追觅 - 2026-02-03

生成时间: 2026−02-03 22:59

分析文章数量: 91

1 A measles virus encoding a CD19/CD3 bispecific T cell engager shows enhanced preclinical anti-BCP-ALL efficacy without significant toxicity

推荐理由: 该研究创新性强，利用改造的麻疹病毒局部分泌CD19×CD3双特异性T细胞接合子，为高危儿童B‑ALL提供了新颖的免疫治疗思路，值得血液学研究者关注。

摘要: Children with high-risk B-cell precursor acute lymphoblastic leukemia (BCP-ALL) continue to face relapse and treatment resistance, emphasizing the urgent need for novel therapeutic strategies. In this study, we developed and characterized a recombinant oncolytic measles virus (MV-Blina) engineered to locally secrete a bispecific T cell engager (bsTE) targeting CD19 and CD3 (secBlina) to enhance antitumor immunity while minimizing systemic toxicity. MV-Blina demonstrated superior replication…

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2 JAK2V617F reprograms Hypoxia Inducible Factor-1 to induce a non-canonical hypoxia regulon in myeloproliferative neoplasms

推荐理由: 该研究利用JAK2V617F驱动的骨髓增殖性肿瘤模型，探讨HIF‑1α在常氧下的激活方式及其对肿瘤发生的影响，对血液恶性疾病的机制研究具有较高的参考价值。

摘要: Hypoxia-inducible factors (HIFs) are master transcriptional regulators, central to cellular survival in hypoxia and frequently activated within malignancy. Whilst malignant context directs the role of HIFs within oncogenesis, these mechanisms are not well characterised. Applying the JAK2V617F myeloproliferative neoplasms (MPNs) oncogene-driver model, in which HIF-1α is stabilised in normoxia (20% O(2)), we sought to determine whether the modality of HIF-1 activation directs its function. Through…

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3 PheCode-guided multi-modal topic modeling of electronic health records improves disease incidence prediction and GWAS discovery from UK Biobank

推荐理由: 该文提出的多模态表型建模方法创新且在大规模UK Biobank数据上验证，可为血液疾病的表型挖掘提供思路，值得血液学研究者了解。

摘要: Phenome-wide association studies rely on disease definitions derived from diagnostic codes, often failing to leverage the full richness of electronic health records (EHR). We present MixEHR-SAGE, a PheCode-guided multi-modal topic model that integrates diagnoses, procedures, and medications to enhance phenotyping from large-scale EHRs. By combining expert-informed priors with probabilistic inference, MixEHR-SAGE identifies over 1000 interpretable phenotype topics from UK Biobank data. Applied to…

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4 Biomarker-integrated prognostic stagings for Alzheimer’s Disease

推荐理由: 该研究提出了融合血浆生物标志物和影像学的阿尔茨海默病预测模型，创新性强且样本量大，值得血液学研究者了解其多组学整合思路，以供跨学科参考。

摘要: Accurately predicting disease progression remains a major challenge in Alzheimer’s disease (AD). Here we show that a biomarker-integrated prognostic staging system can stratify progression risk across the disease course by jointly incorporating cognitive status, established risk factors, plasma biomarkers, and neuroimaging measures. In the K-ROAD cohort (N = 1,263), the dominant prognostic contributors varied by clinical context-GFAP in cognitively unimpaired individuals, hippocampal volume in…

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5 Luteolin attenuates RA-associated chronic pain by targeting the LDHA/H3K9la/NFATC2 axis to suppress Th17 cell differentiation and central infiltration

推荐理由: 该研究揭示了黄酮类化合物 luteolin 通过调控脊髓 CD4^+ T 细胞缓解类风湿关节炎慢性疼痛的机制，对免疫细胞在炎症性疾病中的作用提供了新视角，值得血液学及免疫学研究者参考。

摘要: Chronic joint pain in rheumatoid arthritis (RA) represents a persistent therapeutic challenge, and although luteolin (LUT) exhibits established anti-inflammatory properties, its precise mechanism for alleviating RA-associated chronic pain remains undefined. Through systematic investigation in collagen-induced arthritis (CIA) mice, we demonstrated that LUT administration effectively attenuated chronic pain by modulating spinal cluster of differentiation 4 positive T (CD4^(+) T) cell dynamics and…

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6 <em>Alpseq</em>: an open-source workflow to turbocharge nanobody discovery with high-throughput sequencing

推荐理由: 该文提出的 alpseq 流水线在纳米抗体 NGS 数据处理上具备创新性和实用性，对生物技术研发有重要参考价值，值得血液学研究者了解其方法论。

摘要: Nanobodies have emerged as promising tools for many biotechnological applications due to their small size, high stability and remarkable binding specificity. Next-Generation Sequencing (NGS) enables deep profiling of large nanobody libraries and panning campaigns; however, the scale and diversity of nanobody NGS datasets presents a significant bioinformatic challenge. To this end, we have developed alpseq, an optimized, open-source software pipeline designed specifically for the efficient and…

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7 Wnt-associated DKK3 in keratinocytes mediates radiation-induced hyperplasia, dermatitis and skin fibrosis

推荐理由: 该研究阐明了DKK蛋白在放疗诱导皮肤纤维化中的作用，为放疗副作用的机制提供新视角，值得血液科研究者了解其信号通路的跨学科启示。

摘要: Radiotherapy remains a mainstay of cancer treatment. However, radiotherapy can also elicit acute and chronic adverse effects, including dermal inflammation and skin fibrosis. A comprehensive understanding of the underlying fibrotic processes remains elusive, and currently, no established treatment options exist. Canonical Wnt signaling has emerged as a significant player in fibrotic conditions. The Dickkopf (DKK) protein family comprises key modulators of Wnt signaling. To define the function of…

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8 Lactylation Enhances YTHDF3 Stability to Promote Cisplatin Resistance via m6A-Dependent KDM6B Decay in Bladder Cancer

推荐理由: 该研究首次揭示乳酸诱导的YTHDF3乳酰化在顺铂耐药中的作用，创新性强，对癌症耐药机制有重要启示，值得血液学研究者了解其潜在的跨疾病调控价值。

摘要: Acquired resistance to cisplatin remains a major therapeutic challenge in muscle-invasive bladder cancer. Here, we demonstrate for the first time that lactate accumulation induces AARS2-dependent lactylation of the m6A reader YTHDF3, establishing lactylation as a previously unrecognized regulatory layer of this epitranscriptomic factor. YTHDF3 lactylation stabilizes the protein by antagonizing ubiquitin-mediated degradation. Importantly, a lactylation-deficient YTHDF3 mutant fails to confer…

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9 A broadly protective antibody targeting gammaherpesvirus gB

推荐理由: 该文聚焦γ疱疹病毒的共同融合蛋白gB，提出新颖的抗病毒靶点，对研究EBV等血液系统恶性肿瘤具有一定借鉴价值，值得一读。

摘要: Gammaherpesvirus is a subfamily of herpesvirus, distinct phylogenetically from alpha- and betaherpesvirus and featured by its oncogenic subtypes, including Epstein-Barr virus and Kaposi’s sarcoma-associated herpesvirus^1. It broadly infects humans and other vertebrate animals and causes various diseases and malignancies^(2,3). However, no specific antiviral agents are available for each type or the whole family. gB is the common fusion protein vital for herpesvirus infection and an ideal target…

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10 Luteolin attenuates RA-associated chronic pain by targeting the LDHA/H3K9la/NFATC2 axis to suppress Th17 cell differentiation and central infiltration

推荐理由: 本文揭示了黄酮类化合物 luteolin 通过调控脊髓 CD4^+ T 细胞缓解类风湿关节炎慢性疼痛的机制，对免疫细胞在炎症性疾病中的作用提供了新视角，值得血液免疫学研究者参考。

摘要: Chronic joint pain in rheumatoid arthritis (RA) represents a persistent therapeutic challenge, and although luteolin (LUT) exhibits established anti-inflammatory properties, its precise mechanism for alleviating RA-associated chronic pain remains undefined. Through systematic investigation in collagen-induced arthritis (CIA) mice, we demonstrated that LUT administration effectively attenuated chronic pain by modulating spinal cluster of differentiation 4 positive T (CD4^(+) T) cell dynamics and…

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11 Lactylation Enhances YTHDF3 Stability to Promote Cisplatin Resistance via m6A-Dependent KDM6B Decay in Bladder Cancer

推荐理由: 该研究首次揭示乳酸诱导的YTHDF3乳酰化在顺铂耐药中的作用，提供了新的表观遗传调控视角，对肿瘤及可能的

摘要: Acquired resistance to cisplatin remains a major therapeutic challenge in muscle-invasive bladder cancer. Here, we demonstrate for the first time that lactate accumulation induces AARS2-dependent lactylation of the m6A reader YTHDF3, establishing lactylation as a previously unrecognized regulatory layer of this epitranscriptomic factor. YTHDF3 lactylation stabilizes the protein by antagonizing ubiquitin-mediated degradation. Importantly, a lactylation-deficient YTHDF3 mutant fails to confer…

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12 Gut microbiota-derived butyrate primes systemic immunity in honey bees by mediating lipid metabolic reprogramming

推荐理由: 该研究首次揭示了蜂群肠道丁酸盐在免疫代谢调控中的关键作用，创新性强且对理解免疫机制具有启示意义，值得血液学研究者参考。

摘要: The gut microbiota plays a crucial role in insect immune priming, inducing enhanced immune response that functionally resembles acquired immunity confined to vertebrates. While gut microbiota mediates systemic immune activation in insect hemolymph, the mechanisms underlying remote immunoregulation remain largely unknown. Here we use the honey bee gut microbiota as a model, we identify butyrate as a key microbial metabolite coordinating immune-metabolic crosstalk. Butyrate supplementation…

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13 AI-based multiomics profiling reveals complementary omics contributions to personalized prediction of cardiovascular disease

推荐理由: 该研究创新性强，利用多组学深度学习模型在大规模人群中预测心血管疾病风险，方法与数据可靠，值得血液学研究者了解其多组学分析思路与模型框架。

摘要: Genomics, metabolomics, and proteomics offer complementary insights into cardiovascular disease (CVD) risk. Leveraging UK Biobank data, we introduce the CardiOmicScore, a multitask deep learning framework, to learn disease-specific proteomic (ProScore) and metabolomic (MetScore) risk scores for the six most common CVDs by profiling 2920 proteins and 168 metabolites. Experiments demonstrate that ProScore and MetScore are strong sole CVD risk predictors (C-index range: 0.69-0.82 for ProScore and…

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14 Chinese expert consensus on the diagnosis and treatment of severe pneumonia in immunocompromised hosts

推荐理由: 该文聚焦免疫抑制患者的重症肺炎管理，填补指南空白，对血液病患者（如白血病、造血干细胞移植）具有较高参考价值，值得一读。

摘要: The population of immunocompromised hosts has steadily increased in recent years. Clinical evidence indicates that these individuals are at a significantly higher risk of developing severe pneumonia following infection, with the mortality rates markedly higher than those observed in immunocompetent individuals. However, there is currently a lack of specific national or international guidelines or expert consensus addressing the management of severe pneumonia in this population. To address this…

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15 Daratumumab in systemic lupus erythematosus: a single-arm phase 2 trial

推荐理由: 该研究首次探索抗CD38单抗daratumumab在SLE中的抗ASC作用，提供了血液免疫学视角的创新临床数据，值得血液学研究者关注。

摘要: Antibody-secreting cells (ASCs) play a central role in the pathophysiology of systemic lupus erythematosus (SLE). This single-arm, open-label, phase 2 clinical trial aims to evaluate the safety and efficacy of the ASC-depleting anti-CD38 monoclonal antibody daratumumab in patients with SLE (NCT04810754). The primary endpoint is the reduction in serum anti-double-stranded DNA (anti-dsDNA) antibody levels at week 12. Key secondary end points include safety, clinical efficacy, and immunologic…

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16 PathCLAST: pathway-augmented contrastive learning with attention for interpretable spatial transcriptomics

推荐理由: 该文提出了结合通路结构与组织形态的空间转录组新方法，创新性强，可为肿瘤微环境研究提供机制线索，值得血液肿瘤研究者了解其技术思路。

摘要: Deciphering how molecular programs are spatially organized within tissues is pivotal for understanding tumor evolution and microenvironmental interactions. Existing spatial transcriptomics tools either rely on gene-level features, ignoring the rich topology of biological pathways, or deliver black-box clusters with little mechanistic insight; thus, they limit their translational impact. A method that simultaneously leverages pathway structures and spatially matched histopathology could produce…

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17 A common 19 bp APOE enhancer deletion is protective against Alzheimer’s disease in African Americans

推荐理由: 该研究揭示了非洲裔人群中APOE‑ε4风险的遗传调节机制，创新性强且对阿尔茨海默病的公共健康政策具有重要启示，但与血液疾病关联度较低。

摘要: The APOE-ε4/ε4 genotype is the strongest genetic risk factor for sporadic Alzheimer’s disease, though the relative risk is diminished in individuals with African ancestry. Through analysis of phased APOE alleles, we identify a 19 bp deletion approximately 1.1 kb distal to the APOE 3′UTR in a SPI1 microglial transcription factor binding site. The deletion is present in 60% of African American APOE-ε4 homozygotes and reduces Alzheimer’s disease odds ratio relative to individuals without the…

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18 Bayesian Hyperspherical Graph Mixture-of-Experts Deciphers Cell-Cell Interaction in Spatial Transcriptomics

推荐理由: 该文提出了针对空间转录组数据的创新计算框架，解决了现有方法的平滑与不确定性问题，对血液组织的空间解析具有潜在借鉴价值，值得血液学研究者了解。

摘要: Spatial transcriptomics (ST) technologies have transformed our understanding of tissue biology by capturing gene expression with spatial context, enabling systematic analysis of cell-cell interactions (CCIs) and spatial domains in complex tissues. However, existing computational approaches often rely on fixed proximity graphs, curated ligand-receptor (LR) databases, or deep graph neural networks that are prone to over-smoothing and lack principled uncertainty quantification. These limitations…

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19 Spatial information matters: are traditional imputation methods effective for spatial transcriptomics data?

推荐理由: 该文提出了针对高分辨率空间转录组数据的创新性缺失值填补方法，技术前沿且可为血液系统单细胞空间分析提供思路，值得血液学研究者了解。

摘要: Recent advancements in spatially resolved transcriptomics (SRT) have enabled near single-cell resolution, providing rich spatial context crucial for uncovering biological insights. However, high-resolution SRT datasets remain sparse and prone to dropout events that may impede accurate interpretation. Computational imputation methods are often employed to recover missing values, yet existing state-of-the-art (SOTA) techniques-designed for tabular, single-cell RNA, or general SRT data-have not…

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20 Asprosin-driven metabolic-epigenetic rewiring attenuates mesenchymal stem cell senescence with therapeutic benefits for infarcted hearts

推荐理由: 该研究提出了asprosin调控MSC衰老

摘要: CONCLUSION: Asprosin is a novel MSC-specific rejuvenation factor that antagonizes senescence through metabolic-epigenetic interplay. Targeting the asprosin-driven “Glycolysis-Lactylation-Epigenetics” axis offers a transformative strategy to enhance MSC-based therapies for ischemic heart disease.

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21 Paclitaxel drives TREM2<sup>+</sup> macrophage expansion underlying its inferior therapeutic efficacy compared to Nab-paclitaxel

推荐理由: 该研究通过荟萃分析和机制实验揭示了nab‑paclitaxel在乳腺癌治疗中的优势及其对巨噬细胞TREM2表达的差异调控，对肿瘤免疫微环境的理解具有创新价值，值得血液学研究者关注其免疫细胞调控机制。

摘要: Paclitaxel and nab-paclitaxel differ in therapeutic efficacy and modulation of the tumor immune microenvironment, yet the molecular basis remains poorly defined. Here, based on a meta-analysis, we first show that treatment with nab-paclitaxel results in a higher overall response rate and pathological complete response compared to paclitaxel in female patients with breast cancer. Notably, TREM2 expression in macrophages is elevated in primary tumors of paclitaxel- but not nab-paclitaxel-treated…

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22 Coacervate droplets as pH-regionalized protocells

推荐理由: 该研究创新性强，提供了可控的体外模型来探讨液-液相分离对pH调节的机制，虽与血液疾病关联度不高，但对理解细胞内无膜结构的基本生物学具有参考价值，值得一读。

摘要: The mechanisms governing pH regulation in membrane-less organelles (MLOs) are essentially different from those relying on membrane proteins, yet it remains poorly understood due to the difficulty in directly controlling the conditions across the MLOs interface. Here, we develop a coacervate-based, in vitro model to investigate how liquid-liquid phase separation (LLPS) could contribute to pH regulation in MLOs. We construct peptide-based coacervate droplets using microfluidics and find that…

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23 Counteracting FOX proteins epigenetically control the herpesvirus lytic-latent balance

推荐理由: 该研究首次揭示FOX转录因子在HSV潜伏与激活中的关键作用，创新性强，对病毒学和神经生物学研究具有重要参考价值，值得血液学研究者了解其机制以防止潜在的病毒相关血液并发症。

摘要: The lytic-latent balance is a major viral persistence strategy and obstacle to curing viral diseases, yet its mechanisms remain poorly understood. Following lytic infection in non-neuronal cells, herpes simplex virus (HSV) establishes latency specifically in neurons and is reactivated by stresses. Here we identify forkhead box (FOX) transcription factors that can strongly activate or repress replication of HSV-1 and other alphaherpesviruses, and show that neurons express activating Fox (e.g.,…

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24 European Code Against Cancer 5th edition: 14 ways you can help prevent cancer

推荐理由: 该文阐述了欧洲最新的癌症预防指南，创新性强且对公共健康政策具有重要参考价值，但与血液疾病关联度较低，阅读价值主要在于了解癌症预防的整体趋势和政策制定过程。

摘要: Despite the growing cancer burden in the European Union, public awareness of effective prevention is low. In response, Europe’s Beating Cancer Plan has supported the development of the 5th edition of the European Code Against Cancer (ECAC5). Using a transparent, stepwise decision-making process, around 80 experts reviewed the latest scientific evidence on cancer prevention and used modern communication strategies to update the previous edition. An innovation in ECAC5 is the inclusion of…

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25 Nitroreductase-triggered indazole formation

推荐理由: 该研究在酶促合成靶向吲唑类化合物方面提供了新颖的化学方法，对药物合成具有一定的参考价值，但与血液疾病关联度较低，阅读价值适中。

摘要: Biocatalysis contributes significantly to the development of more sustainable synthetic pathways by using mild reaction conditions and water as a solvent. However, many relevant classes of compounds, including privileged groups in drug design, are not yet accessible via enzymatic pathways. In this context, the development of an enzymatic route to indazoles remains an unmet challenge. Here, we present a nitroreductase-triggered indazole formation, in which 2-nitrobenzylamine derivatives are…

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26 Integrated action for skin NTDs: Deconstructing transmission, addressing knowledge gaps, and championing one health strategies

推荐理由: 该综述系统阐述了皮肤类被忽视热带病的综合诊疗框架，对公共卫生和政策制定具有重要参考价值，但与血液疾病关联较弱，阅读价值主要在于了解跨学科防控思路。

摘要: Skin Neglected Tropical Diseases (skin NTDs) are a critical, underestimated source of chronic pathology, severely impacting vulnerable, rural populations with poor healthcare access. These diseases heighten the risk of systemic infection, amputation, and premature mortality. Their visibility and co-endemic nature present a pivotal opportunity for integrated diagnostics and management at the primary care level. Aligned with the WHO roadmap, this review advocates for a robust One Health framework,…

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27 Asymmetric Pt<sub>1</sub>C<sub>3</sub>-Pt<sub>1</sub>O<sub>1</sub>C<sub>3</sub> catalytic pairs for efficient transfer hydrogenation of azobenzene

推荐理由: 该研究在原子级催化剂设计上具有创新性，可为材料科学提供新思路，但与血液疾病关联度较低，阅读价值主要在跨学科启发。

摘要: Atomic catalytic pairs (CPs) have shown great promise in driving multi-step catalytic transformations, yet the influence of spatial arrangement and coordination asymmetry on homonuclear CPs remain poorly understood. Herein, we construct atomically dispersed homonuclear Pt(1)-Pt(1) CPs with asymmetric Pt(1)C(3)-Pt(1)O(1)C(3) coordination anchored on reduced graphene oxide. By precisely tuning the spacing between the adjacent Pt(1)C(3)-Pt(1)O(1)C(3) CPs to approximately 5.3 Å, the catalyst…

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28 Diffusion-Weighted Magnetic Resonance Imaging and Apparent Diffusion Coefficient Mapping Detect Kidney Infiltration in Acute Myeloid Leukemia: A Case Report

推荐理由: 该病例报告提供了AML伴肾功能急剧恶化的影像学和组织学特征，对血液科医生了解 AML 的肾脏并发症具有一定参考价值。虽然研究规模有限，但创新的 MRI 诊断提示值得关注。

摘要: We describe a case of 70-year-old man with type 2 diabetes and myelodysplastic syndrome progressing to acute myeloid leukemia (AML) who presented with rapidly worsening kidney function. Although computed tomography imaging of the patient’s kidneys was unremarkable, subsequent magnetic resonance imaging (MRI) showed high signal intensity on diffusion-weighted imaging and low signal intensity on the apparent diffusion coefficient map in the kidneys. A kidney biopsy from the region that exhibited…

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29 Advancing A(H5N1) influenza risk assessment in ferrets through comparative evaluation of airborne virus shedding patterns

推荐理由: 该研究提供了新型H5N1病毒的动物模型和气溶胶采样技术，对评估流感大流行风险具有重要参考价值，但与血液疾病关联有限，仅在跨学科视角下具备一定阅读价值。

摘要: Recent A(H5N1) zoonotic cases linked to poultry and cattle in North America highlight the urgent need to assess the pandemic potential of emerging strains. Using male ferrets, we evaluate two B3.13 and two D1.1 genotype A(H5N1) viruses isolated from humans and observe fatal disease and varying capacities for direct contact transmission. To enhance pandemic risk assessment, we conduct aerosol sampling using cyclone BC251 and water condensation capture-based SPOT samplers and perform comparative…

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30 Case Report: FIA plus venetoclax in a patient on hemodialysis

推荐理由: 该文报道了在终末期肾病接受间歇血液透析的AML患者成功使用化疗的罕见案例，对血液科医生在类似高危患者的治疗决策具有参考价值。

摘要: The safe and effective delivery of curative cytotoxic chemotherapy for acute myeloid leukemia (AML) in patients receiving intermittent hemodialysis (IHD) for end-stage renal disease (ESRD) remains a clinical challenge; pharmacological and logistical barriers necessitate close interdisciplinary coordination. In this case, we report a 65-year-old female patient with chronic ESRD on IHD and newly diagnosed AML who achieved complete remission (CR) after treatment with fludarabine, idarubicin, and…

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31 Lactylation: the malignant playbook of hepatocellular carcinoma cells and their roadmap to therapy resistance

推荐理由: 该综述系统阐述了乳酸化在肝癌进展中的新机制，虽与血液疾病关联不大，但对代谢‑表观遗传交叉研究提供了有价值的思路，值得血液学研究者了解。

摘要: Hepatocellular carcinoma (HCC) is a significant global health issue, characterized by a high mortality rate closely linked to treatment resistance and late-stage diagnosis. Lactylation, a distinctive post-translational modification linking cellular metabolism and epigenetics, has recently attracted significant attention due to its potential role in HCC. This review aims to systematically elucidate how lactylation facilitates the malignant progression of HCC through many mechanisms, including…

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32 Lactylation: the malignant playbook of hepatocellular carcinoma cells and their roadmap to therapy resistance

推荐理由: 该综述系统阐述了乳酸化在肝癌进展中的作用，对了解代谢与表观遗传交叉机制有帮助，但与血液疾病关联较弱，阅读价值主要在于肿瘤代谢研究领域。

摘要: Hepatocellular carcinoma (HCC) is a significant global health issue, characterized by a high mortality rate closely linked to treatment resistance and late-stage diagnosis. Lactylation, a distinctive post-translational modification linking cellular metabolism and epigenetics, has recently attracted significant attention due to its potential role in HCC. This review aims to systematically elucidate how lactylation facilitates the malignant progression of HCC through many mechanisms, including…

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33 van der Waals grain boundaries with inert electrical behaviors in inorganic molecular dielectric film

推荐理由: 该研究揭示了多晶无机分子介质薄膜中晶界的惰性电学行为，创新性强且方法严谨，但与血液疾病关联度较低，阅读价值主要在材料科学领域。

摘要: Grain boundaries (GBs) in insulating crystal films generally create lattice reconstruction and excess mid-gap states, which may form the transport pathways of charge carriers and lead to serious degradation of insulating properties. Here, we reveal the inert electrical behaviors of GBs in polycrystalline inorganic molecular dielectric film attributed to its special van der Waals structure. Temperature-dependent electrical measurements and first-principles calculations uncovered that such GBs are…

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34 The Lolal-dpp axis mediates the regulation of host reproduction by gut symbionts in insects

推荐理由: 该研究揭示了肠道菌群通过调控泛素‑蛋白酶体系统影响昆虫生殖的全新机制，创新性突出，但与血液疾病关联度较低，阅读价值适中。

摘要: Gut commensal microbiota can play an integral role in shaping insect reproduction, but the underlying mechanisms remain largely unexplored. Here, we report that gut bacteria promote host reproduction in the oriental fruit fly Bactrocera dorsalis by inducing ubiquitin-proteasome system (UPS)-mediated degradation of the key transcription factor Longitudinals lacking-like (Lolal). Antibiotic-induced gut bacterial depletion impairs ovarian development and fertility. These reproductive defects can be…

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35 An interpretable AI system reduces false-positive MRI diagnoses by stratifying high-risk breast lesions

推荐理由: 该文提出的基于基础模型的AI系统在乳腺癌影像诊断中具备创新性，可为医学影像AI方法提供参考，但与血液疾病关联度低，阅读价值有限。

摘要: Breast cancer diagnosis using magnetic resonance imaging remains limited by high false-positive rates and substantial inter-reader variability, especially for lesions classified as Breast Imaging Reporting and Data System (BI-RADS) category 4, often leading to unnecessary biopsies. Here we show that the BI-RADS 4 Lesions Analysis System (BL4AS), an artificial intelligence system powered by foundation models and leveraging the rich spatiotemporal information of dynamic contrast-enhanced MRI,…

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36 Mechanistic insights into PCBP1-driven unfolding of selected i-motif DNA at G<sub>1</sub>/S checkpoint

推荐理由: 该研究揭示了PCBP1对i‑motif DNA的选择性识别与展开机制，创新性强且方法严谨，对分子生物学研究具有参考价值，但与血液疾病的直接关联较弱，阅读价值主要在于拓展基因结构调控的基础认识。

摘要: I-motifs are non-canonical, four-stranded DNA structures in cytosine-rich genomic regions, yet their protein-mediated regulation remains underexplored. Here, we identify PCBP1 (Poly(rC)-binding protein 1) as a selective i-motif-binding protein that unfolds specific i-motifs depending on their protonation and hairpin-forming propensities. Systematic truncation reveals that individual K-homology (KH) domains of PCBP1 cannot selectively bind or unfold i-motifs, but their coordinated actions restore…

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37 PRMT3-mediated post-translational adaptation to fasting regulates metabolic flexibility

推荐理由: 该研究揭示了PRMT3/ADMA在进食-禁食循环中的调控机制，对肥胖及代谢疾病的干预提供了新思路，但与血液疾病关联有限，阅读价值一般。

摘要: Obesity impairs metabolic flexibility-the capacity to adapt to fluctuating energy demands. Emerging evidence suggests that dietary interventions, particularly time-restricted feeding (TRF), may help restore this flexibility. In this study, we demonstrate that feeding upregulates PRMT3 and asymmetric dimethylarginine (ADMA)-containing proteins via insulin-pAKT signaling, while fasting reduces their expression. Pharmacological inhibition of PRMT3 attenuates diet-induced obesity (DIO) and enhances…

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38 Acoustic shape-morphing micromachines

推荐理由: 该文在超声驱动微型机器人形变机制上具有创新性，对跨学科技术研发有参考价值，但与血液疾病关联度低，社会关注度有限。

摘要: Shape-morphing mechanisms help organisms adapt to their environment and have inspired applications in advanced systems. Designing microrobots that are both miniaturized and capable of fast shape changes is challenging, as performance can be weakened at small scales. Ultrasound offers advantages such as fast response, repeatability, and programmability, making it suitable for enabling shape-morphing microrobots. Here, we introduce an acoustic micromachine composed of two microbubbles connected by…

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39 Cutaneous Toxicities of Small Molecules in Targeted Cancer Therapy Part I - Mechanisms of Toxicity

推荐理由: 该文综述了精准靶向抗癌药物的最新进展，对肿瘤学研究有参考价值，但与血液疾病关联较弱，阅读价值一般。

摘要: Advances in the understanding of cancer biology have led to a shift toward more precise, targeted anticancer therapies. Traditional chemotherapy acts as an intracellular poison to disrupt cell division or induce DNA damage resulting in cytotoxicity^1. However, the effects of traditional chemotherapy are not relegated to neoplastic tissue, resulting in significant off-target cytotoxicity^2. Targeted therapies were developed to provide a more specific approach to cancer treatment, focused on…

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40 Delivery of peptide coacervates to form stable interaction hubs in cells

推荐理由: 该文提出利用蛋白质材料恢复细胞功能的创新思路，对细胞老化和疾病机制有一定启发，但与血液疾病的直接关联较弱，阅读价值一般。

摘要: Cells contain membrane-bound and membraneless organelles that operate as spatially distinct biochemical niches. However, these reaction centers lose fidelity due to aging or diseases. A grand challenge for biomedicine is restoring or augmenting cellular functionalities. An excited strategy is the delivery of protein-based materials that can directly interact with cellular biological networks. In this study, we sought to develop long-lasting materials capable of cellular uptake, akin to…

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41 Publisher Correction: Machine learning predicts meter-scale laboratory earthquakes

推荐理由: 评分失败，请手动查看

摘要: No abstract

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42 A digital platform with activity tracking for energy management support in long COVID: a randomised controlled trial

推荐理由: 评分失败，请手动查看

摘要: In a 6-month pragmatic randomised controlled trial (RCT; ISRCTN16033549), we compared a just-in-time intervention to support energy management in adults with long COVID (LC) to standard care. Participants received either the ‘Pace Me’ app and a wearable activity tracker (intervention) or an app only with data entry screens (control). The intervention group received just-in-time messages on energy management when they reached 50%, 75%, and 100% of their daily ‘activity allowance’. The primary…

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43 Cutaneous Toxicities of Small Molecules in Targeted Cancer Therapy Part II - Approach to Management and Treatment

推荐理由: 该文系统阐述了小分子靶向药物导致的皮肤不良反应及其管理，对提升肿瘤患者生活质量具有一定参考价值，但与血液疾病的直接关联较弱，阅读价值一般。

摘要: With the rapid expansion of small molecule inhibitors (SMIs) in oncology, the incidence and complexity of dermatologic adverse events (dAEs) have significantly risen^1. While SMIs target essential oncogenic pathways, they frequently result in dermatologic toxicities that can impact patient quality of life and lead to dose reduction, treatment interruption, or discontinuation of life-prolonging therapy^1. Effective management of these toxicities is critical not only for preserving skin integrity…

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44 Microvascular inflammation in the kidney transplant, beyond acute antibody-mediated rejection

推荐理由: 该综述系统梳理了微血管炎症的最新机制和Banff分类更新，对移植免疫学有参考价值，但与血液疾病的直接关联较弱，阅读价值一般。

摘要: PURPOSE OF REVIEW: Microvascular inflammation (MVI) is a central feature of allograft rejection, traditionally associated with antibody-mediated rejection (AMR), but its mechanisms and clinical impact extend beyond this framework. This review highlights recent updates in the Banff classification, insights into the mechanisms underlying MVI, and how these developments may refine diagnostic approaches and guide the development of therapeutic strategies.

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45 Development of a Health-Related Quality of Life Tool for Adolescents and Young Adults With Cancer

推荐理由: 该研究开发了适用于不同文化背景的青年癌症患者的HRQOL量表，方法学上具备一定创新性和可靠性，但与血液疾病关联度低，阅读价值相对有限。

摘要: CONCLUSIONS AND RELEVANCE: In this survey study, a measurement tool was developed and tested that captures HRQOL issues of importance and relevance to AYAs from diverse cultures and with different cancer and treatment types. This HRQOL questionnaire could be a reliable and valid tool for both clinical trials and practice.

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46 Continuous fabrication of Janus liquid crystal elastomer fibers with programmable actuation

推荐理由: 该文在软体机器人和自适应纺织材料领域提出了创新的Janus LCE纤维制备技术，技术亮点突出，但与血液疾病研究关联度低，阅读价值主要限于材料与工程方向。

摘要: Smart fibers, particularly liquid crystal elastomer (LCE) fibers, are pivotal in soft robotics and adaptive textiles. However, existing fabrication methods are limited to simple monolithic structures, hindering the realization of complex actuation behaviors. To overcome this limitation, we develop a continuous extrusion platform for producing Janus LCE fibers that emulate asymmetric biological structures, such as plant tendrils, thereby enabling sophisticated actuation. This approach seamlessly…

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47 Engineering plasmids with synthetic origins of replication

推荐理由: 该文在合成生物学领域提供了可调拷贝数的质粒设计，对血液疾病的直接研究帮助有限，但对基因工程工具的开发有一定参考价值。

摘要: Plasmids remain by far the most common medium for delivering engineered DNA to microorganisms. However, the reliance on natural plasmid replication mechanisms limits their tunability, compatibility, and modularity. Here we refactored the natural pMB1 origin and created plasmids with customizable copy numbers by tuning refactored components. We then created compatible origins that use synthetic RNA regulators to implement independent copy control. We further demonstrated that the synthetic origin…

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48 Space-time superoscillations

推荐理由: 该文提出空间‑时间叠加振荡的全新概念，创新性强，但与血液疾病研究关联度低，阅读价值主要在于提供可能的跨学科光学技术思路。

摘要: Superoscillation (SO) refers to the phenomenon in which a wavefield locally oscillates at a rate exceeding its highest spatial or temporal Fourier component. SO has enabled light to be focused into arbitrarily small hotspots, forming the basis of superresolution imaging and metrology far beyond the Abbe-Rayleigh diffraction limit. Here we show that spatial and temporal superoscillations can occur simultaneously at the same point in space-time, a phenomenon we term space-time superoscillation…

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49 Asprosin-driven metabolic-epigenetic rewiring attenuates mesenchymal stem cell senescence with therapeutic benefits for infarcted hearts

推荐理由: 该文提出的asprosin调控MSC衰老的新机制具备创新性，但实验细节和数据不足，血液疾病的直接关联有限，阅读价值一般。

摘要: CONCLUSION: Asprosin is a novel MSC-specific rejuvenation factor that antagonizes senescence through metabolic-epigenetic interplay. Targeting the asprosin-driven “Glycolysis-Lactylation-Epigenetics” axis offers a transformative strategy to enhance MSC-based therapies for ischemic heart disease.

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50 Long-lived remote ion-ion entanglement for scalable quantum repeaters

推荐理由: 该文在量子网络与量子中继技术方面具有创新性和方法学价值，但与血液疾病研究关联度极低，阅读价值对血液学研究者有限。

摘要: Quantum networks, integrating quantum communication, quantum metrology, and distributed quantum computing, could provide secure and efficient information transfer, high-resolution sensing, and an exponential speed-up in information processing^1. Deterministic entanglement distribution over long distances is a prerequisite for scalable quantum networks^(2-5). However, the exponential photon loss in optical fibres prohibits efficient and deterministic entanglement distribution. Quantum repeaters^6,…

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51 2D/2D phosphorene/BiOI S-scheme heterojunction for subminute photocatalytic water disinfection under real sunlight

推荐理由: 该文在提升低收入地区饮用水安全的技术创新和公共健康影响方面价值突出，但与血液疾病的关联和借鉴意义有限，阅读价值一般。

摘要: Solar disinfection (SODIS), as a point-of-use (POU) water disinfection strategy for controlling waterborne microorganisms, serves millions of residents daily in over 50 low- to middle-income countries lacking basic drinking water services. However, SODIS is time consuming (6-48 h of sunlight exposure) due to its strong dependence on UV photons, which account for only  4% of the solar energy. Thus, it is desirable to capture additional energy from visible-light photons ( 50% of the solar energy)…

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52 Hierarchical design and scalable production of radiative cooling film featuring multispectral camouflage

推荐理由: 该文在多光谱伪装与辐射散热材料方面提出新颖的金属聚合物结构，技术创新度较高，但与血液疾病关联度极低，阅读价值主要限于材料科学领域。

摘要: Various outdoor scenarios demand both temperature control and self-protection from environment, which are often contradictory from the optical perspective, thus inspiring many material designs on multispectral camouflage and radiative cooling performance. However, these methods on the basis of one-dimensional photonic crystals or meta-surfaces always rely on stringent fabrication and may result in strong angular dependence. Here, we demonstrate an aluminum-polyamide 66 metal-based polymer…

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53 Harnessing the power of virtual reality technology to enhance public health genomics skills in Africa

推荐理由: 该文提出利用虚拟现实提升非洲基因组学人才培养的创新思路，虽与血液疾病关联度低，但对公共卫生人才建设和政策制定具有一定参考价值。

摘要: Africa must sustainably bridge the public health genomics skills gap to build a workforce that responds with speed, quality, and scale. Virtual reality offers a novel and cost-effective solution to address this gap, but its implementation must follow best practices.

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54 Non-inferiority of robotic versus open pancreatoduodenectomy - a systematic review and meta-analysis of prospective non-randomized and randomized trials

推荐理由: 该文聚焦胰腺手术的机器人与开放方式比较，虽提供了手术安全性的新证据，但与血液疾病关联度低，阅读价值有限。

摘要: BACKGROUND: With the recent publication of the first randomized controlled trials (RCTs) comparing robotic partial pancreatoduodenectomy (RPD) versus open partial pancreaticoduodenectomy (OPD) now providing high-level evidence, this study aims to analyze the short-term outcomes of RPD versus OPD to answer the ongoing clinical debate regarding the advantages and limitations of RPD, particularly in terms of perioperative safety.

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55 Long-term outcomes of Kono-S anastomosis for ileocecal resections in Crohn’s disease: a comparative analysis

推荐理由: 该研究虽提供了Kono‑S吻合术的长期随访数据，对外科治疗克罗恩病有一定参考价值，但与血液疾病关联度低，创新与社会影响有限，阅读价值一般。

摘要: CONCLUSION: After more than 7 years of follow-up, the Kono-S anastomosis demonstrates comparable long-term outcomes to conventional techniques in terms of recurrence, complications, and quality of life. Patient reflections suggest a potential benefit of earlier surgical intervention, highlighting the need for more proactive surgical referral in gastroenterological practice.

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56 Dual Janus foam for directional thermal management

推荐理由: 该文在材料热管理领域提出了新颖的双面Janus泡沫结构，技术创新度高，但与血液疾病研究关联度极低，阅读价值主要限于材料科学或能源利用方向的研究者。

摘要: Directional thermal management is critical for energy harvesting and utilization. The common passive radiative cooling and heating strategies free of electricity input mainly focus on regulating the solar and thermal radiation properties of materials while neglecting the thermal conduction process. The directional thermal management for harvesting thermal energy based on the rare thermal rectifying materials is usually in the absence of radiation regulation. Here, the dual Janus foams with dual…

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57 Contextual conditions define maximum energy-use threshold in low-carbon controlled environment agriculture for agri-food transformation

推荐理由: 该文虽在低碳农业领域具创新性，但与血液疾病研究关联度极低，除非关注跨学科的环境健康影响，否则阅读价值有限。

摘要: Controlled Environment Agriculture has the potential to achieve food security and lower carbon emissions in agri-food systems. However, contextual factors such as what is produced and how it is produced determine the feasibility of meeting these goals. Here we show how the use of a Maximum Energy-use Threshold, shaped by these contextual factors, can define, identify and enable low-carbon operations. Results support the potential of low-carbon controlled environment agriculture over…

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58 Ultra-low dose protocol on photon-counting computed tomography as an alternative to radiographic shunt series in the diagnosis of mechanical ventriculoperitoneal shunt complications - an ex vivo phantom study for children and adults

推荐理由: 该研究提出超低剂量CT在儿科脑室-腹腔分流术并发症检测中的可行性，虽对血液疾病关联不大，但对降低儿童辐射风险具有一定临床价值。

摘要: CONCLUSION: This study demonstrated ULD-CT as an alternative to RSS for the detection of mechanical VP shunt complications, reducing radiation doses in phantoms equivalent to 5 years of age and older while demonstrating the complications equally to RSS. This may be of clinical interest, especially in children due to the reduction of radiation risks.

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59 Risk-Adapted Lung Cancer Screening Starting Ages for Former Smokers

推荐理由: 该研究聚焦于肺癌筛查的风险分层，对血液疾病的直接贡献有限，但对公共健康政策具有一定参考价值。若您关注肺癌筛查策略，可略作阅读。

摘要: CONCLUSIONS AND RELEVANCE: This cohort study of the UK Biobank provides an empirical basis for risk-adapted starting ages for lung cancer screening among former heavy smokers.

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60 Guidelines for Reporting Studies on Large Language Models in Radiology: An International Delphi Expert Survey

推荐理由: 该文提出了针对放射学中大语言模型研究的报告指南，虽具方法学创新，但与血液疾病关联度低，血液学研究者可参考价值有限。

摘要: Large language models (LLMs) have transformative potential in radiology, including textual summaries, diagnostic decision support, proofreading, and image analysis. However, the rapid increase in studies investigating these models, along with the lack of standardized LLM-specific reporting practices, affects reproducibility, reliability, and clinical applicability. To address this, reporting guidelines for LLM studies in radiology were developed using a two-step process. First, a systematic…

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61 Experimentally confirmed ferroelectricity in organic compounds identified by database mining

推荐理由: 该文展示了有机铁电材料的高通量筛选与实验验证方法，对材料科学有创新意义，但与血液疾病关联有限，若对跨学科材料研发感兴趣可参考。

摘要: Compared to inorganic ferroelectrics, the breadth of polarization switching mechanisms in organic ferroelectrics is very broad and far from fully characterized or understood. Here, we experimentally investigate the absence or presence of ferroelectric properties in a selection of organic materials that have been identified by a data mining approach using heuristic measures to identify stretchability, aiming to assess the practical potential of this approach. From a set of 66 candidate materials,…

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62 Mechanical circulatory support for cardiogenic shock in takotsubo syndrome

推荐理由: 该研究聚焦于心源性休克的机械循环支持，虽与血液疾病关联不大，但提供了关于不同MCS装置安全性和疗效的临床观察数据，对心血管危重症管理仍有参考价值。

摘要: CONCLUSION: Active MCS has been increasingly used for the management of cardiogenic shock in patients with TTS. This observational study could not demonstrate an association with improved mortality with an Impella device, but possibly with an IABP when compared to patients with medical management only. MCS-related complications occurred more frequently in the Impella cohort than in the IABP cohort. Further data are required to confirm results of the present study.

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63 AKR1B10 reprograms neutrophils by histone lactylation to foster immune evasion in KRAS(G12C) mutation colorectal cancer liver metastasis

推荐理由: 该研究揭示了AKR1B10在KRAS(G12G)突变结直肠癌肝转移中的免疫逃逸机制，虽与血液疾病关联有限，但对肿瘤免疫微环境和中性粒细胞的研究具有一定参考价值。

摘要: CONCLUSION: AKR1B10 facilitated immune evasion of KRAS^(G12C) mutation CRLM by recruiting and reprogramming neutrophils to remodel the immunosuppressive TME, providing a potential therapeutic target for KRAS^(G12C) mutation CRLM patients.

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64 AKR1B10 reprograms neutrophils by histone lactylation to foster immune evasion in KRAS(G12C) mutation colorectal cancer liver metastasis

推荐理由: 该文仅提供结论，缺乏实验设计、数据和方法细节，难以评估其创新性和可靠性，对血液疾病的直接借鉴价值有限。

摘要: CONCLUSION: AKR1B10 facilitated immune evasion of KRAS^(G12C) mutation CRLM by recruiting and reprogramming neutrophils to remodel the immunosuppressive TME, providing a potential therapeutic target for KRAS^(G12C) mutation CRLM patients.

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65 An insect-scale artificial visual-olfactory bionic compound eye

推荐理由: 虽然与血液疾病关联不大，但该文在仿生视觉‑嗅觉微系统的创新设计上提供了前沿技术，可为血液检测传感器的多模态集成提供思路。

摘要: Compound eyes feature unique optical structures and high-efficiency image processing. The opto-olfactory nervous system of Drosophila has the characteristics of lightweight and low power consumption. Significant efforts have been dedicated to the design and manufacturing of artificial compound eye system. However, it is still challenging to construct a bionic visual-olfactory compound eye microsystem with sensitive photoelectric response and accurate olfactory perception in insect-scale,…

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66 Dynamic plastic deformation delocalization in FCC solid solution metals

推荐理由: 该文揭示了金属塑性变形的新机制，对材料科学有创新价值，但与血液疾病关联度极低，阅读价值对血液学研究有限。

摘要: Metallic materials undergo irreversible deformation under mechanical loading, leading to intense local plastic localization that reduces their mechanical performance. We identify a mechanism of plastic deformation that dynamically promotes the homogenization of plasticity in face-centered cubic solid solution-strengthened metallic alloys. We observe that this mechanism occurs within a narrow range of stacking fault energies and involves competing deformation between nanoscale twinning and slip….

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67 Electrochemical and photocatalytic generation of cis-olefin-bridged carbodication for umpolung [4+1] cycloaddition

推荐理由: 该文介绍了新型碳正离子在有机合成中的潜在应用，虽与血液疾病关联不大，但对探索新化学工具的研究者仍具一定参考价值。

摘要: Carbodications, bearing two positive charges on carbon atoms, are emerging as powerful superelectrophiles in organic synthesis. Traditionally formed through single-electron oxidation of overcrowded electron-rich alkenes or acid-mediated dehydration of diols, these species show high reactivity toward carbon-based nucleophiles. However, their reactivities with heteroatom nucleophiles like amines and water remain underexplored, largely due to difficulties in controlling oxidation and undesirable…

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68 Directed cortico-limbic dialogue in the human brain

推荐理由: 该研究在人体脑连接的电生理映射上具有创新性，但与血液疾病的直接关联较弱，仅对跨学科的神经‑血液交叉研究提供有限参考价值。

摘要: How can one trace the brain’s orderly directed signals amid a tangle of nerve fibers? Because direct access to actual brain signaling is rare in humans, the precise wiring diagrams for cortico-limbic communication during sleep and wake remain essentially unmapped, hampering progress in neuroscience. Now, a unique neurosurgical window on the human brain allows for electrically mapping cortical connections at the hospital, but studies so far have relied on average signals, masking the dynamic…

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69 Global crop-specific energy demand for irrigation

推荐理由: 该文提供了全球尺度的灌溉能耗模型，对农业与能源政策有参考价值，但与血液疾病研究关联度极低，血液学领域的读者可不必重点阅读。

摘要: Global irrigation expansion is expected to enhance agricultural productivity in underperforming cultivated areas, yet its associated crop-specific energy requirements remain insufficiently quantified. Here, we present a spatially distributed, physically based framework that estimates crop-specific irrigation energy consumption at 10 km resolution worldwide. Currently, irrigation consumes about 1.38 × 10^9 gigajoules per year, of which three-quarters are used by surface irrigation systems and…

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70 Formation of giant carbonatite rare earth deposits controlled by deep-seated magma chambers

推荐理由: 该文在碳酸盐岩相关稀土矿床形成机制方面提供了新实验数据和方法，但与血液疾病关联度极低，阅读价值主要限于地球化学或资源开发领域。

摘要: Carbonatite-associated rare earth element (REE) deposits are currently the primary source of REE resources. Their formation requires REE enrichment during prolonged magma evolution, achieved by suppressing REE-rich mineral crystallization and promoting REE-enriched brine melt formation. Our experiments on the fractional crystallization of carbonatitic magmas indicate that pressure (emplacement depth) is the primary factor controlling REE enrichment. High-pressure ( >0.3 GPa) promotes early…

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71 Orbital exchange-mediated current control of magnetism

推荐理由: 该文在磁性材料的电控机制上提供新思路，但与血液疾病研究关联度极低，阅读价值主要限于材料与物理领域的专家。

摘要: Electrical control of magnetism is critical for advancing both fundamental understanding and technological applications of magnetic systems. Although gate-voltage-induced carrier modulation enables tuning of magnetic properties, current-induced mechanisms offer more dynamic and versatile control. To date, such control has been investigated exclusively through spin exchange interactions between itinerant and localized electrons, leaving the role of orbital exchange interactions entirely…

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72 Associations of biomarkers with hypoattenuated leaflet thickening after transcatheter aortic valve replacement

推荐理由: 该探索性研究仅提供假设性关联，统计显著性在多重校正后消失，数据可靠性不足，虽涉及血液凝血与炎症标志物，但结论不

摘要: CONCLUSION: This exploratory study identified associations between HALT and biomarkers of hypercoagulability and inflammation, which did not persist after correction for multiple testing. These findings should be regarded as hypothesis-generating and warrant confirmation in future studies.

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73 Feasibility and diagnostic accuracy of a capsule-sponge device for esophageal squamous neoplasia (EDEN trial)

推荐理由: 该研究聚焦于食管早期癌的胶囊海绵筛查技术，与血液疾病关联度极低，且仅提供结论缺乏详细方法和数据，阅读价值有限。

摘要: CONCLUSION: In this case-enriched cohort, the capsule-sponge was safe and feasible, and cytology with adjunct p53-IHC showed high accuracy for ESN/early ESCC. Validation in asymptomatic high-risk cohorts is warranted to define real-world performance and triage utility (NCT04192695).

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74 Implementing body composition assessment into clinical practice in patients with acute spinal cord injury- a pilot feasibility study

推荐理由: 该研究主要聚焦于营养评估路径的可行性和依从性，对血液疾病的直接关联和借鉴价值极低，阅读价值有限。

摘要: CONCLUSIONS: The ATSCI-Nut pathway is a feasible and acceptable model to deliver body composition assessment despite mixed adherence to the pathway overall. However, barriers to optimal patient care and pathway adaptations need to be explored to improve adherence.

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75 The 7E Teaching Model in Emergency Obstetrics and Gynecology Training: Enhancing Clinical Competency in Residency Education

推荐理由: 该研究聚焦于产科急诊教育模式，与血液疾病关联度低，且方法学局限明显，血液学研究者阅读价值有限。

摘要: CONCLUSION: The 7E-structured curriculum was associated with improved satisfaction and performance across multiple competency domains. The 7E model shows promise as a structured paradigm for competency-based emergency OBGYN education, although causal inferences are limited by the nonrandomized design and single-institution context.

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76 Histone lactylation-derived TET2 enhanced Arg1-mediated MDSC immunosuppression

推荐理由: 该文仅在结论中提到组蛋白乳酸化调控TET2，创新点有限且缺乏实验细节，对血液疾病的直接关联和实际应用价值不明确，阅读价值不高。

摘要: CONCLUSION: This research reveals that the histone lactylation-mediated alteration of TET2 presents a novel therapeutic target for cancer treatment.

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77 Histone lactylation-derived TET2 enhanced Arg1-mediated MDSC immunosuppression

推荐理由: 该文仅在结论中提出组蛋白乳酸化调控TET2作为癌症新靶点，缺乏实验细节和血液疾病相关数据，阅读价值有限。

摘要: CONCLUSION: This research reveals that the histone lactylation-mediated alteration of TET2 presents a novel therapeutic target for cancer treatment.

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78 An all-in-one Ag<sub>2</sub>Se-based flexible solar-thermoelectric generator with photothermal integration

推荐理由: 该文在柔性光热电发电技术上有创新，但与血液疾病研究关联度极低，阅读价值对血液学者有限。

摘要: Flexible solar-thermoelectric generators hold great promise for efficient solar energy harvesting and power supply in wearable electronics. However, the achievement of strong photothermal and thermoelectric performance simultaneously within a single material remains a significant challenge. Here, we propose a fully integrated solar-thermoelectric generator that directly employs Ag(2)Se thermoelectric thin films as the light-absorbing terminal, combined with a bottom infrared-reflective layer and…

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79 Breaking activity-selectivity-stability trade-offs in reverse water-gas shift reaction via high-energy micro-faceted Mo<sub>2</sub>N nanocrystals

推荐理由: 该文主要聚焦于逆水煤气变换反应的催化剂设计，与血液疾病研究关联度极低，除非关注跨学科的材料科学与环境技术，否则阅读价值有限。

摘要: The reverse water-gas shift reaction (RWGSR) is essential for converting CO(2) into fuels using renewable hydrogen, but it remains challenged by the difficulty of simultaneously maximizing catalyst activity, selectivity, and stability. These limitations stem from thermodynamic constraints - specifically, the Gibbs-Curie-Wulff theorem - which restricts the synthetic accessibility of high-energy micro-faceted nanocrystals via conventional methods. To address this, we introduce a near-surface…

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80 Novel, non-invasive technique for fracture reduction in rare pertrochanteric femur fractures in patients with ipsilateral above-knee amputation: a technical report

推荐理由: 该文主要探讨截肢患者骨折复位的新技术，与血液疾病关联度低，且缺乏具体数据和方法学细节，阅读价值有限。

摘要: CONCLUSION: This novel technique provides a safe alternative for fracture reduction in amputees, avoiding the risks associated with invasive hardware. It offers advantages such as minimal soft tissue disruption, which might subsequently improve patient outcomes. Further studies with larger cohorts are necessary to validate its efficacy and determine its broader applicability in clinical practice.

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81 RETRACTION: Histone Lactylation-Driven Upregulation of VRK1 Expression Promotes Stemness and Proliferation of Glioma Stem Cells

推荐理由: 该论文已被撤稿，研究可信度和方法学均存疑，且与血液疾病关联度极低，阅读价值有限。

摘要: J. Li, C. Tang, X. Zhang, R. Xing, and Q. Guo, “Histone Lactylation-Driven Upregulation of VRK1 Expression Promotes Stemness and Proliferation of Glioma Stem Cells,” Advanced Science 12, no. 44 (2025): e03897, https://doi.org/10.1002/advs.202503897. The above article, published online on 24 September 2025, in Wiley Online Library (http://onlinelibrary.wiley.com/), has been retracted by agreement between the authors; the journal Editor-in-Chief, Kirsten Severing; and Wiley-VCH GmbH. Following…

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82 The microwave phase locking in Bloch transistor

推荐理由: 该文主要聚焦量子相位滑移和超导器件，对血液疾病研究直接帮助有限，除非关注跨学科量子技术在医学仪器中的潜在应用，否则不必阅读。

摘要: Recent experimental demonstration of the quantum coherent phase slip and current quantization in the superconductors, the fundamental phenomena dual to the coherent Cooper pair tunneling and voltage quantization (Shapiro steps), enables the development of a new quantum device, the Bloch transistor (BT). BT has a unique functionality: it can deliver quantized non-dissipative current to the quantum circuit. BT consists of two coupled Josephson Junctions (JJ) in the regime of coherent quantum phase…

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83 Publisher Correction: Deciphering the role of complement system genes in pancreatic cancer susceptibility and prognosis

推荐理由: 由于没有提供摘要或任何文章内容，无法评估其创新性、方法学严谨性、数据可靠性以及对血液疾病的相关性和社会影响，故不推荐阅读。

摘要: No abstract

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84 Effects beyond prognosis: Do SGLT2 inhibitors prevent electrical dyssynchrony in HFpEF?

推荐理由: 由于没有提供摘要或任何内容，无法评估该文章的创新性、方法学严谨性、数据可靠性以及对血液疾病的相关性和社会影响，建议先获取全文或摘要后再进行评估。

摘要: No abstract

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85 RETRACTION: Histone Lactylation-Driven Upregulation of VRK1 Expression Promotes Stemness and Proliferation of Glioma Stem Cells

推荐理由: 该论文已被撤稿，数据可靠性存疑且与血液疾病关联度极低，阅读价值有限。

摘要: J. Li, C. Tang, X. Zhang, R. Xing, and Q. Guo, “Histone Lactylation-Driven Upregulation of VRK1 Expression Promotes Stemness and Proliferation of Glioma Stem Cells,” Advanced Science 12, no. 44 (2025): e03897, https://doi.org/10.1002/advs.202503897. The above article, published online on 24 September 2025, in Wiley Online Library (http://onlinelibrary.wiley.com/), has been retracted by agreement between the authors; the journal Editor-in-Chief, Kirsten Severing; and Wiley-VCH GmbH. Following…

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86 Author Correction: Albumin orchestrates a natural host defence mechanism against mucormycosis

推荐理由: 由于未提供摘要，无法判断研究创新性、方法严谨性及血液疾病的相关性，阅读价值有限。

摘要: No abstract

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87 Genome contamination may lead to an overestimation of horizontal gene transfer inferences

推荐理由: 由于未提供摘要，无法判断该文的创新性、方法学严谨性及与血液疾病的关联性，建议先获取完整摘要或全文后再决定是否阅读。

摘要: No abstract

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88 Author Correction: Mid-infrared chirality and chiral thermal emission from twisted α-MoO<sub>3</sub>

推荐理由: 由于没有提供摘要或任何内容，无法评估该文章的创新性、方法学严谨性、数据可靠性以及对血液疾病的相关性和社会影响，建议先获取全文或摘要后再决定是否阅读。

摘要: No abstract

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89 Publisher Correction: Deciphering the role of complement system genes in pancreatic cancer susceptibility and prognosis

推荐理由: 由于没有提供摘要或任何内容，无法评估该文章的创新性、方法学严谨性、数据可靠性以及对血液疾病的相关性和社会影响，建议先获取全文或摘要后再决定是否阅读。

摘要: No abstract

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90 Author Correction: Evidence for oxygen-conserving diamond formation in redox-buffered subducted oceanic crust sampled as eclogite

推荐理由: 由于没有提供摘要或任何内容，无法评估该文章的创新性、方法学严谨性、数据可靠性以及对血液疾病的相关性和社会影响，建议先获取全文或摘要后再决定是否阅读。

摘要: No abstract

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91 Lactylation-driven METTL3 regulates wound healing by enhancing m6A/HNRNPA2B1/DNMT1 signaling in keratinocytes

推荐理由: 由于缺乏摘要和任何研究信息，无法评估创新性、方法学严谨性或对血液疾病的相关性，阅读价值极低。

摘要: No abstract

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