-like network for glabridin biosynthesis

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摘要: Flavonoid diversity arises from modifications of a few precursors by tailored enzymes, yet the complexity of their evolved metabolic networks complicates pathway elucidation and design. Here, by combining chromosome-scale genome assembly with large-scale transcriptome analysis, we identify and reconstruct the glabridin biosynthetic pathway in yeast, enabling de novo production of this antioxidant flavonoid from Glycyrrhiza glabra L. By analyzing 183 licorice transcriptomes, we discover four…

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57 Aeromonas in South Asia: genomic insights into an environmental pathogen and reservoir of antimicrobial resistance

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摘要: Aeromonads are an ecologically versatile group of bacteria that cause infections in aquatic animals and are recognised as emerging human pathogens. Despite this, our understanding of Aeromonas diversity, especially the relationship between clinical and environmental strains, remains limited. Here, we present a genomic analysis of the Aeromonas genus, comprising 1853 genomes, and a detailed comparison of clinical and environmental strains from South Asia, including 996 newly sequenced genomes…

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